Metagenomics bears upon all aspects of microbiology, including our understanding of mitochondrial and eukaryote origin. Recently, ribosomal protein phylogenies show the eukaryote host lineage – the archaeal lineage that acquired the mitochondrion – to branch within the archaea. Metagenomic studies are now uncovering new archaeal lineages that branch more closely to the host than any cultivated archaea do. But how do they grow? Carbon and energy metabolism as pieced together from metagenome assemblies of these new archaeal lineages, such as the (...) Deep Sea Archaeal Group (including Lokiarchaeota) and Bathyarchaeota, do not match the physiology of any cultivated microbes. Understanding how these new lineages live in their environment is important, and might hold clues about how mitochondria arose and how the eukaryotic lineage got started. Here we look at these exciting new metagenomic studies, what they say about archaeal physiology in modern environments, how they impact views on host‐mitochondrion physiological interactions at eukaryote origin. (shrink)

In Divine Providence, Swedish visionary Emanuel Swedenborg describes how God works in our lives to turn us away from evil and toward him while still allow us to make our own choices. Swedenborg addresses a number of questions that challenge people of faith, such as why accidents and disasters happen, and why evil people seem to prosper while others suffer. This edition is a reprint of a 1963 translation by William F. Wunsch.

A discussion of Christian ethics focuses on the physician's image as a parent, warrior against death, expert, and teacher, and the oath that guides his or her practice.

The goal of this chapter is to describe recollective memory and give an account of some of the characteristics of this form of human memory. I take recollective memory to be the type of memory that occurs when an individual recalls a specific episode from their past experience. I start with this very loose definition because a large part of this chapter consists of an attempt to work out a more detailed and analytic description of this form of memory.

Extracorporeal membrane oxygenation (ECMO) is a form of life support for cardiac and/or pulmonary failure with unique ethical challenges compared to other forms of life support. Ethical challenges with ECMO exist when conventional standards of care apply, and are exacerbated during periods of absolute ECMO scarcity when “crisis standards of care” are instituted. When conventional standards of care apply, we propose that it is ethically permissible to withhold placing patients on ECMO for reasons of technical futility or when patients have (...) terminal, short-term prognoses that are untreatable by ECMO. Under crisis standards of care, it is ethically permissible to broaden exclusionary criteria to also withhold ECMO from patients who have a low likelihood of recovery, to maximize the overall number of lives saved. Unilateral withdrawal of ECMO against a patient’s preferences is unethical under conventional standards of care, but is ethical under crisis standards of care to increase access to ECMO to others in society. ECMO should only be rationed when true scarcity exists, and allocation protocols should be transparent to the public. When rationing must occur under crisis standards of care, it is imperative that oversight bodies assess for inequities in the allocation of ECMO and make frequent changes to improve any inequities. (shrink)

This article articulates and defends F. H. Bradley's regress argument against external relations using contemporary analytic techniques and conceptuality. Bradley's argument is usually quickly dismissed as if it were beneath serious consideration. But I shall maintain that Bradley's argument, suitably reconstructed, is a powerful argument, plausibly premised, and free of such obvious fallacies as petitio principii. Thus it does not rest on the question‐begging assumption that all relations are internal, as Russell, and more recently van Inwagen, maintain. Bradley does not (...) attack external relations in order to affirm a doctrine of internal relations, and his monism is not derived from the internality of all relations, but from the self‐contradictory nature of all relations. For Bradley, it is the “relational situation”as such that is ontologically defective. (shrink)

Chernyshevskii (1828-1889), a pivotal figure in the Russian protest movement after the Crimean War, was esteemed by Marx and Lenin. This first thorough treatment of Chernyshevskii in English is a biography and a presentation of his views on philosophy, aesthetics and literary criticism, economics and social relations, politics and revolution.

We use evidence from cognitive psychology and the history of science to examine the issue of the theory-ladenness of perceptual observation. This evidence shows that perception is theory-laden, but that it is only strongly theory-laden when the perceptual evidence is ambiguous or degraded, or when it requires a difficult perceptual judgment. We argue that debates about the theory-ladenness issue have focused too narrowly on the issue of perceptual experience, and that a full account of the scientific process requires an examination (...) of theory-ladenness in attention, perception, data interpretation, data production, memory, and scientific communication. We conclude that the evidence for theory-ladenness does not lead to a relativist account of scientific knowledge. (shrink)

The doctrine of divine simplicity, according to which God is devoid of physical or metaphysical complexity, is widely believed to be incoherent. I argue that although two prominent recent attempts to defend it fail, it can be defended against the charge of obvious incoherence. The defense rests on the isolation and rejection of a crucial assumption, namely, that no property is an individual. I argue that there is nothing in our ordinary concepts of property and individual to warrant the assumption, (...) and that once the assumption is rejected, the way is clear to viewing the divine attributes as self-exemplifying properties whose self-exemplification entails their identity with an individual. (shrink)

Charity is not only about giving to those in need, but in a broader sense about loving your neighbor and doing good things for other people without thought of reward. So wrote Swedish visionary Emanuel Swedenborg, who believed that charity, along with faiths, was part of the foundation of spiritual practice. This work combines two of Swedenborg's unpublished manuscripts to form a practical, inspirational handbook for appying the principle of doing good to daily life.

