This month the American Journal of Bioethics examines the intersectionality of medicine, ethics, and race. In “Race, Power, and COVID-19: A Call for Advocacy Within Bioethics,” Mithani and colleagu...

Fisher’s 1918 paper accomplished two distinct goals: unifying discrete Mendelian genetics with continuous biometric phenotypes and quantifying the variance components of variation in complex human characteristics. The former contributed to the foundation of modern quantitative genetics; the latter was adopted by social scientists interested in the pursuit of Galtonian nature-nurture questions about the biological and social origins of human behavior, especially human intelligence. This historical divergence has produced competing notions of the estimation of variance ratios referred to as heritability. Jay (...) Lush showed that they could be applied to selective breeding on the farm, while the early twin geneticists used them as a descriptive statistic to describe the degree of genetic determination in complex human traits. Here we trace the early history of the heritability coefficient now used by social scientists. (shrink)

Studies of multiple paternity in mammals and other animal species generally report proportion of multiple paternity among litters, mean litter sizes, and mean number of sires per litter. It is shown how these variables can be used to produce an estimate of the probability of reproductive success for a male that has mated with a female. This estimate of male success is more informative about the mating system that alternative measures, like the proportion of litters with multiple paternity or the (...) mean number of sires per litter. The probability of success for a mated male can be measured both theoretically and empirically, and gives an estimate of the intensity of sperm competition and of a male's “confidence of paternity” upon mating. The probability of success for mated males for ten “exemplar” species of mammals is estimated and they are compared for insights into the functioning of their mating systems. (shrink)

Scientific peer reviewers play an integral role in the grant selection process, yet very little has been reported on the levels of participation or the motivations of scientists to take part in peer review. The American Institute of Biological Sciences developed a comprehensive peer review survey that examined the motivations and levels of participation of grant reviewers. The survey was disseminated to 13,091 scientists in AIBS’s proprietary database. Of the 874 respondents, 76% indicated they had reviewed grant applications in the (...) last 3 years; however, the number of reviews was unevenly distributed across this sample. Higher review loads were associated with respondents who had submitted more grant proposals over this time period, some of whom were likely to be study section members for large funding agencies. The most prevalent reason to participate in a review was to give back to the scientific community and the most common reason to decline an invitation to review was lack of time. Interestingly, few suggested that expectation from the funding agency was a motivation to review. Most felt that review participation positively influenced their careers through improving grantsmanship and exposure to new scientific ideas. Of those who reviewed, respondents reported dedicating 2–5% of their total annual work time to grant review and, based on their self-reported maximum review loads, it is estimated they are participating at 56–87% of their capacity, which may have important implications regarding the sustainability of the system. Overall, it is clear that participation in peer review is uneven and in some cases near capacity, and more needs to be done to create new motivations and incentives to increase the future pool of reviewers. (shrink)

This paper discusses the reliance of numerical analysis on the concept of the standard deviation, and its close relative the variance. It suggests that the original reasons why the standard deviation concept has permeated traditional statistics are no longer clearly valid, if they ever were. The absolute mean deviation, it is argued here, has many advantages over the standard deviation. It is more efficient as an estimate of a population parameter in the real-life situation where the data contain tiny errors, (...) or do not form a completely perfect normal distribution. It is easier to use, and more tolerant of extreme values, in the majority of real-life situations where population parameters are not required. It is easier for new researchers to learn about and understand, and also closely linked to a number of arithmetic techniques already used in the sociology of education and elsewhere. We could continue to use the standard deviation instead, as we do presently, because so much of the rest of traditional statistics is based upon it (effect sizes, and the F-test, for example). However, we should weigh the convenience of this solution for some against the possibility of creating a much simpler and more widespread form of numeric analysis for many. (shrink)

Screening for asymptomatic disease is a routine aspect of contemporary public health practice. However, it is also controversial, because it leads to overdiagnosis and overtreatment, with many arguing that programmes are “ineffective,” i.e., the “costs” outweigh the “benefits.” This paper explores a more fundamental objection to screening programmes: that, even if they are effective, they are ethically impermissible because they breach the principle of non-maleficence. In so doing, it suggests a new approach to the ethics of risk, justifying a concern (...) with how policies affect individuals’ absolute ex-ante prospects. Part 1 sets up the tension between screening and non-maleficence. Part 2 introduces and motivates a novel interpretation of the non-maleficence principle, “ex-ante Do No Harm,” which resolves this tension. Part 3 defends and clarifies this principle by discussing its relationship to the ex-ante Pareto principle. Part 4 discusses the worry that risk estimates are too “subjective.”. (shrink)

This paper examines flexibility in ad hoc networks and suggests that, even with cross-layer design as a mechanism to improve adaptation, a fundamental limitation exists in the ability of a single optimization function, defined a priori, to adapt the network to meet all quality-of-service requirements. Thus, code implementing multiple algorithms will have to be positioned within the network. Active networking and programmable networking enable unprecedented autonomy and flexibility for ad hoc communication networks. However, in order to best leverage the results (...) of active and programmable networking, metrics that indicate the nature and location of required flexibility need to be developed. The primary contribution of this paper is to propose a metric that couples network topological rate of change with the ability of a generic service to move itself to an optimal location in concert with the changing network. This metric points to a fundamental tradeoff among adaptation (changing service location), performance (sophistication or estimated minimum code size of the service), and the network’s ability to tune itself to a changing ad hoc network topology. (shrink)

Among the most controversial issues in the United States is the question of whether public or private agencies should adopt preferential treatment programs or be required to pay reparations for slavery. Using a carefully reasoned philosophical approach, Stephen Kershnar argues that programs such as affirmative action and calls for slavery reparations are unjust for three reasons. First, the state has a duty to direct resources to hose persons who, through their abilities, will benefit most from them. Second, he argues (...) that, in the case of slavery, past injustice – where both the victims and perpetrators are long dead – cannot ground current claims to compensation. As terrible as slavery was, those who claim a right to compensation today owe their existence to it, he reasons, and since the events that bring about a person’s existence are normally thought to be beneficial, past injustices do not warrant compensation. Finally, even if past injustices were allowed to serve as the basis of compensation in the present, other variables prevent a reasonable estimation of the amount owed. (shrink)

We argue that heritability estimates cannot be used to make informed judgments about the populations from which they are drawn. Furthermore, predicting changes in heritability from population changes is likely impossible, and of limited value. We add that the attempt to separate human environments into cultural and non-cultural components does not advance our understanding of the environmental multiplier effect.

