Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Hirst always highlighted knowledge when reflecting on the school curriculum. He replaced his early focus on liberal education, the development of mind and theoretical knowledge by emphasizing the practical and practices as a curriculum starting point and for the framing of educational aims. In this paper I explore links between Hirst’s philosophical treatment of knowledge and some currently contested aspects of UK government education policies. I also note some ways in which his work relates to selected present-day debates in philosophy (...) of education. Examples of UK government policy will include Ofsted’s definition of learning as a ‘change in long-term memory’ and the ways in which they place ‘logical sequencing’ at the heart of teaching, learning, and curriculum. Their learning definition treats knowledge as an individual asset rather than something about individuals as embedded in the social world of practices, a perspective more in keeping with Hirst’s later views. The critique of individualistic notions of knowledge and learning includes some explorations of how learners move into the ‘space of reasons’. Where I draw attention to relationships between Hirst’s thought and contemporary philosophy of education debates, I do not always draw any definite conclusions. (shrink)

The modern slavery literature engages with history in an extremely limited fashion. Our paper demonstrates to the utility of historical research to modern slavery researchers by explaining the rise and fall of the ethics-driven market category of “free-grown sugar” in nineteenth-century Britain. In the first decades of the century, the market category of “free-grown sugar” enabled consumers who were opposed to slavery to pay a premium for a more ethical product. After circa 1840, this market category disappeared, even though considerable (...) quantities of slave-grown sugar continued to arrive into the UK. We explain the disappearance of the market category. Our paper contributes to the on-going debates about slavery in management by historicizing and thus problematizing the concept of “slavery”. The paper challenges those modern slavery scholars who argue that lack of consumer knowledge about product provenance is the main barrier to the elimination of slavery from today’s international supply chains. The historical research presented in this paper suggests that consumer indifference, rather than simply ignorance, may be the more fundamental problem. The paper challenges the optimistic historical metanarrative that pervades much of the research on ethical consumption. It highlights the fragility of ethics-driven market categories, offering lessons for researchers and practitioners seeking to tackle modern slavery. (shrink)

Published in 1918, _The View of Life_ is Georg Simmel’s final work. Famously deemed “the brightest man in Europe” by George Santayana, Simmel addressed a variety of topics across his essayistic writings, which have influenced scholars in aesthetics, ethics, epistemology, and sociology. Nevertheless, a set of core issues emerged over the course of his career, most centrally the genesis, structure, and transcendence of social and cultural forms and the nature and genesis of authentic individuality. Composed in the years before his (...) death, _The View of Life_ was, according to Simmel, his “testament,” a capstone work of profound metaphysical inquiry intended to formulate his conception of life in its entirety. Now Anglophone readers can at last read in full the work that shaped the argument of Heidegger’s _Being and Time_ and whose extraordinary impact on European intellectual life between the wars was extolled by Jürgen Habermas. Presented alongside these seminal essays are aphoristic fragments from Simmel’s last journal, providing a beguiling look into the mind of one of the twentieth century’s greatest thinkers. (shrink)

John N Andrews; General Thinking Skills: are there such things?, Journal of Philosophy of Education, Volume 24, Issue 1, 30 May 2006, Pages 71–79, https://doi.o.

Weak panpsychism, the view that mindlike qualities are wide-spread in nature, has recently been argued for by the prominent ecofeminist Val Plumwood and has been used by her to ground an ethic of respect for nature. This ethic advocates a principle of respect for difference, the rejection of moral hierarchy and the inclusion of plants, mountains, rivers and ecosystems within the moral community. I argue that weak panpsychism cannot, convincingly, justify the rejection of moral hierarchy, as it is compatible with (...) it. Also the intentional criterion of mind, employed by weak panpsychism, which includes teleology, has the counter-intuitive implication of giving machines moral status. I cast doubt on the claims that (i) intentionality is a necessary condition for moral status and that (ii) it is sufficient for the ascription of agency. It is suggested that any account of intentionality that allows it to be predicated of mountains, rivers etc. would be widely, and correctly regarded as a reduction of that account. Finally an aesthetic reinterpretation of weak panpsychism is offered. (shrink)