For much of 2021, allocating the scarce supply of Covid‐19 vaccines was the world's most pressing bioethical challenge, and similar challenges may recur for novel therapies and future vaccines. In the United States, the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices (ACIP) identified three fundamental ethical principles to guide the process: maximize benefits, promote justice, and mitigate health inequities. We argue that critical components of the recommended protocol were internally inconsistent with these principles. Specifically, the ACIP (...) violated its principles by recommending overly broad health care worker priority in phase 1a, using being at least seventy‐five years of age as the only criterion to identify individuals at high risk of death from Covid‐19 during phase 1b, failing to recommend place‐based vaccine distribution, and implicitly endorsing first‐come, first‐served allocation. More rigorous empirical work and the development of a complete ethical framework that recognizes trade‐offs between principles may have prevented these mistakes and saved lives. (shrink)

Hegel's objection -- Is Kant's idealism subjective? -- An ambiguity in 'subjectivism' -- The epistemological problem -- The transcendental deduction of the categories and subjectivism -- Are Kant's categories subjective? -- Hegel's suspicion : Kantian critique and subjectivism -- What is kantian philosophical criticism? -- Hegel's suspicion : initial formulation -- A shallow suspicion? -- Deepening the suspicion : criticism, autonomy, and subjectivism -- Directions of response -- Critique and suspicion : unmasking the critical philosophy -- Hegel's transformation of critique (...) -- The rejection of Kantian critique : philosophy, skepticism, and the recovery of the ancient idea -- Hegel's epistemology in the shadow of Schelling -- Schulze's skepticism contra the critical philosophy -- Ancient versus modern skepticism : Hegel's difference -- Against the modern conception of rational cognition -- Against modern self-certainty -- The history of skepticism: decline into dogmatism -- Philosophy counter culture and time -- The return to Kantian critique : recognizing the rights of ordinary consciousness -- Two conceptions of philosophical critique -- The return to critique and the relation of philosophy to its history -- The rights of ordinary consciousness and the need for critique -- Critique as the realization of the science of metaphysics -- Hegel's self-transformational criticism -- Presuppositionless philosophy -- The problem of the criterion -- Self-transformational criticism -- The problem of the we' -- Our transformation -- Hegel's alternative model : critical transformation as self-realization. (shrink)

The question concerning the meaning of life is important, but it immediately confronts the present authors with insurmountable obstacles from a philosophical standpoint, as it would require us to define not only what we hold to be life, but what we hold to be meaning in addition, requiring us to do both in a properly researched context. We unconditionally surrender to that challenge. Instead, we offer a vernacular, armchair approach to life’s origin and meaning, with some layman’s thoughts on the (...) meaning of origins as viewed from the biologist’s standpoint. One can observe that biologists generally approach the concept of biological meaning in the context of evolution. This is the basis for the broad resonance behind Dobzhansky’s appraisal that “Nothing in biology makes sense except in the light of evolution”. Biologists try to understand living things in the historical context of how they arose, without giving much thought to the definition of what life or living things are, which for a biologist is usually not an interesting question in the practical context of daily dealings with organisms. Do humans generally understand life’s meaning in the context of history? If we consider the problem of life’s origin, the question of what constitutes a living thing becomes somewhat more acute for the biologist, though not more answerable, because it is inescapable that there was a time when there were no organisms on Earth, followed by a time when there were, the latter time having persisted in continuity to the present. This raises the question of where, in that transition, chemicals on Earth became alive, requiring, in turn, a set of premises for how life arose in order to conceptualize the problem in relation to organisms we know today, including ourselves, which brings us to the point of this paper: In the same way that cultural narratives for origins always start with a setting, scientific narratives for origins also always start with a setting, a place on Earth or elsewhere where we can imagine what happened for the sake of structuring both the problem and the narrative for its solution. This raises the question of whether scientific origins settings convey meaning to humans in that they suggest to us from what kind of place and what kinds of chemicals we are descended, that is, to which inanimate things we are most closely related. (shrink)

