Non-invasive prenatal testing is at the forefront of prenatal screening. Current uses for NIPT include fetal sex determination and screening for chromosomal disorders such as trisomy 21. However, NIPT may be expanded to many different future applications. There are a potential host of ethical concerns around the expanding use of NIPT, as examined by the recent Nuffield Council report on the topic. It is important to examine what NIPT might be used for before these possibilities become consumer reality. There is (...) limited research exploring views of women on possible future uses of NIPT, particularly those of women who have undergone NIPT. In this study, we examined the views of women who undertook NIPT previously on the acceptability of and interest levels in using NIPT for a number of current and possible future applications. These included several medical conditions encompassing psychiatric, neurodevelopmental and adult-onset conditions as well as non-medical traits such as intelligence. One thousand women were invited to participate and 235 eligible surveys were received. Women generally reported an interest in using NIPT for medical conditions that severely impacted quality of life and with an onset earlier in life and stressed the importance of the accuracy of the test. Concerns were raised about the use of NIPT for non-medical traits. Respondents indicated that termination of pregnancy was not their only reason for testing, particularly in the case of sex. These results can further inform the ethical debate around the increasing integration of NIPT into healthcare systems. (shrink)

What is the nature of the fundamental relation we have to ourselves that makes each of us a self? To answer this question, Charles Larmore develops a systematic theory of the self, challenging the widespread view that the self’s defining relation to itself is to have an immediate knowledge of its own thoughts. On the contrary, Larmore maintains, our essential relation to ourselves is practical, as is clear when we consider the nature of belief and desire. For to believe or (...) desire something consists in committing ourselves to thinking and acting in accord with the presumed truth of our belief or the presumed value of what we desire. Larmore develops this conception with frequent reference to such classic authors as Montaigne, Stendhal, and Proust and by comparing it to other views of the self in contemporary philosophy. He also discusses the important ethical consequences of his theory of the self, arguing that it allows us to better grasp what it means to be ourselves and why self-understanding often involves self-creation. Winner of the Académie Française’s Grand Prix de Philosophie, _The Practices of the Self_ is that rare kind of lucid yet rigorous work that transcends disciplinary boundaries. (shrink)

Blair's account, like the intelligence field in general, treats many distinct constructs as if they were practically interchangeable – this is not self-evident. Paradigm integration and rationalization of redundant nomenclature are important for the continued development of understanding. The prior task is to demonstrate where synonymity of constructs across paradigms occurs, and where it fails. We present arguments why this is the case. (Published Online April 5 2006).

Dynamic Consent is both a model and a specific web-based tool that enables clear, granular communication and recording of participant consent choices over time. The DC model enables individuals to know and to decide how personal research information is being used and provides a way in which to exercise legal rights provided in privacy and data protection law. The DC tool is flexible and responsive, enabling legal and ethical requirements in research data sharing to be met and for online health (...) information to be maintained. DC has been used in rare diseases and genomics, to enable people to control and express their preferences regarding their own data. However, DC has never been explored in relationship to historical collections of bioscientific and genetic heritage or to contexts involving Aboriginal and Torres Strait Islander people.In response to the growing interest by First Peoples throughout Australia in genetic and genomic research, and the increasing number of invitations from researchers to participate in community health and wellbeing projects, this article examines the legal and ethical attributes and challenges of DC in these contexts. It also explores opportunities for including First Peoples' cultural perspectives, governance, and leadership as a method for defining DC on cultural terms that engage best practice research and data analysis as well as respect for meaningful and longitudinal individual and family participation. (shrink)

Christian Baatz argues that individuals have a moral duty to reduce their emissions ‘as far as can be reasonably demanded of them’. In this commentary, I argue that Baatz fails to establish...

