This project evaluates the impact of the National Science Foundation's policy to promote education in the responsible conduct of research. To determine whether this policy resulted in meaningful RCR educational experiences, our study examined the instructional plans developed by individual universities in response to the mandate. Using a sample of 108 U.S. institutions classified as Carnegie “very high research activity”, we analyzed all publicly available NSF RCR training plans in light of the consensus best practices in RCR education that were (...) known at the time the policy was implemented. We found that fewer than half of universities developed plans that incorporated at least some of the best practices. More specifically, only 31% of universities had content and requirements that differed by career stage, only 1% of universities had content and requirements that differed by discipline; and only 18% of universities required some face-to-face engagement from all classes of trainees. Indeed, some schools simply provided hand-outs to their undergraduate students. Most universities had plans that could be satisfied with online programs such as the Collaborative Institutional Training Initiative's RCR modules. The NSF policy requires universities to develop RCR training plans, but provides no guidelines or requirements for the format, scope, content, duration, or frequency of the training, and does not hold universities accountable for their training plans. Our study shows that this vaguely worded policy, and lack of accountability, has not produced meaningful educational experiences for most of the undergraduate students, graduate students, and post-doctoral trainees funded by the NSF. (shrink)

As global business operations expand, managers need more knowledge of foreign cultures, in particular, information on the ethics of doing business across borders. The purpose of this paper is twofold: to share the Islamic perspective on business ethics, little known in the west, which may stimulate further thinking and debate on the relationships between ethics and business, and to provide some knowledge of Islamic philosophy in order to help managers do business in Muslim cultures. The case of Egypt illustrates some (...) divergence between Islamic philosophy and practice in economic life. The paper concludes with managerial implications and suggestions for further research. (shrink)

Socioeconomic differences in behaviour are pervasive and well documented, but their causes are not yet well understood. Here, we make the case that a cluster of behaviours is associated with lower socioeconomic status, which we call “the behavioural constellation of deprivation.” We propose that the relatively limited control associated with lower SES curtails the extent to which people can expect to realise deferred rewards, leading to more present-oriented behaviour in a range of domains. We illustrate this idea using the specific (...) factor of extrinsic mortality risk, an important factor in evolutionary theoretical models. We emphasise the idea that the present-oriented behaviours of the constellation are a contextually appropriate response to structural and ecological factors rather than a pathology or a failure of willpower. We highlight some principles from evolutionary theoretical models that can deepen our understanding of how socioeconomic inequalities can become amplified and embedded. These principles are that small initial disparities can lead to larger eventual inequalities, feedback loops can embed early-life circumstances, constraints can breed further constraints, and feedback loops can operate over generations. We discuss some of the mechanisms by which SES may influence behaviour. We then review how the contextually appropriate response perspective that we have outlined fits with other findings about control and temporal discounting. Finally, we discuss the implications of this interpretation for research and policy. (shrink)

This paper examines beliefs about four aspects of ethical leadership – Character/Integrity, Altruism, Collective Motivation and Encouragement – in Germany and the United States using data from Project GLOBE (Global Leadership and Organizational Behavior Effectiveness) and a supplemental analysis. Within the context of a push toward convergence driven by the demands of globalization and the pull toward divergence underpinned by different cultural values and philosophies in the two countries, we focus on two questions: Do middle managers from the United States (...) and Germany differ in their beliefs about ethical leadership? And, do individuals from these two countries attribute different characteristics to ethical leaders? Results provide evidence that while German and US middle managers, on average, differed in the degree of endorsement for each aspect, they each endorsed Character/Integrity, Collective Motivation and Encouragement as important for effective leadership and had a more neutral view of the importance of Altruism . The findings are reviewed within the social-cultural context of each country. (shrink)

This paper examines beliefs about four aspects of ethical leadership –Character/Integrity, Altruism, Collective Motivation and Encouragement– in Germany and the United States using data from Project GLOBE (Global Leadership and Organizational Behavior Effectiveness) and a supplemental analysis. Within the context of a push toward convergence driven by the demands of globalization and the pull toward divergence underpinned by different cultural values and philosophies in the two countries, we focus on two questions: Do middle managers from the United States and Germany (...) differ in their beliefs about ethical leadership? And, do individuals from these two countries attribute different characteristics to ethical leaders? Results provide evidence that while German and US middle managers, on average, differed in the degree of endorsement for each aspect, they each endorsed Character/Integrity, Collective Motivation and Encouragement as important for effective leadership and had a more neutral view of the importance of Altruism. The findings are reviewed within the social-cultural context of each country. (shrink)

Gillian Brock develops a model of global justice that takes seriously the moral equality of all human beings notwithstanding their legitimate diverse identifications and affiliations. She addresses concerns about implementing global justice, showing how we can move from theory to feasible public policy that makes progress toward global justice.

