The prospect of consumable meat produced in a laboratory setting without the need to raise and slaughter animals is both realistic and exciting. Not only could such in vitro meat become popular due to potential cost savings, but it also avoids many of the ethical and environmental problems with traditional meat productions. However, as with any new technology, in vitro meat is likely to face some detractors. We examine in detail three potential objections: 1) in vitro meat is disrespectful, either (...) to nature or to animals; 2) it will reduce the number of happy animals in the world; and 3) it will open the door to cannibalism. While each objection has some attraction, we ultimately find that all can be overcome. The upshot is that in vitro meat production is generally permissible and, especially for ethical vegetarians, worth promoting. (shrink)

This highly readable theory of life and its origins offers a non-technical discussion of a chemical perspective on the fundamental organisation of living systems. Essays on the biological and philosophical significance of Ganti's work of thirty years indicate not only its enduring theoretical significance, but also the continuing relevance and heuristic power of Ganti's insights.

When this classic work was first published in 1976, its central tenet--more is not necessarily better--placed it in direct conflict with mainstream thought in economics. Within a few years, however, this apparently paradoxical claim was gaining wide acceptance. Scitovsky's ground-breaking book was the first to apply theories of behaviorist psychology to questions of consumer behavior and to do so in clear, non-technical language. Setting out to analyze the failures of our consumerist lifestyle, Scitovsky concluded that people's need for stimulation is (...) so vital that it can lead to violence if not satisfied by novelty--whether in challenging work, art, fashion, gadgets, late-model cars, or scandal. Though much of the book stands as a record of American post-war prosperity and its accompanying problems, the revised edition also takes into account recent social and economic changes. A new preface and a foreword by economist Robert Frank introduce some of the issues created by those changes and two revised chapters develop them, discussing among others the assimilation of counter-cultural ideas throughout American society, especially ideas concerning quality of life. Scitovsky draws fascinating connections between the new elite of college-educated consumers and the emergence of a growing underclass plagued by drugs and violence, perceptively tracing the reactions of these disparate groups to the problems of leisure and boredom. In the wake of the so-called "decade of greed" and amidst calls for a "kindler, gentler" society, The Joyless Economy seems more timely than ever. (shrink)

This paper focuses on the dynamics of ethical perspectives that embody the Golden Rule of Morality. Based on critical analysis of this rule in various cultural and religious contexts, but also from the perspective of humanism, the author presents its paradoxical character, the essence of which is interpreted here in terms of a pointer to metaphysical reality. It turns out that social conditionality, as well as the self-referential concept as a starting point of any ethical reasoning, are serious epistemological challenges (...) for the application of the Golden Rule in the position of universal normativity that this study addresses. On the other hand, Judeo-Christian cosmology and the related basis for ethical foundations is presented here as an inspirational space of ethical reasoning in which the paradoxical character of the Golden Rule becomes rather an indicator of a deeper metaethical interpretation of one's own particular ethical attitudes and outcomes than a practical guide to the discovery of ethical universals. (shrink)

We investigate properties of accessible categories with directed colimits and their relationship with categories arising from ShelahʼsElementary Classes. We also investigate ranks of objects in accessible categories, and the effect of accessible functors on ranks.

This article explores Franz Brentano's opposition to papal infallibility, and sets this in the context of his development as a Catholic scholar. An active participant in the Catholic revival of the nineteenth century, Brentano contributed to the emergence of neoscholasticism through his philosophical rehabilitation of Aristotle. Brentano ultimately left the Church however as the result of intensive scrutiny of his faith occasioned by his analysis of infallibility. This article explores this crisis of faith by analyzing, for the first time, Brentano's (...) position on papal infallibility, and suggesting ways that it informed his philosophical development. (shrink)

Journal for the Theory of Social Behaviour, EarlyView.