We recently discovered a novel subset of beta cells that resemble immature beta cells during pancreas development. We named these “virgin” beta cells as they do not stem from existing mature beta cells. Virgin beta cells are found exclusively at the islet periphery in areas that we therefore designated as the “neogenic niche.” As beta cells are our only source of insulin, their loss leads to diabetes. Islets also contain glucagon‐producing alpha cells and somatostatin‐producing delta cells, that are important for (...) glucose homeostasis and form a mantle surrounding the beta cell core. This 3D architecture is important and determines access to blood flow and innervation. We propose that the distinctive islet architecture may also play an important, but hitherto unappreciated role in generation of new endocrine cells, including beta cells. We discuss several predictions to further test the contribution of the neogenic niche to beta cell regeneration. (shrink)

It is now more than a decade since the release of the Royal Society and Royal Academy of Engineering’s seminal report on nanosciences and nanotechnologies. The report, for the first time, brought together the spectrum of scientific and societal issues underpinning the emergence of the technology. In articulating 21 recommendations, the RA/RAEng provided the United Kingdom Government—and others—with an agenda on how they could, and should, deal with the disparate aspects of the technology. The report provides a baseline to measure (...) progress against. By focusing on the eight recommendations that dealt specifically with regulation and governance, I reflect on the extent, and nature, of this progress; identify key actors in shaping the evolving governance framework; and, importantly, distinguish areas where progress appears to have lagged. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:From the Front NICOLAS ALIFERIS (Translated by Avi Sharon) The poems in Nicolas Aliferis’s 1998 collection “From the Front” offer a panorama of postcard views and epistolary voices from across the Greek oikoumene during the years 1897 through 1922. While the title has military tones, they are not all soldier’s letters. In point of fact, this was a period when the territorial limits of Greece, “the Front,” were (...) undergoing near constant alteration—“like the ink drunk in by blotting paper” as Seferis wrote in a poem about Europe at the beginning of the Second World War. The front, therefore, could be almost anywhere during this period, and certainly in the minds of almost every Greek. The Greco-Turkish War of 1897, stemming from irredentist forces in Crete, was the earliest outbreak, and put that island on a path toward union with the mainland. After that came the string of Balkan conflagrations before, during, and after ww i, that would more than double the land mass and population of Greece. The sequence of Treaties that, one by one, concluded each stage in these disputes (from that of Constantinople in 1897, to Sevres in 1920) brought Crete, Epirus, much of Macedonia, and then Thrace and the Dodecanese islands within the limits of Greece proper. The “front” was therefore more an idea than a line on a map, and the experience of it was not limited to actual soldiers in real trenches. The distinct personae that animate each poem range from conscripts in training camps to villagers turned mercenaries to city-bound merchants and other figures, high and low. The poems themselves are drawn from various sources: some were personal letters in the poet’s own family archive, others were drawn from written history arion 28.2 fall 2020 124 from the front and newspaper scraps, while some are more purely hypothetical. They present an imaginary memento of the experiences and voices of that period, and the struggle, personal and national, that helped inform the shape and meaning of what Greece is today. Nicolas Aliferis 125 the death of chakalarov We did away with Chakalarov and Popov, those terrors to the villages. They’d collect our lira then make their way to the north. When word reached Macedonia it was a huge relief. Now we’re in the mountains, all sixteen of us, walking the trails covered in fog, holed up in the rocks, always on lookout. The cold is fierce: ice, snow, gnashing teeth. Our enemies raging and the Bulgarians wild as bears. So much blood, deep red. Beyond to the east, gleaming peacefully, the lakes, Ostrovou and Sorovitz. 126 from the front dombro betser I received your letter. With so much happening here there was little time to write. But we haven’t forgotten you; every day there’s some mention of your name. How are you finding Macedonia— her mountains, her rivers? You were not joking with our neighbors, I see. Where will this story end for us? The teacher from the Monastery, she asks about you: “And Mr. Pelopidas...” she begins, then lowers her eyes. Here the knives are out. Oh Lord, will we ever get over it? Nicolas Aliferis 127 adrianople 1920 I am well and wish you the same. Living is cheap here— a chicken costs just two and a half drachmas. Lately I’ve gotten to know all the upper level subordinates and quite a few merchants, Turks and Jews. In the evening there’s either study or cards. As for what you write: I say we should learn from the Belgians, Pantelis, just a little. Otherwise, I’m afraid, our race is finished! 128 from the front training camp, 1918 I’ve sent three letters and received none. Only yesterday I heard news from the trenches: the deeds of Yanni and Bicha, how they died. It rained today and is raining still. I sit alone (it’s been a while...) and write you. My comrades are outside, their eyes glued to the open spaces. How necessary for the soul— amid this solitude— to feel human. The need to hear the breath of a comrade, to stand above his gaze, to half close your... (shrink)