Charisma is a concept with a peculiar history. It arose from theological obscurity through social science, from which it passed into popular culture. As a social science concept, its significance derives in large part from the fact that it captures a particular type of leadership. But it fits poorly with other concepts in social science, and is problematic as an explanatory concept. Even Weber himself was torn in his use of the concept between the individual type-concept and a broader use (...) of it to characterize the sacral character of culture and institutions. Which use is fundamental? Neither use seems to be able to be extended to account for the other, and in practice the term serves as a heterogenous residual category. Shils’ argument that the charisma of central institutions was fundamental was an attempt to make sense of the examples of institutional charisma that fell into this residual category, such as the jury, and assimilated charisma to the idea of the holy. But this conflicts with Weber’s idea of the originary or creative character of individual charisma, which by definition cannot derive from preexisting sacral qualities. Weber’s account of individual charisma focuses on success, and this suggests the idea that the power of the charismatic leader arises from the ability to confound and surpass expectations - to be extraordinary. This allows us to reconsider ‘originary’ charisma, and assimilate it both to rational choice and to Steiner’s account of taboo. A leader who produces a change in our risk perceptions by proving our previous perceptions wrong by the success of the leader’s actions is providing a novel rational choice for us: a new option together with new estimates of the risk in a course of action. Weber explained the situation of primitive or magical morality in terms of magical charisma producing taboos that were then rationalized, leading to permanent norms - which relies on the notion of charisma without explaining it. But Steiner goes further, by suggesting that taboo represents the intellectual organization of danger through the act of interdiction. The power to interdict is not based on some other power, but rather the power to organize danger through interdiction is originary. Is there originary charisma today? Or is the commonplace use of the term ‘charisma’ a transformation of the concept into something else? In popular culture, the term refers to role-models who break new ground, and if we consider the ‘dangers’ that they appear to their audiences to overcome, the phenomenon is not so different. Charisma seems to collapse into personal style, but in a world in which the old interdicts have lost their power, style itself becomes a matter of experimental success in the face of social danger. (shrink)

A number of important decision domains, including decisions about hiring, global warming, and weather hazards, are characterized by a global–local incompatibility. These domains involve variables that cannot be observed by a single decision maker (DM) and require the integration of observations from locally available information cues. This paper presents a new bifocal lens model that describes how the structure of the environment can lead to a unique form of overconfidence when generalizing the reliability of the local environment to a global (...) scale. When the local environment does not reliably reflect the global environment, they are incompatible. While local perspectives vary across DMs, global–local incompatibility can be understood using the structure of classical test theory as the difference between (a) perceived estimates of the reliability derived from the local environment and (b) the true reliability of the local environment. I model global–local incompatibility as the difference between the true and estimated reliability when the assumptions of classical test theory are violated. Using a series of case studies and an empirical study, I demonstrate the widespread utility of this framework, and I conclude by discussing implications for cognitive–ecological theory, risk communication, and overconfidence. (shrink)

This paper investigates the possibility of extending the likelihood treatment of support to situations in which the evidence and the hypotheses supported by the evidence are all outcomes of a chance process. An example is when we ask how much support the observed sequence of heads and tails gives to the hypothesis that the next toss will be a head. I begin by discussing Sober’s approach to a problem of this type: that of estimating how much support the observation that (...) I have a mind gives to the hypothesis that you do. I criticize his approach, and offer a general solution to the problem. (shrink)

We address a previous finding in the business ethics literature in which accounting professionals in higher rank levels, i.e., “manager” or “partner” of auditing firms, appear to have lower moral reasoning ability than their junior counterparts. Prior investigations have relied upon a similar methodology for estimating ethical beliefs, namely testing “moral reasoning ability” using either the Moral Judgment Interview or Defining Issues Test. In the present study, we use a multiple vignettes approach to test for the existence of the inverse (...) rank-ethical beliefs effect. With only 2 of the 30 vignettes resulting in both managers and partners being more accepting of the ethically charged behaviors, the results presented here using this alternative methodology are generally not supportive of the inverse rank-ethical beliefs phenomenon. We also use a multivariate analysis in order to control for demographic characteristics. Our results suggest that the most robust predictor of ethical attitudes among accounting practitioners is age, not rank within a firm. (shrink)

We should adopt the following principle with regard to compensatory justice. (1) If an unjust act benefits an innocent person and there is no reasonable way to assess the amount of damages to the victim, then compensatory justice does not require that the innocent beneficiary pay compensation for those damages. We cannot reasonably assess the amount of damages to current racial minorities that have resulted from past discriminatory acts. Problems arise in determining the identity of the injured parties, the identity (...) of the injuring agents and injuring acts (and omissions), and the degree of injury that directly resulted from these acts (or omissions). Since such compensable damages cannot be accurately estimated and since white male applicants are innocent beneficiaries of past discriminatory acts, the value of compensatory justice does not justify strong affirmative action programs. (shrink)