In this paper, we examine the lawfulness of a proposal to provide elective ventilation to incompetent patients who are potential organ donors. Under the current legal framework, this depends on whether the best interests test could be satisfied. It might be argued that, because the Mental Capacity Act 2005 (UK) (and the common law) makes it clear that the best interests test is not confined to the patient's clinical interests, but extends to include the individual's own values, wishes and beliefs, (...) the proposal will be in the patient's best interests. We reject this claim. We argue that, as things currently stand, the proposal could not lawfully be justified as a blanket proposition by reference to the best interests test. Accordingly, a modification of the law would be necessary to render the proposal lawful. We conclude with a suggestion about how that could be achieved. (shrink)

The article reviews several books about philosophical isuuses including "Against Coherence: Truth, Probability, and Justification," by Olsson Erik J., "Fixing Frege," by Burgess John, "Events and Semantic Architecture," by Pietroski Paul M.

This paper is a revalidation of Oliver Sacks's role in the development of medicine's narrative turn and, as such, a reinterpretation of the history of narrative in medicine. It suggests that, from the late 1960s, Sacks pioneered in his ‘Romantic Science’ a new medical mode that reunited the seemingly incommensurable art and science of medicine while also offering a way for medical humanities to shape clinical reasoning more effectively.

This innovative collection offers one of the first analyses of criminologies of the military from an interdisciplinary perspective. While some criminologists have examined the military in relation to the area of war crimes, this collection considers a range of other important but less explored aspects such as private military actors, insurgents, paramilitary groups and the role of military forces in tackling transnational crime. Drawing upon insights from criminology, this book's editors also consider the ways the military institution harbours criminal activity (...) within its ranks and deals with prisoners of war. The contributions, by leading experts in the field, have a broad reach and take a truly global approach to the subject. (shrink)

What job should authorities give to review boards? We are grateful to Soren Holm, Rosamond Rhodes, Julian Savulescu and G Owen Schaefer for their thoughtful commentaries on our answer.1–4 Here we add to the discussion. Let us summarise the claims for which we argued.5 Relevant authorities can task boards with review for consistency with duly established code, thereby making code-consistent activities apt for approval and code-inconsistent activities apt for rejection. They can instead task boards with review for ethical acceptability, making (...) ethically acceptable activities apt for approval and ethically unacceptable activities apt for rejection. For every proposal a board might consider, these two different jobs establish different review bases, and their approvals and rejections also sometimes conflict. Some international and national statements require ECR, others instead require CCR, and others again seem either to require both or just to run the two together. Those responsible for these statements should make them clearer and better aligned here. For reasons of practicality, publicity and separation of powers, authorities do better to task boards with CCR and not ECR. These arguments also count against establishing any code with content that in effect collapses CCR into ECR. If our arguments withstand robust scrutiny, authorities should also remove ‘ethics’ and cognate terms from the names of these boards and their review activities and emphasise code expertise not ethics expertise in the required skill sets of boards. Our article noted that ‘ethical considerations informed the genesis of these boards and express their aspirations’. Rhodes similarly notes: ‘the authors and endorsers of research ethics codes, declarations and regulations … articulating the ethical standards for conducting human subject research’ and ‘This framework embeds the ethical parameters of human subject research into the moral missions of institutions’. Schaefer too …. (shrink)

In this paper I expound and criticise the arguments of two leading exponents of critical ecological feminism. According to critical ecological feminism responsibility for the oppressions of the natural world and the oppressions of racism and sexism can be traced to a logic of domination that is based on suspect value dualities and presupposes an unacceptable ‘moral extensionism’. I argue firstly that critical ecological feminism's critique of value dualism presupposes the truth of the thesis that humans and non‐humans are morally (...) equal, a thesis for which it offers no persuasive arguments . Secondly I maintain that moral extensionism, contrary to the claims of critical ecological feminism, can support a genuine respect for the natural world. Finally I suggest that the arguments for one version of critical ecological feminism, in order to be made convincing, themselves require the truth of moral extensionism. (shrink)