Two critiques of simple adaptationism are distinguished: anti-adaptationism and extended adaptationism. Adaptationists and anti-adaptationists share the presumption that an evolutionary explanation should identify the dominant simple cause of the evolutionary outcome to be explained. A consideration of extended-adaptationist models such as coevolution, niche construction and extended phenotypes reveals the inappropriateness of this presumption in explaining the evolution of certain important kinds of features—those that play particular roles in the regulation of organic processes, especially behavior. These biological or behavioral ‘levers’ are (...) distinctively available for adaptation and exaptation by their possessors and for co-optation by other organisms. As a result they are likely to result from a distinctive and complex type of evolutionary process that conforms neither to simple adaptationist nor to anti-adaptationist styles of explanation. Many of the human features whose evolutionary explanation is most controversial belong to this category, including the female orgasm. (shrink)

Melusine the Serpent Goddess in Myth and Literature examines how women were once worshipped as the life force, but later suppressed with the introduction of monotheism and a changing attitude regarding the sexes. It connects the literary conception of the Melusine story to myths and legends of the snake or dragon goddess, from ancient to contemporary times.

: This paper examines the nature of the harm-benefit tradeoff in early clinical research for interventions that involve remote possibility of direct benefit and likelihood of direct harms to research participants with fatal prognoses, by drawing on the example of gene transfer trials for glioblastoma multiforme. We argue that the appeal made by the component approach to clinical equipoise fails to account fully for the nature of the harm-benefit tradeoff—individual harm for social benefit—that would be required to justify such research. (...) An analysis of what we label "collateral affective benefits," such as the experience of hope or exercise of altruism, shows that the existence of these motivations reinforces rather than mitigates the necessity of justification by reference to social benefit. Evaluations of social benefit must be taken seriously in the research ethics review process to avoid the exploitation of research participants' motivations of hope or altruism and to avoid the possibility of inadvertent exploitation of high-risk research participants and the harms that would associate with such exploitation. (shrink)

Egypt, a less affluent, predominantly Muslim country, suffers from numerous forms of environmental pollution, some severe. This study investigates pro-environmental behaviors of citizens in Cairo, Egypt’s largest metropolis, and studies the relationship between pro-environmental behavior and demographic variables, beliefs, values, and religiosity. Analysis shows that three types of pro-environmental behavior are present: Public Sphere, Private Sphere, and Activist Behavior, with the latter occurring less frequently. Importantly, the study identifies an ecocentric value among respondents which is correlated with Public Sphere Behavior. (...) It also confirms earlier research that characterized Egyptians’ perceptions of the environment as being set in the context of health and cleanliness. Religious teachings and religiosity are shown to be associated with pro-environmental behavior, thus lending support to the presence of an Islamic environmental ethic. (shrink)

Pietroski successfully dismantles the idea of a formal semantic theory based on direct truth conditions and offers new and formally constrained alternatives. In this paper, I summarize the arguments but also provide a number of test cases to show that refusing to accept Pietroski's conclusions condemns the field to constantly restating and technically evading its own self‐created paradoxes. In the final section, I offer some positive proposals in the spirit of the Pietroskian enterprise with respect to thematic roles.

Offering an engaging and accessible portrait of the current state of the field, Philosophy of Science: A New Introduction shows students how to think philosophically about science and why it is both essential and fascinating to do so. Gillian Barker and Philip Kitcher reconsider the core questions in philosophy of science in light of the multitude of changes that have taken place in the decades since the publication of C.G. Hempel's classic work, Philosophy of Natural Science —both in the (...) field and also in history and sociology of science and the sciences themselves. They explore how philosophical questions are connected to vigorous current debates—including climate change, science and religion, race, intellectual property rights, and medical research priorities—showing how these questions, and philosophers' attempts to answer them, matter in the real world. Featuring numerous illustrative examples and extensive further reading lists, Philosophy of Science: A New Introduction is ideal for courses in philosophy of science, history and philosophy of science, and epistemology/theory of knowledge. It is also compelling and illuminating reading for scientists, science students, and anyone interested in the natural sciences and in their place in global society today. (shrink)

Many of the most skilled and educated citizens of developing countries choose to emigrate. How may those societies respond to these facts? May they ever legitimately prevent the emigration of their citizens? Gillian Brock and Michael Blake debate these questions, and offer distinct arguments about the morality of emigration.

