This book uses an incidence approach to look at the economic repercussions of birth defects. The authors investigate eighteen of the most clinically significant birth defects affecting 35,000 newborns each year in our country. Their assessments suggest that the annual cost of these eighteen birth defects, together, is more than eight billion dollars . The authors describe in detail their methodology and data sources while providing thorough accounts of each of the eighteen birth defects. Waitzman, Scheffler, and Romano break (...) new ground by using reports from the California Birth Defects Monitoring Program in order to provide cost estimates. They illustrate to the reader how cost estimates of specific birth defects can be used to justify prevention interventions and strategies. In chapter seven, they provide an important example, showing cost-benefit analysis of a program of folate supplementation of food to prevent neutral tube defects. Contents: List of Tables; Preface; Acknowledgements; Introduction; The Application of Cost-of-Illness Methodology To Birth Defects; The Direct Medical Costs of Birth Defects; Nonmedical Direct Costs of Birth Defects: Developmental Services and Special Education; The Indirect Costs of Birth Defects; Premature Mortality and Heightened Morbidity; An Assessment of Total Costs and Policy Implications; Description of Birth Defects; Description of Major Data Sources; Index. (shrink)

One of the most influential arguments for realism about mathematical objects is the indispensability argument. Simply put, this is the argument that insofar as we are committed to the existence of the physical objects existentially quantified over in our best scientific theories, we are also committed to the mathematical objects existentially quantified over in these theories. Following the Quine–Putnam formulation of the indispensability argument, some proponents of the indispensability argument have made the mistake of taking confirmational holism to be an (...) essential premise of the argument. In this paper, I consider the reasons philosophers have taken confirmational holism to be essential to the argument and argue that, contrary to the traditional view, confirmational holism is dispensable. (shrink)

Distributive, procedural, and interactional justice are constructs that are increasingly being recognized as important factors that affect individual perceptions in the workplace environment. This paper presents a theoretical perspective that suggests that justice is perceived through a subjective lens that consists of individualized beliefs and proposes that cultural attributes and demographic characteristics play an integral part in determining the perception of justice. The distinctions between these three constructs are presented in context with the core beliefs of individual employees – affected (...) by a multitude of perceptual and demographic factors that we briefly identify herein. Based on the theoretical perspective, an instrument that measures the constructs of justice as perceived by individuals was developed. With a focus on justice within the business setting, hypotheses about attitudes related to justice were tested. Survey results confirm that the three constructs of justice are distinct but correlated. Significant differences were found in the perceptions of African-American respondents with regard to procedural justice. Although the empirical findings do not support all the hypotheses, this research highlights the need for further development of measures to assess the perception of justice in business settings and at an applied level, underscores the importance of recognizing cultural attributes and demographic characteristics in understanding how justice is perceived. (shrink)

According to social learning theory, we explored the relation between ethical leadership and knowledge hiding. We developed a moderated mediation model of the psychological safety linking ethical leadership and knowledge hiding. Surveying 436 employees in 78 teams, we found that ethical leadership was negatively related to knowledge hiding, and that this relation was mediated by psychological safety. We further found that the effect of ethical leadership on knowledge hiding was contingent on a mastery climate. Finally, theoretical and practical implications were (...) discussed for leadership and knowledge management. (shrink)

: Because an influenza pandemic would create the most serious hardships for those who already face most serious hardships, countries should take special measures to mitigate the effect of a pandemic on existing social inequalities. Unfortunately, there is little evidence that anybody is thinking about that.

Cognition is context-sensitive, as the same sensory information is processed differently depending on its context (e.g., on its probabilistic association with goal-directed actions and their outcomes). Despite this, the concept of context in studies of higher-order cognitive processes, like cognitive control, is often simplified to nominal stimulus categories (like a target vs. distractor). Here we propose that quantifying contextual information to model cognitive demands is (1) fruitful as it can provide novel insight into the nature of cognitive control, (2) accessible (...) as simple probability models offer a tool for quantifying context and (3) analytically useful as a fine-grained quantification of context can be entered into more complex models as regressors that allow a direct way of appropriately exploring many of the defining tenants of cognitive control (e.g., rapidly changing trial-by-trial neural dynamics). Here, we briefly describe the logic of using context-sensitive measures of cognitive control and highlight recent studies from this approach using simple information theory metrics. (shrink)

