Many diseases and disease symptoms still lack effective treatment. At the same time, certain controversial Schedule I drugs, such as heroin and cannabis, have been reputed to have considerable therapeutic potential for addressing significant medical problems. Yet, there is a paucity of U.S. clinical studies on the therapeutic uses of controlled drugs. For example, people living with HIV/aids experience a variety of disease- and medication-related symptoms. Their chronic pain is intense, frequent, and difficult to treat. Nevertheless, clinical trials of compassionate (...) management for their chronic symptoms, which should be a research priority, are stymied. Stakeholders’ Views on Barriers to Research on Controlled Substances Evelyn Rhodes, Michael Andreae, Tyler Bourgiose, Debbie Indyk, Rosamond Rhodes, and Henry Sacks We employed qualitative methods to develop an understanding of the barriers to research on potential therapeutic uses of Schedule I drugs so that they might be addressed. We elicited the perspectives of key stakeholder groups that would be involved in such studies: people living with HIV/aids, clinicians, and members of institutional review boards. As we identified obstacles to research, we found that all of the stakeholder groups arrived at the same conclusion, that clinical research on the therapeutic potential of these drugs is ethically required. (shrink)

Volume 19, Issue 6, June 2019, Page 19-21.

This case raises a number of complex ethical, legal, and practical issues, some of which cannot be resolved by a research ethics consultation. Sam is an adolescent who has end stage manifestations...

In their article “Ethical Issues in Fecal Microbiota Transplantation in Practice,” Ma and colleagues (2017) raise a number of questions related to the development of fecal microbiota transplants (F...

We examine the ethical, social, and regulatory barriers that may hinder research on therapeutic potential of certain controversial controlled substances like marijuana, heroin, or ketamine. Hazards for individuals and society and potential adverse effects on communities may be good reasons for limiting access and justify careful monitoring of these substances. Overly strict regulations, fear of legal consequences, stigma associated with abuse and populations using illicit drugs, and lack of funding may, however, limit research on their considerable therapeutic potential. We review (...) the surprisingly sparse literature and address the particular ethical concerns pertinent to research with illicit and addictive substances, such as undue inducement, informed consent, therapeutic misconception, and risk to participants, researchers, and institutions. We consider the perspectives of key research stakeholders and explore whether they may be infected with bias. We conclude by proposing an empirical research agenda to provide an evidentiary basis for ethical reasoning. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:84 Reviews THE WAYS OF THE WITTGENSTEINS ACCORDING TO A WAUGH Richard Henry Schmitt U. of Chicago Chicago, il 60637, usa [email protected] AlexanderWaugh. TheHouseofWittgenstein:aFamilyatWar. London: Bloomsbury, 2008. Pp. 366. isbn: 0-7475-9185-7. £20.00 (hb). New York: Doubleday, 2009. Pp. 333. isbn: 0-385-52060-3. us$28.95 (hb). Ezach family is happy and unhappy in its own ways. This is hardly surprising zgiven that the family lies at the crossroad of so much (...) human experience. It is the scene for playing out genetics and for working through the rearing and civilizing of children, both nature and nurture. In economic life it constitutes the primary unit, the household. Despite Tolstoy’s ideal, none can ever be com­ pletely happy for every member all the time. And, there is no reason to think that basically happy families are any more the same than unhappy ones. But then none can ever be completely unhappy; or rather, when a family is com­ pletely unhappy it is unlikely that it will remain one. One other factor, however, intrudes on this picture: we tend to be more interested in bad or scandalous news than good. Vicarious experience brings catharsis, possibly helpful in a way. Yet, as the German language recognizes with the word “Schadenfreudez”, we can experience joy at someone else’s sorrow, despite the questions it raises about our empathy. Alexander Waugh is himself the member of a famous family. He has written December 2, 2009 (5:28 pm) E:\CPBR\RUSSJOUR\TYPE2901\russell 29,1 060 red.wpd E:\CPBR\RUSSJOUR\TYPE2901\russell 29,1 060 red.wpd Reviews 85 its “autobiography” in Fathers and Sons,1 where he is principally concerned with his father Auberon (“Bron”), his grandfather Evelyn, his great-uncle Alec, and his great-grandfather Arthur. Given the family documentation at his disposal and the span of generations, that book covers enough territory, in enough detail, to give us some sense of Waugh family character. You learn what it was like to grow up in the family, down to the odour of Uncle Auberon Herbert’s cologne, “smelling like Cleopatra in her barge on her way to meet Antony for the Wrst time” according to Bron (p. 370, paperback ed.), and the family suspicion that this uncle may have been the illegitimate son of Hilaire Belloc (p. 276). The fathers and sons, from Arthur down to Alexander, all wrote for a living, witty, stylish prose, and sometimes poetry. They especially liked writing about each other in letters, essays, and novels, often to each other in public letters and dedications; and as a consequence Alexander’s book is rich, amusing, intimate, and a bit indiscrete. Arthur’s turn-of-the-century avoidance of emotion in sentimentality grew outmoded, but it was replaced in the family business with newer models, with more Xash and cynicism. When it came to Alexander’s fa­ ther Bron, he was known for his talent at vituperation, and got into verbal and legal scrapes with C. P. Snow and Bertrand Russell among others (p. 407), which led to his getting sacked but only made his journalism more widely read and more valuable to publishers. In Alexander’s disclosure of his family history, there is a sureness of touch that comes from working within his ken. Waugh studied music, and worked as a music critic. In his easy, self-depreci­ ating way, he told an interviewer for The Wall Street Journalz that he got the idea to write this book because of “the most appalling boil on my right index Wnger”. This curtailed his routine enjoyment at the piano, “But then as I sat down and pressed a chord with my left hand I thought of Paul Wittgenstein. I knew about the concerto that Ravel composed for him and I knew that he was Ludwig’s brother. He was bound to have an interesting story.”2 With access to some Witt­ genstein family papers through one of Paul Wittgenstein’s daughters, he began. But a biography of the one-armed pianist soon turned into this “family history”, in part because of the author’s previous success with his own family, but also... (shrink)