A growing body of literature places blame for accounting frauds on the failure of educators to implement ethics training in accounting curriculums in higher educational institutions. Although, the professional accountancy bodies in the UK espouse high ethical standards, others suggest that these bodies are failing to cover ethics in any meaningful way. This study surveys faculty about what is being taught and how much time is dedicated to ethics training. This is the first study to examine whether content suggested by (...) the Ethics Education Framework has been implemented in curriculums in the UK. In addition, we look to determine if there is a notable difference between what is covered in both pre-1992 and post-1992 UK universities. Although we find that post-1992 institutions have implemented the EEF suggestions more than pre-1992 UK universities, current ethics training is insufficient and has not changed much over the last two decades. (shrink)

This book is intended to help transform epistemology - the traditional study of knowledge - into a rigorous discipline by removing conceptual roadblocks and developing formal tools required for a fully naturalized epistemology. The evolutionary approach which Harms favours begins with the common observation that if our senses and reasoning were not reliable, then natural selection would have eliminated them long ago. The challenge for some time has been how to transform these informal musings about evolutionary epistemology into a rigorous (...) theoretical discipline capable of complementing current scientific studies of the evolution of cognition with a philosophically defensible account of meaning and justification. (shrink)

This article examines one of the sources of David Benatar’s anti-natalism. This is the view that ‘all procreation is [morally] wrong.’ (Benatar and Wasserman, 2015:12) One of its sources is the claim that each of our lives is objectively bad, hence bad whether we think so or not. The question I will pose is whether the constraints of metaphysical naturalism allow for an objective devaluation of human life sufficiently negative to justify anti-natalism. My thesis is that metaphysical naturalism does not (...) have the resources to support such a negative evaluation. Metaphysical naturalism is the view that causal reality is exhausted by nature, the space-time system and its contents. The gist of my argument is that the ideal standards relative to which our lives are supposed to be axiologically substandard cannot be merely subjective expressions of our desires and aversions; they must be (i) objectively binding standards that are (ii) objectively possible in the sense of concretely realizable. The realizability condition, however, cannot be satisfied on metaphysical naturalism; ergo, failure to meet these ideal standards cannot show that our lives are objectively bad. (shrink)

The realization that prokaryotes naturally and frequently disperse genes across steep taxonomic boundaries via lateral gene transfer gave wings to the idea that eukaryotes might do the same. Eukaryotes do acquire genes from mitochondria and plastids and they do transfer genes during the process of secondary endosymbiosis, the spread of plastids via eukaryotic algal endosymbionts. From those observations it, however, does not follow that eukaryotes transfer genes either in the same ways as prokaryotes do, or to a quantitatively similar degree. (...) An important illustration of the difference is that eukaryotes do not exhibit pangenomes, though prokaryotes do. Eukaryotes reveal no detectable cumulative effects of LGT, though prokaryotes do. A critical analysis suggests that something is deeply amiss with eukaryote LGT theories. In prokaryotes, genes from the environment can enter the genome via lateral gene transfer. In eukaryote genetics, natural variation comes from within the genome, not from the environment. Yet many reports claim that eukaryotes undergo LGT just like prokaryotes. Such claims do not withstand scrutiny and are probably untrue. (shrink)

Analytic philosophy of existence in the 20th century and beyond has been dominated by two central claims. One is that existence is instantiation. The other is that there are no modes of existence. This article attempts to refute both claims.

This paper was first presented as a plenary lecture to the Association for Education in Journalism and Mass Communication in August, 1985. The author, who is the Cary M. Maguire University Professor of Ethics at Southern Methodist University, discusses the intellectual, moral, and organizational marks of the professional that led reformers at the beginning of the twentieth century to locate professional training in the university. That discussion is followed by consideration of the moral consequences of university education for professionals, and (...) how journalists and all other professionals are, at base, teachers. The third part of the paper reflects upon the peculiarities of journalism as aprofession, and concludes with considerations of the special mission of journalism. (shrink)

End-of-life care, particularly for patients with advanced dementia, tests the medical covenant, both the integrity and aptness of what physicians have to offer and the fidelity with which they offer it. This article considers five ways of justifying the unilateral withholding of future treatment: (1) an affirmation of professional autonomy; (2) a defense of professional integrity; (3) a parentalist exercise of power on behalf of the patient and/or family; (4) a protection of the interests of third parties (footing the bill); (...) or (5) a protection of the interests of second parties (the physician or other providers). The article concludes with a sixth response to care for the stricken patient and family that seeks to attend more fully to the clinical reality of bonded humans in the throes of disease and death. (shrink)

