It is argued that genuinely subsentential phrases, such as a discourse-initial utterance of “From France” to indicate the provenance of an item, provide evidence for the reality of the pragmatic process of free enrichment. I consider recent attempts to treat such discourse-initial fragments as linguistic ellipsis of some kind while accommodating the difference between these cases and accepted types of ellipsis such as sluicing and gapping. I claim that the mechanisms they posit to save an ellipsis story have no role (...) in an account of performance. An argument against the enrichment approach from the indeterminacy of the content of subsentential utterances is discussed, and refuted, and it is shown how this indeterminacy is accommodated in a contextualist pragmatic theory. (shrink)

Objective: There is a demonstrated link between the mental health and substance use comorbidities experienced by young adults, however the vast majority of psychological interventions are disorder specific. Novel psychological approaches that adequately acknowledge the psychosocial complexity and transdiagnostic needs of vulnerable young people are urgently needed. A modular skills-based program for emotion regulation and impulse control addresses this gap. The current one armed open trial was designed to evaluate the impact that 12 weeks exposure to ERIC alongside usual care (...) had on young people's ability to regulate emotions, as well as examine potential moderating mechanisms.Methods: Seventy nine young people were enrolled to the 12 week intervention period. Twenty one practitioners from youth and community health services delivered relevant ERIC modules adjunct to usual care. Linear mixed effects regression was used to examine change over time across the primary outcome of emotion dysregulation and secondary outcomes of depression, anxiety, stress, experiential avoidance and mindfulness. Moderation analyses were conducted to test whether the magnitude of change in emotion dysregulation moderated change over time in secondary outcomes.Results: Analyses revealed significant improvement in the primary outcome of emotion dysregulation with a moderate effect size, in addition to decreases in the secondary outcomes of depression, anxiety, stress and experiential avoidance. No improvements in mindfulness were reported. Moderation analyses revealed that the residualised change over time in emotion dysregulation moderated the change over time in symptoms of distress, depression, anxiety, stress, experiential avoidance, and mindfulness.Conclusion: Reductions in the severity of emotion dysregulation, depression, anxiety, stress and experiential avoidance are promising, and were evident despite the complexity of the participants and the diversity of the service setting. The improvements found in each outcome were only observed for those young people whose emotion regulation also improved, providing preliminary evidence for the role of emotion regulation as a key treatment target in this population. (shrink)

Abstract: A current debate in semantics and pragmatics is whether all contextual effects on truth-conditional content can be traced to logical form, or 'unarticulated constituents' can be supplied by the pragmatic process of free enrichment. In this paper, I defend the latter position. The main objection to this view is that free enrichment appears to overgenerate, not predicting where context cannot affect truth conditions, so that a systematic account is unlikely (Stanley, 2002a). I first examine the semantic alternative proposed by (...) Stanley and others, which assumes extensive hidden structure acting as a linguistic trigger for pragmatic processes, so that all truth-conditional effects of context turn out to be instances of saturation. I show that there are cases of optional pragmatic contributions to the proposition expressed that cannot plausibly be accounted for in this way, and that advocates of this approach will therefore also have to appeal to free enrichment. The final section starts to address the question of how free enrichment is constrained: I argue that it involves only local development or adjustment of parts of logical form, any global developments being excluded by the requirement for the proposition expressed to provide an inferential warrant for the intended implications of the utterance. (shrink)

This article evaluates the oversight of drugs and medical devices by the U.S. Food and Drug Administration using an integration of public policy, law, and bioethics approaches and employing multiple assessment criteria, including economic, social, safety, and technological. Criteria assessment and expert elicitation are combined with existing literature, case law, and regulations in an integrative historical case studies approach. We then use our findings as a tool to explore possibilities for effective oversight and regulatory mechanisms for nanobiotechnology. Section I describes (...) oversight mechanisms for human drugs and medical devices and presents current nanotechnology products. Section II describes the results of expert elicitation research. Section III highlights key criteria and relates them to the literature and larger debate. We conclude with broad lessons for the oversight of nanobiotechnology informed by Sections I-III in order to provide useful analysis from multiple disciplines and perspectives to guide discussions regarding appropriate FDA oversight. (shrink)

