Light effects on the activity of several genes have recently been exploited in studies of plant gene expression. We discuss here some examples involving nuclear genes of higher plants, with emphasis on responses mediated by the phytochrome system. Recent work has revealed considerable diversity in the responses of different genes, indicating that several different regulatory programs are probably involved. A start has been made in studies of nuclear events associated with the changes in expression. Transcriptional regulation almost certainly occurs, although (...) many details remain to be studied and effects on mRNA processing and turnover have not been ruled out. Recent in vitro mutagenesis and gene transfer experiments with the gene for the small subunit of RuBP carboxylase indicate that sequences involved in regulating the level of expression in the light are located 5′ to the gene within about 1 kb of the start of transcription. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in (...) the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Biological evolution provides a creative fount of complex and subtle adaptations, often surprising the scientists who discover them. However, because evolution is an algorithmic process that transcends the substrate in which it occurs, evolution’s creativity is not limited to nature. Indeed, many researchers in the field of digital evolution have observed their evolving algorithms and organisms subverting their intentions, exposing unrecognized bugs in their code, producing unexpected adaptations, or exhibiting outcomes uncannily convergent with ones in nature. Such stories routinely reveal (...) creativity by evolution in these digital worlds, but they rarely fit into the standard scientific narrative. Instead they are often treated as mere obstacles to be overcome, rather than results that warrant study in their own right. The stories themselves are traded among researchers through oral tradition, but that mode of information transmission is inefficient and prone to error and outright loss. Moreover, the fact that these stories tend to be shared only among practitioners means that many natural scientists do not realize how interesting and lifelike digital organisms are and how natural their evolution can be. To our knowledge, no collection of such anecdotes has been published before. This paper is the crowd-sourced product of researchers in the fields of artificial life and evolutionary computation who have provided first-hand accounts of such cases. It thus serves as a written, fact-checked collection of scientifically important and even entertaining stories. In doing so we also present here substantial evidence that the existence and importance of evolutionary surprises extends beyond the natural world, and may indeed be a universal property of all complex evolving systems. (shrink)

The volume documents, and makes an original contribution to, an astonishing period in twentieth-century philosophy—the progress of Arne Naess's ecophilosophy from its inception to the present. It includes Naess's most crucial polemics with leading thinkers, drawn from sources as diverse as scholarly articles, correspondence, TV interviews and unpublished exchanges. The book testifies to the skeptical and self-correcting aspects of Naess's vision, which has deepened and broadened to include third world and feminist perspectives. Philosophical Dialogues is an essential addition to the (...) literature on environmental philosophy. (shrink)

This book is a collection of secondary essays on America's most important philosophic thinkers—statesmen, judges, writers, educators, and activists—from the colonial period to the present. Each essay is a comprehensive introduction to the thought of a noted American on the fundamental meaning of the American regime.

A critique of several recent objections to John Searle's Chinese-Room Argument against the possibility of "strong AI" is presented. The objections are found to miss the point, and a stronger argument against Searle is presented, based on a distinction between "syntactic" and "semantic" understanding.

Originally published in 1991, this book focuses on the concept of virtue, and in particular on the virtue of wisdom or knowledge, as it is found in the epic poems of Homer, some tragedies of Sophocles, selected writings of Plato, Aristotle, and the Stoic and Epicurean philosophers. The key questions discussed are the nature of the virtues, their relation to each other, and the relation between the virtues and happiness or well-being. This book provides the background and interpretative framework to (...) make classical works on Ethics, such as Plato’s _Republic_ and Aristotle’s _Nicomachean Ethics_, accessible to readers with no training in the classics. (shrink)