To combat the OneHealth threat of antimicrobial resistance (AMR), the use of antibiotics in agriculture is subject to significant governance-led initiatives to change food system behaviours, including promoting more responsible use of antibiotics on farms through market-level interventions. To combat knowledge gaps about how consumers perceive risks associated with antibiotic use and AMR in farming, the current study carried out an in-depth qualitative focus group study incorporating a risk information exposure exercise with food consumers on the island of Ireland (_n_ (...) = 36). Using a theoretical lens of social representation theory, a thematic analysis of the collected data identified how participants made sense of, often new, information on agricultural antibiotic use and AMR. Participants displayed high awareness and concern for AMR but low understanding and misconceptions around AMR transmission from the agri-food sector. Social representations about antibiotics and food and farming systems shaped preferences for a movement away from antibiotics in farming, and in particular, prophylactic use. However, participants acknowledged the role of antibiotics to protect animal health and the integrity of the food supply chain. They debated the lack of a simple fix to antibiotics in the agri-food system and revealed preferences for preventive actions at farm level and supporting actions at market level. The study highlights the need to first tackle low levels of public understanding through effective risk communication including strategies such as targeted message framing and proactive, cross-sector OneHealth awareness campaigns, followed by the introduction of a trusted antibiotic use food labelling system. (shrink)

Although their doctrinal propositions differ significantly, process theology and evangelical theology may find common cause by considering convergences of method. These possibilities are currently limited by underlying assumptions about authority and openness to novelty that characterize the opposing camps. The methodology of Karl Barth holds out the promise of reinvigorating evangelical theology through an appreciation of his willingness to consider novel conclusions that spring from familiar premises. Likewise, process theology should emulate Barth’s passion for the historical doctrines of the Christian (...) faith and the rich resources of scripture. In lieu of the divisions created by the categories of authority and obedience, process and evangelical thinkers alike can reorient themselves toward shared sources in terms of fidelity and loyalty, and therein find common ground. (shrink)

Engaging images accompany information about animal control officers. The combination of high-interest subject matter and light text is intended for students in grades 3 through 7.

"Does God Take Naps? answers questions such as Does God live in a house? Does God have a family? How can I talk to God? Does God have a nickname? How does God talk to me? How old is God? Does God go to church?"--Amazon.com.

This article uses a case study of vocational training in Norway to explore the conditions under which employers will cooperate to increase the skill level of their workforce. It generates two sets of insights into the political economy of training in coordinated market economies. First, by demonstrating that cooperation among employers was a recent achievement that required the creation of specific, targeted mechanisms, it suggests that a cooperative outcome is difficult to attain, even amid the generally hospitable institutional environment characteristic (...) of these economies. Second, it demonstrates that the employer collective action problem with respect to the initial training of apprentices differs from that posed by the additional raining of experienced workers. This means that even within a single economy, there are several varieties of training politics, each characterized by different patterns of cooperation and conflict; this further complicates the task of creating a coordinated training regime. (shrink)