This study has two purposes. First, the study evaluates the reliability of self-reports of argumentativeness by comparing self-reported argumentativeness with two other reports of the same target: evaluations by friends and evaluations by intimates. Second, the study examines whether particular characteristics presage a larger or smaller disparity in different reporters’ reports. We found the reliability of both the approach and avoidance subscales to be acceptable for the intimate partner’s responses, but only marginally acceptable when the scale was answered by a (...) friend; on a basic level, we did not find individuals over or under-estimating their level of argumentativeness, self-over and under estimating has limited impact on the self-reporting of argumentativeness, though males are more likely to over-report argumentativeness; and while relational history had little effect on other-reports, there were effects for same-sex couples that should be further explored. (shrink)

:Statisticians have proposed formal techniques for evaluation of treatments, often in the context of models that do not explicitly specify how treatments are generated. Under such procedures they run the risk of attributing causation in settings where the implementation neutrality condition required for causal interpretation of parameter estimates is not satisfied. When treatment assignments are explicitly modelled, as economists recommend, these issues can be formally analysed, and the existence of implementation neutrality, and therefore quantifiable causation, can be determined. Examples are (...) given. (shrink)

Purpose The purpose of this paper is to explore Turkish students’ perceived relevance of Facebook, the value of Facebook advertisements and the ethics of Facebook targeting users with advertisements. Design/methodology/approach Latent class cluster analysis is estimated to determine whether segments exist and whether covariates differ among segments. Findings Segments differ on Facebook relevance and advertisement targeting ethics and usefulness and the covariates gender, hours spent on Facebook during the week and personality. The segment that finds Facebook most relevant and uses (...) it the most disapproves of Facebook’s targeted advertisements. Facebook is an organization that relies heavily on advertising dollars for survival. This fact should be emphasized; otherwise, Facebook may not be able to sustain itself. Originality/value The paper provides an understanding of Facebook from a marketing perspective for a country at the crossroads of Europe and Asia. (shrink)

This exploration of the virtue of accurate self-appraisal in great people as seen by some philosophers argues that a justified belief in one's fundamental superiority need not entail arrogant or egotistical behaviour towards others, but can harmonize with marked tendencies to respectfulness, generosity and understanding, although not with moral permissiveness. Even if accurate self-appraisal means thinking oneself basically better, this virtue can be consistent with social dispositions that contemporary egalitarians admire. ;The proposal to interpret humility as accurate knowledge of one's (...) merits comes from current writers who reject any merit in humility's more traditional associations of self-effacement. The new humility, they claim, can apply to those preeminent in any field, who keep their exceptional merits in perspective in spite of recognizing them. This self-restraint is attributed to an underlying assumption that all persons have equal worth or rights. The thesis disputes the adequacy of this account by noting that moral virtues themselves can be regarded as merits of unrivalled importance and that, with regard to their distribution, people are basically unequal. Consequently, humility in highly moral people might be better seen as a kind of accurate self-estimate that balances an assumption of human equality with an equally crucial awareness that one's moral character and concomitant judgments are basically superior. The assumption of equality is claimed to be fully compatible with the belief in personal superiority and not the sine qua non of moral decency in social relations. ;Aristotle's megalopsuchos, or "great soul," and Spinoza's good person, while not egalitarians, know themselves morally preeminent, yet both possess many still admirable beliefs and traits. The same applies to one interpretation of Nietzsche's noble soul. These thinkers suggest the compatibility of self-preference with respectfulness towards all--sometimes especially towards the weakest--people. Kant's egalitarian view downplays any notion of personal superiority, but not convincingly. Aquinas suggests a tension between humility and moral competence in worldly dealings, but only because he tries to uphold the Aristotelian great soul while not jettisoning the recurrent Christian motif of self-denigration. (shrink)

The fundamental faith of the metaphysicians is the faith in opposite values. . . .For one may doubt, first, whether there are any opposites at all, and secondly whether these popular valuations and opposite values on which the metaphysicians put their seal, are not perhaps merely foreground estimates, only provisional perspectives, perhaps even from some nook, perhaps from below, frog perspectives, as it were, to borrow an expression painters use. For all the value that the true, the truthful, the selfless (...) may deserve, it wouldstill be possible that a higher and more fundamental value for life might have to be ascribed to deception, selfishness, and lust. . . .Maybe! (Nietzsche, BGE, #2). (shrink)

There is a large literature on social epistemology, some of which is concerned with expert knowledge. Formal representations of the aggregation of decisions, estimates, and the like play a larger role in these discussions. Yet these discussions are neither sufficiently social nor epistemic. The assumptions minimize the role of knowledge, and often assume independence between observers. This paper presents a more naturalistic approach, which appeals to a model of epistemic gain from others, as mutual consilience—a genuinely social notion of epistemology. (...) Using the example of Michael Polanyi’s account of science as an illustration, it introduces the notion of double heuristics: that individuals, each with their own heuristics, each with cognitive biases and limitations, are aggregated by a decision procedure, like voting, and this second order procedure produces its own heuristic, with its own cognitive biases and limitations. An example might be the limited ability of democracies to assimilate expert knowledge. (shrink)