In highly structured organisational fields individual efforts to deal rationally with uncertainty and constraints tend to lead, in the aggregate, to greater homogeneity in structure, culture and output. Drawing on institutional theory, this paper develops research propositions regarding the nature and scope of corporate social responsibility (CSR) engagement at trade/industry association level. The cases of the water and sewerage and film industries are used in order to test these propositions. The findings suggest that (a) trade associations in more homogeneous industries (...) are more likely to engage with CSR‐related issues; (b) trade associations in industries that face greater external scrutiny and threats to legitimacy are more likely to engage with CSR‐related issues; and (c) trade associations are more likely to engage with those substantive CSR issues that are of greater concern to the industry's most salient stakeholders. The findings also suggest that trade associations may have a greater tendency to engage in symbolic legitimation efforts through CSR if faced with the task of repairing industry legitimacy. (shrink)

We live in the Information Age. Advances over the past 50 years in computing technology have enabled ever-expanding capacity to generate, store, transfer, process and analyse information about people, societies, products, services, the environment—nearly every aspect of the world. In parallel, concerns over how such data is being used have emerged, focusing especially on issues of privacy and confidentiality. Yet as technological capabilities continue to expand, the debate over ethical uses of data inevitably has evolved as well. Whereas we used (...) to just talk about data, now there is great concern over Big Data. This chapter explores what, exactly, Big Data is; the ethical ramifications of its emergence, particularly for consent and anonymization; and what sorts of policy solutions are being proposed to address these emerging challenges. We will not defend one particular approach, but hope this chapter can be a useful reference for those who are contemplating difficult questions surrounding responsible management of Big Data. (shrink)

Ethical decision-making frameworks assist in identifying the issues at stake in a particular setting and thinking through, in a methodical manner, the ethical issues that require consideration as well as the values that need to be considered and promoted. Decisions made about the use, sharing, and re-use of big data are complex and laden with values. This paper sets out an Ethics Framework for Big Data in Health and Research developed by a working group convened by the Science, Health and (...) Policy-relevant Ethics in Singapore Initiative. It presents the aim and rationale for this framework supported by the underlying ethical concerns that relate to all health and research contexts. It also describes a set of substantive and procedural values that can be weighed up in addressing these concerns, and a step-by-step process for identifying, considering, and resolving the ethical issues arising from big data uses in health and research. This Framework is subsequently applied in the papers published in this Special Issue. These papers each address one of six domains where big data is currently employed: openness in big data and data repositories, precision medicine and big data, real-world data to generate evidence about healthcare interventions, AI-assisted decision-making in healthcare, public-private partnerships in healthcare and research, and cross-sectoral big data. (shrink)

The future of health research will be characterised by three continuing trends: rising demand for health data; increasing impracticability of obtaining specific consent for secondary research; and decreasing capacity to effectively anonymise data. In this context, governments, clinicians and the research community must demonstrate that they can be responsible stewards of health data. IRBs and RECs sit at heart of this process because in many jurisdictions they have the capacity to grant consent waivers when research is judged to be of (...) particular value. However, several different terms are used to refer to this value, indicating a lack of conceptual clarity regarding the appropriate test for access to health data for research without consent. In this paper we do three things. First we describe the current confusion and instability in terminology relating to public interest in the context of consent waivers. Second we argue for harmonisation of terminology on the grounds of clarity, transparency and consistency. Third we argue that the term ‘public interest’ best reflects the normative work required to justify consent waivers because it is the broadest of the competing terms. ‘Public interest’ contains within its scope positive and negative implications of a study, as well as welfare, justice and rights considerations. In making this argument, we explain the normative basis for consent waivers, and provide a starting place for further discussion about the precise conditions in which a given study can be said to advance the public interest. Ipsos MORI study found that: … the public would be broadly happy with administrative data linking for research projects provided Those projects have social value, broadly defined. Data are de-identified. Data are kept secure. Businesses are not able to access the data for profit. (shrink)