Increasing genetic knowledge over the last decade has enabled hundreds of genetic variants associated with inherited cardiac conditions to be identified, many of which cause increased risk of sudden cardiac death. While individually these conditions are rare, taken together they impose a significant burden. The severity of these conditions—the possibility that they might cause sudden unheralded death of a teenager or young adult—juxtaposed with uncertainty about the pathology linked with many of the genetic variants is significant in terms of professional (...) practice because, increasingly, clinicians have been encouraged to cascade out genetic testing from the proband or consultand to other family members who may be at risk of developing the same condition. This process often involves sharing human tissue samples, DNA or personal information. This paper reviews the legal and regulatory frameworks which may apply when tissue and DNA samples are collected, used and retained, both for the purpose of diagnosis and for benefiting other family members, when a suspected or definitive diagnosis of an inherited cardiovascular condition is made. Sometimes the interests of family members may conflict, and it may be difficult for practitioners to reconcile the interests of one family member with another, particularly if the balance of benefits and harms from testing is unclear. The paper then examines some of the ethical tensions which may arise in practice and concludes that all involved should be conversant with the legal and ethical frameworks that apply. (shrink)

This article evaluates the oversight of drugs and medical devices by the U.S. Food and Drug Administration using an integration of public policy, law, and bioethics approaches and employing multiple assessment criteria, including economic, social, safety, and technological. Throughout, assessments employing both the multiple criteria and a method of expert elicitation are combined with the existing literature, case law, and regulations providing an integrative historical case study approach. The goal is to provide useful information from multiple disciplines and perspectives to (...) guide discussions regarding appropriate oversight frameworks for nanobiotechnology applications under the FDA’s purview. (shrink)

BackgroundMulti-centre studies generally cost more than single-centre studies because of larger sample sizes and the need for multiple ethical approvals. Multi-centre studies include clinical trials, clinical quality registries, observational studies and implementation studies. We examined the costs of two large Australian multi-centre studies in obtaining ethical and site-specific approvals.MethodsWe collected data on staff time spent on approvals and expressed the overall cost as a percent of the total budget.ResultsThe total costs of gaining approval were 38 % of the budget for (...) a study of 50 centres (mean cost AUD $6960 per site) and 2 % for a study of 11 centres (mean cost AUD $2300 per site). Seventy-five and 90 % of time was spent on repeated tasks, respectively, and many time-consuming tasks, such as reformatting documents, did nothing to improve the study design or participant safety.ConclusionsImprovements have been made to the ethical approval application system, but more gains could be made without increasing risks of harm to research participants. We propose that ethical review bodies and individual sites publish statistics on how long they take to process approvals which could then be nationally benchmarked. (shrink)

Word count (excluding abstract and references): 2,498 words. Address for correspondence: T. Kushnir, Psychology Department, University of California, 3210 Tolman Hall #1650, Berkeley, CA 94720-1650. Phone: 510-205-9847. Fax: 510-642- 5293. E-mail: [email protected].

We live in an era where our health is linked to that of others across the globe, and nothing brings this home better than the specter of a pandemic. This paper explores the findings of town hall meetings associated with the Canadian Program of Research on Ethics in a Pandemic , in which focus groups met to discuss issues related to the global governance of an influenza pandemic. Two competing discourses were found to be at work: the first was (...) based upon an economic rationality and the second upon a humanitarian rationality. The implications for public support and the long-term sustainability of new global norms, networks, and regulations in global public health are discussed. (shrink)

Material traces of the past are notoriously inscrutable; they rarely speak with one voice, and what they say is never unmediated. They stand as evidence only given a rich scaffolding of interpretation which is, itself, always open to challenge and revision. And yet archaeological evidence has dramatically expanded what we know of the cultural past, sometimes demonstrating a striking capacity to disrupt settled assumptions. The questions we address in Evidential Reasoning are: How are these successes realized? What gives us confidence (...) in the credibility and robustness, the trustworthiness, of the evidential claims based on archaeological data? And, what constitute best practices in building evidential claims, critically scrutinizing them and putting them to work in archaeological contexts? Rather than retreat to abstractions about how how science operates in the ideal, we approach this question by interrogating a number of close-to-the-ground case studies with the aim of teasing out the wisdom embodied in archaeological practice. The cases we consider – of fieldwork, strategies for working with old evidence, and the role of external resources – illuminate the role of various types of inferential scaffolding and bring into focus practice-grounded epistemic norms that we believe serve archaeologists better than the all-or-nothing ideals of truth and objectivity that dominate programmatic debate. (shrink)

Recently, the theory theory has led to much interesting research. However, this is the first book to look at the theory in extensive detail and to systematically contrast it with other theories.

I argue that understanding why p involves a kind of intellectual know how and differsfrom both knowledge that p and knowledge why p (as they are standardly understood).I argue that understanding, in this sense, is valuable.