Food insecurity, and its extreme form, hunger, occur whenever the accessibility to an adequate supply of nutritional and safe foods becomes restricted or unpredictable. They are recurring problems in certain regions of the US, as well as in many parts of the world. According to nation-wide surveys conducted by the US Bureau of the Census, between 1996 and 1998 an estimated 9.7% of US households were classified as food insecure (6.2% being food insecure without evidence of hunger, and 3.5% being (...) food insecure with moderate to severe hunger). This means that approximately 10 million households each year did not always have access to enough food to meet basic needs. A potential tool in the fight against food insecurity and hunger is information technology (IT), since its use and range of application continue to grow at astonishing rates. The study presented here examined the question of how information technology, particularly the Internet, can be used to promote food security. The study used an action science research approach, and a case study strategy, with the food security system of Oktibbeha County, Mississippi selected as the case for study. The research design was a two-phase process. Phase one consisted of a needs assessment among food assistance organizations in Oktibbeha County, and included interviews of key food assistance personnel. Phase one also included a survey of IT subject matter experts to seek their opinions about the current state of Web-based information technology. Phase two involved an analysis of various IT implementation issues, as well as the development of a Web-based food security information system prototype tool. The needs assessment results indicated that (a) certain food security system and information needs existed among the food assistance organizations in Oktibbeha County, and (b) appropriate information technologies existed that could be applied to these needs. The food security needs related to better communication and coordination of information, such as program information, food site inventory information, client history information, food donation information, and nutrition education information. In regard to technology development, a variety of scenarios were examined. These included client-side approaches, server-side approaches, simple e-mail-based systems, Java-based systems, systems based on the Common Gateway Interface (CGI), and commercial database systems. In applying the needs assessment and survey results, the researcher developed a prototype Web site (including a series of online database tools) that could be used to promote food security in counties such as Oktibbeha County. The results of this research show that appropriate, Internet-based, IT holds promise for the reduction of certain social problems, such as food insecurity and hunger. (shrink)

In a recent paper [2] David Lewis offered an extremely interesting and, if correct, important solution to the main unsolved problem of Carnap's program for inductive logic—the choice of an appropriate C-function. The gist of Lewis' solution is to first obtain a pilot sample from the target population and then select, on the basis of this sample, from among the immodestλ-methods. An immodest inductive method is one which estimates that the mean squared error of its estimates of population relative frequencies (...) is less than or equal that of any other inductive method. By great ingenuity Lewis apparently shows that on any evidence e there is one and only one immodest λ-method. I will attempt to show that Lewis made a conceptual error in formulating the equations to be solved and that when it is corrected it can be easily demonstrated that all admissible λ-methods are immodest and hence that Lewis' criterion is of no value. (shrink)

Summary Contrary to previous views of an acute shortage of chemists at the beginning of the twentieth century, this study found that the number of chemists identifiable by name in the Manchester area was substantial, even in 1902. Moreover, the majority were qualified to some extent. The total number of chemists and their degree of formal qualification increased rapidly during the period 1902-36. Employment data demonstrate that they worked not only in the chemical industry, but in a wide range of (...) manufacturing industry and commerce. Only a relatively small proportion was employed in education. Research chemists were active in the area in the late nineteenth century: by 1936, 28% of Manchester chemists recorded their job title as research chemist or research manager. If Manchester were typical of Britain as a whole the number of chemists employed in 1902 would greatly exceed previous estimates. More speculatively, the number of chemists in Britain in 1902 may even have been comparable to that in Germany. (shrink)

We normally think that public health policy is an important political activity. In turn, we normally understand the value of public health policy in terms of the promotion of health or some health-related good (such as opportunity for health), on the basis of the assumption that health is an important constituent or determinant of wellbeing. In this paper, I argue that the assumption that the value of public health policy should be understood in terms of health leads us to overlook (...) important benefits generated by such policy. To capture these benefits we need to understand the ends of public health policy in terms of the promotion of 'physical safety'. I then go on to argue that the idea that 'health' is an important category for evaluating or estimating individuals' wellbeing in the normative context of social policy is confused. I then clarify the relationship between my arguments and QALY-based accounts of health assessment. In the final section of the paper, I defend this surprising conclusion against various attacks. (shrink)

There is a widespread assumption that Berkeley and Spinoza have little in common, even though early Jesuit critics in France often linked them. Later commentators have also recognized their similarities. My essay focuses on how Berkeley 's comments on the Arnauld-Malebranche debate regarding objective and formal reality and his treatment of god's creation of finite minds within the order of nature relate his theory of knowledge to his doctrine in a way similar to that of Spinoza. On estime souvent (...) que Berkeley et Spinoza ont peu en commun, même si les premières critiques jésuites en France les ont souvent liés. D'autres commentateurs ont également reconnu leurs similitudes. Mon essai se concentre sur la manière dont 1 / les remarques de Berkeley sur la discussion entre Arnauld et Malebranche concernant la réalité objective et formelle et 2 / son traitement de la création par Dieu des esprits finis dans l'ordre de la nature mettent en relation sa théorie de la connaissance et sa doctrine de la liberté dans une manière semblable à celle de Spinoza. (shrink)

We present three experiments using a novel problem in which participants update their estimates of propensities when faced with an uncertain new instance. We examine this using two different causal structures (common cause/common effect) and two different scenarios (agent‐based/mechanical). In the first, participants must update their estimate of the propensity for two warring nations to successfully explode missiles after being told of a new explosion on the border between both nations. In the second, participants must update their estimate of the (...) accuracy of two early warning tests for cancer when they produce conflicting reports about a patient. Across both experiments, we find two modal responses, representing around one‐third of participants each. In the first, “Categorical” response, participants update propensity estimates as if they were certain about the single event, for example, certain that one of the nations was responsible for the latest explosion, or certain about which of the two tests is correct. In the second, “No change” response, participants make no update to their propensity estimates at all. Across the three experiments, the theory is developed and tested that these two responses in fact have a single representation of the problem: because the actual outcome is binary (only one of the nations could have launched the missile; the patient either has cancer or not), these participants believe it is incorrect to update propensities in a graded manner. They therefore operate on a “certainty threshold” basis, whereby, if they are certain enough about the single event, they will make the “Categorical” response, and if they are below this threshold, they will make the “No change” response. Ramifications are considered for the “categorical” response in particular, as this approach produces a positive‐feedback dynamic similar to that seen in the belief polarization/confirmation bias literature. (shrink)

