Large-scale sequencing tests, including whole-exome and whole-genome sequencing, are rapidly moving into clinical use. Sequencing is already being used clinically to identify therapeutic opportunities for cancer patients who have run out of conventional treatment options, to help diagnose children with puzzling neurodevelopmental conditions, and to clarify appropriate drug choices and dosing in individuals. To evaluate and support clinical applications of these technologies, the National Human Genome Research Institute and National Cancer Institute have funded studies on clinical and research sequencing under (...) the Clinical Sequencing Exploratory Research program as well as studies on return of results. Most of these studies use sequencing in real-world clinical settings and collect data on both the application of sequencing and the impact of receiving genomic findings on study participants. They are occurring in the context of controversy over how to obtain consent for exome and genome sequencing. (shrink)

The extensive literature on the Learning Organisation proposes that a competitive advantage can be achieved through the systematised generation and application of knowledge. Consequently, much of the debate concerns the processes, routines and organisational features that a firm should adopt to learn more, and faster, than its competitors. Less attention is given to understanding the nature of the knowledge that is created by these Learning Organisations. We hold that the topic is more important than its current weight in the literature (...) because the performance claims of the models proposed critically depend upon the newly acquired knowledge replacing ignorance or knowledge with less utility. In this paper we explore the nature of knowledge that Learning Organisation theory seeks to create by articulating implicit epistemological assumptions found within the literature. We show that the capacities of each epistemology to help an organisation reject falsehood and make greater use of its knowledge are critically undermined by these very routines. The paper concludes by highlighting the importance of a sceptical epistemology and outlines a process that would strengthen doubting behaviour. (shrink)

Realist evaluation and Q Methodology are established approaches in social science. However, integration of Q methodology within a realist evaluation is scarce. This paper attempts to illustrate how Q methodology can support a realist evaluation. The paper attempts to capture the philosophical compatibility of the two approaches creating an argument for Q’s integration within realist evaluation. Through the case study selected the iterative methodological process is presented, capturing a snapshot of the findings from the evaluation. This illuminates how Q met (...) the philosophical aims of a realist evaluation to make sense of how and why and under what circumstances a programme or intervention works. It is argued that Q methodology is entirely suitable for capturing the three key stages in a realist evaluation of developing, testing, and refining programme theory. It is intended that this paper can contribute to inspire other realist evaluators and methodologists to make use of Q as a tool in their evaluation. (shrink)

: Medical research is widely thought to have a fundamentally therapeutic orientation, in spite of the fact that clinical research is thought to be ethically distinct from medical care. We need an entirely new conception of clinical research ethics—one that looks to science instead of the doctor-patient relationship.

Steven French articulates and defends the bold claim that there are no objects in the world. He draws on metaphysics and philosophy of science to argue for structural realism--the position that we live in a world of structures--and defends a form of eliminativism about objects that sets laws and symmetry principles at the heart of ontology.

We present an investigation of the ways in which speakers' subjective perspectives are likely to affect the meaning of gradable adjectives like tall or heavy. We present the results of a study showing that people tend to use themselves as a yardstick when ascribing these adjectives to human figures of varied measurements: subjects' height and weight requirements for applying tall and heavy are found to be positively correlated with their personal measurements. We draw more general lessons regarding the definition of (...) subjectivity and the ways in which a standard of comparison and a significant deviation from that standard are specified. (shrink)

Existentialism exerts a continuing fascination on students of philosophy and general readers. As a philosophical phenomenon, though, it is often poorly understood, as a form of radical subjectivism that turns its back on reason and argumentation and possesses all the liabilities of philosophical idealism but without any idealistic conceptual clarity. In this volume of original essays, the first to be devoted exclusively to existentialism in over forty years, a team of distinguished commentators discuss the ideas of Kierkegaard, Nietzsche, Heidegger, Sartre, (...) Merleau-Ponty and Beauvoir and show how their focus on existence provides a compelling perspective on contemporary issues in moral psychology and philosophy of mind, language and history. A further sequence of chapters examines the influence of existential ideas beyond philosophy, in literature, religion, politics and psychiatry. The volume offers a rich and comprehensive assessment of the continuing vitality of existentialism as a philosophical movement and a cultural phenomenon. (shrink)

