Results for 'synthetic biology'

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  1. Synthetic Biology and the Ethics of Knowledge.T. Douglas & J. Savulescu - 2010 - Journal of Medical Ethics 36 (11):687-693.
    Synthetic biologists aim to generate biological organisms according to rational design principles. Their work may have many beneficial applications, but it also raises potentially serious ethical concerns. In this article, we consider what attention the discipline demands from bioethicists. We argue that the most important issue for ethicists to examine is the risk that knowledge from synthetic biology will be misused, for example, in biological terrorism or warfare. To adequately address this concern, bioethics will need to broaden (...)
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  2. Synthetic Biology and Synthetic Knowledge.Christophe Malaterre - 2013 - Biological Theory (8):346–356.
    Probably the most distinctive feature of synthetic biology is its being “synthetic” in some sense or another. For some, synthesis plays a unique role in the production of knowledge that is most distinct from that played by analysis: it is claimed to deliver knowledge that would otherwise not be attained. In this contribution, my aim is to explore how synthetic biology delivers knowledge via synthesis, and to assess the extent to which this knowledge is distinctly (...)
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  3.  52
    Synthetic Biology Between Technoscience and Thing Knowledge.Axel Gelfert - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (2):141-149.
    Synthetic biology presents a challenge to traditional accounts of biology: Whereas traditional biology emphasizes the evolvability, variability, and heterogeneity of living organisms, synthetic biology envisions a future of homogeneous, humanly engineered biological systems that may be combined in modular fashion. The present paper approaches this challenge from the perspective of the epistemology of technoscience. In particular, it is argued that synthetic-biological artifacts lend themselves to an analysis in terms of what has been called (...)
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  4.  31
    Knowledge-Making Distinctions in Synthetic Biology.Maureen O'Malley, Alexander Powell, Jonathan Davies & Jane Calvert - 2008 - Bioessays 30 (1):57-65.
    Synthetic biology is an increasingly high-profile area of research that can be understood as encompassing three broad approaches towards the synthesis of living systems: DNA-based device construction, genome-driven cell engineering and protocell creation. Each approach is characterized by different aims, methods and constructs, in addition to a range of positions on intellectual property and regulatory regimes. We identify subtle but important differences between the schools in relation to their treatments of genetic determinism, cellular context and complexity. These distinctions (...)
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  5.  45
    Synthetic Biology: A Bridge Between Functional and Evolutionary Biology.Michel Morange - 2009 - Biological Theory 4 (4):368-377.
    The interests of synthetic biologists may appear to differ greatly from those of evolutionary biologists. The engineering of organisms must be distinguished from the tinkering action of evolution; the ambition of synthetic biologists is to overcome the limits of natural evolution. But the relations between synthetic biology and evolutionary biology are more complex than this abrupt opposition: Synthetic biology may play an important role in the increasing interactions between functional and evolutionary biology. (...)
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  6.  39
    Synthetic Biology Needs A Synthetic Bioethics.Paul B. Thompson - 2012 - Ethics, Policy and Environment 15 (1):1 - 20.
    Recent developments in synthetic biology are described and characterized as moving the era of biotechnology into platform technologies. Platform technologies enable rapid and diffuse innovations and simultaneous product development in diffuse markets, often targeting sectors of the economy that have traditionally been thought to have little relationship to one another. In the case of synthetic biology, pharmaceutical and biofuel product development are occurring interactively. But the regulatory and ethical issues associated with these two applications share very (...)
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  7.  14
    Synthetic Biology: From Having Fun to Jumping the Gun.Manuel Porcar - 2016 - NanoEthics 10 (1):105-109.
    Synthetic biology aims at making life easier to an engineer by applying biotechnology engineering principles such as standardization and modularity. I argue that living organisms are inherently non-machine, non-standardized entities and that the current state-of-the-art in SynBio combines pre- and post-standardization efforts, in a scenario without evidence that full standardization in biology is even possible. I finally propose a new view on SynBio based on purpose rather than on technicalities.
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  8. Can Synthetic Biology Shed Light on the Origin of Life?Christophe Malaterre - 2009 - Biological Theory 4 (4):357-367.
    It is a most commonly accepted hypothesis that life originated from inanimate matter, somehow being a synthetic product of organic aggregates, and as such, a result of some sort of prebiotic synthetic biology. In the past decades, the newly formed scientific discipline of synthetic biology has set ambitious goals by pursuing the complete design and production of genetic circuits, entire genomes or even whole organisms. In this paper, I argue that synthetic biology might (...)