Does natural selection favor veridical percepts—those that accurately depict objective reality? Perceptual and cognitive scientists standardly claim that it does. Here we formalize this claim using the tools of evolutionary game theory and Bayesian decision theory. We state and prove the “Fitness-Beats-Truth Theorem” which shows that the claim is false: If one starts with the assumption that perception involves inference to states of the objective world, then the FBT Theorem shows that a strategy that simply seeks to maximize expected-fitness payoff, (...) with no attempt to estimate the “true” world state, does consistently better. More precisely, the FBT Theorem provides a quantitative measure of the extent to which the fitness-only strategy dominates the truth strategy, and of how this dominance increases with the size of the perceptual space. The FBT Theorem supports the Interface Theory of Perception, which proposes that our perceptual systems have evolved to provide a species-specific interface to guide adaptive behavior, and not to provide a veridical representation of objective reality. (shrink)

The red tape and delays around research ethics and governance approvals frequently frustrate researchers yet, as the lesser of two evils, are largely accepted as unavoidable. Here we quantify aspects of the research ethics and governance approvals for one interview- and questionnaire-based study conducted in England which used the National Health Service procedures and the electronic Integrated Research Application System. We demonstrate the enormous impact of existing approvals processes on costs of studies, including opportunity costs to focus on the substantive (...) research, and suggest directions for radical system change. We have recorded 491 exchanges with 89 individuals involved in research ethics and governance approvals, generating 193 pages of email text excluding attachments. These are conservative estimates. The exchanges were conducted outside IRAS, expected to be the platform where all necessary documents are provided and questions addressed. Importantly, the figures exclude the actual work of preparing the ethics documentation. We propose six areas of work to enable system change: 1. Support the development of a broad range of customised research ethics and governance templates to complement generic, typically clinical trials orientated, ones; 2. Develop more sophisticated and flexible frameworks for study classification; 3. Link with associated processes for assessment, feedback, monitoring and reporting, such as ones involving funders and patient and public involvement groups; 4. Invest in a new generation IT infrastructure; 5. Enhance system capacity through increasing online reviewer participation and training; and 6. Encourage researchers to quantify the approvals processes for their studies. Ethics and governance approvals are burdensome for historical reasons and not because of the nature of the task. There are many opportunities to improve their efficiency and analytic depth in an age of innovation, increased connectivity and distributed working. If we continue to work under current systems, we are perpetuating, paradoxically, an unethical system of research approvals by virtue of its wastefulness and impoverished ethical debate. (shrink)

In the mid-1990s, several state legislatures enacted a "second generation" of small group health insurance reforms that required guaranteed issue of all products and prohibited the use of health as a rating factor. We use data from two large employer surveys to compare the behavior of small business in nine states that adopted these reforms between 1993 and 1997 to the behavior of small business in 11 states and the District of Columbia, where neither of these small group health insurance (...) market reforms existed prior to 1997 (N = 8,465 in 1993; N = 12,219 in 1997). Our analyses focus on several outcomes: health insurance offer and enrollment rates in any employer plan, and in an HMO plan; turnover in offer decisions; and premiums, variability in premiums, and the rate of change in premiums. Overall, we find no effect of small group reform on any of the outcomes; the sign of the effect is not consistent across reform states, the estimates rarely attain statistical significance, and they show no consistent pattern across the outcomes within each state. Therefore, predictions of the harm these regulations might cause to the market have not come to pass. On the other hand, proponents' hopes for a solution to low coverage rates among small businesses have not materialized either. (shrink)

This study investigates the pattern of institutional shareholding in the U.K. and its relationship with socially responsible behavior by companies within a sample of over 500 UK companies. We estimate a set of ownership models that distinguish between long- and short-term investors and their largest components and which incorporate both aggregated and disaggregated measures of corporate social performance (CSP). The results suggest that long-term institutional investment is positively related to CSP providing further support for earlier studies by Johnson and Greening (...) (1999, Academy of Management Journal 42, 564–576) and Graves and Waddock (1994, Academy of Management Journal 37, 1034–1046). Disaggregation of CSP into its constituent components suggests that the pattern of institutional investment is also related to the form which CSP takes. Investigation of the impact of investment screens on the selection of stocks suggests that long-term institutional investors select primarily through exclusion, rejecting those firms which have the worst CSP. (shrink)

Through an interdisciplinary approach, I attempt to construct a partial ethno-agronomy of the Seneca people in late pre-contact times and examine it for relevance to modern agriculture.Diohe'ko, the Three Sisters, had been cultivated for at least five hundred years prior to contact by the Seneca, an Iroquoian tribe inhabiting western New York State. The Three Sisters, corn, beans and squash (pumpkins, gourds), were planted together in hills in fields, cultivated and harvested by work parties of women.Changes of village sites and (...) patterns of village movement respond to the adoption of agriculture as well as other factors. Evaluating land use, crop yields and carrying capacity, I question the accuracy of Seneca population estimates.The Three Sisters was an important cultural complex. The Sisters are protagonists of a number of Seneca tales, myths, ceremonies and legends.As an agricultural strategy, Three Sisters embodies several efficiencies in growth patterns, nutrient, solar and water use, harvest and nutritional use. Microhabitat manipulation was practiced by the Seneca. The plants exhibit a high degree of cooperation, or commensality, in the association.Some preliminary judgments can be made about specific varieties of the Sisters in use among the Seneca prior to contact. Northern Flint Corn, Cutshort or Cornhill Beans, and Cucurbita pepo such as Crookneck Squashes are likely the eldest varieties in the area.Three Sisters agriculture demonstrates qualities of permanence and sustainability, especially as related to the Seneca cultural fabric. A conservative ethic, like Handsome Lake's teaching, it binds together people in culture and people and nurture in nature. Mary Jemison, who farmed both the colonial and Three Sisters ways, seems to have favored the latter's “leisurely” approach. (shrink)

