We report on the deliberations of an interdisciplinary group of experts in science, law, and philosophy who convened to discuss novel ethical and policy challenges in stem cell research. In this report we discuss the ethical and policy implications of safety concerns in the transition from basic laboratory research to clinical applications of cell-based therapies derived from stem cells. Although many features of this transition from lab to clinic are common to other therapies, three aspects of stem cell biology pose (...) unique challenges. First, tension regarding the use of human embryos may complicate the scientific development of safe and effective cell lines. Second, because human stem cells were not developed in the laboratory until 1998, few safety questions relating to human applications have been addressed in animal research. Third, preclinical and clinical testing of biologic agents, particularly those as inherently complex as mammalian cells, present formidable challenges, such as the need to develop suitable standardized assays and the difficulty of selecting appropriate patient populations for early phase trials. We recommend that scientists, policy makers, and the public discuss these issues responsibly, and further, that a national advisory committee to oversee human trials of cell therapies be established. **NB we did not reccommend a NAC, we think it might be appropriate**. (shrink)

If stem cell-based therapies are developed, we will likely confront a difficult problem of justice: for biological reasons alone, the new therapies might benefit only a limited range of patients. In fact, they might benefit primarily white Americans, thereby exacerbating long-standing differences in health and health care.

How is it that we think and refer in the first-person way? For most philosophers in the analytic tradition, the problem is essentially this: how two apparently conflicting kinds of properties can be reconciled and united as properties of the same entity. What is special about the first person has to be reconciled with what is ordinary about it. The range of responses reduces to four basic options. The orthodox view is optimistic: there really is a way of reconciling these (...) apparently contradictory properties as contained within the same thing. The heretical views are pessimistic and content to be so: there is no such way, and that is because there is simply nothing to reconcile – because there is really nothing special about what is in question; or there is really nothing ordinary about it; or there is really nothing …. (shrink)

Lucy O'Brien argues that a satisfactory account of first-person reference and self-knowledge needs to concentrate on our nature as agents. Clearly written, with rigorous discussion of rival views, this book will be of interest to anyone working in the philosophy of mind and action.

In this paper I want to propose that we see solipsism as arising from certain problems we have about identifying ourselves as subjects in an objective world. The discussion will centre on Wittgenstein.

Although connectionism is advocated by its proponents as an alternative to the classical computational theory of mind, doubts persist about its _computational_ credentials. Our aim is to dispel these doubts by explaining how connectionist networks compute. We first develop a generic account of computation—no easy task, because computation, like almost every other foundational concept in cognitive science, has resisted canonical definition. We opt for a characterisation that does justice to the explanatory role of computation in cognitive science. Next we examine (...) what might be regarded as the “conventional” account of connectionist computation. We show why this account is inadequate and hence fosters the suspicion that connectionist networks aren’t genuinely computational. Lastly, we turn to the principal task of the paper: the development of a more robust portrait of connectionist computation. The basis of this portrait is an explanation of the representational capacities of connection weights, supported by an analysis of the weight configurations of a series of simulated neural networks. (shrink)

My aim in this paper is to articulate further what may be called an agency theory of self-knowledge. Many theorists have stressed how important agency is to self- knowledge, and much work has been done drawing connections between the two notions.² However, it has not always been clear what _epistemic_ advantage agency gives us in this area and why it does so. I take it as a constraint on an adequate account of how a subject knows her own mental states (...) and acts, that it construe the known mental states and acts realistically and as independent of their self-ascription, and that it deliver genuine epistemic standing to the knower. The main task of the paper will, then, be to explore how our having rational agency with respect to our mental states may be able to secure genuine epistemic warrant for our self-ascriptions of states or acts independent of the ascriptions. This task will be carried out by focussing on the question of what account we should give of our knowledge of what I call our acts of judging. In the remainder of this section, I will do a little to clarify what is meant by that question. Section 2 will attempt to introduce us to elements of the best way to approach the question by considering some alternative strategies. Section 3 is devoted to forming some idea of what _kind_ of warrant we are looking for when considering how agency might give us self-knowledge. Section 4 aims to present a suggestion as to how agency gives us the kind of warrant identified over our acts of judging. Section 5 deals with some objections. (shrink)