In this work, I attempt a four-part task: to explicate Heidegger's notion of the Fourfold, to show its necessary relation to technology, to think the limit that separates these, and to show how this constellation of the Fourfold and technology escapes from the "metaphysics of presence" with which Heidegger has been charged. ;1. The Fourfold is the belonging together of Earth, Sky, Mortals, and Divinities. Heidegger inherits the components from Holderlin, but transforms then in his thought. The gathering of these (...) four goes to make up the presencing of a singular and delimited entity . Such a thing exists as unique and irreplaceable. ;2. This singular mode of presence is only understandable against the background of limitless technological circulation. Influenced by Ernst Junger, Heidegger sees technology as setting into place a world of instantaneous replacement and sameness. The name for this manner of replaceable presence is "Bestand ." ;3. The unworld of technology is no simple "opposite" to the Fourfold, however. Rather the two modes of presence belong together. Heidegger repeatedly emphasizes how there can never be a complete loss of world in the enframing of technology. Conversely, the Fourfold is never free of the Bestand. A play of revelation and concealment is operative here and intimately related to Heidegger's new notion of essence. I examine this intricate and intimate co-belonging of technology and the Fourfold. ;4. This interpretation is used to counter the charge that Heidegger would think in terms of metaphysical presence, i.e., in terms of complete, self-present, and pure presence. Such a charge is leveled in the early work of Jacques Derrida. I show that Heidegger's thinking is already a thought of the trace. Since there is consequently no total presence or absence for Heidegger , there can be no simple overcoming of metaphysics either. Metaphysics cannot be so easily left behind, but must undergo a transformation . This is nothing more than a recognition of the trace and its place at the limit of singular, finite existence. ;The first chapter treats the circulation of technology, the remaining four address in series the elements of the Fourfold. (shrink)

In December 2013, the Nonhuman Rights Project (NhRP) filed a petition for a common law writ of habeas corpus in the New York State Supreme Court on behalf of Tommy, a chimpanzee living alone in a cage in a shed in rural New York (Barlow, 2017). Under animal welfare laws, Tommy’s owners, the Laverys, were doing nothing illegal by keeping him in those conditions. Nonetheless, the NhRP argued that given the cognitive, social, and emotional capacities of chimpanzees, Tommy’s confinement constituted (...) a profound wrong that demanded remedy by the courts. Soon thereafter, the NhRP filed habeas corpus petitions on behalf of Kiko, another chimpanzee housed alone in Niagara Falls, and Hercules and Leo, two chimpanzees held in research facilities at Stony Brook University. Thus began the legal struggle to move these chimpanzees from captivity to a sanctuary, an effort that has led the NhRP to argue in multiple courts before multiple judges. The central point of contention has been whether Tommy, Kiko, Hercules, and Leo have legal rights. To date, no judge has been willing to issue a writ of habeas corpus on their behalf. Such a ruling would mean that these chimpanzees have rights that confinement might violate. Instead, the judges have argued that chimpanzees cannot be bearers of legal rights because they are not, and cannot be persons. In this book we argue that chimpanzees are persons because they are autonomous. (shrink)

This paper provides finitary jointly necessary and sufficient acceptance and rejection conditions for the logical constants of a first order quantificational language. By introducing the notion of making an assignment as a distinct object level practice—something you do with a sentence—(as opposed to a meta-level semantic notion) and combining this with the practice of (hypothetical and categorical) acceptance and rejection and the practice of making suppositions one gains a structure that is sufficiently rich to fully characterize the class of classical (...) first order theories. The analysis thus provides a way of characterizing classical first order quantification by expressivist means. (shrink)

We submit this brief in support of the Nonhuman Rights Project’s efforts to secure habeas corpus relief for the elephant named Happy. We reject arbitrary distinctions that deny adequate protections to other animals who share with protected humans relevantly similar vulnerabilities to harms and relevantly similar interests in avoiding such harms. We strongly urge this Court, in keeping with the best philosophical standards of rational judgment and ethical standards of justice, to recognize that, as a nonhuman person, Happy should be (...) released from her current confinement and transferred to an appropriate elephant sanctuary, pursuant to habeas corpus. (shrink)

In this brief, we argue that there is a diversity of ways in which humans (Homo sapiens) are ‘persons’ and there are no non-arbitrary conceptions of ‘personhood’ that can include all humans and exclude all nonhuman animals. To do so we describe and assess the four most prominent conceptions of ‘personhood’ that can be found in the rulings concerning Kiko and Tommy, with particular focus on the most recent decision, Nonhuman Rights Project, Inc v Lavery.