Categorical loudness scaling (CLS) measures provide useful information about an individual’s loudness perception across the dynamic range of hearing. A probability model of CLS categories has previously been described as a multi-category psychometric function (MCPF). In the study, a representative “catalog” of potential listener MCPFs was used in conjunction with maximum-likelihood estimation to derive CLS functions for participants with normal hearing and with hearing loss. The approach of estimating MCPFs for each listener has the potential to improve the accuracy of (...) the CLS measurements, particularly when a relatively low number of data points are available. The present study extends the MCPF approach by using Bayesian inference to select stimulus parameters that are predicted to yield maximum expected information (MEI) during data collection. The accuracy and reliability of the MCPF-MEI approach were compared to the standardized CLS measurement procedure (ISO16832:2006). A non-adaptive, fixed-level, paradigm served as a “gold-standard” for this comparison. The test time required to obtain measurements in the standard procedure is a major barrier to its clinical uptake. Test time was reduced from approximately 15 minutes to approximately 3 minutes with the MEI-adaptive procedure. Results indicated that the test-retest reliability and accuracy of the MCPF-MEI adaptive procedures were similar to the standardized CLS procedure. Computer simulations suggest that the reliability and accuracy of the MEI procedure were limited by intrinsic uncertainty of the listeners represented in the MCPF catalog. In other words, the MCPF provided insufficient predictive power to significantly improve adaptive-tracking efficiency under practical conditions. Concurrent optimization of both the MCPF catalog and the MEI-adaptive procedure have the potential to produce better results. Regardless of the adaptive-tracking method used in the CLS procedure, the MCPF catalog remains clinically useful for enabling maximum-likelihood determination of loudness categories. (shrink)

In this book a distinguished group of environmental experts argues that in order to solve global environmental problems, we must view them in a broad interdisciplinary perspective that recognizes the relations—the interconnected circle—among ecology, economics, and ethics. Currently the circle is broken, they say, because environmental policy is decided on short-term estimations of material that take little account of the economic or moral burdens that will be borne by future generations if we deplete our resources now. We must, assert the (...) authors, have a better knowledge of the science underlying our environmental problems, we must understand their causes and consequences in relation to our economic and political systems, and we must recognize that an effective response will require a shift in a technologically oriented society’s ethical attitude toward the natural environment. The authors address a wide range of concerns from global atmospheric degradation and spreading toxification of the environment to loss of forests and massive species extinctions. They offer to general readers, students, and professionals practical assessments and remedies for many of these problems. They suggest, for example, mechanisms that provide economic incentives for conservation; engineering and technical adaptations to use resources more effectively and dispose of waste products; better economic accounting procedures for measuring the real environmental costs of our depletion of natural resources; and a remodeled education system that better prepares us to see each individual’s responsibility to the environment. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:F. R. Leavis (Modern Cultural Theorists)Stephen OgdenF. R. Leavis (Modern Cultural Theorists), by Anne Samson; x & 196 pp. Toronto: University of Toronto Press, 1992, $45.00 cloth, $16.95 paper.If it is an overstatement to say that the waves of change currently disturbing the teaching of English in universities originated from the splash made by F. R. Leavis at Cambridge beginning in 1933, Anne Samson’s account of the (...) theorist’s influence scarcely admits it. Her chapter titles—“Leavis and the Growth of English Studies,” “English as a University Subject,” “Literary ‘Theory’ and Constituting the Canon”—indicate not only the range of issues connected with F. R. Leavis’s name but also his significant involvement in their genesis.Samson’s book portrays Leavis as the efficient cause in the establishment of university English as a critical, or more accurately a diagnostic, enterprise. At an early professional cost (he was denied faculty appointment at Cambridge for five years), Leavis helped cut English curricula free from philology, languages, and classical studies; a responsibility Samson partially excuses by connecting Leavis’s motivating principles back through Matthew Arnold to Dickens and Carlyle and even to one “Reverend H. J. Rose, a leading figure in the founding of King’s College, London... declaring in a sermon delivered in 1826 that literature teaches ‘the wisdom of men better and wiser than ourselves’ and prepares for the ‘examination of those moral and intellectual truths which are not only the worthiest exercise of our reason, but most concern our future destiny’” (p. 12).This moralism Samson sees as the central and redeeming principle in Leavis’s system. Specifically, she identifies the Condition of England debate—over the state of culture and economics in a “‘technologico-Benthamite world’” (p. 63)—as the key to Leavis’s literary criticism, his influential journal Scrutiny, and his wide-ranging reform endeavors. “Literature mattered to Leavis because he believed it to be the means, above all others, of combating the ills of a mechanised, constantly changing world and of restoring the heritage of those dispossessed by the machine” (p. 3).Professionally asserting the primacy of criticism over scholarship, then in his writings making no distinction between the literary and the social, Leavis ultimately refused any separation between literature and life. Samson carefully [End Page 360] traces this development in Leavis’s general theory in order to bring out its easily-overlooked implication for the social position of a literary academic. She quotes this crucial passage from Leavis: “The critic... is as much concerned with the health of the mind as any doctor with the health of the body. To set up as a critic is to set up as a judge of values... For the arts are inevitably and quite apart from any intentions of the artist an appraisal of existence” (pp. 15–16). No longer a mere scholar, or the type of irrelevant empiric Leavis so hated in the person of C. P. Snow, the Leavisite theorist is the grand physician diagnosing all society’s ills. Literary artists and their writings, so far from forming the most important part of literature, become perfectly irrelevant—“quite apart”—with the medicocritic prescribing universally “of existence.”Samson’s treatment of Leavis is analytical, though enjoyably and consistently biographical. For instance, her final, and largest, chapter shows the moralist model of the literary critic (the “judge of values”) in action by detailing the history of Leavis’s complete reversal of estimation between T. S. Eliot and D. H. Lawrence. Leavis originally gave Eliot “hero-worship” (p. 162) and dismissed Lawrence as “mechanical” (p. 157). But concurrent with Eliot’s progress to Anglo-Catholicism, Leavis’s moral judgments overturned and, true to type, he increasingly censured Eliot’s writings by diagnosing problems in the man, while he grew to idolize Lawrence; ironically for “rescuing life from... inner mechanisation” (p. 169).Such inconstancy, here expressed in every word, Samson sees as an historical mark of character which places Leavis among the “Great Men of Ideas” (p. 172).Stephen OgdenSimon Fraser UniversityCopyright © 1995 The Johns Hopkins University Press... (shrink)