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  9. The Mismeasure of Machine: Synthetic Biology and the Trouble with Engineering Metaphors.Maarten Boudry & Massimo Pigliucci - 2013 - Studies in History and Philosophy of Biological and Biomedical Sciences (4):660-668.
    The scientific study of living organisms is permeated by machine and design metaphors. Genes are thought of as the ‘‘blueprint’’ of an organism, organisms are ‘‘reverse engineered’’ to discover their func- tionality, and living cells are compared to biochemical factories, complete with assembly lines, transport systems, messenger circuits, etc. Although the notion of design is indispensable to think about adapta- tions, and engineering analogies have considerable heuristic value (e.g., optimality assumptions), we argue they are limited in several important respects. In (...)
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  10.  55
    Synthetic Biology: Drawing a Line in Darwin's Sand.Christopher J. Preston - 2008 - Environmental Values 17 (1):23-39.
    Maintaining the coherence of the distinction between nature and artefact has long been central to environmental thinking. By building genomes from scratch out of 'bio-bricks', synthetic biology promises to create biotic artefacts markedly different from anything created thus far in biotechnology. These new biotic artefacts depart from a core principle of Darwinian natural selection – descent through modification – leaving them with no causal connection to historical evolutionary processes. This departure from the core principle of Darwinism presents a (...)
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  11.  20
    Synthetic Biology and Morality: Artificial Life and the Bounds of Nature.Gregory E. Kaebnick & Thomas H. Murray (eds.) - 2013 - MIT Press.
    A range of views on the morality of synthetic biology and its place in public policy and political discourse.
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  12.  27
    Synthetic Biology Ethics: A Deontological Assessment.Patrick Heavey - 2013 - Bioethics 27 (8):442-452.
    In this article I discuss the ethics of synthetic biology from a broadly deontological perspective, evaluating its morality in terms of the integrity of nature, the dignity of life and the relationship between God and his creation. Most ethical analyses to date have been largely consequentialist in nature; they reveal a dual use dilemma, showing that synbio has potential for great good and great evil, possibly more so than any step humanity has taken before. A deontological analysis may (...)
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  13. Synthetic Biology and Biofuels.Catherine Kendig - 2014 - In Paul B. Thompson & David M. Kaplan (eds.), Encyclopedia of Food and Agricultural Ethics. Springer.
    Synthetic biology is a field of research that concentrates on the design, construction, and modification of new biomolecular parts and metabolic pathways using engineering techniques and computational models. By employing knowledge of operational pathways from engineering and mathematics such as circuits, oscillators, and digital logic gates, it uses these to understand, model, rewire, and reprogram biological networks and modules. Standard biological parts with known functions are catalogued in a number of registries (e.g. Massachusetts Institute of Technology Registry of (...)
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  14.  35
    Synthetic Biology and the Emergence of a Dual Meaning of Noise.Andrea Loettgers - 2009 - Biological Theory 4 (4):340-356.
    The question is discussed how noise gained a functional meaning in the context of biology. According to the common view, noise is considered a disturbance or perturbation. I analyze how this understanding changed and what kind of developments during the last 10 years contributed to the emergence of a new understanding of noise. Results gained during a field study in a synthetic biology laboratory show that the emergence of this new research discipline—its highly interdisciplinary character, its new (...)
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  15. The Mismeasure of Machine: Synthetic Biology and the Trouble with Engineering Metaphors.Maarten Boudry & Massimo Pigliucci - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (4):660-668.
    The scientific study of living organisms is permeated by machine and design metaphors. Genes are thought of as the ‘‘blueprint’’ of an organism, organisms are ‘‘reverse engineered’’ to discover their functionality, and living cells are compared to biochemical factories, complete with assembly lines, transport systems, messenger circuits, etc. Although the notion of design is indispensable to think about adaptations, and engineering analogies have considerable heuristic value (e.g., optimality assumptions), we argue they are limited in several important respects. In particular, the (...)
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  16.  31
    Synthetic Biology and Genetic Causation.Gry Oftedal & Veli-Pekka Parkkinen - 2013 - Studies in History and Philosophy of Biological and Biomedical Sciences 44 (2):208-216.
    Synthetic biology research is often described in terms of programming cells through the introduction of synthetic genes. Genetic material is seemingly attributed with a high level of causal responsibility. We discuss genetic causation in synthetic biology and distinguish three gene concepts differing in their assumptions of genetic control. We argue that synthetic biology generally employs a difference-making approach to establishing genetic causes, and that this approach does not commit to a specific notion of (...)