Feminist standpoint theory has been marginal to mainstream philosophical analyses of science–indeed, it has been marginal to science studies generally–and it has had an uneasy reception among feminist theorists. Critics of standpoint theory have attributed to it untenable foundationalist assumptions about the social identities that can underpin an epistemically salient standpoint, and implausible claims about the epistemic privilege that should be accorded to those who occupy subdominant social locations. I disentangle what I take to be the promising core of feminist (...) standpoint theory from this conflicted history of debate. I argue that non-foundationalist, non-essentialist arguments can be given (and have been given) for attributing epistemic advantage (rather than privilege) to some social locations and standpoints. They presuppose a situated knowledge thesis, and posit contingent advantage relative to epistemic purpose. I illustrate these claims in terms of the epistemic advantages that accrue to a fictional character, from Neely’s novel Blanche on the Lam, who represents a type of standpoint invoked by diverse advocates of standpoint theory: that of a race, class, and gender disadvantaged “insider-outsider” who has no choice, given her social location, but to negotiate the world of the privileged while at the same time being grounded in a community whose marginal status generates a fundamentally different understanding of how the world works. (shrink)

Understanding causal structure is a central task of human cognition. Causal learning underpins the development of our concepts and categories, our intuitive theories, and our capacities for planning, imagination and inference. During the last few years, there has been an interdisciplinary revolution in our understanding of learning and reasoning: Researchers in philosophy, psychology, and computation have discovered new mechanisms for learning the causal structure of the world. This new work provides a rigorous, formal basis for theory theories of concepts and (...) cognitive development, and moreover, the causal learning mechanisms it has uncovered go dramatically beyond the traditional mechanisms of both nativist theories, such as modularity theories, and empiricist ones, such as association or connectionism. (shrink)

I argue that explanation should be thought of as the phenomenological mark of the operation of a particular kind of cognitive system, the theory-formation system. The theory-formation system operates most clearly in children and scientists but is also part of our everyday cognition. The system is devoted to uncovering the underlying causal structure of the world. Since this process often involves active intervention in the world, in the case of systematic experiment in scientists, and play in children, the cognitive system (...) is accompanied by a theory drive, a motivational system that impels us to interpret new evidence in terms of existing theories and change our theories in the light of new evidence. What we usually think of as explanation is the phenomenological state that accompanies the satisfaction of this drive. However, the relation between the phenomenology and the cognitive system is contingent, as in similar cases of sexual and visual phenomenology. Distinctive explanatory phenomenology may also help us to identify when the theory-formation system is operating. (shrink)

This paper argues that there are powerful similarities between cognitive development in children and scientific theory change. These similarities are best explained by postulating an underlying abstract set of rules and representations that underwrite both types of cognitive abilities. In fact, science may be successful largely because it exploits powerful and flexible cognitive devices that were designed by evolution to facilitate learning in young children. Both science and cognitive development involve abstract, coherent systems of entities and rules, theories. In both (...) cases, theories provide predictions, explanations, and interpretations. In both, theories change in characteristic ways in response to counterevidence. These ideas are illustrated by an account of children's developing understanding of the mind. (shrink)

At least since Augustine, philosophers have constructed developmental just-so stories about the origins of certain concepts. In these just-so stories, philosophers tell us how children must develop these concepts. However, philosophers have by and large neglected the empirical data about how children actually do develop their ideas about the world. At best they have used information about children in an anecdotal and unsystematic, though often illuminating, way.

This chapter examines several ways in which philosophical attention to intuition can contribute to empirical scientific psychology. The authors then discuss one prevalent misuse of intuition. An unspoken assumption of much argumentation in the philosophy of mind has been that to articulate our folk psychological intuitions, our ordinary concepts of belief, truth, meaning, and so forth, is itself sufficient to give a theoretical account of what belief, truth, meaning, and so forth, actually are. It is believed that this assumption rests (...) on an inadequate understanding of the nature of intuition and its appropriate applications, and that it results in errors. Three notable examples of this sort of misuse of intuition in philosophy are briefly discussed. Finally, the authors provide developmental evidence for the mutability and fallibility of everyday intuitions about the mind, evidence that undermines arguments, that depend on taking such intuitions as a final authority for substantive claims about what the mind is like. (shrink)

When students read Difference and Repetition for the first time, they face two main hurdles: the wide range of sources that Deleuze draws upon and his dense writing style. This Edinburgh Philosophical Guide helps students to negotiate these hurdles, taking them through the text step by step. It situates Deleuze within Continental philosophy more broadly and explains why he develops his philosophy in his unique way. Seasoned Deleuzians will also be interested in Somers-Hall's novel interpretation of Difference and Repetition.

