Nanomedicine is yielding new and improved treatments and diagnostics for a range of diseases and disorders. Nanomedicine applications incorporate materials and components with nanoscale dimensions where novel physiochemical properties emerge as a result of size-dependent phenomena and high surface-to-mass ratio. Nanotherapeutics and in vivo nanodiagnostics are a subset of nanomedicine products that enter the human body. These include drugs, biological products, implantable medical devices, and combination products that are designed to function in the body in ways unachievable at larger scales. (...) Nanotherapeutics andin vivonanodiagnostics incorporate materials that are engineered at the nanoscale to express novel properties that are medicinally useful. These nanomedicine applications can also contain nanomaterials that are biologically active, producing interactions that depend on biological triggers. Examples include nanoscale formulations of insoluble drugs to improve bioavailability and pharmacokinetics, drugs encapsulated in hollow nanoparticles with the ability to target and cross cellular and tissue membranes and to release their payload at a specific time or location, imaging agents that demonstrate novel optical properties to aid in locating micrometastases, and antimicrobial and drug-eluting components or coatings of implantable medical devices such as stents. (shrink)

A far-reaching and influential view in evolutionary biology claims that species are cohesive units held together by gene flow. Biologists have recognized empirical problems facing this view; after sharpening the expression of the view, we present novel conceptual problems for it. At the heart of these problems is a distinction between two importantly different concepts of cohesion, what we call integrative and response cohesion. Acknowledging the distinction problematizes both the explanandum of species cohesion and the explanans of gene flow that (...) are central to the view we discuss. We conclude by tracing four broader implications for the study and conceptualization of species. (shrink)

Abstract:The purpose of this paper is to suggest that at least one strain of what has come to be called “stakeholder theory” has roots that are deeply libertarian. We begin by explicating both “stakeholder theory” and “libertarian arguments.” We show how there are libertarian arguments for both instrumental and normative stakeholder theory, and we construct a version of capitalism, called “stakeholder capitalism,” that builds on these libertarian ideas. We argue throughout that strong notions of “freedom” and “voluntary action” are the (...) best possible underpinnings for stakeholder theory, and in doing so, seek to return “stakeholder theory” to its managerial and libertarian roots found in Freeman (1984). (shrink)

Growing interest in workplace spirituality has led to the development of a new paradigm in organizational science. Theoretical assumptions abound as to how workplace spirituality might enhance organizational performance, most postulating a significant positive impact. Here, that body of research has been reviewed and analyzed, and a resultant values framework for workplace spirituality is introduced, providing the groundwork for empirical testing. A discussion of the factors and assumptions involved for future research are outlined.

Extended Essay Review of the 26 chapters in the collection Global Epistemologies and Philosophies of Science, Routledge, 2021.

Although its roots can be traced to the 19th century, progress in the study of nonlinear dynamical systems has taken off in the last 30 years. While pertinent source material exists, it is strewn about the literature in mathematics, physics, biology, economics, and psychology at varying levels of accessibility. A compendium research methods reflecting the expertise of major contributors to NDS psychology, Nonlinear Dynamical Systems Analysis for the Behavioral Sciences Using Real Data examines the techniques proven to be the most (...) useful in the behavioral sciences. The editors have brought together constructive work on new practical examples of methods and application built on nonlinear dynamics. They cover dynamics such as attractors, bifurcations, chaos, fractals, catastrophes, self-organization, and related issues in time series analysis, stationarity, modeling and hypothesis testing, probability, and experimental design. The analytic techniques discussed include several variants of the fractal dimension, several types of entropy, phase-space and state-space diagrams, recurrence analysis, spatial fractal analysis, oscillation functions, polynomial and Marquardt nonlinear regression, Markov chains, and symbolic dynamics. The book outlines the analytic requirements faced by social scientists and how they differ from those of mathematicians and natural scientists. It includes chapters centered on theory and procedural explanations for running the analyses with pertinent examples and others that illustrate applications where a particular form of analysis is seen in the context of a research problem. This combination of approaches conveys theoretical and practical knowledge that helps you develop skill and expertise in framing hypotheses dynamically and building viable analytic models to test them. (shrink)

The literature on organizational ethicality to date has focused primarily on elements of the cultural, social, and political factors that enhance positive behaviors, interspersed with isolated accounts of malfeasance and wrongdoing. This treatise defines the anatomy of organizational dysfunction as a matter of ethicality, reframing the relationship from individual transgression to the organization itself. It is argued that the structure of an organization predisposes in large part whether it is itself conducive or prohibitive to unethical acts. Our approach allows for (...) a new stream of ethics research whose focus is how an organization functions rather than on the specific acts of those within it. (shrink)

Perceptual symbol systems form a theoretically plausible alternative to amodal symbol systems. At this point it is unclear whether there is any truly diagnostic empirical evidence to decide between these systems. We outline some possible avenues of research in the domain of language comprehension that might yield such evidence. Language comprehension will be an important arena for tests of the two types of symbol systems.