The distinction between harm that is intended as a means or end, and harm that is merely a foreseen side-effect of one’s action, is widely cited as a significant factor in a variety of ethical contexts. Many use it, for example, to distinguish terrorist acts from certain acts of war that may have similar results as side-effects. Yet Bennett and others have argued that its application is so arbitrary that if it can be used to cast certain harmful actions in (...) a more favorable light, then it can equally be manipulated to do the same for any kind of harmful action. In response, some have tried to block such extensions of the intend/foresee distinction by rejecting its application in cases where the relation between the plainly intended means and the harm is “too close”. This move, however, has been attacked as vague and obscure, and Bennett has argued that all the plausible candidates for explicating the idea of excessive closeness ultimately fail. In this paper, I develop and defend an account of excessive closeness with the aim of rescuing the intend/foresee distinction from such charges of arbitrariness. The account is based on the distinction between merely causal and constitutive relations among states of affairs, and I show both how it escapes Bennett’s objections to other accounts and how it applies to a variety of cases. Finally, I also examine Quinn’s alternative move of shifting the focus of the intend/foresee distinction in an attempt to sidestep the issue of closeness, and argue that it is not ultimately successful. In fact, Quinn’s view has shortcomings that can be resolved only by returning to an appeal to some notion of closeness, underscoring the need for the sort of account I offer. (shrink)

There is perhaps no more widely shared conviction in contemporary metaethics, even among those who hold otherwise divergent views, than that practical normativity must be capable of being naturalized (i.e., captured fully within a metaphysically naturalist worldview). My aim is to illuminate the central reasons for skepticism about this. While certain naturalizing projects are plausible for very limited purposes, it is unlikely that any can provide everything we might reasonably want from an account of goodness and badness, rightness and wrongness, (...) and unqualified reasons for acting—at least if we are unwilling to accept certain deflationary or bullet-biting moves. Some naturalizing views can be shown to fail outright to capture the relevant normative facts or properties, while others have more promise but can also be seen to have certain limitations and costs, failing to capture elements that some of us take to be important to an adequate theory of practical normativity. There are, of course, far more naturalizing moves than can be considered here, so the aim is not to establish the truth of nonnaturalism through a process of elimination. But I hope to say enough to bring out the central worries about naturalizing projects and to pose some challenges that apply more widely, with the aim of showing that ethical nonnaturalism remains an attractive and well-motivated option at least for those of us who reject both nihilism and various forms of ethical deflation. (shrink)

We develop and apply a multi-dimensional account of explanatory depth towards a comparative analysis of inflationary and bouncing paradigms in primordial cosmology. Our analysis builds on earlier work due to Azhar and Loeb (2021) that establishes initial conditions fine-tuning as a dimension of explanatory depth relevant to debates in contemporary cosmology. We propose dynamical fine-tuning and autonomy as two further dimensions of depth in the context of problems with instability and trans-Planckian modes that afflict bouncing and inflationary approaches respectively. In (...) the context of the latter issue, we argue that the recently formulated trans-Planckian censorship conjecture leads to a trade-off for inflationary models between dynamical fine-tuning and autonomy. We conclude with the suggestion that explanatory preference with regard to the different dimensions of depth is best understood in terms of differing attitudes towards heuristics for future model building. (shrink)

The past forty years or so have witnessed a renaissance in the philosophy of religion. New tools (modal logic, probability theory, and so on) and new historical research have prompted many thinkers to take a fresh look at old topics (God’s existence, the problem of evil, faith and reason, and the like). Moreover, sophisticated examinations of contentious new issues, such as the problem of religious diversity or the role of emotions and other non-evidential factors in shaping rationally held religious beliefs, (...) have also emerged. Addressing the need for an authoritative reference work to make sense of this rapidly growing and ever more complex corpus of scholarly literature, Philosophy of Religion is a new title in the Routledge Major Works series, Critical Concepts in Philosophy. Edited by a leading scholar, it is a four-volume collection which brings together key examples of the most important recent work, together with carefully selected historical pieces needed to understand them. Volume I focuses on concepts of the divine while Volume II explores arguments for and against the existence of a divine reality, with special attention to the problem of evil, the problem of divine hiddenness, and the case for naturalism. Volume III and the first part of Volume IV are devoted to broadly epistemic issues: the cognitive value of religious experience; the proper role of evidence in the formation of religious belief; the nature of justified religious belief; and pragmatic arguments for religious belief. The remainder of Volume IV introduces some of the best recent work on religious diversity, tolerance, and the public role of religion in a pluralistic society. The Philosophy of Religion is fully indexed and has a comprehensive introduction, newly written by the editor, which places the material in its historical and intellectual context. It is an essential work of reference and is destined to be valued by scholars and students as a vital one-stop research resource. Available now at a special introductory price. This price is applicable until 3 months after publication. For more information, please contact us ( [email protected] ). (shrink)