We submit this brief in support of the Nonhuman Rights Project’s efforts to secure habeas corpus relief for the elephant named Happy. The Supreme Court, Bronx County, declined to grant habeas corpus relief and order Happy’s transfer to an elephant sanctuary, relying, in part, on previous decisions that denied habeas relief for the NhRP’s chimpanzee clients, Kiko and Tommy. Those decisions use incompatible conceptions of ‘person’ which, when properly understood, are either philosophically inadequate or, in fact, compatible with Happy’s personhood.

It is argued that the "inner" negation $\mathord{\sim}$ familiar from 3-valued logic can be interpreted as a form of "conditional" negation: $\mathord{\sim}$ is read '$A$ is false if it has a truth value'. It is argued that this reading squares well with a particular 3-valued interpretation of a conditional that in the literature has been seen as a serious candidate for capturing the truth conditions of the natural language indicative conditional (e.g., "If Jim went to the party he had a (...) good time"). It is shown that the logic induced by the semantics shares many familiar properties with classical negation, but is orthogonal to both intuitionistic and classical negation: it differs from both in validating the inference from $A \rightarrow \nega B$ to $\nega(A\rightarrow B)$ to. (shrink)

A globally expressivist analysis of the indicative conditional based on the Ramsey Test is presented. The analysis is a form of ‘global’ expressivism in that it supplies acceptance and rejection conditions for all the sentence forming connectives of propositional logic (negation, disjunction, etc.) and so allows the conditional to embed in arbitrarily complex sentences (thus avoiding the Frege–Geach problem). The expressivist framework is semantically characterized in a restrictor semantics due to Vann McGee, and is completely axiomatized in a logic dubbed (...) ICL (‘Indicative Conditional Logic’). The expressivist framework extends the AGM (after Alchourron, Gärdenfors, Makinson) framework for belief revision and so provides a categorical (‘yes’–‘no’) epistemology for conditionals that complements McGee’s probabilistic framework while drawing on the same semantics. The result is an account of the semantics and acceptability conditions of the indicative conditional that fits well with the linguistic data (as pooled by linguists and from psychological experiments) while integrating both expressivist and semanticist perspectives. (shrink)

It is argued that indicative conditionals are best viewed as having truth conditions (and so they are in part factual) but that these truth conditions are ‘gappy’ which leaves an explanatory gap that can only be filled by epistemic considerations (and so indicative conditionals are in part epistemic). This dual nature of indicative conditionals gives reason to rethink the relationship between logic viewed as a descriptive discipline (focusing on semantics) and logic viewed as a discipline with a normative import (focusing (...) on epistemic notions such as ‘reasoning’, ‘beliefs’ and ‘assumptions’). In particular, it is argued that the development of formal models for epistemic states can serve as a starting point for exploring logic when viewed as a normative discipline. (shrink)

Non-bivalent languages (languages containing sentences that can be true, false or neither) are given a probabilitistic interpretation in terms of betting quotients. Necessary and sufficient conditions for avoiding Dutch books—the laws of non-bivalent probability—in such a setting are provided.

The paper presents a non-monotonic inference relation on a language containing a conditional that satisfies the Ramsey Test. The logic is a weakening of classical logic and preserves many of the ‘paradoxes of implication’ associated with the material implication. It is argued, however, that once one makes the proper distinction between supposing that something is the case and accepting that it is the case, these ‘paradoxes’ cease to be counterintuitive. A representation theorem is provided where conditionals are given a non-bivalent (...) semantics and epistemic states are represented via preferential models. (shrink)

In this paper we look at the manual analysis of arguments and how this compares to the current state of automatic argument analysis. These considerations are used to develop a new approach combining a machine learning algorithm to extract propositions from text, with a topic model to determine argument structure. The results of this method are compared to a manual analysis.