Bringing together evolutionary biology, psychology, and philosophy, Henry Plotkin presents a new science of knowledge, one that traces an unbreakable link between instinct and our ability to know.

This book constitutes one of the most important contributions to recent Kant scholarship. In it, one of the pre-eminent interpreters of Kant, Henry Allison, offers a comprehensive, systematic, and philosophically astute account of all aspects of Kant's views on aesthetics. The first part of the book analyses Kant's conception of reflective judgment and its connections with both empirical knowledge and judgments of taste. The second and third parts treat two questions that Allison insists must be kept distinct: the normativity (...) of pure judgments of taste, and the moral and systematic significance of taste. The fourth part considers two important topics often neglected in the study of Kant's aesthetics: his conceptions of fine art, and the sublime. (shrink)

Henry Allison is one of the foremost interpreters of the philosophy of Kant. This new volume collects all his recent essays on Kant's theoretical and practical philosophy. All the essays postdate Allison's two major books on Kant, and together they constitute an attempt to respond to critics and to clarify, develop and apply some of the central theses of those books. Two are published here for the first time. Special features of the collection are: a detailed defence of the (...) author's interpretation of transcendental idealism; a consideration of the Transcendental Deduction and some other recent interpretations thereof; further elaborations of the tensions between various aspects of Kant's conception of freedom and of the complex role of this conception within Kant's moral philosophy. (shrink)

Henry E. Allison presents a comprehensive commentary on Kant's Groundwork for the Metaphysics of Morals. Allison pays special attention to the structure of the work and its historical and intellectual context. He argues that, despite its relative brevity, the Groundwork is the single most important work in modern moral philosophy.

Henry Sidgwick,, philosopher, classicist, lecturer and fellow of Trinity College, Cambridge, and supporter of women's university education, is well known for his Method of Ethics, a significant and influential book on moral theory. First published in 1883, this work considers the role the state plays in economic life, and whether economics should be considered an Art or a Science. Sidgwick applies his utilitarian views to economics, defending John Stuart Mill's 1848 treatise of the same name. The book calls for (...) a return to traditional political economy by eliminating 'needless polemics'. Sidgwick also outlines the need to bridge the gap between his analytical or deductive method and the inductive method employed by Mill's critics, the new generation of economic philosophers including John Elliot Cairnes and William Stanley Jevons. The second edition, reissued here, was published in 1887. (shrink)

Henry E. Allison presents a comprehensive commentary on Kant's Groundwork for the Metaphysics of Morals . Allison pays special attention to the structure of the work and its historical and intellectual context. He argues that, despite its relative brevity, the Groundwork is the single most important work in modern moral philosophy.