This paper describes the SNePS knowledge-representation and reasoning system. SNePS is an intensional, propositional, semantic-network processing system used for research in AI. We look at how predication is represented in such a system when it is used for cognitive modeling and natural-language understanding and generation. In particular, we discuss issues in the representation of fictional entities and the representation of propositions from fiction, using SNePS. We briefly survey four philosophical ontological theories of fiction and sketch an epistemological theory of fiction (...) using a story operator and rules for allowing propositions to migrate into and out of story spaces. (shrink)

I begin by distinguishing two general approaches to metaethics and ontology. One in effect puts our experience as engaged ethical agents on hold while independent metaphysical and epistemological inquiries, operating by their own lights, deliver metaethical verdicts on acceptable interpretations of our ethical lives; the other instead keeps engaged ethical experience in focus and allows our reflective interpretation of it to shape our metaphysical and epistemological views, including our ontology. While the former approach often leads to deflationary views, the latter (...) may lead us to enrich our metaethical picture as needed to capture robust objectivity and categorical normative authority for ethics. Assuming, as I have argued elsewhere, that this requires positing irreducibly evaluative or normative properties and facts, the question I take up here is what ontological implications this has. I argue against quietist non-naturalist views, which maintain that positing such properties and facts either has no ontological implications or has only domain-specific ontological implications that likewise imply nothing about what the world contains. Against these views, I advocate a worldly, dual-aspect view, locating irreducibly evaluative or normative properties as features of relevant worldly things. But while I have previously defended this view as a form of non-naturalism, I here explore the possibility of instead seeing it as a new, more expansive form of naturalism—what might be called “Non-Scientistic Naturalism”—inspired by parallel attempts in the philosophy of mind to accommodate irreducibly phenomenal properties within a more expansive physicalism. (shrink)

Introduction: characterizing ethical realismIt is useful to begin a survey of recent work on ethical realism with a look at current disputes over what makes a theory of ethics count as ‘realist’ in the first place. Nearly all characterizations of ethical realism include some version of the following two core claims: Ethical discourse is assertoric and descriptive: ethical claims purport to state ethical facts by attributing ethical properties to people, actions, institutions, etc., and are thus true or false depending on (...) whether their descriptions of things are accurate or not . 1 At least some ethical claims, when literally construed, are true in the above sense.Sayre-McCord maintains that these two conditions are necessary and sufficient to characterize ethical realism; others argue that further conditions must be added to yield ethical realism, or at least ‘paradigmatic’ or ‘robust’ ethical realism. Before turning to that, however, it is worth noting that some have recently denied that the above two conditions are even necessary for ethical realism. In probing new work on metaethical taxonomy, Miller argues that the core of ethical realism is simply the metaphysical commitment to objective ethical properties and facts, which is strictly independent of the semantic claims above. If one holds that there are objective facts about the wrongness of slavery, for example, then one ought to count as an ethical realist regardless of whatever views one might hold about the semantics of the contingent forms of discourse that have evolved among language users. Even if our ethical discourse turns out primarily to express conative states ), or all moral claims turn out to be false because …. (shrink)