Steven French and Decio Krause examine the metaphysical foundations of quantum physics. They draw together historical, logical, and philosophical perspectives on the fundamental nature of quantum particles and offer new insights on a range of important issues. Focusing on the concepts of identity and individuality, the authors explore two alternative metaphysical views; according to one, quantum particles are no different from books, tables, and people in this respect; according to the other, they most certainly are. Each view comes with (...) certain costs attached and after describing their origins in the history of quantum theory, the authors carefully consider whether these costs are worth bearing. Recent contributions to these discussions are analyzed in detail and the authors present their own original perspective on the issues. The final chapter suggests how this perspective can be taken forward in the context of quantum field theory. (shrink)

*Tackles the Thomistic debate surrounding the inherent good and evil of human actions*.

Encountering Tragedy contests Rousseau's munificent ontological presumption, probes the necessary and disturbing fictions of the Founding and delineates the ...

The contemporary system of prospective oversight of human subjects research has been criticized as inefficient and ineffective. Plausible approaches to research oversight range from no prospective review, to review-and-comment, to the current review-and-approve regime. Articulating this spectrum offers an opportunity to consider systematically the strengths and disadvantages of each.

Temporal passage is an irrefragable and ineliminable feature of our lived experience of time. In this essay, I argue that, regardless of whether one adopts a three-dimensional, A theory of time or a four-dimensional, B theory of time, the subject of lived experience of time has to be conceived of as something that stands outside of the physical order in order for the experience of temporal passage to actually occur. This implies the truth of Dualism as the only account of (...) mind that can accommodate the facts of the lived experience of time. (shrink)

Spinoza's Ethics is one of the most remarkable, important, and difficult books in the history of philosophy: a treatise simultaneously on metaphysics, knowledge, philosophical psychology, moral philosophy, and political philosophy. It presents, in Spinoza's famous 'geometric method', his radical views on God, Nature, the human being, and happiness. In this wide-ranging 2006 introduction to the work, Steven Nadler explains the doctrines and arguments of the Ethics, and shows why Spinoza's endlessly fascinating ideas may have been so troubling to his (...) contemporaries, as well as why they are still highly relevant today. He also examines the philosophical background to Spinoza's thought and the dialogues in which Spinoza was engaged - with his contemporaries, with ancient thinkers, and with his Jewish rationalist forebears. His book is written for the student reader but will also be of interest to specialists in early modern philosophy. (shrink)

In Hegel's Critique of Liberalism , Steven B. Smith examines Hegel's critique of rights-based liberalism and its relevance to contemporary political concerns. Smith argues that Hegel reformulated classic liberalism, preserving what was of value while rendering it more attentive to the dynamics of human history and the developmental structure of the moral personality. Hegel's goal, Smith suggests, was to find a way of incorporating both the ancient emphasis on the dignity and even architectonic character of political life with the (...) modern concern for freedom, rights, and mutual recognition. Smith's insightful analysis reveals Hegel's relevance not only to contemporary political philosophers concerned with normative issues of liberal theory but also to political scientists who have urged a revival of the state as a central concept of political inquiry. (shrink)

In this book Steven Levine explores the relation between objectivity and experience from a pragmatic point of view. Like many new pragmatists he aims to rehabilitate objectivity in the wake of Richard Rorty's rejection of the concept. But he challenges the idea, put forward by pragmatists like Robert Brandom, that objectivity is best rehabilitated in communicative-theoretic terms - namely, in terms that can be cashed out by capacities that agents gain through linguistic communication. Levine proposes instead that objectivity is (...) best understood in experiential-theoretic terms. He explains how, in order to meet the aims of the new pragmatists, we need to do more than see objectivity as a norm of rationality embedded in our social-linguistic practices; we also need to see it as emergent from our experiential interaction with the world. Innovative and carefully argued, this book redeems and re-actualizes for contemporary philosophy a key insight developed by the classical pragmatists. (shrink)