Conditionals that contain a modality in the consequent give rise to a particular semantic phenomenon whereby the antecedent of the conditional blocks possibilities when interpreting the modality in the consequent. This explains the puzzling logical behaviour of constructions like "If you don't buy a lottery ticket, you can't win", "If you eat that poison, it is unlikely that you will survive the day" and "If you kill Harry, you ought to kill him gently". In this paper it is argued that (...) a semantic version of the Ramsey Test provides a key in the analysis of such constructions. The logic for this semantics is axiomatized and some examples are studied, among them a well-known puzzle for contrary-to-duty obligations. (shrink)

An alleged counterexample to causal decision theory, put forward by Andy Egan, is studied in some detail. It is argued that Egan rejects the evaluation of causal decision theory on the basis of a description of the decision situation that is different from—indeed inconsistent with—the description on which causal decision theory makes its evaluation. So the example is not a counterexample to causal decision theory. Nevertheless, the example shows that causal decision theory can recommend unratifiable acts which presents a problem (...) in the dynamics of intentions. It is argued that we can defuse this problem if we hold that decision theory is a theory of rational decision making rather than a theory of rational acts. It is shown how decisions can have epistemic side-effects that are not mediated by the act and that there are cases where one can only bring oneself to perform the best act by updating by imaging rather than by conditioning. This provides a pragmatic argument for updating by imaging rather than by conditioning in these cases. (shrink)

This paper calls for a re-appraisal of McGee's analysis of the semantics, logic and probabilities of indicative conditionals presented in his 1989 paper Conditional probabilities and compounds of conditionals. The probabilistic measures introduced by McGee are given a new axiomatisation built on the principle that the antecedent of a conditional is probabilistically independent of the conditional and a more transparent method of constructing such measures is provided. McGee's Dutch book argument is restructured to more clearly reveal that it introduces a (...) novel contribution to the epistemology of semantic indeterminacy, and shows that its more controversial implications are unavoidable if we want to maintain the Ramsey Test along with the standard laws of probability. Importantly, it is shown that the counterexamples that have been levelled at McGee's analysis|generating a rather wide consensus that it yields `unintuitive' or `wrong' probabilities for compounds |fail to strike at their intended target; for to honour the intuitions of the counterexamples one must either give up the Ramsey Test or the standard laws of probability. It will be argued that we need to give up neither if we take the counterexamples as further evidence that the indicative conditional sometimes allows for a non-epistemic `causal' interpretation alongside its usual epistemic interpretation. (shrink)

When a belief set is contracted only some beliefs are eligible for removal. By introducing eligibility for removal as a new semantic primitive for contraction and combining it with epistemic entrenchment we get a contraction operator with a number of interesting properties. By placing some minimal constraint upon eligibility we get an explicit contraction recipe that exactly characterises the so called interpolation thesis, a thesis that states upper and lower bounds for the amount of information to be given up in (...) contraction. As a result we drop the controversial property of recovery. By placing additional constraints on eligibility we get representation theorems for a number of contraction operators of varying strength. In addition it is shown that recovery contraction is a special case that we get if eligibility is explicitly constructed in terms of logical relevance. (shrink)

The problems that surround iterated contractions and expansions of beliefs are approached by studying hypertheories, a generalisation of Adam Grove's notion of systems of spheres. By using a language with dynamic and doxastic operators different ideas about the basic nature of belief change are axiomatised. It is shown that by imposing quite natural constraints on how hypertheories may change, the basic logics for belief change can be strengthened considerably to bring one closer to a theory of iterated belief change. It (...) is then argued that the logic of expansion, in particular, cannot without loss of generality be strengthened any further to allow for a full logic of iterated belief change. To remedy this situation a notion of directed expansion is introduced that allows for a full logic of iterated belief change. The new operation is given an axiomatisation that is complete for linear hypertheories. (shrink)

Go to Grazia Ietto-Gillies’ paper here ›.