This four volume set is a collection of some of the most significant scholarship published on the philosophy of Socrates in the last half century. The contributors include many of the most prominent scholars in this field. As the growth in Socratic studies in the past three decades is due in large part to the influential work of Gregory Vlastos, articles by him figure prominently in the collection, and works by other authors are generally related to his work. The volumes (...) deal with different areas of Socratic thought. The first volume begins with the question whether and to what degree we can discern a distinctive philosophy of Socrates in the ancient sources. The second volume deals with the trial of Socrates and the philosophical issues that arise from it. The third volume considers the philosophical methodology of Socrates and the fourth his moral philosophy. This collection shares some material with earlier collections on the philosophy of Socrates, but it is more extensive and up-to-date. Unlike other collections, which may offer the reader only a single article on a given topic, this collection offers a conversation in-depth. The reader can thus get a sense of the dimensions of the scholarly debate on these central issues in the philosophy of Socrates. No collection can be complete, but this aims at a representative portrait of Socratic studies in the last fifty years. (shrink)

In this article I argue (against the views of Russell Dancy and Gregory Vlastos, but in support of the views of R. E. Allen, Gail Fine, and Francesco Fronterotta) that Euthyphro 5c-d and 6d-e show that Socrates had a metaphysics, early version of the theory of forms. I disagree with Fronterotta only on the separation of the forms in the Euthyphro.

In this essay I argue that sports at their best qualify as final ends, that is, as ends whose value is such that they ground not only the practices whose ends they are, but everything else we do as human agents. The argument I provide to support my thesis is derived from Harry Frankfurt's provocative work on the importance of the things we care about, more specifically, on his claim that it is by virtue of caring about things and practices, (...) really caring about them ? even loving them ? we are able to regard and treat them as final ends. Sports, I claim, are paradigmatic examples of practices cared about and loved in these deep ways, and as such deserve to be considered, rather than dismissed because of their supposed triviality, as one of those ends around which a life most worth living can be legitimately forged. (shrink)

Scholars often assume that when Plato said that Forms are paradeigmata he meant that they were exemplars of the property they represent. I argue that "paradeigma" is better read as "pattern" than "exemplar." This reading is compatible with Plato's use of the term in all passages except Parm. 132d, where Parmenides misinterprets the term to make the theory of Forms susceptible to the Third Man Argument.

A standard line in the contemporary philosophical literature has it that physical theories are equivalent only when they agree on their empirical content, where this empirical content is often understood as being encoded in the equations of motion of those theories. In this article, we question whether it is indeed the case that the empirical content of a theory is exhausted by its equations of motion, showing that (for example) considerations of boundary conditions play a key role in the empirical (...) equivalence (or otherwise) of theories. Having argued for this, we show that philosophical claims made by Weatherall (2016) that electromagnetism in the Faraday tensor formalism is equivalent to electromagnetism in the vector potential formalism, and by Knox (2011) that general relativity is equivalent to teleparallel gravity, can both be called into question. We then show that properly considering the role of boundary conditions in theory structure can potentially restore these claims of equivalence and close with some remarks on the pragmatics of adjudications on theory identity. (shrink)

I argue that it was not Plato's intention in his Socratic dialogues to provide a biography of Socrates. Rather, his intention was to describe and defend the philosophical life against its critics. The Socratic dialogues are "unhappy encounters" between Socrates, defender of the life of philosophy, and those who do not comprehend or who reject that life.

Recently, we have seen the emergence of the international laboratory in scientific research. These laboratories, characterized by internationally distributed members working to accomplish a unified goal, provide advantages such as cost savings and access to facilities and equipment. However, maintaining responsible conduct of research (RCR) in an international laboratory is complicated by the requirement for technology-mediated communication, lack of trust between local and distant group members, and cultural heterogeneity among lab members. Here we discuss issues we experienced while working in (...) a international laboratory as part of the Singapore-M.I.T. Alliance for Research and Technology, and from our experience, we propose guidelines to maintain RCR in an international laboratory. With proper oversight and cognizance of RCR, work in an international laboratory harbors great benefit for scientists and provides unique opportunity to exchange ideas, data, and insight with scientists of distinct cultural backgrounds. (shrink)