In “Mindsets, Informed Consent and Research,” Lynn Jansen opens a promising new window onto consent for early‐phase cancer trials. She hypothesizes that patients who have agreed to take part in these trials, most of whom have incurable cancers, adopt different cognitive orientations or mindsets during the predecisional “deliberative” phase than they do during the postdecisional “implementation” phase. The different objectives that individuals hold during these phases—choosing among courses of action during the former, implementing the chosen action during the latter—lead to (...) the adaptive and preconscious application of different cognitive and attentional filters. If this is the case, then the prevalent practice of using surveys and interviews with postdecisional research participants, who on average markedly overestimate the potential for benefit that these trials offer, to extrapolate to the ethically central but much less studied deliberative phase, is methodologically suspect. As Jansen correctly notes, her thesis has numerous implications for the theory and study of informed consent. Three, in particular, deserve further discussion. (shrink)

Investigating the concepts and material realities of energy coursing through the arts: a foundational text. This book investigates energies—in the plural, the energies embedded and embodied in everything under the sun— as they are expressed in the arts. With contributions from scholars and critics from the visual arts, art history, anthropology, music, literature, and the history of science, it offers the first multidisciplinary investigation of the concepts and material realities of energy coursing through the arts. Just as Douglas Kahn's earlier (...) books helped introduce sound as a category for study in the arts, this new volume will be a foundational volume for future explorers in a largely uncharted domain. The modern concept of energy is only two hundred years old—an abstraction grounded in extraction—but this book takes a more expansive view. It opens with a clap: the sonic energies in a ceremony of the indigenous Goolarabooloo people of Australia. Other chapters explore the energies of photography; responses of artists in the early twentieth century—including Marcel Duchamp—to scientific discoveries in electricity and electromagnetism; the aestheticization of entropy in works by Hans Haacke and Robert Smithson; free-jazz musician Milford Graves's cross-cultural engagement with music, science, and spiritualism; energy field performance; and the self-generating energy of rumor and gossip as artwork. Contributors include such leading scholars as Linda Dalrymple Henderson, John Tresch, and Caroline A. Jones. Practicing artists and students of art history will find Energies in the Arts an essential work. Contributors Susan Ballard, Jennifer Biddle, Marcus Boon, Joan Brassil, Steven Connor, Milford Graves, Daniel Hackbarth, Linda Dalrymple Henderson, Caroline A. Jones, Douglas Kahn, David Mather, Stephen Muecke, James Nisbet, Daniela Silvestrin, Michael Taussig, John Tresch, Melissa Warak. (shrink)

The central concern of this article is whether the semantic approach has the resources to appropriately capture the core tenets of structural realism. Chakravartty (2001) has argued that a realist notion of correspondence cannot be accommodated without introducing a linguistic component, which undermines the approach itself. We suggest that this worry can be addressed by an appropriate understanding of the role of language in this context. The real challenge, however, is how to incorporate the core notion of `explanatory approximate truth' (...) in such a way that the emphasis on structure is retained. (shrink)

From Pulitzer Prize-finalist Steven Nadler, an engaging guide to what Spinoza can teach us about life’s big questions In 1656, after being excommunicated from Amsterdam’s Portuguese-Jewish community for “abominable heresies” and “monstrous deeds,” the young Baruch Spinoza abandoned his family’s import business to dedicate his life to philosophy. He quickly became notorious across Europe for his views on God, the Bible, and miracles, as well as for his uncompromising defense of free thought. Yet the radicalism of Spinoza’s views has (...) long obscured that his primary reason for turning to philosophy was to answer one of humanity’s most urgent questions: How can we lead a good life and enjoy happiness in a world without a providential God? In Think Least of Death, Pulitzer Prize–finalist Steven Nadler connects Spinoza’s ideas with his life and times to offer a compelling account of how the philosopher can provide a guide to living one’s best life. In the Ethics, Spinoza presents his vision of the ideal human being, the “free person” who, motivated by reason, lives a life of joy devoted to what is most important—improving oneself and others. Untroubled by passions such as hate, greed, and envy, free people treat others with benevolence, justice, and charity. Focusing on the rewards of goodness, they enjoy the pleasures of this world, but in moderation. “The free person thinks least of all of death,” Spinoza writes, “and his wisdom is a meditation not on death but on life." An unmatched introduction to Spinoza’s moral philosophy, Think Least of Death shows how his ideas still provide valuable insights about how to live today. (shrink)