We investigated cultural differences between U.S. and Japanese color preferences and the ecological factors that might influence them. Japanese and U.S. color preferences have both similarities and differences. Complex gender differences were also evident that did not conform to previously reported effects. Palmer and Schloss's weighted affective valence estimate procedure was used to test the Ecological Valence Theory's prediction that within-culture WAVE-preference correlations should be higher than between-culture WAVE-preference correlations. The results supported several, but not all, predictions. In the second (...) experiment, we tested color preferences of Japanese–U.S. multicultural participants who could read and speak both Japanese and English. Multicultural color preferences were intermediate between U.S. and Japanese preferences, consistent with the hypothesis that culturally specific personal experiences during one's lifetime influence color preferences. (shrink)

This paper provides a method for characterizing space events using the framework of conceptual spaces. We focus specifically on estimating and ranking the likelihood of collisions between space objects. The objective is to design an approach for anticipatory decision support for space operators who can take preventive actions on the basis of assessments of relative risk. To make this possible our approach draws on the fusion of both hard and soft data within a single decision support framework. Contextual data is (...) also taken into account, for example data about space weather effects, by drawing on the Space Domain Ontologies, a large system of ontologies designed to support all aspects of space situational awareness. The framework is coupled with a mathematical programming scheme that frames a mathematically optimal approach for decision support, providing a quantitative basis for ranking potential for collision across multiple satellite pairs. The goal is to provide the broadest possible information foundation for critical assessments of collision likelihood. (shrink)

We present a theoretical model and corresponding research design (Bronfenbrenner & Ceci 1994) that could yield stronger evidence for (or perhaps against) Howe et al.'s conclusions. The model assesses levels of heritability (h²) under different amounts of training and practice, thus providing estimates of the independent contribution of “innate talent” to the quality of development outcomes. The design can also reveal the extent to which this independent contribution varies systematically as a function of other influential factors identified by Howe et (...) al. (shrink)

We give a comparison inequality that allows one to estimate the tail probabilities of sums of independent Banach space valued random variables in terms of those of independent identically distributed random variables. More precisely, let X1, . . . , Xn be independent Banach-valued random variables. Let I be a random variable independent of X1, . . . , Xn and uniformly distributed over {1, . . . , n}. Put ˜.

The overall goal of the approach developed in this paper is to estimate the likelihood of a given kinetic kill scenario between hostile spacebased adversaries using the mathematical framework of Complex Conceptual Spaces Single Observation. Conceptual spaces are a cognitive model that provide a method for systematically and automatically mimicking human decision making. For accurate decisions to be made, the fusion of both hard and soft data into a single decision framework is required. This presents several challenges to this data (...) fusion framework. The first is the challenge involved in handling multiple complex terminologies, which is addressed by drawing on a set of Space Domain Ontologies. Another challenge is the complex combinatorics involved when considering all possible feature combinations. This can be mitigated by using integer linear programming optimization that is outlined by the Complex Conceptual Spaces Single Observation mathematical model framework. A third challenge is the complicated physics that is involved in a spacecraft collision that must be addressed to obtain a better understanding of threat assessment. Overcoming these various challenges allows for a quantitative ranking for the potential of a kinetic kill collision across multiple spacecraft pairs. In addition to overcoming these challenges this paper will break down threat assessment into four domains and identify a ranking of threat both for each individual domain and for the four domains combined. Simulation results are shown to verify the developed concepts. (shrink)

© 2017. The American Astronomical Society. All rights reserved.We present new observations of the low-mass companion to HD 984 taken with the Gemini Planet Imager as a part of the GPI Exoplanet Survey campaign. Images of HD 984 B were obtained in the J and H bands. Combined with archival epochs from 2012 and 2014, we fit the first orbit to the companion to find an 18 au orbit with a 68% confidence interval between 14 and 28 au, an eccentricity (...) of 0.18 with a 68% confidence interval between 0.05 and 0.47, and an inclination of 119°with a 68% confidence interval between 114°and 125°. To address the considerable spectral covariance in both spectra, we present a method of splitting the spectra into low and high frequencies to analyze the spectral structure at different spatial frequencies with the proper spectral noise correlation. Using the split spectra, we compare them to known spectral types using field brown dwarf and low-mass star spectra and find a best-fit match of a field gravity M6.5 ±1.5 spectral type with a corresponding temperature of K. Photometry of the companion yields a luminosity of log=2.88 ± 0.07 dex with DUSTY models. Mass estimates, again from DUSTY models, find an age-dependent mass of 34 ±1 to 95 ±4 M Jup. These results are consistent with previous measurements of the object. (shrink)

