BackgroundRandomized controlled trials (RCTs) are often complex and expensive to perform. Less than one third achieve planned recruitment targets, follow-up can be labor-intensive, and many have limited real-world generalizability. Designs for RCTs conducted using cohorts and routinely collected health data, including registries, electronic health records, and administrative databases, have been proposed to address these challenges and are being rapidly adopted. These designs, however, are relatively recent innovations, and published RCT reports often do not describe important aspects of their methodology in (...) a standardized way. Our objective is to extend the Consolidated Standards of Reporting Trials (CONSORT) statement with a consensus-driven reporting guideline for RCTs using cohorts and routinely collected health data.MethodsThe development of this CONSORT extension will consist of five phases. Phase 1 (completed) consisted of the project launch, including fundraising, the establishment of a research team, and development of a conceptual framework. In phase 2, a systematic review will be performed to identify publications (1) that describe methods or reporting considerations for RCTs conducted using cohorts and routinely collected health data or (2) that are protocols or report results from such RCTs. An initial “long list” of possible modifications to CONSORT checklist items and possible new items for the reporting guideline will be generated based on the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) and The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statements. Additional possible modifications and new items will be identified based on the results of the systematic review. Phase 3 will consist of a three-round Delphi exercise with methods and content experts to evaluate the “long list” and generate a “short list” of key items. In phase 4, these items will serve as the basis for an in-person consensus meeting to finalize a core set of items to be included in the reporting guideline and checklist. Phase 5 will involve drafting the checklist and elaboration-explanation documents, and dissemination and implementation of the guideline.DiscussionDevelopment of this CONSORT extension will contribute to more transparent reporting of RCTs conducted using cohorts and routinely collected health data. (shrink)

Here I consider the two most venerated arguments about the existence of God: the Ontological Argument and the Argument from Evil. The Ontological Argument purports to show that God’s nature guarantees that God exists. The Argument from Evil purports to show that God’s nature, combined with some plausible facts about the way the world is, guarantees (or is very compelling grounds for thinking) that God does not exist. Obviously, both arguments cannot be sound. But I argue here that they are (...) both unsound for the very same reason. (shrink)

Most contemporary chemists consider quantum mechanics to be the foundational theory of their discipline, although few of the calculations that a strict reduction would seem to require have ever been produced. In this essay I discuss contemporary algebraic and diagrammatic representations of molecular systems derived from quantum mechanical models, specifically configuration interaction wavefunctions for ab initio calculations and molecular orbital energy diagrams. My aim is to suggest that recent dissatisfaction with reductive accounts of chemical theory may stem from both the (...) inability of standard accounts of reduction to incorporate the diverse forms of representation found in chemical practice and our philosophical predilection to analyze all connections between theories in terms of logical reduction. (shrink)

This study examined linguistic patterns in mothers’ reports about their toddlers’ involvement in everyday household work, as a way to understand the parental ethnotheories that may guide children’s prosocial helping and development. Mothers from two cultural groups – US Mexican-heritage families with backgrounds in indigenous American communities and middle-class European American families – were interviewed regarding how their 2- to 3-year-old toddler gets involved in help with everyday household work. The study’s analytic focus was mothers’ responses to interview questions asking (...) about the child’s efforts to help with a variety of everyday household work tasks. Results showed that mothers responded with linguistic patterns that were indicative of ethnotheoretical assumptions regarding children’s agency and children’s prosocial intentions, with notable contrasts between the two cultural groups. Nearly all US Mexican-heritage mothers reported children’s contributions and participation using linguistic forms that centered children’s agency and prosocial initiative, which corresponds with extensive evidence suggesting the centrality of both children’s autonomy and supportive prosocial expectations in how children’s helpfulness is supported in this and similar cultural communities. By contrast, middle-class European American mothers frequently responded to questions about their child’s efforts to help with linguistic forms that “pivoted” to either the mother as the focal agent in the child’s prosocial engagement or to reframing the child’s involvement to emphasize non-help activities. Correspondence between cultural differences in the linguistic findings and existing literature on socialization of children’s prosocial helping is discussed. Also discussed is the analytic approach of the study, uncommon in developmental psychology research, and the significance of the linguistic findings for understanding parental ethnotheories in each community. (shrink)