Previous research suggests that children can infer causal relations from patterns of events. However, what appear to be cases of causal inference may simply reduce to children recognizing relevant associations among events, and responding based on those associations. To examine this claim, in Experiments 1 and 2, children were introduced to a “blicket detector”, a machine that lit up and played music when certain objects were placed upon it. Children observed patterns of contingency between objects and the machine’s activation that (...) required them to use indirect evidence to make causal inferences. Critically, associative models either made no predictions, or made incorrect predictions about these inferences. In general, children were able to make these inferences, but some developmental differences between 3- and 4- year-olds were found. We suggest that children’s causal inferences are not based on recognizing associations, but rather that children develop a mechanism for Bayesian structure learning. Experiment 3 explicitly tests a prediction of this account. Children were asked to make an inference about ambiguous data based on the base-rate of certain events occurring. Fouryear-olds, but not 3-year-olds were able to make this inference. (shrink)

As a working hypothesis for philosophy of science, the unity of science thesis has been decisively challenged in all its standard formulations; it cannot be assumed that the sciences presuppose an orderly world, that they are united by the goal of systematically describing and explaining this order, or that they rely on distinctively scientific methodologies which, properly applied, produce domain-specific results that converge on a single coherent and comprehensive system of knowledge. I first delineate the scope of arguments against global (...) unity theses. However implausible old-style global unity theses may now seem, I argue that unifying strategies of a more local and contingent nature do play an important role in scientific inquiry. This is particularly clear in archaeology where, to establish evidential claims of any kind, practitioners must exploit a range of inter-field and inter-theory connections. At the same time, the robustness of these evidential claims depends on significant disunity between the sciences from which archaeologists draw background assumptions and auxiliary hypotheses. This juxtaposition of unity with disunity poses a challenge to standard positions in the debate about scientific unity. (shrink)

This chapter contains section titled: The Theory Theory The Theory Theory vs. Other Empiricist Alternatives Innate Theories and Starting‐state Nativism Phenomenological and Social Objections Universality, Uniformity, and Learning Theory Formation and Language.

This paper argues that there are powerful similarities between cognitive development in children and scientific theory change. These similarities are best explained by postulating an underlying abstract set of rules and representations that underwrite both types of cognitive abilities. In fact, science may be successful largely because it exploits powerful and flexible cognitive devices that were designed by evolution to facilitate learning in young children. Both science and cognitive development involve abstract, coherent systems of entities and rules, theories. In both (...) cases, theories provide predictions, explanations, and interpretations. In both, theories change in characteristic ways in response to counterevidence. These ideas are illustrated by an account of children's developing understanding of the mind. (shrink)

Five studies investigated (a) children’s ability to use the dependent and independent probabilities of events to make causal inferences and (b) the interaction between such inferences and domain-specific knowledge. In Experiment 1, preschoolers used patterns of dependence and independence to make accurate causal inferences in the domains of biology and psychology. Experiment 2 replicated the results in the domain of biology with a more complex pattern of conditional dependencies. In Experiment 3, children used evidence about patterns of dependence and independence (...) to craft novel interventions across domains. In Experiments 4 and 5, children’s sensitivity to patterns of dependence was pitted against their domain-specific knowledge. Children used conditional probabilities to make accurate causal inferences even when asked to violate domain boundaries. (shrink)

The vagaries of evidential reasoning in archaeology are notorious: the material traces that comprise the archaeological record are fragmentary and profoundly enigmatic, and the inferential gap that archaeologists must cross to constitute them as evidence of the cultural past is a peren­nial source of epistemic anxiety. And yet we know a great deal about the cultural past, including vast reaches of the past for which this material record is our only source of evidence. The contents of this record stand as (...) evidence only under interpretation, but however much a construct it is, archaeological evidence has a striking capacity to disrupt settled assump­tions, redirecting inquiry and expanding interpretive horizons in direc­tions no one could have anticipated. It is this capacity for constraining inference and interpretation that I am concerned to understand. I outline a model of evidential reasoning based on archaeological practice that integrates insights drawn from philosophical theories of confirmation, model building and hypothesis testing. Given growing interest in the uses of material evidence in fields that had been resolutely text-based, the archaeological principles of evidential reasoning may have much wider reach than this particular social/historical discipline. (shrink)