The project of the paper is a critical examination of the "strong thesis of eliminative materialism" in the philosophy of mind--The claim that all the mental entities that constitute the framework of commonsense psychology are, In principle at least, Eliminable from our ontology. The central conclusion reached is that the traditional formulation of this thesis is demonstrably untenable as it rests on a mistaken view of the relationship between our psychological self-Knowledge and language.

This commentry focuses on the one major ecumenical theme propounded in Andy Clark's Being There that I find difficult to accept; this is Clark’s advocacy, especially in the third and final part of the book, of the extended nature of the embedded, embodied mind.

Reformers urge that representation no longer earns its explanatory keep in cognitive science, and that it is time to discard this troublesome concept. In contrast, we hold that without representation cognitive science is utterly bereft of tools for explaining natural intelligence. In order to defend the latter position, we focus on the explanatory role of representation in computation. We examine how the methods of digital and analog computation are used to model a relatively simple target system, and show that representation (...) plays an in-eliminable explanatory role in both cases. We conclude that, to the extent that biologic systems engage in computation, representation is destined to play an explanatory role in cognitive science. (shrink)

In their target article, Hutto and Satne eloquently articulate the failings of most current attempts to naturalize mental content. Furthermore, we think they are correct in their insistence that the only way forward is by drawing a distinction between two kinds of intentionality, one of which is considerably weaker than—and should be deployed to explain—the propositional variety most philosophers take for granted. The problem is that their own rendering of this weaker form of intentionality—contentless intentionality—is too weak. What’s needed is (...) a species of intentionality distinct from both the industrial-strength version beloved by philosophers and the intentionality lite recommended by Hutto and Satne. We briefly motivate and sketch this alternative, and say a few words about the account of cognition that it spawns. (shrink)

In Connectionism and the Philosophy of Psychology, Horgan and Tienson (1996) argue that cognitive processes, pace classicism, are not governed by exceptionless, “representation-level” rules; they are instead the work of defeasible cognitive tendencies subserved by the non-linear dynamics of the brain’s neural networks. Many theorists are sympathetic with the dynamical characterisation of connectionism and the general (re)conception of cognition that it affords. But in all the excitement surrounding the connectionist revolution in cognitive science, it has largely gone unnoticed that connectionism (...) adds to the traditional focus on computational processes, a new focus – one on the vehicles of mental representation, on the entities that carry content through the mind. Indeed, if Horgan and Tienson’s dynamical characterisation of connectionism is on the right track, then so intimate is the relationship between computational processes and representational vehicles, that connectionist cognitive science is committed to a resemblance theory of mental content. (shrink)

We think the best prospect for a naturalistic explanation of phenomenal consciousness is to be found at the confluence of two influential ideas about the mind. The first is the _computational _ _theory of mind_: the theory that treats human cognitive processes as disciplined operations over neurally realised representing vehicles.1 The second is the _representationalist theory of _ _consciousness_: the theory that takes the phenomenal character of conscious experiences (the “what-it-is-likeness”) to be constituted by their representational content.2 Together these two (...) theories suggest that phenomenal consciousness might be explicable in terms of the representational content of the neurally realised representing vehicles that are generated and manipulated in the course of cognition. The simplest and most elegant hypothesis that one might entertain in this regard is that conscious experiences are identical to (i.e., are one and the same as) the brain’s representing vehicles. (shrink)

The author proposes an analysis of boredom. The analysis he proposes is that boredom is an unpleasant mental state consisting of weariness, restlessness, and lack of interest, where certain causal relations exist among the components. He goes on to elaborate on and defend his analysis, concluding with some thoughts on the idea that boredom has some grand metaphysical significance.