P.F. Strawson’s (1962) “Freedom and Resentment” has provoked a wide range of responses, both positive and negative, and an equally wide range of interpretations. In particular, beginning with Gary Watson, some have seen Strawson as suggesting a point about the “order of explanation” concerning moral responsibility: it is not that it is appropriate to hold agents responsible because they are morally responsible, rather, it is ... well, something else. Such claims are often developed in different ways, but one thing remains (...) constant: they meant to be incompatible with libertarian theories of moral responsibility. The overarching theme of this paper is that extant developments of “the reversal” face a dilemma: in order to make the proposals plausibly anti-libertarian, they must be made to be implausible on other grounds. I canvas different attempts to articulate a “Strawsonian reversal”, and argue that none is fit for the purposes for which it is intended. I conclude by suggesting a way of clarifying the intended thesis: an analogy with the concept of funniness. The result: proponents of the “reversal” need to accept the difficult result that if we blamed small children, they would be blameworthy, or instead explain how their view escapes this result, while still being a view on which our blaming practices “fix the facts” of moral responsibility. (shrink)

Tens of thousands of students have learned to be more discerning at constructing and evaluating arguments with the help of Patrick J. Hurley. Hurley’s lucid, friendly, yet thorough presentation has made A CONCISE INTRODUCTION TO LOGIC the most widely used logic text in North America. In addition, the book’s accompanying technological resources, such as CengageNOW and Learning Logic, include interactive exercises as well as video and audio clips to reinforce what you read in the book and hear in class. (...) In short, you’ll have all the assistance you need to become a more logical thinker and communicator. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version. (shrink)

Psychiatry has witnessed a new wave of approaches to clinical phenotyping and the study of psychopathology, including the National Institute of Mental Health’s Research Domain Criteria, clinical staging, network approaches, the Hierarchical Taxonomy of Psychopathology, and the general psychopathology factor, as well as a revival of interest in phenomenological psychopathology. The question naturally emerges as to what the relationship between these new approaches is – are they mutually exclusive, competing approaches, or can they be integrated in some way and used (...) to enrich each other? In this opinion piece, we propose a possible integration between clinical staging and phenomenological psychopathology. Domains identified in phenomenological psychopathology, such as selfhood, embodiment, affectivity, etc., can be overlaid on clinical stages in order to enrich and deepen the phenotypes captured in clinical staging (‘high resolution’ clinical phenotypes). This approach may be useful both ideographically and nomothetically, in that it could complement diagnosis, enrich clinical formulation, and inform treatment of individual patients, as well as help guide aetiological, prediction, and treatment research. The overlaying of phenomenological domains on clinical stages may require that these domains are reformulated in dimensional rather than categorial terms. This integrative project requires assessment tools, some of which are already available, that are sensitive and thorough enough to pick up on the range of relevant psychopathology. The proposed approach offers opportunities for mutual enrichment: clinical staging may be enriched by introducing greater depth to phenotypes; phenomenological psychopathology may be enriched by introducing stages of severity and disorder progression to phenomenological analysis. (shrink)

In this paper, we introduce and defend the recurrent model for understanding bodily spatial phenomenology. While Longo, Azañón and Haggard (2010) propose a bottom-up model, Bermúdez (2017) emphasizes the top-down aspect of the information processing loop. We argue that both are only half of the story. Section 1 intro- duces what the issues are. Section 2 starts by explaining why the top- down, descending direction is necessary with the illustration from the ‘body-based tactile rescaling’ paradigm (de Vignemont, Ehrsson and Haggard, (...) 2005). It then argues that the bottom-up, ascending direction is also necessary, and substantiates this view with recent research on skin space and tactile field (Haggard et al., 2017). Section 3 discusses the model’s application to body ownership and bodily self-representation. Implications also extend to topics such as sense modality individuation (Macpherson, 2011), the constancy- based view of perception (Burge, 2010), and the perception/cognition divide (Firestone and Scholl, 2016). (shrink)

In this paper we critically evaluate Trenton Merricks’s recent attempt to provide a “new” way of defending compatibilism about divine foreknowledge and human freedom. We take issue with Merricks’s claim that his approach is fundamentally different from Ockhamism. We also seek to highlight the implausibility of Merricks’s rejection of the assumption of the fixity of the past, and we also develop a critique of the Merricks’s crucial notion of “dependence.”.