Introduction of human plasma protein genes into the mouse genome to produce transgenic mice furnishes an in vivo model for correlating chromosomal DNA sequences with developmental and tissue‐specific expression. The liver produces an array of plasma proteins that circulate throughout the body contributing to homeostasis. Non‐hepatic tissue sites of synthesis have been identified where a local provision of plasma proteins in needed. Analysis of expression of human plasma protein genes in ageing transgenic mice appears especialy promising in identifying DNA sequences (...) that respond to environmental adversities such as inflammatory factors, hormonal changes and metal toxicity. The results indicate that human genes encoding and controlling liver plasma proteins serve as useful models for studying genetic regulation in the background of development and ageing. (shrink)

This essay explores the contingency of music's value, and the significant ways that contingency qualifies (or should qualify) our understandings of the utility of instructional method. More specifically, it raises the possibility that the altruistic pursuit of methodological purity may serve ends dramatically different than those espoused by practitioners. Music making, music study, and music learning may be liberating, empowering, and educational; but they may also serve precisely opposite ends. More simply put, neither music nor its study is unconditionally or (...) inherently good. The essay explores various ways nihilism may be manifest in musical/instructional practices, and advances alternatives grounded in agency, action, and the acceptance of resistance and responsibility. (shrink)

This essay argues that making a diagnosis in medicine is essentially a hermeneutic enterprise, one in which interpretation skills play a major part in understanding a disease. The clinical encounter is an event comprised of two voices; one is the voice of science which is grounded in empiricism, the other is that of human experience, which is grounded in story-telling and the interpretation of those stories.Using two voices, one from the Diagnostic and Statistical Manual of Mental Disorders-III-Revised, which describes alcohol (...) abuse and alcohol dependence, and the other, that of Claire, a character in Edward Albee's play, A Delicate Balance, who is conversing with her brother-in-law, Tobias, I apply principles from Hans-Georg Gadamer's hermeneutics to the clinical diagnostic process. The essay will demonstrate that we overlook an enormous amount of information about alcoholism by an overreliance on objective data and that our hope for understanding alcoholics is in listening to their voices, and sharing the interpretation of their experiences with them. (shrink)

After the publication of the Foundations of the Entire Wissenschaftslehre was greeted with largely uninformed and hostile criticism, Fichte claimed that the presentation of his ideas in this work had been deficient and thus resolved to recast them in a new and more intelligible form. Many of the works written during the rest of his years in Jena, which ended with his resignation in 1799, were intended to overcome the difficulties involved in understanding the original version of the Wissenschaftslehre.

The scope of noninvasive prenatal testing (NIPT) could expand in the future to include detailed analysis of the fetal genome. This will allow for the testing for virtually any trait with a genetic contribution, including “non-medical” traits. Here we discuss the potential use of NIPT for these traits. We outline a scenario which highlights possible inconsistencies with ethical decision-making. We then discuss the case against permitting these uses. The objections include practical problems; increasing inequities; increasing the burden of choice; negative (...) impacts on the child, family, and society; and issues with implementation. We then outline the case for permitting the use of NIPT for these traits. These include arguments for reproductive liberty and autonomy; questioning the labeling of traits as “non-medical”; and the principle of procreative beneficence. This summary of the case for and against can serve as a basis for the development of a consistent and coherent ethical framework. (shrink)

I outline the current debate over the European Union democratic deficit in terms of differing methodological approaches towards the realization of freedom and basic rights to political participation. Federalists opt for a model of freedom as noninterference and autonomous self-determination by proposing to tie basic rights in the EU to a univocal form of European-wide popular sovereignty. Although skeptics argue that the EU lacks the fundamental basis for such European-wide democratic self-determination, they ultimately defend a similar view of freedom as (...) noninterference with their appeal to the collective will of the member states. Democratic revisionists instead point to the novel democratic potential of institutions in the EU such as the Open Method of Coordination for mediating overlapping sovereignties. I conclude using the example of basic rights to effective participation for immigrants and minorities to illustrate the strengths of the revisionist view over views that appeal to the principle of subsidiarity. (shrink)