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  17.  33
    Synthetic Biology: Challenging Life in Order to Grasp, Use, or Extend It.Kepa Ruiz-Mirazo & Alvaro Moreno - 2013 - Biological Theory 8 (4):376-382.
    In this short contribution we explore the historical roots of recent synthetic approaches in biology and try to assess their real potential, as well as identify future hurdles or the reasons behind some of the main difficulties they currently face. We suggest that part of these difficulties might not be just the result of our present lack of adequate technical skills or understanding, but could spring directly from the nature of the biological phenomenon itself. In particular, if life (...)
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  18.  18
    Synthetic Biology as Red Herring.Beth Preston - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (4b):649-659.
    It has become commonplace to say that with the advent of technologies like synthetic biology the line between artifacts and living organisms, policed by metaphysicians since antiquity, is beginning to blur. But that line began to blur 10,000 years ago when plants and animals were first domesticated; and has been thoroughly blurred at least since agriculture became the dominant human subsistence pattern many millennia ago. Synthetic biology is ultimately only a late and unexceptional offshoot of this (...)
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  19.  14
    Synthetic Biology as a Technoscience: The Case of Minimal Genomes and Essential Genes.Massimiliano Simons - 2021 - Studies in History and Philosophy of Science Part A 85:127-136.
    This article examines how minimal genome research mobilizes philosophical concepts such as minimality and essentiality. Following a historical approach the article aims to uncover what function this terminology plays and which problems are raised by them. Specifically, four historical moments are examined, linked to the work of Harold J. Morowitz, Mitsuhiro Itaya, Eugene Koonin and Arcady Mushegian, and J. Craig Venter. What this survey shows is a historical shift away from historical questions about life or descriptive questions about specific organisms (...)
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  20.  43
    From Bricolage to BioBricks™: Synthetic Biology and Rational Design.Tim Lewens - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (4b):641-648.
    Synthetic biology is often described as a project that applies rational design methods to the organic world. Although humans have influenced organic lineages in many ways, it is nonetheless reasonable to place synthetic biology towards one end of a continuum between purely ‘blind’ processes of organic modification at one extreme, and wholly rational, design-led processes at the other. An example from evolutionary electronics illustrates some of the constraints imposed by the rational design methodology itself. These constraints (...)
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  21.  72
    Synthetic Biology and the Moral Significance of Artificial Life: A Reply to Douglas, Powell and Savulescu.Andreas Christiansen - 2016 - Bioethics 30 (5):372-379.
    I discuss the moral significance of artificial life within synthetic biology via a discussion of Douglas, Powell and Savulescu's paper 'Is the creation of artificial life morally significant’. I argue that the definitions of 'artificial life’ and of 'moral significance’ are too narrow. Douglas, Powell and Savulescu's definition of artificial life does not capture all core projects of synthetic biology or the ethical concerns that have been voiced, and their definition of moral significance fails to take (...)
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  22.  19
    Is Synthetic Biology Mechanical Biology?Sune Holm - 2015 - History and Philosophy of the Life Sciences 37 (4):413-429.
    A widespread and influential characterization of synthetic biology emphasizes that synthetic biology is the application of engineering principles to living systems. Furthermore, there is a strong tendency to express the engineering approach to organisms in terms of what seems to be an ontological claim: organisms are machines. In the paper I investigate the ontological and heuristic significance of the machine analogy in synthetic biology. I argue that the use of the machine analogy and the (...)
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  23.  37
    Making Knowledge in Synthetic Biology: Design Meets Kludge.Maureen A. O’Malley - 2009 - Biological Theory 4 (4):378-389.
    Synthetic biology is an umbrella term that covers a range of aims, approaches, and techniques. They are all brought together by common practices of analogizing, synthesizing, mechanicizing, and kludging. With a focus on kludging as the connection point between biology, engineering, and evolution, I show how synthetic biology’s successes depend on custom-built kludges and a creative, “make-it-work” attitude to the construction of biological systems. Such practices do not fit neatly, however, into synthetic biology’s (...)
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  24.  19
    Synthetic Biology and its Alternatives. Descartes, Kant and the Idea of Engineering Biological Machines.Werner Kogge & Michael Richter - 2013 - Studies in History and Philosophy of Biological and Biomedical Sciences 44 (2):181-189.