abstract: Religion for many of Canada's earliest Chinese community was not about faith or belief in God, the Buddha, or the Goddess of Compassion (Guanyin). While the majority of Chinese migrants did not convert to Christianity or Buddhism before 1947, a very large number of them joined and became converted to Chinese nationalism (Zhongguo guomindang, aka KMT). This paper reflects on the findings of sixteen years of ethnographic and archival research to understand how sixty-two years of institutionalized racism in Canada, (...) along with bioregionalism and the built environment, determined Chinese migrant religious identities and behaviors in Canada up to 1947. Different Canadian provinces not only had different race-based laws that restricted individual rights and freedoms, they also had varying bioregional characteristics that influenced experiences and interactions with the built environments of churches, temples, and clubhouses. Chinese migrants adapted to legislation that limited their personal rights and freedoms by being efficacious or ling by professing Christian identities in public settings. They might have made offerings to Buddhist deities and frequented Buddhist temples in their home village before migration. But in Canada, being Buddhist was associated with being Japanese, and it was efficacious to be a practicing Buddhist in private. For Canada's Chinese migrants, it was conversion to Chinese nationalism and the veneration of Sun Yat-sen that was the epitome of ling. Being a devoted member met important practical as well as spiritual needs. (shrink)

Judith Butler's contribution to feminist political thought is usually approached in terms of her concept of performativity, according to which gender exists only insofar as it is ritualistically and repetitively performed, creating permanent possibilities for performing gender in new and transgressive ways. In this paper, I argue that Butler's politics of performativity is more fundamentally grounded in the concept of genealogy, which she adapts from Foucault and, ultimately, Nietzsche. Butler understands women to have a genealogy: to be located within a (...) history of overlapping practices and reinterpretations of femininity. This genealogical understanding of femininity allows Butler to propose a coalitional feminist politics, which requires no unity among women but only loosely overlapping connections. For Butler, feminist coalitions should aim to subvert, not consolidate, entrenched norms concerning femininity. Butler has been criticized, however, for failing to explain either how subversive agency is possible or why the subversion of gender norms is desirable. Reviewing these criticisms, I argue that Butler offers a convincing explanation of the possibility of subversive agency, but that the normative dimension of her political thought remains relatively underdeveloped. I explore how the normative aspect of Butler's thought could be strengthened by recasting her notion of genealogy along more thoroughly Nietzschean and materialist lines, in terms of an idea of active and multiple bodily forces. (shrink)

In this paper, we report on the development and validity of the Professional Decision-Making in Research measure, a vignette-based test that examines decision-making strategies used by investigators when confronted with challenging situations in the context of empirical research. The PDR was administered online with a battery of validity measures to a group of NIH-funded researchers and research trainees who were diverse in terms of age, years of experience, types of research, and race. The PDR demonstrated adequate reliability and parallel form (...) correlation. As hypothesized, the PDR was significantly negatively correlated with narcissism, cynicism, moral disengagement, and compliance disengagement; it was not correlated with socially desirable responding. In regression analysis, the strongest predictors of higher PDR scores were low compliance disengagement, speaking English as a native language, conducting clinical research with human subjects, and low levels of narcissism. Given that the PDR was written at an eighth grade reading level to be suitable for use with English as a second language participants and that only one-fourth of items focused on clinical research, further research into the possible roles of culture and research ethics training across specialties is warranted. This initial validity study demonstrates the potential usefulness of the PDR as an educational outcome assessment measure and a research instrument for studies on professionalism and integrity in research. (shrink)

Philosophy has the dubious distinction of attracting and retaining proportionally fewer women than any other field in the humanities, indeed, fewer than in all but the most resolutely male-dominated of the sciences. This short article introduces a thematic cluster that brings together five short essays that probe the reasons for and the effects of these patterns of exclusion, not just of women but of diverse peoples of all kinds in Philosophy. It summarizes some of the demographic measures of exclusion that (...) are cause for concern and identifies key themes that cross-cut these discussions: gender stereotypes and climate issues, ‘cognitive distortions’ and disciplinary norms. (shrink)

Philosophers and Buddhist scholars have noted the affinities between David Hume's empiricism and the Buddhist philosophical tradition. I show that it was possible for Hume to have had contact with Buddhist philosophical views. The link to Buddhism comes through the Jesuit scholars at the Royal College of La Fleche. Charles Francois Dolu was a Jesuit missionary who lived at the Royal College from 1723-1740, overlapping with Hume's stay. He had extensive knowledge both of other religions and cultures and of scientific (...) ideas. Dolu had had first-hand experience with Theravada Buddhism as part of the second French embassy to Siam in 1687-1688. In 1727, Dolu also had talked with Ippolito Desideri, a Jesuit missionary who visited Tibet and made an extensive study of Tibetan Buddhism from 1716-1721. It is at least possible that Hume heard about Buddhist ideas through Dolu. (shrink)