Facial appearance changes with age and health affecting skin color as well as facial and head hair. Yet somehow the brain is able to see past shared structure and dynamic deformations to focus on subtle details that distinguish one face from another. This article argues that the brain takes an efficient approach to this problem using prior knowledge about the structure of faces in its analysis. It employs intrinsic norms to focus on subtle variations in the shared face configuration that (...) differentiate one face from another. The study reviews evidence that the brain uses multiple norms to extract face identity that these norms are shaped by visual experience, and that norm-based coding is well-suited to meeting the challenges of image-based face perception mentioned above. By encoding faces with reference to stored perceptual norms the visual system can focus on what is unique to each individual, allowing for the discrimination of thousands of faces despite their similarity. (shrink)

By executive order, the US adopted an immigration policy that looks remarkably similar to a Muslim ban, and threatened to deport long-settled residents, such as the so-called Dreamers. Our defunct refugee system has not dealt adequately with increased refugee flows, forcing desperate people to undertake increasingly risky measures in efforts to reach safe havens. Meanwhile increased migration flows over recent years appear to have contributed to a rise in right-wing populism, apparently driving phenomena such as Brexit and Trumpism. In this (...) original and insightful book Gillian Brock offers answers and tools that assist us in evaluating current migration policy and in helping to determine which policies may be permissible and which are normatively indefensible. She offers a comprehensive framework for responding to the many challenges which have recently emerged, and for delivering justice for people on the move along with those affected by migration. (shrink)

Some writers object to logical pluralism on the grounds that logic is normative. The rough idea is that the relation of logical consequence has consequences for what we ought to think and h...

Phenomenologists recognize the insights to be gained from looking at cognitive development. But our understanding of development, in turn, can be illuminated by ideas from ecology. Developmental studies in psychology and biology share with ecosystem ecology a concern with stability—with how things stay the same despite changes in the surrounding conditions, and how processes of change lead reliably to similar outcomes despite environmental variability. Recently, both ecologists and psychologists have reconsidered their earlier assumptions about the sources of stability, and explored (...) new conceptions of resilience: a system’s ability to “bounce back” from a disturbance, to absorb change without harm, or to overcome obstacles to achieve good adaptive functioning. Developmental biologists, meanwhile, have explored related issues through conceptions of developmental plasticity and canalization. Distinct theoretical frameworks for resilience have emerged in these different fields, yet the phenomena that they treat are closely intertwined. Ecological work on resilience focuses on relationships between resilience, chaotic change, and adaptive function across multiple scales of nested systems, and implications for intervention or management. With some assistance from developmental biology, this body of work offers rich theoretical resources and important lessons for related thinking about cognitive development. (shrink)

The prevalence of academic dishonesty is a matter of considerable concern for institutions of higher education everywhere. We explored students’ perceptions of academic dishonesty using Q methodology, which provides insights that are different from those obtained through surveys or interviews. South African students ranked 48 statements, giving reasons why students cheat, on an 11-column grid, anchored by strongly agree and strongly disagree. Q factor analysis was used to identify groups of individuals who share the same perspective. The three perspectives that (...) emerged viewed academic dishonesty as moral transgressions, pressure transgressions, or confused transgressions. These suggest different approaches to addressing the issue. (shrink)

In the current academic climate, teaching is often seen as secondary to research. Teaching Philosophy seeks to bring teaching philosophy higher on the academic agenda.An international team of contributors, all of whom share the view that philosophy is a subject that can transform students, offers practical guidance and advice for teachers of philosophy. The book suggests ways in which the teaching of philosophy at undergraduate level might be facilitated. Some of the essays place the emphasis on individual self discovery, others (...) focus on the wider political context, many offer practical ideas for enhancing the teaching of philosophy through exercises that engage students in often unconventional ways. The integration of students' views on teaching provides a necessary reminder that teaching is not a one-way process, but a project that will ultimately succeed through cooperation and a shared sense of achievement amongst participants. (shrink)