This article looks at two sorts of conceptual work in Cristina Rocha’s John of God: The Globalization of Brazilian Faith Healing : theoretical appliqué and comparative contextualization. The first involves using an ad hoc set of concepts to set out series of partial interpretations. Despite not offering one unified interpretation, this approach has the advantages of respecting the complexity of the case and indicating a range of relevant interpretative pathways. The second involves the standard work, in the study of religion, (...) of placing the religious movement or other object of study in relation to its religious landscape, influences and competitors, by comparing and contrasting beliefs and practices. Though the book would be better if both of these dimensions of conceptual work had been pushed further, Rocha’s theoretical appliqué is worth considering for its value as a model for other work. The goal of this article is to highlight the value of theoretical appliqué and to suggest how it could be done effectively. (shrink)

Christopher Tollefsen, relying on the new natural law theory, has suggested that in the Phoenix abortion case, the action might be characterized simply as removing the baby rather than killing the baby. Tollefsen and other proponents of the new natural law theory fail to give proper weight to the observable facts of the world around us, and thereby tend to ignore the importance of observable causes in shaping the character of our intentions and our actions. An appreciation of the role (...) of causes reveals that our intentions cannot so readily land on one description of an action and exclude other descriptions. For the Phoenix case, the description “harming the baby” cannot fall outside the doctors’ intention. National Catholic Bioethics Quarterly 14.2 : 273–293. (shrink)

John Finnis claims that in order to judge actions we must approach them from the perspective of the acting person, so that the moral evaluation of actions appears to become private. This paper examines Elizabeth Anscombe’s claim that interior intentions can be discovered through exterior actions. Because deliberation is shaped by the causal features of the world, these causal structures can, when viewed from the outside, serve as a window into the private life of the mind. Therefore, we can usually (...) determine someone’s intention through his observable actions, so that the moral character of actions can become public by way of signs. Causal connections are both effects of intention and causes of intention. Neither of these relations by itself serves as an adequate sign of intention, but the combination of these two (causal structures both as effects and as causes of intention) can serve as signs of intention. (shrink)

Abraham Lincoln’s hallowed place in American memory is secure: He saved the Union, put an end to slavery, and was assassinated for these very successes. At the same time, Lincoln’s many undeniable achievements came at terrible—and lasting—democratic cost. Informed by the work of Carl Schmitt and Giorgio Agamben, this essay aspires to illuminate that cost by analyzing two cases where Lincoln exercised a sovereign decisionism—one involving the exile of Ohio politician Clement Vallandigham for publicly opposing the Civil War and the (...) draft, a second involving the mass execution of Dakota Sioux Indians for daring to rise up and enact their own sovereign prerogatives during the war. This decisionism reveals Lincoln’s problematic resort to anti-political practices to deal with adversaries. Given the damage Lincoln did to American democracy, the essay also investigates what he might have done to make amends for it. Finally, it explores how Lincoln’s place in American history might be remembered more agonistically, architecturally speaking, on the Mall in Washington, D.C. (shrink)

While it is sometimes thought that free Athenian women were hemmed in by surveillance within the oikos, this article argues that the obstacle that impeded them when they attempted to control property was that they were excluded from the impersonal and formal systems of surveillance of male citizens. Athenian public life, lived in the view of others, dramatically extended the agency of those within it. While women could compensate for their legal incapacities by cultivating the personal trust of men, this (...) required them to treat some of the people closest to them instrumentally, thus transforming their affectionate relationships. (shrink)

This article continues from where the author's 2008 book The Meaning of Video Games concluded and concerns what he learned from playing the simulation game Spore by Sims-creator Will Wright, especially the extent to which a social-network model had become during the development process the infrastructural backbone of the game. Spore's approach to the problem of building an asynchronous content-creation and content-sharing system aligned the video game with the most important trends in text-based digital humanities scholarship today. Thus this article (...) compares video games and digital texts, not in terms of their supposedly shared narrative content (not in terms of their content at all) but, rather, formally—in terms of how they model complex systems, how both video games and digital-text environments work by creating networked environments for the production, reproduction, transmission, and reception (indeed for the continual reediting) of their respective content-objects. Both texts and video games are systems, with their own special affordances and constraints, that provide both “spores” and “spurs,” seeds and provocations, prompts for new performances of meaning. (shrink)

Topics in Cognitive Science, Volume 14, Issue 1, Page 31-44, January 2022.

