Pharmacogenetics is the study of inherited variations in drug response Pharmacogenetics uses the techniques of pharmacology, population genetics, biochemical genetics and, most recently, molecular biology, to study the biological basis for individual variation in therapeutic response and in the occurrence of adverse reactions to medications. Most pharmacogenetic experiments deal with inherited differences in drug metabolism. The discussion here will review inherited variation in the activity of thiopurine methyltransferase, an enzyme that catalyzes the methyl conjugation of an important group of drugs, (...) the thiopurines. (shrink)

Richard Swinburne presents a substantially rewritten and updated edition of his most celebrated book. No other work has made a more powerful case for the probability of the existence of God. Swinburne gives a rigorous and penetrating analysis of the most important arguments for theism: the cosmological argument; arguments from the existence of laws of nature and the 'fine-tuning' of the universe; from the occurrence of consciousness and moral awareness; and from miracles and religious experience. He claims that while (...) none of these arguments are deductively valid, they do give inductive support to theism and that, even when the argument from evil is weighed against them, taken together they offer good grounds to support the probability that there is a God. The overall structure of the discussion and its conclusion have been retained for this new edition, but much has been changed in order to strengthen the argumentation and to take account of Swinburne's subsequent work on the nature of consciousness and the problem of evil, and of the latest philosophical and scientific writing, especially in respect of the laws of nature and the argument from fine-tuning. This is now the definitive version of a classic in the philosophy of religion. (shrink)

Richard Swinburne presents a substantially rewritten and updated edition of his most celebrated book. No other work has made a more powerful case for the probability of the existence of God. Swinburne gives a rigorous and penetrating analysis of the most important arguments for theism: the cosmological argument; arguments from the existence of laws of nature and the 'fine-tuning' of the universe; from the occurrence of consciousness and moral awareness; and from miracles and religious experience. He claims that while (...) none of these arguments are deductively valid, they do give inductive support to theism and that, even when the argument from evil is weighed against them, taken together they offer good grounds to support the probability that there is a God. The overall structure of the discussion and its conclusion have been retained for this new edition, but much has been changed in order to strengthen the argumentation and to take account of Swinburne's subsequent work on the nature of consciousness and the problem of evil, and of the latest philosophical and scientific writing, especially in respect of the laws of nature and the argument from fine-tuning. This is now the definitive version of a classic in the philosophy of religion. (shrink)

Richard Swinburne offers an answer to one of the most difficult problems of religious belief: why does a loving God allow humans to suffer so much? It is the final instalment of Swinburne's acclaimed four-volume philosophical examination of Christian doctrine.

This volume collects a number of important and revealing interviews with Richard Rorty, spanning more than two decades of his public intellectual commentary, engagement, and criticism. In colloquial language, Rorty discusses the relevance and nonrelevance of philosophy to American political and public life. The collection also provides a candid set of insights into Rorty's political beliefs and his commitment to the labor and union traditions in this country. Finally, the interviews reveal Rorty to be a deeply engaged social thinker (...) and observer. (shrink)

Richard Gaskin offers an original defence of literary humanism, according to which works of imaginative literature have an objective meaning which is fixed at the time of production and not subject to individual readers' responses. He shows that the appreciation of literature is a cognitive activity fully on a par with scientific investigation.

Jacques Derrida, one of the most influential, controversial and complex thinkers of our time, has come to be at the centre of many political debates. This is the first book to consider the political implications of Derrida's deconstruction. It is a timely response both to Derrida's own recent shift towards thinking about the political, and to the political focus of contemparary Continental philosophy. Richard Beardsworth's study, Derrida and the Political , locates a way of thinking about deconstruction using the (...) tools of political philosophy. Richard Beardsworth has provided students of philosophy, politics and critical theory with a thought-provoking, upper level introduction to Derrida'a work as a political theorist. (shrink)

Richard Swinburne presents a powerful new case for substance dualism and for libertarian free will. He argues that pure mental events are distinct from physical events and interact with them, and claims that no result from neuroscience or any other science could show that interaction does not take place. Swinburne goes on to argue for agent causation, and claims that it is we, and not our intentions, that cause our brain events. It is metaphysically possible that each of us (...) could acquire a new brain or continue to exist without a brain; and so we are essentially souls. Brain events and conscious events are so different from each other that it would not be possible to establish a scientific theory which would predict what each of us would do in situations of moral conflict. Hence, we should believe that things are as they seem to be: that we make choices independently of the causes which influence us. It follows that we are morally responsible for our actions. (shrink)

