BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

When physicist Alan Sokal recently submitted an article to the postmodernist journal Social Text, the periodical's editors were happy to publish it--for here was a respected scientist offering support for the journal's view that science is a subjective, socially constructed discipline. But as Sokal himself soon revealed in Lingua Franca magazine, the essay was a spectacular hoax--filled with scientific gibberish anyone with a basic knowledge of physics should have caught--and the academic world suddenly awoke to the vast gap that (...) has opened between the scientific community and their mould-be critics. But the truth is that not only postmodern critics but Americans in general have a weak grasp on scientific principles and facts. In Connected Knowledge, physicist Alan Cromer offers a way to bridge the chasm, with a lively, lucid account of scientific thinking and a provocative new agenda for American education. Science, Cromer argues, is anything but common sense: It requires a particular habit of mind that does not come naturally. For example, something as simple as buoyancy can only be explained through Archimedes' principle--that a body in a fluid is subject to an upward force equal to the weight of fluid it displaces--yet few scientists could arrive at this ancient concept by trial and error. School children, however, are often given a ball and a tank of water, and asked to explain buoyancy any way they can. Today's de emphasis on teaching pupils necessary facts and principles, he argues, "far from empowering them, makes them slaves of their own subjective opinions." This movement in education, known as Constructivism, has close ties to postmodern critics (such as the editors of Social Text) who question the objectivity of science, and with it the existence of an objective reality. Cromer offers a ringing defense of the knowability of the world, both as an objective reality and as a finite landscape of discovery. The advance of scientific knowledge, he argues, is not unlike the mapping of the continents; at this point, we have found them all. He shows how the advent of quantum mechanics, rather than making knowledge less certain, actually offers a more precise understanding of the behavior of atoms and electrons. Turning from philosophy to education, he argues that instead of allowing students to flounder, however creatively, schools should follow a progressive curriculum that returns theoretical knowledge to the classroom. Connected Knowledge, however, goes much farther. As a discipline that insists upon connecting theory with measurable reality, physical science offers a new direction for reforming the social sciences. Cromer also shows how some of the hottest issues in public policy--including the debates over special education and group variations in I.Q., can be resolved through clear, hard headed thinking. For example, he argues for use of the G.E.D. as a national educational standard, with a new "politics of intelligence" to guide the distribution of school resources. Always forthright and articulate, Alan Cromer offers a startling new vision for integrating science, philosophy, and education. (shrink)

This chapter presents a new model of coreferential NP anaphora processing, JANUS, within the mental models framework. It summarises previous research on NP anaphora that is most pertinent to JANUS, and outlines two previous attempts to provide an integrated theory of NP anaphora: Centering Theory and Almor’s Informational Load Hypothesis. Each has it problems, but the Informational Load Hypothesis is more firmly rooted in psychology, and closer to our own approach. JANUS incorporates many ideas from the Informational Load Hypothesis, but (...) attempts to address its problems. JANUS assumes that the semantic content of an anaphor should be justified by two types of role that the anaphoric expression plays. Backward-looking roles are primarily concerned with identifying the antecedent (and referent) of the anaphor. Forward-looking roles relate to what is to be said about the referent in upcoming discourse. These two types of roles give JANUS its name. (shrink)

Alan H. Goldman argues for the internalist or subjectivist view of practical reasons on the grounds that it is simpler, more unified, and more comprehensible ...

This remarkably clear and comprehensive account of empirical knowledge will be valuable to all students of epistemology and philosophy. The author begins from an explanationist analysis of knowing—a belief counts as knowledge if, and only if, its truth enters into the best explanation for its being held. Defending common sense and scientific realism within the explanationist framework, Alan Goldman provides a new foundational approach to justification. The view that emerges is broadly empiricist, counteracting the recently dominant trend that rejects (...) that framework entirely. Topics treated include the Gettier problem, the nature of explanation and inductive inference, the justification of foundations for knowledge in terms of inference to the best explanation, the possibility of realist interpretations of contemporary science, reference, and the relations between empirical psychology and epistemology. Professor Goldman defends the need for a foundational theory of justification and presents a version that refutes standard criticisms of that doctrine. His defense of realism takes into account contemporary advances in semantics and philosophy of science. It attempts to clarify the kinds of skeptical argument the philosopher must take seriously, without succumbing to them. While recent epistemology has tended to dismiss the traditional foundational approach, it has not provided a suitable alternative. Goldman breaks new ground by adapting that approach within his explanationist, inductive theory. (shrink)

Bakhsh-i avval. Akhlāq-i Islāmī -- Bakhsh-i duvvum. Ādāb-i ijtimāʻī.

Life's Values offers new analyses of the nature of pleasure, happiness, well-being, and meaning in life. Recognizing how individuals have different priorities, Goldman explains what is of ultimate value in our lives and argues that making our desires rational - relevantly informed of what it's like to satisfy them - maximizes well-being.

The teaching of the ethical implications of scientific advances in science courses for undergraduates has significant advantages for both science and non-science majors. The article describes three courses taught by the author as examples of the concept, and examines the disadvantages as well as the advantages. A significant advantage of this approach is that many students take the courses primarily because of the ethical component who would not otherwise take science. A disadvantage is less time in the course for the (...) science; arguably, this is outweighed by the greater retention of the science when it is put into context. (shrink)

In this concise survey, intended for advanced undergraduate students of aesthetics, Alan Goldman focuses on the question of aesthetic value, using many practical examples from painting, music, and literature to make his case. Although he treats a wide variety of views, he argues for a nonrealist view of aesthetic value, showing that the personal element can never be factored out of evaluative aesthetic judgments and explaining why this is so.

Part I. Philosophy of novels. 1. Introduction: philosophical content and literary value -- 2. Interpreting novels -- 3. The sun also rises: incompatible interpretations -- 4. The appeal of the mystery -- Part II. Philosophy in novels. 5. Moral development in Pride and prejudice -- 6. Huckleberry Finn and moral motivation -- 7. What we learn about rules from The cider house rules -- 8. Nostromo and the fragility of the self.

This books examines the fundamental values and principles of conduct in the professions, focusing specifically on four areas: law, politics, medicine and business. One central question unifies its inquiry into the different professions: should the principles for judging the actions of professionals be the same as those used to judge private individuals, or do these professions require special moral principles to guide their conduct. The author considers arguments deriving from the underlying institutional goals of each profession in turn.

Collected lectures of the author on Sufism and Islamic philosophy.

Collection of author's lectures on Sufism and Islamic philosophy.

Man (Islam); Islamic philosophy; Islamic ethics.