    The engineering-based approach of synthetic biology is characterized by an assumption that ‘engineering by design’ enables the construction of ‘living machines’. These ‘machines’, as biological machines, are expected to display certain properties of life, such as adapting to changing environments and acting in a situated way. This paper proposes that a tension exists between the expectations placed on biological artefacts and the notion of producing such systems by means of engineering; this tension makes it seem implausible that biological (...)
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  25.  39
    Synthetic Biology and Ethics: Past, Present, and Future.Matti Häyry - 2017 - Cambridge Quarterly of Healthcare Ethics 26 (2):186-205.
    :This article explores the ethical issues that have been identified in emerging technologies, from early genetic engineering to synthetic biology. The scientific advances in the field form a continuum, and some ethical considerations can be raised time and again when new developments occur. An underlying concern is the cumulative effect of scientific advances and ensuing technological innovation that can change our understanding of life and humanity.
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  26.  28
    A Critical Perspective on Synthetic Biology.Michel Morange - 2009 - Hyle 15 (1):21 - 30.
    Synthetic biology emerged around 2000 as a new biological discipline. It shares with systems biology the same modular vision of organisms, but is more concerned with applications than with a better understanding of the functioning of organisms. A herald of this new discipline is Craig Venter who aims to create an artificial microorganism with the minimal genome compatible with life and to implement into it different 'functional modules' to generate new micro-organisms adapted to specific tasks. Synthetic (...)
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  27.  20
    Synthetic Biology: A Utilitarian Perspective.Kevin Smith - 2013 - Bioethics 27 (8):453-463.
    I examine the positive and negative features of synthetic biology (‘SynBio’) from a utilitarian ethical perspective. The potential beneficial outcomes from SynBio in the context of medicine are substantial; however it is not presently possible to predict precise outcomes due to the nascent state of the field. Potential negative outcomes from SynBio also exist, including iatrogenesis and bioterrorism; however it is not yet possible to quantify these risks. I argue that the application of a ‘precautionary’ approach to SynBio (...)
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  28. This is the Synthetic Biology That Is. [REVIEW]Daniel Liu - 2017 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 63:89-93.
    Review of: Sophia Roosth, Synthetic: How Life Got Made (University of Chicago Press, 2017); and Andrew S. Balmer, Katie Bulpin, and Susan Molyneux-Hodgson, Synthetic Biology: A Sociology of Changing Practices (Palgrave Macmillan, 2016).
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  29.  50
    Synthetic Biology: A Challenge to Mechanical Explanations in Biology?Michel Morange - 2012 - Perspectives in Biology and Medicine 55 (4):543-553.
    The construction of synthetic life might appear to be the natural objective of the emerging discipline of synthetic biology. The situation, though, is not that simple. Plans to synthesize life appeared quite early, at the beginning of the 20th century (Bensaude-Vincent 2009; Deichmann 2009; Fox Keller 2002; Pereto and Catala 2007). Nor can synthetic biology be identified with work on the origin of life. Nevertheless, it is remarkable that a new, more integrated approach to the (...)
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  30. Dreaming of a Universal Biology: Synthetic Biology and the Origins of Life.Massimiliano Simons - 2021 - Hyle: International Journal for Philosophy of Chemistry 27:91-116.
    Synthetic biology aims to synthesize novel biological systems or redesign existing ones. The field has raised numerous philosophical questions, but most especially what is novel to this field. In this article I argue for a novel take, since the dominant ways to understand synthetic biology’s specificity each face problems. Inspired by the examination of the work of a number of chemists, I argue that synthetic biology differentiates itself by a new regime of articulation, i.e. (...)
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  31.  26
    Rational Engineering Principles in Synthetic Biology: A Framework for Quantitative Analysis and an Initial Assessment.Bernd Giese, Stefan Koenigstein, Henning Wigger, Jan C. Schmidt & Arnim von Gleich - 2013 - Biological Theory 8 (4):324-333.
    The term “synthetic biology” is a popular label of an emerging biotechnological field with strong claims to robustness, modularity, and controlled construction, finally enabling the creation of new organisms. Although the research community is heterogeneous, it advocates a common denominator that seems to define this field: the principles of rational engineering. However, it still remains unclear to what extent rational engineering—rather than “tinkering” or the usage of random based or non-rational processes—actually constitutes the basis for the techniques of (...)
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  32.  54
    Synthetic Biology As a Replica of Synthetic Chemistry? Uses and Misuses of History.Bernadette Bensaude-Vincent - 2009 - Biological Theory 4 (4):314-318.
  33. Synthetic Biology, Deontology and Synthetic Bioethics.Robin Attfield - 2012 - Ethics, Policy and Environment 15 (1):29-32.