The revival of virtue ethics in contemporary moral philosophy had a major impact on business ethicists, among whom the virtues have become a staple subject of inquiry. Aristotle’s phronēsis is one of those virtues, and a number of texts have examined it in some detail. But analyses of phronēsis in business ethics have neglected some of its most significant and interesting elements. In this paper, I dissect two neglected components of practical wisdom as outlined in Book VI of the Nicomachean (...) Ethics: sunesis, a capacity to perceptively evaluate testimony, and gnomē, a capacity to rightly discern exceptions to ‘universal’ moral rules. Practical wisdom is a product of experience, so I examine the role that experience plays in the development of these deliberative capacities, asking what it is that the practically wise will have taken away from their experiences. It is, in particular, everyday, ‘mundane’ experience that begets these excellences, so I concentrate specifically on that kind of experience in the domains of sunesis and gnomē as I search for insights about how we develop phronēsis and how we might better do what is right. (shrink)

ABSTRACTEmotional distractors can impair perception of subsequently presented targets, a phenomenon called emotion-induced blindness. Do emotional distractors lose their power to disrupt perception when appearing with increased frequency, perhaps due to desensitisation or enhanced recruitment of proactive control? Non-emotional tasks, such as the Stroop, have revealed that high frequency distractors or conflict lead to reduced interference, and distractor frequency appears to modulate attentional capture by emotional distractors in spatial attention tasks. But emotion-induced blindness is thought to reflect perceptual competition between (...) targets and emotional distractors, and it is unclear whether high frequency emotional stimuli cause less disruption at this relatively early stage of processing. In four experiments, participants searched streams of images for a rotated target image. A negative or neutral distractor appeared before the target, and their relative frequency was manipulated. Across all exper... (shrink)

The story of one of the most important—and incendiary—books in Western history When it appeared in 1670, Baruch Spinoza's Theological-Political Treatise was denounced as the most dangerous book ever published—"godless," "full of abominations," "a book forged in hell... by the devil himself." Religious and secular authorities saw it as a threat to faith, social and political harmony, and everyday morality, and its author was almost universally regarded as a religious subversive and political radical who sought to spread atheism throughout Europe. (...) Yet Spinoza's book has contributed as much as the Declaration of Independence or Thomas Paine's Common Sense to modern liberal, secular, and democratic thinking. In A Book Forged in Hell, Steven Nadler tells the fascinating story of this extraordinary book: its radical claims and their background in the philosophical, religious, and political tensions of the Dutch Golden Age, as well as the vitriolic reaction these ideas inspired. It is not hard to see why Spinoza's Treatise was so important or so controversial, or why the uproar it caused is one of the most significant events in European intellectual history. In the book, Spinoza became the first to argue that the Bible is not literally the word of God but rather a work of human literature; that true religion has nothing to do with theology, liturgical ceremonies, or sectarian dogma; and that religious authorities should have no role in governing a modern state. He also denied the reality of miracles and divine providence, reinterpreted the nature of prophecy, and made an eloquent plea for toleration and democracy. A vivid story of incendiary ideas and vicious backlash, A Book Forged in Hell will interest anyone who is curious about the origin of some of our most cherished modern beliefs. (shrink)