Perhaps the best-known theory of fairness is John Broome’s: that fairness is the proportional satisfaction of claims. In this article, I question whether claims are the appropriate focus for a theory of fairness, at least as Broome understands them in his current theory. If fairness is the proportionate satisfaction of claims, I argue, then the following would be true: fairness could not help determine the correct distribution of claims; fairness could not be used to evaluate the distribution of claims; fairness (...) could not guide us in distributing claims (or unowed goods); we could not have a claim to be treated fairly; and we would not be wronged when treated unfairly. These entailments mean that it is questionable that fairness is concerned with claims in the way Broome suggests. At the very least, the relationship between fairness and claims appears to be more complex than the picture painted by Broome. (shrink)

Bertrand's Paradox Revisited: Why Bertrand's 'Solutions' Are All Inapplicable.

According to a traditional view, one lies if and only if one asserts what one believes is false and with the intent to deceive one’s audience. Recently, many theorists have challenged the requirement of intent to deceive. The principal reason offered appeals to so-called bald-faced lies wherein one asserts what one believes is false without intent to deceive. I argue that, assuming a reasonable model of assertion, two of the most prominent examples of bald-faced lies fail to be genuinely assertoric. (...) As such, they fail as counter-examples to the view that intent to deceive is a necessary condition on lying. (shrink)

This essay attempts to interrogate the distinct character of Peter Sloterdijk’s declaration of the absolute imperative that concludes his work, You Must Change Your Life, by contextualizing it within the development of his notion of anthropotechnics. In particular, the essays examine the claim that his is a new and unprecedented form of the absolute imperative that is alone able to address, in an effective way, the contemporary global crises that are confronting us now. The first sections trace out the ways (...) in which this new imperative differs from previous forms of the imperative, including the categorical, the aesthetic, and the existential-ontological. The latter sections then discuss how the new form of the imperative is connected to Sloterdijk’s radical attempt at a rethinking of the essence of the human as always already technological, which is the very project of anthropotechnics. This leads finally to a discussion of Sloterdijk’s polemical engagement with Heidegger’s question concerning technology, in which I trace out his attempt at a sweeping translation of Heidegger’s notion of enframing [Gestell] into enhousing [Gehäuse] and the consequences thereof. (shrink)

This paper shows that Bertrand's proposed 'solutions' to his own question, which generates his chord paradox, are inapplicable. It uses a simple analogy with cake cutting. The problem is that none of Bertrand's solutions considers all possible cuts. This is no solace for the defenders of the principle of indifference, however, because it emerges that the paradox is harder to solve than previously anticipated.

Some interpreters claim Kant distinguishes between organisms and living things. I argue that this claim is underdetermined by the textual evidence. Once this is recognized, it becomes a real possibility that Kant’s various remarks about the essential properties of living things generalize to organisms as such. This, in turn, generates a puzzle. Kant repeatedly claims that the capacity for representation is essential to the nature of a living thing. If he does not distinguish between living things and organisms, then how (...) might the capacity for representation be essential to the latter? Drawing on the writings of Kant and his contemporaries, I reconstruct a framework within which representational capacities might conceivably be thought to play this role. On this view, what distinguishes an organism from mechanically explicable products of nature is its capacity for endogenous behavior that is instinctual and representationally mediated. (shrink)

This article shows that Popper’s measure of corroboration is inapplicable if, as Popper argued, the logical probability of synthetic universal statements is zero relative to any evidence that we might possess. It goes on to show that Popper’s definition of degree of testability, in terms of degree of logical content, suffers from a similar problem. 1 The Corroboration Function and P(h|b) 2 Degrees of Testability and P(h|b).