Twelve essays in literary theory, philosophy, and religion--about atheism, freedom, and "the Jesus thought experiment"--connect, but don't conclude. A recurring theme is the "nothing" at the heart of the deep atheism of George Eliot, Walter Pater, Oscar Wilde, Rudyard Kipling, and Thomas Hardy, who approach "nothing" with a directness lacking in their English-speaking philosophical contemporaries. How does being in the world--Thomas Nagel's "what-it's-likeness"--and how do values--Alasdair MacIntyre's justice and misericordia--fare in the face of the mindless "It" that Hardy finds at (...) the heart of things? A pivotal essay compares the theism of Paul Ricoeur and the atheism of Daniel Dennett--the subtitle is a response to the latter's latest book. Writing and Freedom defends (a strong version of) free will as necessarily interpersonal: my freedom is nothing but my acceptance of yours. This is how Milton, Rossetti, and Dickinson treat their readers, and how scientists and philosophers ideally treat each other. The book's open-ended essays model freedom so understood. Moreover, both "nothing" and "freedom" are fundamental to biblical and religious narratives (Mark and Newman). God, being "out of all relation" with the finite, cannot be known from the text of the world. Yet as "nothing," God may be said to grant unconditional autonomy to his creatures, and therefore to be present in his absence. It is round "nothing," therefore, that atheists and theists endlessly circulate. But that is what the deep atheism of European thinkers--Nietzsche, Freud, Lacan, and Zizek--say we all do anyway, however excitedly we pretend to ourselves that we don't. (shrink)

In his Critique of Pure Reason, Kant makes the interesting, but obscure claim that the normative constraints that constitute the objectivity of our representations have their source ultimately in transcendental apperception. Keller focuses on this claim. He interprets Kant’s condition of transcendental apperception as the claim that I must represent myself in an impersonal way, and he argues that impersonal self-consciousness is a necessary condition under which I can distinguish my particular take on things from the way things are independently (...) of my own perspective on them. He elaborates his interpretation and defense of the condition of transcendental self-consciousness by discussing its role in each of the central arguments in the Critique in which the notion importantly figures: the transcendental deduction in both the first edition and in the second, the Analogies of Experience, the Paralogisms, and the second-edition refutation of idealism. (shrink)

William F. May, a leading expert on medical ethics, here explores two of today's most crucial tests of the traditional covenant between physicians and patients--active euthanasia and health care reform.

A word, first, about the religious sensibility that I have found helpful to describe the care professionals owe to dying patients, particularly patients with advanced dementia.That word is covenant. It is a biblical term; but, today, it covers such dubious devices as real estate covenants. A real estate covenant often operates below the moral level of a contract to wall some people out of a neighborhood. Classically understood, however, the word covenant helps probe the obligations of doctors to their patients (...) more deeply than the notion of a contract. Covenants of the sort I have in mind and contracts appear to be first cousins; they both include an agreement and an exchange between parties. But, in spirit, contracts and covenants differ markedly. Contracts are external; covenants are internal to the parties involved. We sign contracts in order to discharge them expediently. Contracts are limited and time-bound — whether a contract to fix plumbing or to charge such and such for a medical procedure. (shrink)

Recounts the author's experiences and reasons that led him to reject the Democratic Party and become a conservative.

Leibniz’ 1669-1671 manuscript “Elements of Natural Right” – first published in the 21st century – provides keen insights into problems of political philosophy and marks the outset of Leibniz’ engagement with the Hobbesian indivisible sovereignty idea. While concurring with the Sage of Malmesbury that any state worthy of the name is a security system, Leibniz – via reversal of Hobbes’ contention security produces happiness – throws open a series of questions related to “retrotraction” and the state legitimacy problematic. Citizens’ cognitive (...) capacity to link current state crisis manifestations to past ones - to “retrotract” - is seen as determining whether dissolution of the state is immanent, and the functioning of such capacity is described as intimately linked to self-perceived happiness of individuals. The plurality of happiness possibilities in various polities in turn is conceptualized by Leibniz as proof of degrees of state quality and sovereignty, degrees of sovereignty constituting Hobbes’ bête noire. (shrink)

How Do I Save My Honor? is a powerful exploration of individual moral responsibility in a time of war. When individuals conclude that their leaders have violated fundamental ethical principles, what are they to do? Through the compelling personal stories of those in the U.S. and British government and military who struggled with these thorny issues during the war in Iraq, William F. Felice analyzes the degrees of moral responsibility that public officials, soldiers, and private citizens bear for the (...) actions of their governments. Examining the struggles of these contemporary men and women, as well as of historical figures facing similar dilemmas, the author weighs the profound difficulties of overcoming the intense pressures of misguided loyalty, patriotism, and groupthink that predominate during war. (shrink)