The analytic/synthetic distinction looks simple. It is a distinction between two different kinds of sentence. Synthetic sentences are true in part because of the way the world is, and in part because of what they mean. Analytic sentences - like all bachelors are unmarried and triangles have three sides - are different. They are true in virtue of meaning, so no matter what the world is like, as long as the sentence means what it does, it will be true. -/- (...) This distinction seems powerful because analytic sentences seem to be knowable in a special way. One can know that all bachelors are unmarried, for example, just by thinking about what it means. But many twentieth-century philosophers, with Quine in the lead, argued that there were no analytic sentences, that the idea of analyticity didn't even make sense, and that the analytic/synthetic distinction was therefore an illusion. Others couldn't see how there could fail to be a distinction, however ingenious the arguments of Quine and his supporters. -/- But since the heyday of the debate, things have changed in the philosophy of language. Tools have been refined, confusions cleared up, and most significantly, many philosophers now accept a view of language - semantic externalism - on which it is possible to see how the distinction could fail. One might be tempted to think that ultimately the distinction has fallen for reasons other than those proposed in the original debate. -/- In Truth in Virtue of Meaning, Gillian Russell argues that it hasn't. Using the tools of contemporary philosophy of language, she outlines a view of analytic sentences which is compatible with semantic externalism and defends that view against the old Quinean arguments. She then goes on to draw out the surprising epistemological consequences of her approach. (shrink)

Logical monists and pluralists disagree about how many correct logics there are; the monists say there is just one, the pluralists that there are more. Could it turn out that both are wrong, and that there is no logic at all?

Are corporations morally defensible sorts of entities? How might we go about showing that they are? Thomas Donaldson offers us the most detailed contractarian justification for the moral defensibility of corporations. In this paper I show how we can significantly develop this sort of justification to yield a more compelling contractarian justification, though one that is importantly conditional. The primary points I take up in this paper are these:1. The question Donaldson poses to generate his contract is not quite as (...) simple as may appear. The sort of transformation we need to consider is more complex than the sort Donaldson describes.2. Partly because of considerations that arise in discussing the first point, the contract we are considering is a more conditionalagreement. The terms of the agreement will vary depending on the kind of state we are assuming prevails. The sort of contract we wantto draw up is at least a three-way contract: between society, productive organizations and the state. The sort of agreement we reach will have the following form: society a agrees to allow productive organizations of type b to exist if we assume state c will do various things (d1 to dn), productive organizations will do various things (e1 to en) and members of society will do various things (f1 to fn). Importantly, if state c is not doing d1 to dn, productive organizations may not be morally defensible.3. The terms of the contract that can be derived would benefit from the introduction of some of Rawls’s apparatus.4. When we consider the right questions, with more of the background institutions filled in, and when we include some more social contract apparatus, we get a better contract which fills in for us not only the obligations of business but, importantly, many obligationsfor government as well. (shrink)

Between Feminism and Materialism is a bold attempt to make sense of the relationship between feminist theory and capitalism. Addressing a number of philosophical problems that have engaged feminists over the last few decades - universals and reason, nature and essentialism, identity and non-identity, sex and gender, power and patriarchy, local and global - this innovative book breaks through feminist waves and explains the paradoxes of feminist theory by demonstrating the on-going relevance of dialectics and the concepts of exploitation, ideology, (...) and reification. Drawing on first, second and third 'waves' of feminist theory, this exciting combination of existentialism, phenomenology and critical theory delivers a problem-based, micro-political and coalitional feminism ready to respond to the challenges presented by our thoroughly modern times. (shrink)

The effects of grandparent survival on child survival and mean interbirth interval, both independent of and relative to parent survival, were investigated in a historical population. Families for the data set were reconstituted from the parish and census records of Cambridgeshire, 1770–1861. In a logistic regression analysis, only the mother’s and the maternal grandmother’s survival were found to be significant predictors of child survival. Maternal grandmother’s survival was found to influence child survival both via maternal survival and independent of maternal (...) survival. Grandparent survival was not found to influence mean interbirth interval. These findings are reviewed with respect to other studies of grandmothering, the Grandmother Hypothesis, and the evolutionary significance of human female postreproductive lifespan. (shrink)

This article theorizes a research process in a highly politicized environment in which we, as feminist researchers, found ourselves standing outside the feminist standpoint which dominated Irish public discourse, viz advocacy of a Swedish-style, neo-abolitionist, prostitution policy. We suggest that our increasing personal and intellectual discomfort as that policy position gained support contained valuable epistemic insight. We theorize this principally by drawing on Pillow’s concept of ‘reflexivities of discomfort’. This article offers an account of the messy dynamics of a research (...) process in which we, in time, recognized our own psychosocial worlds as sites of social critique. We contribute to debates about reflexivity by exploring the insights which this approach brought when applied to the dynamics of power politics between us as researchers and the wider policy field within which we were immersed. (shrink)