We report the results of an experiment in which human subjects were trained to perform a perceptual matching task. Subjects were asked to manipulate comparison objects until they matched target objects using the fewest manipulations possible. An unusual feature of the experimental task is that efficient performance requires an understanding of the hidden or latent causal structure governing the relationships between actions and perceptual outcomes. We use two benchmarks to evaluate the quality of subjects’ learning. One benchmark is based on (...) optimal performance as calculated by a dynamic programming procedure. The other is based on an adaptive computational agent that uses a reinforcement-learning method known as Q-learning to learn to perform the task. Our analyses suggest that subjects were successful learners. In particular, they learned to perform the perceptual matching task in a near-optimal manner (i.e., using a small number of manipulations) at the end of training. Subjects were able to achieve near-optimal performance because they learned, at least partially, the causal structure underlying the task. In addition, subjects’ performances were broadly consistent with those of model-based reinforcement-learning agents that built and used internal models of how their actions influenced the external environment. We hypothesize that people will achieve near-optimal performances on tasks requiring sequences of action—especially sensorimotor tasks with underlying latent causal structures—when they can detect the effects of their actions on the environment, and when they can represent and reason about these effects using an internal mental model. (shrink)

Ethical decision-making in public health rarely involves simply avoiding a bad choice in favor of a good choice. Instead, it requires policymakers to strike a balance among conflicting goals that are all good—goals such as the health of populations and individuals, knowledge gained through scientific research, autonomy, social justice, and the efficient use of limited resources. This balance can be elusive, and perfect examples are the legal instruments governing dual-use research, a term describing scientific endeavors meant to produce beneficial knowledge (...) or technology, but that could also be misapplied. Dual-use research of concern policies were implemented... (shrink)

Individuals are a prominent part of the biological world. Although biologists and philosophers of biology draw freely on the concept of an individual in articulating both widely accepted and more controversial claims, there has been little explicit work devoted to the biological notion of an individual itself. How should we think about biological individuals? What are the roles that biological individuals play in processes such as natural selection (are genes and groups also units of selection?), speciation (are species individuals?), and (...) organismic development (do genomes code for organisms)? Much of our discussion here will focus on organisms as a central kind of biological individual, and that discussion will raise broader questions about the nature of the biological world, for example, about its complexity, its organization, and its relation to human thought. (shrink)

Empirical research pertaining to cardiopulmonary resuscitation (CPR), clinician behaviors related to do-not-resuscitate (DNR) orders and substituted judgment suggests potential contributions to medical ethics. Research quantifying the likelihood of surviving CPR points to the need for further philosophical analysis of the limitations of the patient autonomy in decision making, the nature and definition of medical futility, and the relationship between futility and professional standards. Research on DNR orders has identified barriers to the goal of patient involvement in these life and death (...) discussions. The initial data on surrogate decision making also points to the need for a reexamination of the moral basis for substituted judgment, the moral authority of proxy decision making and the second-order status of the best interests standard. These examples of empirical research suggest that an interplay between empirical research, ethical analysis and policy development may represent a new form of interdisciplinary scholarship to improve clinical medicine. (shrink)

Where do our moral beliefs come from? Theologians and scientists provide often conflicting answers. Robert Hinde resolves these conflicts to offer a groundbreaking, multidisciplinary response, drawing on psychology, philosophy, evolutionary biology and social anthropology. Hinde argues that understanding the origins of our morality can clarify the debates surrounding contemporary ethical dilemmas such as genetic modification, increasing consumerism and globalisation. Well-chosen examples and helpful summaries make this an accessible volume for students, professionals and others interested in contemporary and historical ethics.

The Quest for Community, published in 1953, stands as one of the most persuasive accounts of the dilemmas confronting modern Society. --.

The collusive relationship between the U.S. Forest Service and the lumber industry substantially harms the public interest, and inspires Congressional clearcutting and stumping policies. An anthropocentric1 (or homocentric) culture milieu fosters destruction of America''s old growth forests which results in ethically-relevant questions. It is proposed that corporate moral responsibility be extended to indirect stakeholders and that a transcendent environmental ethic, biocentrism2 (or deep ecology), oblige management to expand the sphere of external stakeholders to include environment objects such as animals, trees, (...) and biotic communities. (shrink)

The Legitimacy of Miracle defends the view that miracles, in the strong sense of being events produced by a supernatural agent overriding the usual course of nature, can take place without violating any laws of nature. This means that the evidence for miracles cannot be judged to be in conflict with the evidence for the laws of nature; the result being that Humean objections to the rationality of belief in miracles fail.

Annotated bibliography of works on externalism and internalism in the philosophy of mind.

J'entreprends de défendre la conception leibnizienne de la liberté de la volonté selon laquelle on peut être libre sans que l'on n'ait le pouvoir causal de choisir autrement que l'on ne fait. La liberté d'indifférence en revanche est irrecevable et sort d'une analyse erronée de ce que c'est un pouvoir de décider hic et nunc. Un tel pouvoir est indiscernable d'avec la décision même. Par conséquent un recours à la liberté d'indifférence préconisé entre autres par Duns Scotus est à la (...) fois superflu et aporétique. (shrink)

An anthology of the life and teachings of Tsongkhapa that includes transcendental aspects of sutra, tantra, insight meditation, mystic conversations, spiritual songs, and a new introduction by Robert Thurman.

This is a bilingual edition of the selected peer-reviewed papers that were submitted for the International Symposium on Jesuit Studies on the thought of the Jesuit Francisco Suárez (1548-1617). The symposium was co-organized in Seville in 2018 by the Departamento de Humanidades y Filosofía at Universidad Loyola Andalucía and the Institute for Advanced Jesuit Studies at Boston College. Suárez was a theologian, philosopher and jurist who had a significant cultural impact on the development of modernity. Commemorating the four-hundredth anniversary of (...) his death, the symposium studied the work of Suárez and other Jesuits of his time in the context of diverse traditions that came together in Europe between the late Middle Ages, the Renaissance, and early modernity. (shrink)