Boethius was a Roman senator who rose to high office under the Gothic king Theoderic the Great. He translated into Latin all he knew of Plato and Aristotle, and was profoundly interested in the issues of theology and philosophy. The Consolations were written while he awaited the execution of a tyrannical death sentence. The Consolations of Philosophy have been translated into English by King Alfred, Geoffrey Chaucer, and Queen Elizabeth I. This scholarly study by Henry Chadwick, the first this (...) century since the War, has stimulated new interest in these remarkable works. (shrink)

_Epistemology and Inference _ was first published in 1983. Minnesota Archive Editions uses digital technology to make long-unavailable books once again accessible, and are published unaltered from the original University of Minnesota Press editions. Henry Kyburg has developed an original and important perspective on probabilistic and statistical inference. Unlike much contemporary writing by philosophers on these topics, Kyburg's work is informed by issues that have arisen in statistical theory and practice as well as issues familiar to professional philosophers. In (...) two major books and many articles, Kyberg has elaborated his technical proposals and explained their ramifications for epistemology, decision-making, and scientific inquiry. In this collection of published and unpublished essays, Kyburg presents his novel ideas and their applications in a manner that makes them accessible to philosophers and provides specialists in probability and induction with a concise exposition of his system. (shrink)

A biography of Augustine's thought life, as interpreted by the acclaimed church historian, the late Professor Henry Chadwick. Augustine's intellectual development is recounted with clarity and warmth, providing a characteristically rigorous yet sympathetic narrative of this central figure in the history of Christian thought.

The reductive nature of Kincaid's undertaking comes into sharper focus when we compare his kind of critical inquiry with that, say, of [Sheldon] Sacks or [Ralph] Rader. Kincaid concludes where they begin. For Sacks, the identification of some type, such as satire, is what initiates the critical process. What then remains is to move beyond type, which exists at the highest level of generality, to form and finally to those detailed analyses which will account for the peculiar powers (...) of unique works. His types, as he says, are "only elementary distinctions," and he adds that "at some point in an adequate criticism of a single literary work, we will inevitably be discussing those variations which distinguish a particular literary work from all other literary works of its class, even if that class has been defined according to the most subtle and intricate combination of variables possible."1 Similarly for Rader, our intuitions about formal principles and intentions are but first steps in critical inquiry. "My theory, " he says, "attempts not to establish 'general laws' . . . but to render explicit the structural features of our tacit experiences of literature in a way that will allow us to bring all its implications to bear simultaneously upon our explanation of any particular literary work."2 Such procedures as these, which are designed to give us particular knowledge, are ruled out by Kincaid's program, the most specific formal principle of which is something quite general: the competition among narrative patterns. There is finally, then, very little knowledge to be shared, for our inquiries will always arrive at the same conclusion. Although readers, in his view, can intend one thing rather than another, writers cannot, and this assumption that agents are somehow set apart from the other members of the species means, I suspect, that Kincaid is right about one thing: his effort to mediate does indeed place him in a "no-man's land." · 1. Sheldon Sacks, Fiction and the Shape of Belief , pp. 25-26 n.· 2. Rader, "Explaining Our Literary Understanding," Critical Inquiry 1 : 905. Robert Denham, editor of Northrop Frye: An Enumerative Bibliography and the forthcoming Northrop Frye on Culture and Literature , is associate professor and chairman of the department of English at Emory and Henry College. In this essay Robert Denham replies to James R. Kincaid's "Coherent Readers, Incoherent Texts" Critical inquiry, Summer 1977. (shrink)

In the face of limited resources during the COVID-19 pandemic response, public health experts and ethicists have sought to apply guiding principles in determining how those resources, including vaccines, should be allocated.

THE Concluding Unscientific Postscript is generally regarded as the most philosophically significant of Kierkegaard's works. In terms of a subjectivistic orientation it seems to present both an elaborate critique of the pretensions of the Hegelian philosophy and an existential analysis which points to the Christian faith as the only solution to the "human predicament." Furthermore, on the basis of such a straightforward reading of the text, Kierkegaard has been both vilified as an irrationalist and praised as a profound existential thinker (...) who has uncovered the only legitimate starting point for a philosophical analysis of the religious life and a Christian apologetic. (shrink)

An EXACT reproduction from the original book BODY AND WILL: BEING AN ESSAY CONCERNING WILL IN ITS METAPHYSICAL, PHYSIOLOGICAL and PATHOLOGICAL ASPECTS by Henry Maudsley first published in 1884. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print (...) as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. (shrink)