The greatest challenge for Cultural Selection Theory, which holds that Darwinian natural selection contributes to cultural evolution, lies is the paucity of evidence for structural mechanisms in cultural systems that are sufficient for adaptation by natural selection. In part, clarification is required with respect to the interaction between cultural systems and their purported selective environments. Edmonds, Hull, and others have argued that Cultural Selection Theory requires simple, conclusive, unambiguous case studies in order to meet this challenge. To this end, I (...) am employing the songs of the Rufous-collared Sparrow, which seem to exhibit cultural adaptations that minimize signal degradation relative to local environments (Handford, et al.). Specifically, the more forested the habitat, the more the tail end of the song resembles a whistle rather than a trill; yet, variation in song is uncorrelated with genetic variation. I explore the mechanisms responsible for these putative acoustic adaptations through a series of computer simulations. I modify the framework of Alexander and Skyrms’ ‘Bargaining with Neighbours’: this dynamic evolutionary game theoretic framework is well-suited for my investigation because the local interactions between agents provide a basis for modeling song transmission from adults to fledglings. In the simplest version of the model, each bird adopts one of two song types – trill or whistle – and sings that song type for the duration of its life. These song strategies are communicated to other birds in neighboring territories, which are arranged as a grid composed of two acoustic habitats (forest and field). Birds have a set probability of dying in each year, and deceased birds are succeeded by fledglings. The likelihood that a fledgling adopts a particular song type depends on (i) the popularity of a particular song-type among neighboring birds and (ii) the relative ‘audibility’ of each signal, which is a joint function of the habitat and song type of the signaling bird. The main point of this research is not to test this model, but to demonstrate that models of this type have the resources to meet the outstanding challenges in Cultural Selection Theory. The benefits of this research are threefold. First, it will lend much needed empirical support to Cultural Selection Theory by clarifying the nature of the interaction between culture and environment. Second, it will support Alexander and Skyrms’ work by providing a set of empirically testable consequences for their model. Finally, it will contribute to evolutionary theory by clarifying the scope and limits of adaptation by natural selection. (shrink)

Santa Constanza est une des deux églises qui font partie de la première architecture chrétienne à Rome. Il ne reste aujourd'hui qu'un bâtiment circulaire de 29 m de diamètre. Il est probable que Santa Constanza fut à l'origine le mausolée impérial de la Via Nomentana à l'époque de l'empereur Julien. La mort de sa femme fut l'occasion de la construction de l'édifice. Nous possédons des preuves documentaires sur la sépulture de sa femme qui repose à côté de sa soeur. La (...) décoration de Santa Constanza semblait représenter et saluer l'ensemble des dieux, les païens et le chrétien. (shrink)

Dans plusieurs publications récentes, on peut trouver mention du soi-disant mausolée de Galla Placidia de Ravenne. Puisqu'il est certain, d'après les caractéristiques architecturales, qu'il s'agit d'une chapelle funéraire, le soi-disant se rapporte à l'impératrice. Or, les éléments iconographiques de la chapelle sont étroitement liés à la vie et l'histoire de Galla Placidia. L'auteur revient donc sur la question suivante : qui est inhumé dans cette chapelle et, s'il n'y a personne, qui devait être l'occupant du tombeau ?

Wood, Kressel, Joshi, and Louie thoroughly evaluate the evidence for menstrual cycle shifts in ratings of several male characteristics and conclude that their analyses fail to provide supportive evidence for consistent cycle effects. The topic of menstrual cycle shifts in mate preferences has been strongly debated, with disagreements over both scientific content and practice. Here, we attempt to take a step back from these acrimonious exchanges and focus instead on how to interpret menstrual cycle shifts in mate preference tasks, independently (...) from the question of when, or if, task performance varies with cycle stage. A greater consideration of domain-general mechanisms could provide an opportunity for investigating how evolved predispositions interact with socially transmitted information in biasing women’s responses on mate preference tasks. (shrink)

Why is it important for people to agree on and articulate shared reasons for just laws, rather than whatever reasons they personally find compelling? What, if any, practical role does public reason play in liberal democratic politics? We argue that the practical role of public reason can be better appreciated by examining the confluence of normative and positive political theory; the former represented here by liberal social contract theory of John Rawls and others, and the latter by rational choice or (...) game theory. Citizens in a diverse society face a practical as well as a moral problem. How can they have confidence that others will reciprocate their commitment to supporting governing principles that depart from their own ideal conceptions of truth and value in order to be reasonable to all? Citizens face a practical problem of mutual assurance that public reason helps them solve, and solve as a matter of common knowledge. The solution, on both views, requires citizens’ reciprocal commitment to basing law on a system of shared reasons. Both views place public reason at the core of liberal democratic politics in conditions of diversity, and for quite similar reasons. Our argument illustrates the complementary roles of positive and values-based analysis in constitutional design. (shrink)

A review essay of Gillian Brock Global Justice: A Cosmopolitan Account (Oxford University Press, 2009).