The principle of universal instantiation plays a pivotal role both in the derivation of intensional paradoxes such as Prior’s paradox and Kaplan’s paradox and the debate between necessitism and contingentism. We outline a distinctively free logical approach to the intensional paradoxes and note how the free logical outlook allows one to distinguish two different, though allied themes in higher-order necessitism. We examine the costs of this solution and compare it with the more familiar ramificationist approaches to higher-order logic. Our assessment (...) of both approaches is largely pessimistic, and we remain reluctantly inclined to take Prior’s and Kaplan’s derivations at face value. (shrink)

This paper explores the possibility that causal decision theory can be formulated in terms of probabilities of conditionals. It is argued that a generalized Stalnaker semantics in combination with an underlying branching time structure not only provides the basis for a plausible account of the semantics of indicative conditionals, but also that the resulting conditionals have properties that make them well-suited as a basis for formulating causal decision theory. Decision theory (at least if we omit the frills) is not an (...) esoteric science, however unfamiliar it may seem to an outsider. Rather it is a systematic exposition of the consequences of certain well-chosen platitudes about belief, desire, preference and choice. It is the very core of our common-sense theory of persons, dissected out and elegantly systematized. (David Lewis, Synthese 23:331–344, 1974, p. 337). A small distortion in the analysis of the conditional may create spurious problems with the analysis of other concepts. So if the facts about usage favor one among a number of subtly different theories, it may be important to determine which one it is. (Robert Stalnaker, A Defense of Conditional Excluded Middle, pp. 87–104, 1980, p. 87). (shrink)

Ever since [4], systems of spheres have been considered to give an intuitive and elegant way to give a semantics for logics of theory- or belief- change. Several authors [5, 11] have considered giving up the rather strong assumption that systems of spheres be linearly ordered by inclusion. These more general structures are called hypertheories after [8]. It is shown that none of the proposed logics induced by these weaker structures are compact and thus cannot be given a strongly complete (...) axiomatization in a finitary logic. Complete infinitary axiomatizations are given for several intuitive logics based on hypertheories that are not linearly ordered by inclusion. (shrink)

The view that decision methods can only be justified by appeal to pragmatic considerations is defended. Pragmatic considerations are viewed as providing the underlying subject matter (“semantics”) of decision theories. It is argued that other approaches (e.g. justifying principles by appeal to obviousness, common usage, etc.) fail to provide grounds for a normative decision theory.It is argued that preferences that can lead to pragmatically adverse outcomes in a relevantly similar possible decision situation are pragmatically unsound, even if the decision situation (...) never arises. This rebuts several standard objections to money-pump and Dutch book arguments. However, because one can only appeal to relevantly similar decision situations in pragmatic arguments, these will have a less general scope than is often imagined. A conclusion is that pragmatic arguments for strong unconditional principles such as ‘always maximise expected utility!’ do not work. Pragmatic considerations can however be used to argue for conditional principles of the form ‘if conditions X, Y and Z are satisfied, then one ought to satisfy W’, where W need not follow logically from X, Y and Z.The notion of a sound pragmatic argument is defined in terms of particular notion of coherence, it is shown how this can be applied and how it handles problematic cases such as van Fraassen’s Dutch book for the principle of Reflection. (shrink)

The view that decision methods can only be justified by appeal to pragmatic considerations is defended. Pragmatic considerations are viewed as providing the underlying subject matter (“semantics”) of decision theories. It is argued that other approaches (e.g. justifying principles by appeal to obviousness, common usage, etc.) fail to provide grounds for a normative decision theory.It is argued that preferences that can lead to pragmatically adverse outcomes in a relevantly similar possible decision situation are pragmatically unsound, even if the decision situation (...) never arises. This rebuts several standard objections to money-pump and Dutch book arguments. However, because one can only appeal to relevantly similar decision situations in pragmatic arguments, these will have a less general scope than is often imagined. A conclusion is that pragmatic arguments for strong unconditional principles such as ‘always maximise expected utility!’ do not work. Pragmatic considerations can however be used to argue for conditional principles of the form ‘if conditions X, Y and Z are satisfied, then one ought to satisfy W’, where W need not follow logically from X, Y and Z.The notion of a sound pragmatic argument is defined in terms of particular notion of coherence, it is shown how this can be applied and how it handles problematic cases such as van Fraassen’s Dutch book for the principle of Reflection. (shrink)