    Paul Thompson argues that current synthetic biology amounts to synthetic genomics, comprising a ‘platform’ technology, and that Christopher Preston's deontological objections based on its supposed rejection of the historical process of evolution miscarry. This makes it surprising that Thompson's normative ethic consists in a deontological appeal to Kantian duties of imperfect obligation. Construed as obligations subject to choice, such constraints risk being excessively malleable where the ethical objections to deployment of this technology concern land rights and/or exploitation. (...)
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  34.  41
    Disease, Dysfunction, and Synthetic Biology.Sune Holm - 2014 - Journal of Medicine and Philosophy 39 (4):329-345.
    Theorists analyzing the concept of disease on the basis of the notion of dysfunction consider disease to be dysfunction requiring. More specifically, dysfunction-requiring theories of disease claim that for an individual to be diseased certain biological facts about it must be the case. Disease is not wholly a matter of evaluative attitudes. In this paper, I consider the dysfunction-requiring component of Wakefield’s hybrid account of disease in light of the artifactual organisms envisioned by current research in synthetic biology. (...)
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  35.  27
    Autonomy and Fear of Synthetic Biology: How Can Patients’ Autonomy Be Enhanced in the Field of Synthetic Biology? A Qualitative Study with Stable Patients.Milenko Rakic, Isabelle Wienand, David Shaw, Rebecca Nast & Bernice S. Elger - 2017 - Science and Engineering Ethics 23 (2):375-388.
    We analyzed stable patients’ views regarding synthetic biology in general, the medical application of synthetic biology, and their potential participation in trials of synthetic biology in particular. The aim of the study was to find out whether patients’ views and preferences change after receiving more detailed information about synthetic biology and its clinical applications. The qualitative study was carried out with a purposive sample of 36 stable patients, who suffered from diabetes or (...)
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  36.  6
    Philosophy and Synthetic Biology: The BrisSynBio Experiment.Darian Meacham & Miguel Prado Casanova - 2020 - NanoEthics 14 (1):21-25.
    This article provides an overview of the relation between synthetic biology and philosophy as understood from within the Ethics, Philosophy and Responsible Innovation programme of BrisSynBio (a BBSRC/EPSCR Synthetic Biology Research Centre). It also introduces the special issue of NanoEthics devoted to synthetic biology and philosophy.
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  37.  41
    Interactive Models in Synthetic Biology: Exploring Biological and Cognitive Inter-Identities.Leonardo Bich - 2020 - Frontiers in Psychology 11.
    The aim of this article is to investigate the relevance and implications of synthetic models for the study of the interactive dimension of minimal life and cognition, by taking into consideration how the use of artificial systems may contribute to an understanding of the way in which interactions may affect or even contribute to shape biological identities. To do so, this article analyzes experimental work in synthetic biology on different types of interactions between artificial and natural systems, (...)
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  38.  23
    Discipline-Building in Synthetic Biology.Bernadette Bensaude-Vincent - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (2):122-129.
    Despite the multidisciplinary dimension of the kinds of research conducted under the umbrella of synthetic biology, the US-based founders of this new research area adopted a disciplinary profile to shape its institutional identity. In so doing they took inspiration from two already established fields with very different disciplinary patterns. The analogy with synthetic chemistry suggested by the term ‘synthetic biology’ is not the only model. Information technology is clearly another source of inspiration. The purpose of (...)
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  39.  32
    Policy on Synthetic Biology: Deliberation, Probability, and the Precautionary Paradox.Christopher Wareham & Cecilia Nardini - 2015 - Bioethics 29 (2):118-125.
    Synthetic biology is a cutting-edge area of research that holds the promise of unprecedented health benefits. However, in tandem with these large prospective benefits, synthetic biology projects entail a risk of catastrophic consequences whose severity may exceed that of most ordinary human undertakings. This is due to the peculiar nature of synthetic biology as a ‘threshold technology’ which opens doors to opportunities and applications that are essentially unpredictable. Fears about these potentially unstoppable consequences have (...)
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  40.  27
    Synthetic Biology: A Jewish View.Shimon Glick - 2012 - Perspectives in Biology and Medicine 55 (4):571-580.
    To illustrate dramatically the progress and potential in the field of synthetic biology, one can begin the story with the 2011 winner of the Lasker Clinical Medical Research Award (Youyou 2011). She was an 81-year-old Chinese scientist, Dr. Tu Youyou, who was given an assignment in 1969 by the Chinese government to find a treatment for malaria from among Chinese herbal medicines. She investigated more than 2,000 Chinese herbal preparations, winnowed them down to some 640 possibilities, obtained 380 (...)