ABSTRACT This paper argues for a version of sceptical invariantism about knowledge on which the acceptability of knowledge-attributing sentences varies with the context of assessment.

Take a correct sequent of formal logic, perhaps a simple logical truth, like the law of excluded middle, or something with premises, like disjunctive syllogism, but basically a claim of the form \.Γ can be empty. If you don’t like my examples, feel free to choose your own, everything I have to say should apply to those as well. Such a sequent attributes the properties of logical truth or logical consequence to a schematic sentence or argument. This paper aims to (...) answer the question of how beliefs in such attributions are justified, on both its descriptive and normative interpretations; I aim to say when we generally take ourselves to be justified in forming such beliefs, and to make it plausible that beliefs formed this way really are justified.We can ask such questions about many domains but there are special difficulties for answering them in logic. Some of the difficulties stem from the fact that logic is thought t.. (shrink)

ABSTRACTThere is a growing body of literature describing conceptual frameworks for working with participatory visual methods. Through a global health lens, this paper examines some key themes within these frameworks. We reflect on our experiences of working with with an array of PVM to engage community members in Vietnam, Kenya, the Philippines and South Africa in biomedical research and public health. The participants that we have engaged in these processes live in under-resourced areas with high prevalence of communicable and non-communicable (...) diseases. Our paper describes some of the challenges that we have encountered while using PVM to foster knowledge exchange, build relationships and facilitate change among individuals and families, community members, health workers, biomedical scientists and researchers. We consider multiple ethical situations that have arisen through our work and discuss the ways in which we have navigated and negotiated them. We offer our reflections and learning from facil... (shrink)

In recent years, a number of important challenges have been raised about whether arguments for granting group rights in virtue of ethnicity can really stand up to scrutiny. Two of the most pressing issues involve whether granting rights to groups in virtue of ethnicity involves a certain unfairness to non-members and whether granting such rights licenses unfairness to members . If arguments for indigenous rights are to succeed, they must address these challenges and show how there is no important unfairness (...) to non-members or members.Several arguments for indigenous rights are discussed, to show how they fall prey to one or both of the unfairness objections. The article goes on to offer an argument as to how proponents of indigenous rights might respond to claims that such rights discriminate obnoxiously between groups. This approach can accommodate the force of indigenous peoples’ claims and so grant certain kinds of groups rights, without at the same time licensing the group's oppression of its more vulnerable members. Moreover, since the argument appeals to considerations typically thought persuasive in liberal theory, it should be attractive to liberals. (shrink)

Trinucleotide repeat expansions are now a well‐established mutational mechanism in human genetic disease. An unstable CAG repeat is known to be responsible for three neurodegenerative disorders: Huntington's disease, spinal and bulbar musclar atrophy and spinocerebellar ataxia type 1. Similarities in the genetics of these diseases, the size of the repeat expansions and the position of the unstable repeat within the gene (when known) suggest a common basis to the observed phenotypes. The cloning of two regions at which chromosome breakage can (...) be induced (FRAXA and FRAXE) has in each case uncovered an unstable CG‐rich triplet repeat which becomes methylated when fully expanded. In addition to these two classes of mutation, the presence of an expanded CTG repeat in the 3′ untranslated region of a protein kinase causes myotonic dystrophy. The size of the respective expansions, repeat stability, mutational origins and possible mechanisms of action are discussed. (shrink)

In this paper I examine the method Aristotle uses in the inquiry into the nature of happiness in the "Nicomachean Ethics". Through analysis of some of the method's features, I explain why labelling it "the onion approach to developing and fleshing out a hypothesis" is appropriate. I show how Aristotle derives a set of necessary conditions and a set of other criteria, or reliable indicators, which any adequate account of the nature of happiness must meet. There are definite benefits to (...) understanding the strategy in these terms. Having derived a set of criteria that an adequate account must meet, we are in a position to examine which of the two rival hypotheses about the nature of happiness best satisfies the criteria. The life of theoretical study emerges as the clear winner at meeting the criteria Aristotle himself imposes on an adequate account. (shrink)