Interdisciplinary work is intractable because the search for knowledge in different fields entails different interests, and thereby different values too; and the different possibilities of knowledge about different subjects also lead to different epistemologies. Thus differ ences among practitioners of the various disciplines are pervasive and aptly described as cultural ones, and interdisciplinary work requires transcending unconscious habits of thought. The more those unconscious habits are explicated and the more we under stand how the disparate characteristics of the various intellectual (...) cultures are related to the necessarily different interests, values, and epistemologies, the more feasible becomes the goal of transcending thought habits. Two sorts of interdisciplinary effort seem to have been successful: specific, delimited problems have been solved by teams in what is actually multidisciplinary rather than interdisciplinary work, and new disciplines have sprung up at the intersections of existing ones. STS fits neither of those patterns. Can it nevertheless be viable? (shrink)

Experimental observations are often taken in order to assist in making a choice between relevant hypotheses ~H and H. The power of observations in this decision is here metrically defined by information-theoretic concepts and Bayes' theorem. The exact of a new observation to increase or decrease Pr the prior probability that H is true; the power of that observation to modify the total amount of uncertainty involved in the choice between ~H and H: the power of a new observation to (...) reduce uncertainty toward the ideal amount, zero; all these powers are systematically shown to be exact metrical functions ofwhere the numerator is the likelihood of the new observation given H, and the denominator is the “expectedness” of the observation. (shrink)

Decisions concerning proof of facts in criminal law must be rational because of what is at stake, but the decision‐making process must also be cognitively feasible because of cognitive limitations, and it must obey the relevant legal–procedural constraints. In this topic three approaches to rational reasoning about evidence in criminal law are compared in light of these demands: arguments, probabilities, and scenarios. This is done in six case studies in which different authors analyze a manslaughter case from different theoretical perspectives, (...) plus four commentaries on these case studies. The aim of this topic is to obtain more insight into how the different approaches can be applied in a legal context. This will advance the discussion on rational reasoning about evidence in law and will contribute more widely to cognitive science on a number of topics, including the value of probabilistic accounts of cognition and the problem of dealing with cognitive biases in reasoning under uncertainty in practical contexts. (shrink)

Dans cet entretien, Henry Bernstein revient sur la fondation des études agraires critiques et les principaux concepts qu’il a développés pour une étude marxiste de la sociologie rurale. Il montre comment l’opposition entre léninisme et populisme se rejoue dans l’épistémologie de la structure de classe de la paysannerie.

If I choose two words in the book that I think have been most influential, I would choose "mutually exclusive." Sacks was scarcely the first critic to observe that the kinds of fiction are usually actions, apologues, or satires. But no other theoretician has insisted so cogently as he did that, as principles governing the interaction of parts in a coherent work, these principles are mutually exclusive, "mutually incompatible." The reason Sacks became a great journal editor was that (...) the firmness of his own principles never blinded him to the value of other and very different theoretical questions which might be addressed to a work of fiction. And his tone of voice was never brazen but always that of the eighteenth-century gentleman: Come, let us reason together. Yet he never blinked his adherence to the truths he saw: he stated them directly, and he taught us to strive equally to face the consequences of holistic recognition of forms: "One cannot create an action which is also a satire any more than he can write an active sentence which is also a passive sentence in English. To carry the analogy a step farther, the observation that the types are mutually incompatible is no more an attempt to dictate to writers what they may or may not do than is the observation that active sentences are not passive sentences" . Mary Doyle Springer, associate professor of English at Saint Mary's College of California, is the author of Forms of the Modern Novella and A Rhetoric of Literary Character: Some Women of Henry James. She is presently at work on a companion theoretical study dealing with the rhetoric of dramatic character in performance. (shrink)

Direct-to-Consumer genomics has been a controversial topic for over a decade. Much work has been done on the legal issues it raises. This article asks a different question: What will DTC genomics and its legal issues look like in ten to twenty years? After discussing the five current uses of DTC genomics, it describes three current legal issues: medical uses, privacy of genomic information, and privacy in collection and analysis of human DNA. It then suggests that changes in human genomics (...) and how it is used will make the first of those DTC genomics legal issues less important in the future, but that the third will be increasingly significant. (shrink)

Johnson and colleagues (2015) report a retrospective review of the experience of an ethics consultation service at a single, highly specialized children's hospital over an 11-year period. Despite i...