Some consequences of direct realism and William James’s philosophy of mind are considered in terms of American naturalism as seen in the debate between John Dewey and Roy Wood Sellars. Sellars’s critical realism and evolutionary naturalism is compared and contrasted with Dewey’s pragmatic realism and emphatically evolutionary naturalism. Though these naturalisms are similar, there are significant differences between methodology, their critiques of James’s reflex arc concept in his Principles of Psychology, and the mind-body problem. Sellars’s critical realism and naturalism retains (...) a priori commitments to fixed categories and concepts, whereas Dewey’s emphatically evolutionary pragmatic naturalism is empirical and sees continuities where Sellars insists on discontinuities. One significant difference is Sellars’s maintaining a place for introspection as methodologically appropriate and Dewey’s’ rejection of it. These differences are illustrated through Sellars’s modification of the reflex arc to include an organic but interpretative step, and Dewey’s radical criticism of approaches like James’s and Sellars’s as recapitulating the Cartesian dualism that such views intended to overcome. These differences are finally contrasted in Sellars’s maintaining a privacy of mind by constraining it to the brain in a dual-aspect theory, while Dewey advocates mind as sociocultural, expanding mind into body and world. (shrink)

Cognitive science and its philosophy have been far too long consumed with representation. This concern is indicative of a creeping Cartesianism that many scientists and philosophers wish to evade. However, their naturalism is often insufficiently evolutionary to fully appreciate the lessons of pragmatism. If cognitive neuroscience and pragmatism are to be mutually beneficial, the representational-friendly scientists and the anti-representational pragmatists need an alternative to representation that still accounts for what many find so attractive about representation, namely intentionality. I propose that (...) instead of representations we philosophers and scientists begin thinking in terms of cultural affordances. Like Gibsonian affordances, cultural affordances are opportunities for action. However, unlike Gibsonian affordances, which are merely biological and available for immediate action in the immediately present environment, cultural affordances also present opportunities for thinking about the past and acting into the future—tasks typically attributed to representations. (shrink)

Recent work in neurophilosophy has either made reference to the work of John Dewey or independently developed positions similar to it. I review these developments in order first to show that Dewey was indeed doing neurophilosophy well before the Churchlands and others, thereby preceding many other mid-twentieth century European philosophers’ views on cognition to whom many present day philosophers refer (e.g., Heidegger, Merleau-Ponty). I also show that Dewey’s work provides useful tools for evading or overcoming many issues in contemporary neurophilosophy (...) and philosophy of mind. In this introductory review, I distinguish between three waves among neurophilosophers that revolve around the import of evolution and the degree of brain-centrism. Throughout, I emphasize and elaborate upon Dewey’s dynamic view of mind and consciousness. I conclude by introducing the consciousness-as-cooking metaphor as an alternative to both the consciousness-as-digestion and consciousness-as-dancing metaphors. Neurophilosophical pragmatism—or neuropragmatism—recognizes the import of evolutionary and cognitive neurobiology for developing a science of mind and consciousness. However, as the cooking metaphor illustrates, a science of mind and consciousness cannot rely on the brain alone—just as explaining cooking entails more than understanding the gut—and therefore must establish continuity with cultural activities and their respective fields of inquiry. Neuropragmatism advances a new and promising perspective on how to reconcile the scientific and manifest images of humanity as well as how to reconstruct the relationship between science and the humanities. (shrink)

For people to contribute to discourse, they must do more than utter the right sentence at the right time. The basic requirement is that they add to their common ground in an orderly way. To do this, we argue, they try to establish for each utterance the mutual belief that the addressees have understood what the speaker meant well enough for current purposes. This is accomplished by the collective actions of the current contributor and his or her partners, and these (...) result in units of conversation called contributions. We present a model of contributions and show how it accounts for a variety of features of everyday conversations. (shrink)

Coronary by-pass surgery has been performed in hundreds of thousands of patients in the last 15 years with a high standard of technical and surgical perfection. The indications for this kind of surgery, however, are still controversial because in spite of many retrospective and several prospective studies it cannot be proven convincingly that in a given patient this surgical procedure will prolong life or prevent myocardial infarction. The present attempt to analyze the causes for this controversy shows that the main (...) reasons for this uncertainty lie: (a) in the enigma of the underlying (ischemic heart) disease itself, which is supposed to lend itself to surgical therapy; (b) in the inadequate methods available up until now for characterizing the state of the disease, its probable course, and its pathogenesis; and (c) in the professional group interests which have a momentum of their own. (shrink)