D. Alan Shewmon has advanced a well-documented challenge to the widely accepted total brain death criterion for death of the human being. We show that Shewmon's argument against this criterion is unsound, though he does refute the standard argument for that criterion. We advance a distinct argument for the total brain death criterion and answer likely objections. Since human beings are rational animals – sentient organisms of a specific type – the loss of the radical capacity for sentience involves a (...) substantial change, the passing away of the human organism. In human beings total brain death involves the complete loss of the radical capacity for sentience, and so in human beings total brain death is death. (shrink)

Innovative therapy is the name we give to novel medical interventions, radically different from the standard of care, provided in order to benefit a patient, rather than to acquire new knowledge. They are paradigmshifting, not incremental, responses to serious patient problems that standard medical care inadequately addresses. Innovative therapies are often devised by clinicians, not basic science researchers; they do not follow the linear model of basic research, to translation, to clinical research, to application. Instead, they come from thinking backwards (...) from the patient’s circumstances, and forward from deep knowledge of how the body functions, to challenge the limits of current mechanisms for effecting cures. (shrink)

Many people have the intuition that the failure to impose punishment on perpetrators of such serious human rights violations as murder, torture and rape that occurred in the course of violent conflict preceding a society’s transition from authoritarianism to democracy amounts to an injustice. This intuition is to an appreciable extent accounted for by the retributivist outlook of a high proportion of those who share it. Colleen Murphy, however, though she accepts that retributivism may justify punishment of offenders in stable (...) democracies, claims in her recent book on transitional justice that retributivism is inapplicable in the circumstances of transitional justice. I argue that the four arguments she provides in support of this claim are unsuccessful and that retributivism, assuming it to be a tenable rationale for punishment, justifies the subjection of perpetrators of at least some serious human rights abuses to sanctions in at least some transitional societies. (shrink)

Some claim Kant’s commitment to the explanatory priority of judgments over concepts is one of his most important contributions to the philosophy of mind. There is, however, extensive disagreement over the nature and extent of this commitment. Existing interpretations ignore a substantial body of textual evidence and offer no account of the origins of Kant’s view. This paper corrects for these deficiencies. I explain, first, the relevant accounts of concept possession Kant encountered in the writings of his predecessors; and, second, (...) how within this context he first expressed a commitment to the view that conceptual content is explanatorily dependent on acts of judgment. I then argue that Kant endorsed a second form of discursive primacy, namely, the view that every use of a concept in conscious thought about an object has the form of a judgment. (shrink)

Griinbaum's own article sets forth his views on the ontology of the curvature of empty space, especially in the geometrodynamics of Clifford and Wheeler. ...

Veltman’s test semantics and developments thereof reject the canon about semantic contents and attitude ascriptions in favor of dynamic alternatives. According to these theories the semantic content of a sentence is not a proposition, but a context change potential (CCP). Similarly, beliefs are not taken to be relations between agents and propositions, but agents and CCPs. These deviations from the canon come at the cost of an elegant explanation about the correctness of belief. Standardly, it is taken that the content (...) of a belief is correct just in case the content of that belief is true. The proponent of the test semantics cannot appeal to this explanation since they hold that certain contents, namely epistemically modalized contents, do not express propositions, and are neither true nor false. After motivating the need for an account of the correctness of belief within the dynamic framework, I argue that the few extant accounts in the literature are unsatisfactory. A novel account is proposed that avoids the problems of competing views. (shrink)

We characterize Weihrauch reducibility in $ \operatorname {\mathrm {E-PA^{\omega }}} + \operatorname {\mathrm {QF-AC^{0,0}}}$ and all systems containing it by the provability in a linear variant of the same calculus using modifications of Gödel’s Dialectica interpretation that incorporate ideas from linear logic, nonstandard arithmetic, higher-order computability, and phase semantics.

One contested moral commitment shared by the American Medical Association and American Nurses Association has to do with the place of conscience in the practice of medicine. These organizations, each in their own way, urge their respective members to engage in careful moral discernment regarding their professional life, and they assert the existence of an obligation on the part of others to respect the conscientious objections of healthcare professionals and to accommodate objecting individuals. Yet despite the value that these organizations (...) place on conscience and objector rights, these organizations do not offer elaborate philosophical defenses of their positions. This shortcoming is exposed by the light of contemporary philosophical challenges to conscience-friendly policies. What such challenges demand is a philosophical defense of these organizations’ moral commitments and corresponding policy recommendations. The point of this article is to indicate how the Catholic philosophical tradition’s account of the nature and importance of conscience can philosophically underwrite these organizations’ conscience-related principles and practices. It can be seen, then, that the Catholic tradition is far from inimical to the contemporary practice of medicine and that, on the contrary, this tradition offers philosophically serious grounds on which to rest some of the most morally significant values and guidelines endorsed by these contemporary health-professional organizations and their members. (shrink)