In assessing what the paradoxes meant to Plato, O'Brien uses certain broad principles of inquiry. First, he insists, any platonic doctrine must be placed in the context of Plato's whole philosophy--a truism not always honored. Second, the conversations of the dialogue form do not merely embellish Plato's philosophical statements but radically affect their expression. Originally published in 1967. A UNC Press Enduring Edition -- UNC Press Enduring Editions use the latest in digital technology to make available again books from our (...) distinguished backlist that were previously out of print. These editions are published unaltered from the original, and are presented in affordable paperback formats, bringing readers both historical and cultural value. (shrink)

_An Introduction to the Theory of Knowledge_ guides the reader through the key issues and debates in contemporary epistemology. Lucid, comprehensive and accessible, it is an ideal textbook for students who are new to the subject and for university undergraduates. The book is divided into five parts. Part I discusses the concept of knowledge and distinguishes between different types of knowledge. Part II surveys the sources of knowledge, considering both _a priori_ and _a posteriori_ knowledge. Parts III and IV provide (...) an in-depth discussion of justification and scepticism. The final part of the book examines our alleged knowledge of the past, other minds, morality and God. O'Brien uses engaging examples throughout the book, taking many from literature and the cinema. He explains complex issues, such as those concerning the private language argument, non-conceptual content, and the new riddle of induction, in a clear and accessible way. This textbook is an invaluable guide to contemporary epistemology. (shrink)

I am working on a substantially revised second edition of this. It is due to be published by Palgrave in 2024.

My concern is this paper is to consider the nature of obsessive thoughts with the aim of getting a clearer idea about the extent to which they are rightly identified as passive or as active. The nature of obsessive thoughts is of independent interest, but my concern with the question is also rooted in a general concern to map the extent of mental activity, and to defend the importance and centrality of a view of self-knowledge that appeals to agency. I (...) hold that much of our mental lives is active, and that the distinctive knowledge we have of our own minds is in many cases best explained by appealing to agency. Along with many others, I take knowledge of our actions and activities to be distinctive. We know our actions and activities in a way that we do not know anything else, and in a way that is distinctively and essentially self-conscious. (shrink)

Spirituality in Nursing: Standing On Holy Ground, Sixth Edition explores the relationship between spirituality and the practice of nursing.

It is an extraordinary thing that Descartes' famous Cogito argument is still being puzzled over; this paper is another fragment in an untiring tradition of puzzlement. The paper will argue that, if I were to ask the question the Cogito could provide for a positive answer. In particular, my aim in this is to argue, in opposition to recent discussion by John Campbell, that there is a way of construing conscious thinking on which the Cogito can be seen to provide (...) a non-question begging argument for one's own existence. (shrink)

Any creature that must move around in its environment to find nutrients and mates, in order to survive and reproduce, faces the problem of sensorimotor control. A solution to this problem requires an on-board control mechanism that can shape the creature’s behaviour so as to render it “appropriate” to the conditions that obtain. There are at least three ways in which such a control mechanism can work, and Nature has exploited them all. The first and most basic way is for (...) a creature to bump into the things in its environment, and then, depending on what has been encountered, seek to modify its behaviour accordingly. Such an approach is risky, however, since some things in the environment are distinctly unfriendly. A second and better way, therefore, is for a creature to exploit ambient forms of energy that carry information about the distal structure of the environment. This is an improvement on the first method since it enables the creature to respond to the surroundings without actually bumping into anything. Nonetheless, this second method also has its limitations, one of which is that the information conveyed by such ambient energy is often impoverished, ambiguous and intermittent. (shrink)

Doctors have an ethical and legal duty to respect patient confidentiality. We consider the basis for this duty, looking particularly at the meaning and value of autonomy in health care. Enabling patients to decide how information about them is disclosed is an important element in autonomy and helps patients engage as active partners in their care.Good quality data is, however, essential for research, education, public health monitoring, and for many other activities essential to provision of health care. We discuss whether (...) it is necessary to choose between individual rights and the wider public interest and conclude that this should only rarely be necessary. The paper makes some recommendations on practical steps which could help ensure that good quality information is available for work which benefits society and the public health, while still enabling patients’ autonomy to be respected. (shrink)