Chloroquine-resistant plasmodium falciparum malaria is a serious public health threat that is spreading rapidly across Sub-Saharan Africa. It affects over three quarters (80%) of malarial endemic countries. Of the estimated 300-500 million cases of malaria reported annually, the vast majority of malarial-related morbidities occur among young children in Africa, especially those concentrated in the remote rural areas with inadequate access to appropriate health care services. In Liberia, in vivo studies conducted between 1993 and 2000 observed varying degrees of plasmodium falciparum (...) malaria infections that were resistant to chloroquine, including sulfadiazine-pyrimethamine. As the country emerges from a prolonged civil war, the health care delivery system may not be adequately prepared to implement an effective nation-wide malarial control strategy. As a result, the management of uncomplicated malaria in Liberia poses a significant public health challenge for the government-financed health care delivery system. Therefore, based on extensive literature review, we report the failure of chloroquine as an effective first-line drug for the treatment of uncomplicated plasmodium falciparum malaria in Liberia and recommend that national health efforts be directed at identifying alternative drug(s) to replace it. (shrink)

Worldwide, obesity has become a major cause of preventable death, disease, and disability. While the epidemic of obesity is a significant public health issue in many developed nations, the United States has the highest prevalence of obesity among adults and children internationally. The National Health and Nutrition Examination Survey estimates that over 60 percent of U.S. adults are overweight or obese. According to the Centers for Disease Control and Prevention, “overweight” refers to adults whose body mass index, a number calculated (...) using weight and height measurements, is between 25 and 29.9. “Obese” refers to adults whose BMI is 30 or higher. Among American children and adolescents, approximately 17 percent are overweight. (shrink)

DBS Think Tank IX was held on August 25–27, 2021 in Orlando FL with US based participants largely in person and overseas participants joining by video conferencing technology. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers and researchers can freely discuss current and emerging deep brain stimulation technologies as well as the logistical and ethical issues facing the field. The consensus among the DBS Think Tank IX speakers was that DBS expanded in (...) its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. After collectively sharing our experiences, it was estimated that globally more than 230,000 DBS devices have been implanted for neurological and neuropsychiatric disorders. As such, this year’s meeting was focused on advances in the following areas: neuromodulation in Europe, Asia and Australia; cutting-edge technologies, neuroethics, interventional psychiatry, adaptive DBS, neuromodulation for pain, network neuromodulation for epilepsy and neuromodulation for traumatic brain injury. (shrink)

Rationale Treatment guidelines recommend a more conservative surgical approach than mastectomy for early stage breast cancer and a stronger emphasis on adjuvant therapy. Registry data at South Australian teaching hospitals have been used to monitor survivals and treatment in relation to these guidelines.Aims and objectives To use registry data to: (1) investigate trends in survival and treatment; and (2) compare treatment with guidelines.Methods Registry data from three teaching hospitals were used to analyse trends in primary courses of treatment of breast (...) cancers during 1977–2003 (n = 4671), using univariate analyses and multiple logistic regression. Disease-specific survivals were analysed using Kaplan–Meier product limit estimates and multivariable Cox proportional hazards regression.Results The 5-year survival was 79.9%, but with a secular increase, reaching 83.6% in 1997–2003. The relative risk of death (95% confidence limits) was 0.74 (0.62, 0.88) for 1997–2003, compared with previous diagnoses, after adjusting for tumour node metastasis stage, grade, age and place of residence. Treatment changes included an increase in conservative surgery (as opposed to mastectomy) from 51.7% in 1977–1990 to 76.8% in 1997–2003 for stage I (P < 0.001) and from 31.1% to 52.2% across these periods for stage II (P < 0.001). Adjuvant radiotherapy also became more common (P < 0.001), with 20.6% of patients receiving this treatment in 1977–1990 compared with 60.7% in 1997–2003. Radiotherapy generally was more prevalent when conservative surgery was provided, although also relatively common in mastectomy patients when tumour diameters exceeded 50 mm or when there were four or more involved nodes. The proportion of patients receiving chemotherapy increased (P < 0.001), from 19.6% in 1977–1990 to 36.9% in 1997–2003, and the proportion having hormone therapy also increased (P < 0.001), from 34.3% to 59.4% between these periods.Conclusions Survivals appear to be increasing and treatment trends are broadly consistent with guideline directions, and the earlier research on which these recommendations were based. (shrink)

Two experiments were conducted for the derivation of psychophysical scales of the following audio descriptors: spectral centroid, spectral spread, spectral skewness, odd-to-even harmonic ratio, spectral deviation, and spectral slope. The stimulus sets of each audio descriptor were synthesized and independently controlled through appropriate synthesis techniques. Partition scaling methods were used in both experiments, and the scales were constructed by fitting well-behaving functions to the listeners' ratings. In the first experiment, the listeners' task was the estimation of the relative differences between (...) successive levels of a particular audio descriptor. The median values of listeners' ratings increased with increasing feature values, which confirmed listeners' abilities to estimate intervals. However, there was a large variability in the reliability of the derived interval scales depending on the stimulus spacing in each trial. In the second experiment, listeners had control over the stimulus values and were asked to divide the presented range of values into perceptually equal intervals, which provides a ratio scale. For every descriptor, the reliability of the derived ratio scales was excellent. The unit of a particular ratio scale was assigned empirically so as to facilitate qualitative comparisons between the scales of all audio descriptors. The construction of psychophysical scales based on univariate stimuli allowed for the establishment of cause-and-effect relations between audio descriptors and perceptual dimensions, contrary to past research that has relied on multivariate stimuli and has only examined the correlations between the two. Most importantly, this study provides an understanding of the ways in which the sensation magnitudes of several audio descriptors are apprehended. (shrink)