Critiques of Western feminists’ attempts to extend claims about gender injustice to the global context highlighted a dilemma facing Western feminists, what I call the global gender justice dilemma. In response to this dilemma, Alison M. Jaggar argues that Western feminists should turn our attention away from trying to resolve it and, instead, toward examination of our own complicity in the processes that produce injustice. I suggest that this kind of approach is helpful in responding to an additional dilemma that (...) confronts the Western feminist, namely the epistemic dilemma. Western feminists can speak for women of the global South and run the risk of distorting those women’s experience and further silencing their voices, or we can refuse to speak and abdicate our responsibilities to address injustice. I argue that we should address this dilemma not by trying to resolve it but by examining our role in the reproduction of epistemically unjust practices. To explain this response, I offer a preliminary account of epistemic injustice as epistemic oppression. I conclude by claiming that our own epistemic complicity in epistemically oppressive social practices is a weighty reason for us to work to transform those practices. (shrink)

In Women’s Activism, Feminism, and Social Justice, Margaret McLaren develops and argues for a new theoretical framework, the feminist social justice approach, that can guide ongoing feminist transnational solidarity projects. I briefly map out the main lines of argumentation in McLaren’s book and highlight some of the valuable contributions these arguments make to the intersecting sub-fields of global ethics, global justice, development ethics, and feminist philosophy. I then note two critical thoughts on the book. First, I argue that McLaren’s concessions (...) to rights discourse as a valuable tool for transformative activism undermine and potentially even contradict her own strong critique of rights discourse. Second, I argue that McLaren doesn’t explicitly or develop the latent social epistemology of her feminist social justice approach and discussions of “training” and “education” potentially run counter to this promising but again latent social epistemology. (shrink)

Mitochondria contain a molecular genetic system to express the 13 protein components of the electron transport system encoded in the mitochondrial genome (mtDNA). Defects in the function of this system result in some diaseases, many of which are multisystem disorders, prominently involving highly aerobic, postmitotic tissues. These defects can be caused by large‐scale rearrangements of mtDNA, by point mutations, or by nuclear gene mutations resulting in abnormalities in mtDNA. Although any of these mutations would be expected to produce a similar (...) clinical phenotype by compromising oxidative phosphorylation, the surprising and puzzling result is that different clinical phenotypes are generally associated with specific mtDNA mutations. Moreover, the same mutation can produce a distinct clinical phenotype in different individuals or pedigrees. MtDNA rearrangements are also found in aged individuals, but at a subclinical level, suggesting that normal and pathological processes can differ by the effect of genetic or environmental factors on the error rate of mtDNA replication. (shrink)

Even though Kant’s theory of cognition (Erkenntnis) is central to his Critique of Pure Reason, it has rarely been asked what exactly Kant means by the term “cognition”. Against the widespread assumption that cognition (in the most relevant sense of that term) can be identified with knowledge or if not, that knowledge is at least a species of cognition, we argue that the concepts of cognition and knowledge in Kant are not only distinct, but even disjunct. To show this, we (...) first (I) investigate Kant’s explicit characterizations of the nature of cognition. As it turns out, he introduces several different notions that must be carefully distinguished before identifying the one that is central to his project in the first Critique. We then (II) consider the basic features of Kant’s conception of knowledge, indicating both how it involves assent and objective justification and how it relates to our contemporary conception. Next (III), we compare and contrast Kant’s understanding of cognition and his conception of knowledge in a way that allows us to present their fundamental differences and connections. We argue that while cognition, in the most relevant sense, is a species of representation that differs from other representations in that it involves the conceptual determination of a sensibly given object, knowledge (for Kant) is a kind of assent to a judgment that requires consciousness of a sufficient epistemic ground. Finally (IV), by appreciating the differences between cognition and knowledge, we explain several of the implications this conception of cognition has for some of Kant’s main claims in the Critique of Pure Reason as a whole. Among other things, we show how Kant can deny cognition of specific things in themselves while allowing philosophical knowledge about things in themselves in general (e.g. that they exist, are not in space and time, etc.). (shrink)

Standard animalists are committed to a stringent form of restricted composition, thereby denying the existence of brains, hands, and other proper parts of an organism . One reason for positing this near-nihilistic ontology comes from various challenges to animalism such as the Thinking Parts Argument, the Unity Argument, and the Argument from the Problem of the Many. In this paper, I show that these putatively distinct arguments are all instances of a more general problem, which I call the ‘Too Many (...) Candidates Problem’ . Given my formulation of the problem, it is evident that standard animalists are mistaken in believing that restricting composition is the only solution. I show that there is another option for solving the TMC. The advantage of such a position, which I call ‘unrestricted animalism’, is that it is compatible with unrestricted composition and the existence of brains and other proper parts of an organism. I conclude by sketching several strategies one can take regarding this latter solution to the TMC. (shrink)