In this paper we defend a position we call radical connectionism. Radical connectionism claims that cognition _never_ implicates an internal symbolic medium, not even when natural language plays a part in our thought processes. On the face of it, such a position renders the human capacity for abstract thought quite mysterious. However, we argue that connectionism is committed to an analog conception of neural computation, and that representation of the abstract is no more problematic for a system of analog vehicles (...) than for a symbol system. Natural language is therefore not required as a representational medium for abstract thought. Since natural language is arguably not a representational medium _at all_, but a conventionally governed scheme of communicative signals, we suggest that the role of internalised (i.e., self- directed) language is best conceived in terms of the coordination and control of cognitive activities within the brain. (shrink)

Drawing on the problem of deviance, I present a novel line of argumentation against causal theories of action. The causalist faces a dilemma: either she adopts a simple account of the causal route between intention and outcome, at the cost of failing to rule out deviance cases, or she adopts a more sophisticated account, at the cost of ruling out cases of intentional action in which the causal route is merely unusual. Underlying this dilemma, I argue, is that the agent's (...) perspective plays an ineliminable role in determining which causal pathways are deviant and which are not. (shrink)

O'Brien provides a critical assessment of Ernest Mandel's 1975 monograph Late Capitalism. In so doing, he offers a historical narrative that puts into question Mandel's framing of 'waves' of capitalist development as a process of capital accumulation that was dependent upon uneven development in the Third World. O'Brien starts by problematising Mandel's argument that an initial concentration of money, capital and bullion in the hands of Europeans explains combined and uneven development. He goes on to demonstrate that Mandel's notion of (...) imperialism as a necessary conduit for the flow of surplus capital from industrialising Europe does not stand up to the historical evidence. In fact, O'Brien maintains an alternative thesis, namely that these marginalised regions were insuffciently penetrated by European capital. (shrink)

Proponents of ecological restoration view the practice as a means of both repairing damage done to ecosystems by humans and creating an avenue to re-establish respectful and cooperative human-environment relationships. One debate affecting ecological restoration focuses on the place of 'exotic' species in restored ecosystems. Though popular, campaigns against exotics have been criticized for their troubling rhetorical parallels with nativism aimed at human immigrants. I point to some of the reasons why this critique of nativism persists, despite protests that no (...) xenophobic intent is evident, emphasizing the intimacy between social metaphors and claims about exotic nature. Language is but one facet of an entanglement of nature and society that ecological restoration strives to take seriously; however, restoration practice remains ambivalent toward this dichotomy permitting a longing for lost community purity that is embraced in nativism. Regarding defenses of nativism, I point out limitations of attempts to reframe the issue from a reactionary rejection of the foreign Other toward an argument for protecting communities from a process akin to 'cultural imperialism'. (shrink)

The connectionist vehicle theory of phenomenal experience in the target article identifies consciousness with the brain’s explicit representation of information in the form of stable patterns of neural activity. Commentators raise concerns about both the conceptual and empirical adequacy of this proposal. On the former front they worry about our reliance on vehicles, on representation, on stable patterns of activity, and on our identity claim. On the latter front their concerns range from the general plausibility of a vehicle theory to (...) our specific attempts to deal with the dissociation studies. We address these concerns, and then finish by considering whether the vehicle theory we have defended has a coherent story to tell about the active, unified subject to whom conscious experiences belong. (shrink)

In this innovative and cogent presentation of her concept of sustainable happiness, Catherine O’Brien outlines how the leading recommendations for transforming education can be integrated within a vision of _well-being for all_. Solution-focused, the book demonstrates how aspects of this vision are already being realized, and the potential for accelerating education transitions that enable people and ecosystems to flourish. Each chapter assists educators to understand how to apply the lessons learned, both personally and professionally. The aim is to support (...) educators to experience themselves as change-makers with growing confidence to implement new teaching strategies and inspire their students to become change-makers as well—engaged in deep learning that develops character, connections with life, and invigorating collaborations that revitalize the very purpose of education. (shrink)