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  41.  30
    Synthetic Biology, Gödel, and the Blind Watchmaker.Andrés Moya - 2009 - Biological Theory 4 (4):319-322.
  42.  95
    The Ethics of Synthetic Biology: Guiding Principles for Emerging Technologies.Amy Gutmann - 2011 - Hastings Center Report 41 (4):17-22.
    The Presidential Commission for the Study of Bioethical Issues released its first report, New Directions: The Ethics of Synthetic Biology and Emerging Technologies, on December 16, 2010.1 President Barack Obama had requested this report following the announcement last year that the J. Craig Venter Institute had created the world’s first self-replicating bacterial cell with a completely synthetic genome. The Venter group’s announcement marked a significant scientific milestone in synthetic biology, an emerging field of research that (...)
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  43.  32
    Mammalian Synthetic Biology – From Tools to Therapies.Dominique Aubel & Martin Fussenegger - 2010 - Bioessays 32 (4):332-345.
  44. Playing God and the Intrinsic Value of Life: Moral Problems for Synthetic Biology?Hans-Jürgen Link - 2013 - Science and Engineering Ethics 19 (2):435-448.
    Most of the reports on synthetic biology include not only familiar topics like biosafety and biosecurity but also a chapter on ‘ethical concerns’; a variety of diffuse topics that are interrelated in some way or another. This article deals with these ‘ethical concerns’. In particular it addresses issues such as the intrinsic value of life and how to deal with ‘artificial life’, and the fear that synthetic biologists are tampering with nature or playing God. Its aim is (...)
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  45.  9
    Misconceptions of Synthetic Biology: Lessons From an Interdisciplinary Summer School.Cyprien Verseux, Carlos G. Acevedo-Rocha, Fabio Chizzolini & Lynn J. Rothschild - 2016 - NanoEthics 10 (3):327-336.
    In 2014, an international group of scholars from various fields analysed the “societal dimensions” of synthetic biology in an interdisciplinary summer school. Here, we report and discuss the biologists’ observations on the general perception of synthetic biology by non-biologists who took part in this event. Most attendees mainly associated synthetic biology with contributions from the best-known public figures of the field, rarely mentioning other scientists. Media extrapolations of those contributions appeared to have created unrealistic (...)
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  46.  72
    Knowledge‐Making Distinctions in Synthetic Biology.Maureen A. O'Malley, Alexander Powell, Jonathan F. Davies & Jane Calvert - 2008 - Bioessays 30 (1):57-65.
  47.  33
    Life as a Technological Product: Philosophical and Ethical Aspects of Synthetic Biology.Joachim Boldt - 2013 - Biological Theory 8 (4):391-401.
    Synthetic biology is a new biotechnology that is developing at an impressive pace and attracting a considerable amount of attention from outside the scientific community as well. In this article, two main philosophically and ethically relevant characteristics of this field of research will be laid bare, namely its reliance on mechanistic metaphors to denominate simple forms of life and its appeal to the semantic field of creativity. It is argued that given these characteristics synthetic biology can (...)
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  48.  13
    Machine Metaphors and Ethics in Synthetic Biology.Joachim Boldt - 2018 - Life Sciences, Society and Policy 14 (1):1-13.
    The extent to which machine metaphors are used in synthetic biology is striking. These metaphors contain a specific perspective on organisms as well as on scientific and technological progress. Expressions such as “genetically engineered machine”, “genetic circuit”, and “platform organism”, taken from the realms of electronic engineering, car manufacturing, and information technology, highlight specific aspects of the functioning of living beings while at the same time hiding others, such as evolutionary change and interdependencies in ecosystems. Since these latter (...)
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  49.  12
    The Diversity of Engineering in Synthetic Biology.Massimiliano Simons - 2020 - NanoEthics 14 (1):71-91.
    A recurrent theme in the characterization of synthetic biology is the role of engineering. This theme is widespread in the accounts of scholars studying this field and the biologists working in it, in those of the biologists themselves, as well as in policy documents. The aim of this article is to open this black-box of engineering that is supposed to influence and change contemporary life sciences. Too often, both synthetic biologists and their critics assume a very narrow (...)
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  50.  27
    Synthetic Biology Already Has a Model to Follow.Robb E. Eason - 2012 - Ethics, Policy and Environment 15 (1):21 - 24.
    Ethics, Policy & Environment, Volume 15, Issue 1, Page 21-24, March 2012.
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