Normality Does Not Equal Mental Health: The Need to Look Elsewhere for Standards of Good Mental Health is the first book to question the equation of psychological normality and mental health. It is also the first book to take contemporary psychiatry and clinical psychology to task for deeply flawed thinking when they accept the diagnostic system propounded by the DSM, which reifies syndromes into alleged “mental disorders.” Where Thomas Szasz argued that “mental disorders” are myths, Bartlett makes the much more (...) damaging charge that reifying mental disorders involves a provable form of fallacious thinking, producing a variety of epistemological nonsense. /// -/- -/- The author weighs the evidence, and with strict logic, compelling evidence, and careful analysis, challenges the current paradigm of mental health theorists and practitioners. Never has the case against the standard of psychological normality and against the non-scientific creation of “mental disorders” been made with such boldness, multidisciplinary knowledge, solid scholarship, and clarity of language. /// -/- -/- Normality Does Not Equal Mental HealthAlthough the need to question psychological normality as a satisfactory standard of good mental health has been staring us in the face for a long time, no one, clinical professional or scholar, has had the courage or the intellectual willingness to face with unflinching honesty the shortcomings and disappointments of psychological normality and to propose that we should look elsewhere for standards of good psychological health. /// -/- -/- Contemporary psychiatry and clinical psychology, on the contrary, base their conception of mental health on the standard of psychological normality. This supposition has come to be accepted uncritically and without question, and yet it has become fundamental to current clinical theory and practice, and forms the core of the psychiatric classification system of the DSM, which has become today’s diagnostic authority. /// -/- -/- While touting today’s scientific gold standard of “evidence-based” research, DSM’s authoritative classification of “mental disorders” is itself hardly “evidence-based,” for it is recognized, but seldom emphasized, that the majority of DSM’s “mental disorders” have no known empirical, organic basis. /// -/- -/- Normality Does Not Equal Mental Health takes DSM to task not only for its failure to adhere to today’s evidence-based standard, but for its failure to rein in its highly speculative diagnostic labeling, in accordance with the modern paradigm of rigorous science, which repudiates metaphorical reifications whose alleged validity rests only on the voting preferences of a professional membership. /// -/- -/- The book is a carefully argued critique of the dominant assumption in current psychiatry and clinical psychology that psychological normality is fundamental to mental health and therefore good. In place of this unsatisfactory presumption, Normality Does Not Equal Mental Health proposes a positive and constructive revision in our understanding of mental health and of our conception of mental disorders. (shrink)

The verbs cause, enable, and prevent express beliefs about the way the world works. We offer a theory of their meaning in terms of the structure of those beliefs expressed using qualitative properties of causal models, a graphical framework for representing causal structure. We propose that these verbs refer to a causal model relevant to a discourse and that “A causes B” expresses the belief that the causal model includes a link from A to B. “A enables/allows B” entails that (...) the model includes a link from A to B, that A represents a category of events necessary for B, and that an alternative cause of B exists. “A prevents B” entails that the model includes a link from A to B and that A reduces the likelihood of B. This theory is able to account for the results of four experiments as well as a variety of existing data on human reasoning. (shrink)

We propose a causal model theory to explain asymmetries in judgments of the intentionality of a foreseen side-effect that is either negative or positive (Knobe, 2003). The theory is implemented as a Bayesian network relating types of mental states, actions, and consequences that integrates previous hypotheses. It appeals to two inferential routes to judgment about the intentionality of someone else's action: bottom-up from action to desire and top-down from character and disposition. Support for the theory comes from three experiments that (...) test the prediction that bottom-up inference should occur only when the actor's primary objective is known. The model fits intentionality judgments reasonably well with no free parameters. (shrink)

The clinical and para-clinical examination of residual self-consciousness in non-communicative severely brain damaged patients remains exceptionally challenging. Passive presentation of the patient’s own name and own face are known to be effective attention-grabbing stimuli when clinically assessing consciousness at the patient’s bedside. Event-related potential and functional neuroimaging studies using such self-referential stimuli are currently being used to disentangle the cognitive hierarchy of self-processing. We here review neuropsychological, neuropathological, electrophysiological and neuroimaging studies using the own name and own face paradigm obtained (...) in conscious waking, sleep, pharmacological coma, pathological coma and related disorders of consciousness. Based on these results we discuss what we currently do and do not know about the functional significance of the neural network involved in “automatic” and “conscious” self-referential processing. (shrink)