In trying to establish the view that there are no non-living macrophysical objects, Trenton Merricks has produced an influential argument—the Overdetermination Argument—against the causal efficacy of composite objects. A serious problem for the Overdetermination Argument is the ambiguity in the notion of overdetermination that is being employed, which is due to the fact that Merricks does not provide any theory of causation to support his claims. Once we adopt a plausible theory of causation, viz. interventionism, problems with the Overdetermination will (...) become evident. After laying out the Overdetermination Argument and examining one extant objection to it, I will explicate the relevant aspects of an interventionist theory of causation and provide a characterization of overdetermination that follows from such an account. From this, I will argue that the Causal Principle that undergirds the Overdetermination Argument is false and hence the argument is invalid; and I claim that the only other available characterization of overdetermination would render a key premise in the argument false. Thus, the Overdetermination Argument fails to provide us with any reason to deny the causal efficacy of macrophysical objects, and therefore provides no reason to doubt their existence. (shrink)

According to Eric Olson, the Thinking Animal Argument (TAA) is the best reason to accept animalism, the view that we are identical to animals. A novel criticism has been advanced against TAA, suggesting that it implicitly employs a dubious epistemological principle. I will argue that other epistemological principles can do the trick of saving the TAA, principles that appeal to recent issues regarding disagreement with peers and experts. I conclude with some remarks about the consequence of accepting these modified (...) principles, drawing out some general morals in defending animalism. (shrink)

The overwhelming majority of those who theorize about implicit biases posit that these biases are caused by some sort of association. However, what exactly this claim amounts to is rarely specified. In this paper, I distinguish between different understandings of association, and I argue that the crucial senses of association for elucidating implicit bias are the cognitive structure and mental process senses. A hypothesis is subsequently derived: if associations really underpin implicit biases, then implicit biases should be modulated by counterconditioning (...) or extinction but should not be modulated by rational argumentation or logical interventions. This hypothesis is false; implicit biases are not predicated on any associative structures or associative processes but instead arise because of unconscious propositionally structured beliefs. I conclude by discussing how the case study of implicit bias illuminates problems with popular dual-process models of cognitive architecture. (shrink)

A recent solution to the Body-Minus problem, which is a problem of material constitution, claims that ordinary proper parts (such as left feet) exist, but the complements of these objects (such as left-foot complements) do not exist. In this paper, I examine a defense of this solution from the worry of arbitrariness and from its ineffectiveness against a revised version of the problem that focuses on the head, and I show that this defense fails.

This review of 122 research reports (184 independent samples, 14,900 subjects) found average r ϭ .274 for prediction of behavioral, judgment, and physiological measures by Implicit Association Test (IAT) measures. Parallel explicit (i.e., self-report) measures, available in 156 of these samples (13,068 subjects), also predicted effectively (average r ϭ .361), but with much greater variability of effect size. Predictive validity of self-report was impaired for socially sensitive topics, for which impression..

The properties colored and red stand in a special relation. Namely, red is a determinate of colored, and colored is determinable relative to red. Many other properties are similarly related. The determination relation is an interesting topic of logical investigation in its own right, and the prominent philosophical inquiries into this relation have, accordingly, operated at a high level of abstraction.1 It is time to return to these investigations, not just as a logical amusement, but for the payoffs such investigation (...) can yield in solving some basic metaphysical problems. The goal in what follows is twofold. First, I argue for a novel understanding of the determination relation. Second, this understanding is applied to yield insights into property instance (e.g., trope) individuation, how different property types can share an instance, the relation between property types and property instances, as well as applications to causation (mental causation, in particular). (shrink)

Sellars and McDowell, among others, attribute a prominent role to the Myth of the Given. In this paper, I suggest that they have in mind two different versions of the Myth of the Given and I argue that Kant is not the target of one version and, though explicitly under attack from the other, has resources sufficient to mount a satisfactory response. What is essential to this response is a proper understanding of (empirical) concepts as involving unifying functions that can (...) take sensations as input and deliver normative representations as outputs. By understanding concepts in this way, one need not, as the second version of the Myth of the Given maintains, take sensations to be both natural and normative. Instead, they can be understood as the natural effects of external objects on us, but natural effects that can nonetheless play a role in a normative process because the concepts that are responsible for the normativity of the results can require that such natural effects be present as inputs into the process. (shrink)