The philosophical problem of pictorial conversational implicatures can be summarized as follows: We have three propositions that are independently plausible and jointly inconsistent. -/- (Non-P) Anti-propositionalism: pictures do not have context-independent, conventionally encoded propositional content (propositional function). -/- (C) Only those representations can be used to convey conversational implicatures which have associated with them a context-independent, conventionally encoded propositional content (function). -/- (I) Pictures can be used to convey conversational implicatures. -/- There are three ways of responding to the problem: (...) affirm (Non-P) and (C) while denying (I); affirm (C) and (I) while denying (Non-P); or affirm (Non-P) and (I) while denying (C). (shrink)

This paper contributes an analysis and formalisation of Damasio’s theory on core consciousness. Three important concepts in this theory are ‘emotion’, ‘feeling’ and ‘feeling a feeling’ . In particular, a simulation model is described of the dynamics of basic mechanisms leading via emotion and feeling to core consciousness, and dynamic properties are formally specified that hold for these dynamics at a more global level. These properties have been automatically checked for the simulation model. Moreover, a formal analysis is made of (...) relevant notions of representation used by Damasio. As part of this analysis, specifications of representation relations have been verified and confirmed against the simulation model. (shrink)

In pathological conditions associated with persistent increases in hemodynamic workload (old myocardial infarction, high blood pressure, valvular heart disease), a number of signalling pathways are activated in the heart, all of which promote hypertrophic growth of the heart, characterised at the cellular level by increases in individual cardiac myocyte size. Some of these pathways are required for a successful adaptation to cardiac injury. Other pathways are maladaptive, however, as they lead to progressive contractile dysfunction and heart failure. The free radical (...) gas nitric oxide and natriuretic peptides, both of which are produced in the heart, have emerged as endogenous inhibitors of maladaptive hypertrophy signalling. Overall, it appears that cardiac hypertrophy is controlled by an interplay of pro‐ and antihypertrophic signalling networks. This delicate balance can tip towards adaptation or heart failure. In the future, patients living with cardiac disease may benefit from therapeutic strategies targeting maladaptive hypertrophy signalling pathways. BioEssays 26:608–615, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Over the past three decades, cognitive science has been making a turn towards pragmatism. Here we outline steps towards completing this turn. As a handful of cognitive scientists and philosophers have been arguing more recently, the insights of William James, John Dewey, and George Herbert Mead are not only being re-discovered, they are also proving rather prescient in light of growing research. The new field of neuropragmatism aims to take these insights seriously and further into new directions for both pragmatism (...) and cognitive science. In this manifesto, a brief history of the relationship between classical pragmatism and the sciences of life and mind is offered as a background for twelve proposed theses of neuropragmatism. These theses serve as general guidelines for further philosophical and scientific research. To illustrate the possibilities and consequences of this neuropragmatic framework, neuropragmatist views on traditional questions of philosophy of mind, such as the mind-body relationship, are situated among other leading philosophical perspectives, like enactive, embodied, and embedded theories of cognition and mentation. Such views, however, when taken from a neuropragmatist perspecitve, have significant consequences for the philosophical project of reconciliation be- tween what Wilfrid Sellars called the scientific and manifest images of humanity. The difference in conceptions of experience and subesequently science are crucial for understanding the difference between Sellarsian neurophilosophy and neuropragmatism, as well as how to reach rapprochement between the sciences and the humanities. (shrink)

The COVID-19 pandemic has both exposed and created deep rifts in society. It has thrust us into deep ethical thinking to help justify the difficult decisions many will be called upon to make and to protect from decisions that lack ethical underpinnings. This paper aims to highlight ethical issues in six different areas of life highlighting the enormity of the task we are faced with globally. In the context of COVID-19, we consider health inequity, dilemmas in triage and allocation of (...) scarce resources, ethical issues associated with research, ethical considerations relating to tracing apps, and exit strategies such as immunity passports and COVID-19 vaccines. Finally, we consider environmental issues in light of COVID-19. The paper also offers some ethical reflection on these areas as many parts of the world contemplate the recovery phase. (shrink)