I defend the position argued previously by Germain Grisez and me that total brain death is a valid criterion of death on the grounds that a human being is essentially a rational animal, and a brain-dead body lacks the radical capacity for rational actions. I reply to Josef Seifert’s objection that our positions rest on a reductionist view of the human person, and to other objections concerning the inter-relation between the human soul, its powers, and functions of the brain. I (...) argue that a brain-dead body lacks the material dispositions needed for having the form or soul of a human being. (shrink)

I assess the justification for the granting of amnesty in the circumstances of ‘transitional justice’ advanced by certain of its supporters according to which this device is morally legitimate because it amounts to an act of mercy. I consider several prominent definitions of ‘mercy’ with a view to determining whether amnesty counts as mercy under each and what follows for its moral status. I argue that amnesty cannot count as mercy under any definition in accordance with which an act or (...) practice’s amounting to mercy lends it justificatory support, while its qualifying as mercy under certain morally neutral definitions provides no basis for considering it justified. (shrink)

In his Discourses, Rousseau argues that inequalities of rank, wealth, and power are the inevitable result of the civilizing process. If inequality is intolerable - and Rousseau shows with unparalleled eloquence how it robs us not only of our material but also of our psychological independence - then how can we recover the peaceful self-sufficiency of life in the state of nature? We cannot return to a simpler time, but measuring the costs of progress may help us to imagine alternatives (...) to the corruption and oppressive conformity of modern society. Rousseau's sweeping account of humanity's social and political development epitomizes the innovative boldness of the Enlightenment, and it is one of the most provocative and influential works of the eighteenth century. This new translation includes all Rousseau's own notes, and Patrick Coleman's Introduction builds on recent key scholarship, considering particularly the relationship between political and aesthetic thought. (shrink)

BackgroundThere is increasing need for peer reviewers as the scientific literature grows. Formal education in biostatistics and research methodology during residency training is lacking. In this pilot study, we addressed these issues by evaluating a novel method of teaching residents about biostatistics and research methodology using peer review of standardized manuscripts. We hypothesized that mentored peer review would improve resident knowledge and perception of these concepts more than non-mentored peer review, while improving review quality.MethodsA partially blinded, randomized, controlled multi-center study (...) was performed. Seventy-eight neurology residents from nine US neurology programs were randomized to receive mentoring from a local faculty member or not. Within a year, residents reviewed a baseline manuscript and four subsequent manuscripts, all with introduced errors designed to teach fundamental review concepts. In the mentored group, mentors discussed completed reviews with residents. Primary outcome measure was change in knowledge score between pre- and post-tests, measuring epidemiology and biostatistics knowledge. Secondary outcome measures included level of confidence in the use and interpretation of statistical concepts before and after intervention, and RQI score for baseline and final manuscripts.ResultsSixty-four residents (82%) completed initial review with gradual decline in completion on subsequent reviews. Change in primary outcome, the difference between pre- and post-test knowledge scores, did not differ between mentored (−8.5%) and non-mentored (−13.9%) residents (p = 0.48). Significant differences in secondary outcomes (using 5-point Likert scale, 5 = strongly agree) included mentored residents reporting enhanced understanding of research methodology (3.69 vs 2.61; p = 0.001), understanding of manuscripts (3.73 vs 2.87; p = 0.006), and application of study results to clinical practice (3.65 vs 2.78; p = 0.005) compared to non-mentored residents. There was no difference between groups in level of interest in peer review (3.00 vs 3.09; p = 0.72) or the quality of manuscript review assessed by the Review Quality Instrument (RQI) (3.25 vs 3.06; p = 0.50).ConclusionsWe used mentored peer review of standardized manuscripts to teach biostatistics and research methodology and introduce the peer review process to residents. Though knowledge level did not change, mentored residents had enhanced perception in their abilities to understand research methodology and manuscripts and apply study results to clinical practice. (shrink)