Foundational theories of mental content seek to identify the conditions under which a mental representation expresses, in the mind of a particular thinker, a particular content. Normativists endorse the following general sort of foundational theory of mental content: A mental representation r expresses concept C for agent S just in case S ought to use r in conformity with some particular pattern of use associated with C. In response to Normativist theories of content, Kathrin Glüer-Pagin and Åsa Wikforss propose a (...) dilemma, alleging that Normativism either entails a vicious regress or falls prey to a charge of idleness. In this paper, I respond to this argument. I argue that Normativism can avoid the commitments that generate the regress and does not propose the sort of explanation required to charge that its explanation has been shown to be problematically idle. The regress-generating commitment to be avoided is, roughly, that tokened, contentful mental states are the product of rule-following. The explanatory task Normativists should disavow is that of explaining how it is that beliefs and other contentful mental states are produced. I argue that Normativism, properly understood as a theory of content, does not provide this kind of psychological explanation, and therefore does not entail that such explanations are to be given in terms of rule-following. If this is correct, Normativism is not the proper target of the dilemma offered by Glüer-Pagin and Wikforss. Understanding why one might construe Normativism in the way Glüer-Pagin and Wikforss must, and how, properly understood, it avoids their dilemma, can help us to appreciate the attractiveness of a genuinely normative theory of content and the importance of paying careful attention to the sort of normativity involved in norm-based theories of content. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Argumentative Structure of Kant’s Metaphysical Foundations Of Natural ScienceEric Watkinsone of kant’s most fundamental aims is to justify Newtonian science. However, providing a detailed explanation of even the main structure of his argument (not to mention the specific arguments that fill out this structure) is not a trivial enterprise. While it is clear that Kant’s Critique of Pure Reason (1781), his Metaphysical Foundations of Natural Science (1786), and (...) his unpublished (and incomplete) Opus postumum should in some way constitute the core of this justification, it is less clear how each of these works does so in detail. In this paper I shall first argue that the standard view of the relationship between the Critique of Pure Reason and the Metaphysical Foundations of Natural Science (hereafter simply Metaphysical Foundations) is mistaken. I shall then present my own interpretation of how the Metaphysical Foundations contributes to the justification of Newtonian science. Finally, I shall conclude by considering an important interpretation of the argument of the Metaphysical Foundations developed by Michael Friedman. However, it is first necessary to present briefly Kant’s conception of science (in particular what conditions a body of knowledge must satisfy for Kant in order to be considered science proper) as well as Kant’s own understanding of the relevant differences between his projects in the first Critique, the Metaphysical Foundations, and the Opus postumum.Kant’s conception of science is rather strict if measured by contemporary standards. For in the preface to the Metaphysical Foundations Kant establishes three substantive conditions that a body of knowledge must satisfy in order to be considered science proper.1 (1) It must not consist in empirical principles, [End Page 567] but rather must be obtained solely from pure, a priori principles;2 (2) It must be apodictically certain;3 (3)4 It must be a systematically ordered whole (which means that its various propositions must be related as, for example, antecedents and consequents).5 After stating these conditions, Kant then argues that all natural science proper requires a pure part upon which its apodictic certainty is based. In other words, satisfaction of the first condition immediately implies satisfaction of the second condition as well.6 Accordingly, these three conditions (and the first one in particular) imply that natural science proper requires (or rather presupposes) a justification by something distinct from it that Kant calls a metaphysics of nature.7 But what exactly does a metaphysics of nature encompass? Kant distinguishes two different parts of the metaphysics of nature: a transcendental part and a special part. A metaphysics of nature [End Page 568] is transcendental insofar as it concerns “the laws that make the concept of nature in general possible, even without relation to any determinate object of experience, and [insofar as it is] thus indeterminate with respect to the nature of this or that thing in the sensible world,” whereas a metaphysics of nature is special to the extent that “it is concerned with a special nature of this or that kind of thing of which an empirical concept is given, but so that except for what lies in this concept no other empirical principle is used for knowledge thereof.”8 In short, a transcendental metaphysics, revealing how experience in general is possible, is not supposed to presuppose an empirical concept, whereas a special metaphysics does make such an assumption insofar as it is concerned with the special natures of things.How do the three works cited above relate to Kant’s distinction between a transcendental and a special metaphysics of nature? In the preface to the Metaphysical Foundations Kant clearly indicates that he intends the Metaphysical Foundations to constitute the special metaphysics of nature. Although he does not explicitly refer to the first Critique in the preface, it is also relatively clear that he sees it (or at least the ‘System of Pure Reason’ that Kant foresees as following upon it and as incorporating its fundamental results)9 as constituting [End Page 569] the transcendental part of a metaphysics of nature.10 The Principles of Pure Understanding (‘Grundsätze des reinen Verstandes’) in the Transcendental Analytic argue for what could naturally be described as “laws... (shrink)