Neuropragmatism offers a non-dualistic conception of experience from which scientific inquiries can provide resources for sociocultural critique. This reconstructive effort addresses what Emma Dowling calls the care crisis without succumbing to what Mike W. Martin calls therapeutic tyranny. This tyranny relies on problematic dualisms, between mind/body, mind/world, and fact/value, that are also found in neuropsychoanalysis. While pragmatism and psychoanalysis more generally share an evolutionary perspective and can overlap in therapeutic approaches, neuropsychoanalysis diverges from this effort in its dual-aspect monism and (...) positivistic conception of science. Where neuropsychoanalysis seeks to reconcile the first-person subjectivity of lived experience with the third-person objectivity of science, neuropragmatism offers reconstruction. In taking the neuropragmatic turn, neuropsychoanalysts can better utilize Freudian therapies in conjunction with active inference principles, such as the free-energy principle and allostasis. Along with neuropragmatism’s conception of experience as organism-environment dynamic engagement, neuropsychoanalysis can benefit from allostatic approaches to experience and inquiry without reducing experience to brute mechanism or denying the utility of such mechanisms for prediction and intervention. Understanding the value-ladenness of experience, primary and secondary, in everyday waking life and in reflective inquiry, empowers people to better care for themselves without succumbing to merely coping with neoliberal oppression. (shrink)

Sustainable development will shortly become the core issue of our everyday life. This article argues that only a nature-driven economy and society could give a final answer to sustainability questions.

Abstract: What follows is a contribution to the field of user modeling for adaptive teaching and learning programs especially in the medical field. The paper outlines existing approaches to the problem of extracting user information in a form that can be exploited by adaptive software. We focus initially on the so-called stereotyping method, which allocates users into classes adaptively, reflecting characteristics such as physical data, social background, and computer experience. The user classifications of the stereotyping method are however ad hoc (...) and unprincipled, and they can be exploited by the adaptive system only after a large number of trials by various kinds of users. We argue that the remedy is to create a database of user ontologies from which readymade taxonomies can be derived in such a way as to enable associated software to support a variety of different types of users. (shrink)

Pragmatism has resurged explicitly in neopragmatism and implicitly in neurophilosophy. Neopragmatists have focused primarily on ideals, like human freedom, but at the expense of science. Neurophilosophers have focused primarily on scientific facts, but with an eye toward dismissing aspects of our self-conception like free will as illusory. In both cases, these resurgences are impoverished as each neglects what Dewey referred to as the method of intelligence. Neurophilosophical pragmatism - neuropragmatism - aims to overcome the deficiencies of neopragmatism and neurophilosophy by (...) carrying forth the project of reconstruction by taking both the methods and results of experimental inquiry as the means for attaining ends-in-view such as human freedom. (shrink)

I address the problem of caring for our body-mind through neuropragmatism, cybernetics, and Larry Hickman’s work on John Dewey and the philosophy of technology. The problems of body-mind health are related to Emma Dowling’s The Care Crisis. I address this crisis by drawing on Jay Schulkin’s conception of viability as the creative tension between stability and precarity. From this, I extend body-mind health to questions of democracy, leading to the proposal of body-mind-world as an elaboration of neuropragmatism’s evolutionary and ecological (...) conception of experience as Œ and Hickman’s distinction between the merely valued nature-as-nature and the valuable nature-as-culture. I conclude with a reimagination of creative democracy as a moral ideal for dealing with the care crisis. (shrink)

High degrees of uncertainty and a lack of effective therapeutic treatments have characterized the COVID-19 pandemic and the provision of drug products outside research settings has been controversial. International guidelines for providing patients with experimental interventions to treat infectious diseases outside of clinical trials exist but it is unclear if or how they should apply in settings where clinical trials and research are strongly regulated. We propose the Professional Oversight of Emergency-Use Interventions and Monitoring System as an alternative pathway based (...) on guidance developed for the ethical provision of experimental interventions to treat COVID-19 in Singapore. We support our proposal with justifications that establish moral duties for physicians to record outcomes data and for institutions to establish monitoring systems for reporting information on safety and effectiveness to the relevant authorities. Institutions also have a duty to support generation of evidence for what constitutes good clinical practice and so should ensure the unproven intervention is made the subject of research studies that can contribute to generalizable knowledge as soon as practical and that physicians remain committed to supporting learning health systems. We outline key differences between POEIMS and other pathways for the provision of experimental interventions in public health emergencies. (shrink)