In debates about rationalizing action explanation causalists assume that the psychological states that explain an intentional action have both causal and rational features. I scrutinize the presuppositions of those who seek and offer rationalizing action explanations. This scrutiny shows, I argue, that where rational features play an explanatory role in these contexts, causal features play only a presuppositional role. But causal features would have to play an explanatory role if rationalizing action explanation were a species of causal explanation. Consequently, we (...) should conclude that action explanation is not a species of causal explanation. (shrink)

Boredom: A History of Western Philosophical Perspectives The essayist Joseph Epstein has remarked, "Boredom is after all part of consciousness, and about consciousness the neurologists still have much less to tell us than do the poets and the philosophers." Although not a major topic for Western philosophers, some important Western philosophers have spoken of it, … Continue reading Boredom →.

The “New Natural Law” Theory (NNL) of Germain Grisez, John Finnis, Joseph Boyle, and their collaborators offers a distinctive account of intentional action, which underlies a moral theory that aims to justify many aspects of traditional morality and Catholic doctrine. -/- In fact, we show that the NNL is committed to premises that entail the permissibility of many actions that are irreconcilable with traditional morality and Catholic doctrine, such as elective abortions. These consequences follow principally from two aspects of the (...) NNL. The first aspect is its distinctive version of the planning theory of intention, in which adopting the 'first-person perspective' of an agent is a sufficient, and not merely necessary, condition for determining the nature of his intentional action; this planning theory rests upon an implicitly Cartesian conception of human behavior, in which behavior chosen by an agent has no intrinsic “intentionalness” apart from what he confers upon it as part of his plan. The second aspect is the NNL's distinctive account of basic human goods' incommensurability, according to which there is no common factor shared by basic human goods that allows them to be comparatively ranked in any way that directs practical deliberation. -/- The entailments of these two aspects of the NNL, we argue, amount to a reductio ad absurdum. Pace the proponents of the NNL account, we sketch an alternative hylomorphic conception of intentional action that avoids untoward moral implications by grounding human agency in the exercise of basic powers that are either (a) essential constituents of human nature or (b) acquired through participation in social practices. This conception of intentional action provides a stronger foundation for natural law theory. (shrink)

In recent years, a number of contemporary proponents of psychoanalysis have sought to derive support for their conjectures about the _dynamic_ unconscious from the empirical evidence in favor of the _cognitive_ unconscious. It is our contention, however, that far from supporting the dynamic unconscious, recent work in cognitive science suggests that the time has come to dispense with this concept altogether. In this paper we defend this claim in two ways. First, we argue that any attempt to shore up the (...) dynamic unconscious with the cognitive unconscious is bound to fail, simply because the latter, as it is understood in contemporary cognitive science, is incompatible with the former, as it is traditionally conceived by psychoanalytic theory. Second, we show how psychological phenomena traditionally cited as evidence for the operation of a dynamic unconscious can be accommodated more parsimoniously by other means. (shrink)

Any creature that must move around in its environment to find nutrients and mates, in order to survive and reproduce, faces the problem of sensorimotor control. A solution to this problem requires an on-board control mechanism that can shape the creature’s behaviour so as to render it “appropriate” to the conditions that obtain. There are at least three ways in which such a control mechanism can work, and Nature has exploited them all. The first and most basic way is for (...) a creature to bump into the things in its environment, and then, depending on what has been encountered, seek to modify its behaviour accordingly. Such an approach is risky, however, since some things in the environment are distinctly unfriendly. A second and better way, therefore, is for a creature to exploit ambient forms of energy that carry information about the distal structure of the environment. This is an improvement on the first method since it enables the creature to respond to the surroundings without actually bumping into anything. Nonetheless, this second method also has its limitations, one of which is that the information conveyed by such ambient energy is often impoverished, ambiguous and intermittent. (shrink)