My dissertation asks how we affect conversational context and how it affects us when we participate in any conversation—including philosophical conversations. Chapter 1 argues that speakers make pragmatic presuppositions when they use proper names. I appeal to these presuppositions in giving a treatment of Frege’s puzzle that is consistent with the claim that coreferential proper names have the same semantic value. I outline an explanation of the way presupposition carrying expressions in general behave in belief ascriptions, and suggest that substitutivity (...) failure is a special case of this behavior. Chapter 2 develops a compositional probabilistic semantics for the language of subjective uncertainty, including epistemic adjectives scoped under quantifiers. I argue that we should distinguish sharply between the effects that epistemically hedged statements have on conversational context, and the effects that they have on belief states. I also suggest that epistemically hedged statements are a kind of doxastic advice, and explain how this hypothesis illuminates some otherwise puzzling phenomena. Chapter 3 argues that ordinary causal talk is deeply sensitive to conversational context. The principle that I formulate to characterize that context sensitivity explains at least some of the oddness of ‘systematic causal overdetermination,’ and explains why some putative overgenerated causes are never felicitously counted, in conversation, as causes. But the principle also makes metaphysical theorizing about causation rather indirectly constrained by ordinary language judgments. (shrink)

Constituent ontologies maintain that the properties of an object are either parts or something very much like parts of that object. Recently, such a view has been criticized as leading to a bizarre and problematic form of substance dualism and implying the existence of impossible objects. After briefly presenting constituent and relational ontologies, I respond to both objections, arguing that constituent ontology does not yield either of these two consequences and so is not shown to be an unacceptable ontological framework.

Many philosophers appeal to intuitions to support some philosophical views. However, there is reason to be concerned about this practice as scientific evidence has documented systematic bias in philosophically relevant intuitions as a function of seemingly irrelevant features (e.g., personality). One popular defense used to insulate philosophers from these concerns holds that philosophical expertise eliminates the influence of these extraneous factors. Here, we test this assumption. We present data suggesting that verifiable philosophical expertise in the free will debate-as measured by (...) a reliable and validated test of expert knowledge-does not eliminate the influence of one important extraneous feature (i.e., the heritable personality trait extraversion) on judgments concerning freedom and moral responsibility. These results suggest that, in at least some important cases, the expertise defense fails. Implications for the practice of philosophy, experimental philosophy, and applied ethics are discussed. (shrink)

It is often claimed (most recently by Michael Friedman) that Kant intended to justify Newton’s most fundamental claims expressed in the Principia, such as his laws of motion and the law of universal gravitation. In this article, I argue that the differences between Newton’s laws of motion and Kant’s laws of mechanics are not superficial or merely apparent. Rather, they reflect fundamental differences in their respective projects. This point can be seen especially clearly by considering the nature of the various (...) projects undertaken in Germany prior to Kant that discuss the laws of motion. Wolff and his followers qua metaphysicians were especially interested in providing nonempirical justifications of their laws of motion as well as an intelligible account of the fundamental properties of bodies in terms of substance, accident, and force. Maupertuis and Euler, despite often being seen as Newtonians, both drew on traditions other than Newton’s. Physics textbooks (by figures such as Erxleben, Karsten, ‘s Gravesande, and Musschenbroek) vary considerably in their aims, but in none of these cases is Newton’s main argument of the Principia presented. In light of the fact that these projects are distinct in significant ways from Newton’s project, the differences between Newton’s laws of motion and Kant’s laws of mechanics are most likely not merely apparent but reflect the fact that Kant, too, was pursuing a project fundamentally distinct from Newton’s. (shrink)

ABSTRACTIn this paper I argue that Kant’s complex argument against materialism involves not only his generic commitment to the existence of non-spatio-temporal and thus non-material things in themselves, but also considerations pertaining to reason and the subject of our thoughts. Specifically, I argue that because Kant conceives of reason in such a way that it demands a commitment to the existence of the unconditioned so that we can account for whatever conditioned objects we encounter in experience, our thoughts, which are (...) also conditioned, require something unconditioned that, because it is unconditioned, cannot be material. In this way, Kant’s attitude towards materialism is based not only on abstract features of his metaphysics and epistemology, but also on specific features that were under serious discussion in the early modern period. (shrink)

A Non-Technical Introduction to Ethnomethodological Investigations of the Foundations of Mathematics through the Use of a Theorem of Euclidean Geometry* I ...

Relationships between children and parents pervade the Star Wars saga, especially if people include surrogate parents. Anakin's relationship with his mother, Shmi, in the prequels impacts his trajectory toward the dark side. In The Mandalorian, Mando's role as a surrogate father to Grogu transforms them into a “Clan of Two”. But the most significant parent‐child relationship in the saga may be the one between Luke Skywalker and Darth Vader. Confucius's teachings highlight the importance of benevolence, social order, and ritual propriety (...) among other virtues and values. This chapter shows that understanding Luke's surrender to Vader in terms of Confucian filial piety makes sense of how Luke is able to overcome the allure of the dark side and become a Jedi. Confucius's Analects has a moral framework called “exemplarism”. This is the idea that moral knowledge and practice do not start with principles, rules, duties, consequences, or character traits. (shrink)

I argue that moral judgments function as commitment strategies that rely on a deflection of attention from our motivations and values. Revealing the hidden workings of these strategies allows me to illustrate and explain some of the widely unrecognized practical downsides of moral discourse. I recommend a departure from moral discourse in favor of paying more and better attention to our actual concerns. Important strengths of my approach over contemporary forms of moral abolitionism lie in my ability to sidestep moral (...) error theories, my acknowledgment of the significant value of moral discourse, and thus the restricted target of my recommendation. (shrink)

Aarons recognizes the usefulnes of markets, but argues that without some conscious human control they are unsustainable and would ultimately destroy the conditions for human life on the planet.

Aarons recognizes the usefulnes of markets, but argues that without some conscious human control they are unsustainable and would ultimately destroy the conditions for human life on the planet.

In this article, we discuss the ethical dimensions for the prescribing behaviours of opioids for a chronic pain patient, a scenario commonly witnessed by many physicians. The opioid epidemic in the USA and Canada is well known, existing since the late 1990s, and individuals are suffering and dying as a result of the easy availability of prescription opioids. More recently, this problem has been seen outside of North America affecting individuals at similar rates in Australia and Europe. We argue that (...) physicians are also confronted with an ethical crisis where a capitalist-consumerist society is contributing to this opioid crisis in which societal, legal and business interests push physicians to overprescribe opioids. Individual physicians often find themselves unequipped and unsupported in attempts to curb the prescribing of opioid medications and balance competing goals of alleviating pain against the judicious use of pain medications. Physicians, individually and as a community, must reclaim the ethical mantle of our profession, through a more nuanced understanding of autonomy and beneficence. Furthermore, physicians and the medical community at large have a fiduciary duty to patients and society to play a more active role in curbing the widespread distribution of opioids in our communities. (shrink)

There have been recent disagreements in the philosophy of neuroscience regarding which sorts of scientific models provide mechanistic explanations, and which do not. These disagreements often hinge on two commonly adopted, but conflicting, ways of understanding mechanistic explanations: what I call the “representation-as” account, and the “representation-of” account. In this paper, I argue that neither account does justice to neuroscientific practice. In their place, I offer a new alternative that can defuse some of these disagreements. I argue that individual models (...) do not provide mechanistic explanations by themselves. Instead, individual models are always used to complement a huge body of background information and pre-existing models about the target system. With this in mind, I argue that mechanistic explanations are distributed across sets of different, and sometimes contradictory, scientific models. Each of these models contributes limited, but essential, information to the same mechanistic explanation, but none can be considered a mechanistic explanation in isolation of the others. (shrink)

Before the story can be told, however, some stage-setting is necessary. First, it is important to be clear about the most basic doctrines of Pre-established Harmony, Occasionalism, and Physical Influx. Physical Influx asserts intersubstantial causation amongst finite substances. For instance, when I appear to kick a ball, I really am the cause of the ball's motion. Pre-established Harmony denies intersubstantial causation, but affirms intrasubstantial causation. According to Pre-established Harmony, then, I am not the cause of the ball's motion, but rather (...) the ball is simply causing itself to move. Occasionalism, like Pre-established Harmony, denies intersubstantial causation, but, unlike Pre-established Harmony, it denies intrasubstantial causation as well. Occasionalism typically asserts that God alone, that is, an infinite substance, is the cause of all changes, and thus of the ball's motion. Though there are other ways of defining these causal theories, this way has the advantage that the causal theories form an exhaustive disjunction. (shrink)