Stories offer us some of the richest and most enduring insights into the human condition and have preoccupied philosophy since Aristotle. On Stories presents in clear and compelling style just why narrative has this power over us and argues that the unnarrated life is not worth living. Drawing on the work of James Joyce, Sigmund Freud's patient 'Dora' and the case of Oscar Schindler, Richard Kearney skilfully illuminates how stories not only entertain us but can determine our lives and (...) personal identities. He also considers nations as stories, including the story of Romulus and Remus in the founding of Rome. Throughout, On Stories stresses that, far from heralding the demise of narrative, the digital era merely opens up new stories. (shrink)

Richard Sorabji presents a ground-breaking study of ancient Greek views of the emotions and their influence on subsequent theories and attitudes, Pagan and Christian. While the central focus of the book is the Stoics, Sorabji draws on a vast range of texts to give a rich historical survey of how Western thinking about this central aspect of human nature developed.

What makes us human? Richard Swinburne presents new philosophical arguments, supported by modern neuroscience, for the view that we are immaterial souls sustained in existence by our brains.

Richard Sorabji; VII*—Aristotle On the Rôle of Intellect in Virtue, Proceedings of the Aristotelian Society, Volume 74, Issue 1, 1 June 1974, Pages 107–129, htt.

Richard Swinburne presents a new edition of the final volume of his acclaimed trilogy on philosophical theology. Faith and Reason is a self-standing examination of the implications for religious faith of Swinburne's famous arguments about the coherence of theism and the existence of God.By practising a particular religion, a person seeks to achieve some or all of three goals - that he worships and obeys God, gains salvation for himself, and helps others to attain their salvation. But not all (...) religions commend worship, and different religions have different conceptions of salvation. Faced with these differences, Richard Swinburne argues that we should practice that religion which has the best goals and is more probably true than the creeds of other religions. He proposes criteria by which to determine the probabilities of different religious creeds, and he argues that, while requiring total commitment, faith does not demand fully convinced belief. While maintaining the same structure and conclusions as the original classic, this second edition has been substantially rewritten, both in order to relate its ideas more closely to those of classical theologians and philosophers and to respond to more recent views. In particular he discusses, and ultimately rejects, the view of Alvin Plantinga that the 'warrant' of a belief depends on the process which produced it, and John Hick's contention that all religions offer valid paths to salvation. (shrink)

Richard Swinburne presents a new edition of the final volume of his acclaimed trilogy on philosophical theology. Faith and Reason is a self-standing examination of the implications for religious faith of Swinburne's famous arguments about the coherence of theism and the existence of God. By practising a particular religion, a person seeks to achieve some or all of three goals - that he worships and obeys God, gains salvation for himself, and helps others to attain their salvation. But not (...) all religions commend worship, and different religions have different conceptions of salvation. Faced with these differences, Richard Swinburne argues that we should practice that religion which has the best goals and is more probably true than the creeds of other religions. He proposes criteria by which to determine the probabilities of different religious creeds, and he argues that, while requiring total commitment, faith does not demand fully convinced belief. While maintaining the samestructure and conclusions as the original classic, this second edition has been substantially rewritten, both in order to relate its ideas more closely to those of classical theologians and philosophers and to respond to more recent views. In particular he discusses, and ultimately rejects, the view of Alvin Plantinga that the 'warrant' of a belief depends on the process which produced it, and John Hick's contention that all religions offer valid paths to salvation. (shrink)

Richard Sorabji presents a unique discussion of the development of moral conscience over a period of 2500 years, from the playwrights of the fifth century BCE to the present. He addresses key topics including the original meaning and continuing nature of conscience, the ideas of freedom of religion and conscience with climaxes in the early Christian centuries and the seventeenth, the disputes on absolution or 'terrorisation' of conscience, dilemmas of conscience, and moral double-bind, the reliability of conscience if it (...) is shaped by local custom, and modern opposition to the idea of conscience and its role in legislation. (shrink)

In “Theories of Justification,” Richard Fumerton begins an overview of several prominent positions on the nature of justification by isolating epistemic justification from nonepistemic justification. He also distinguishes between “having justification for a belief” and “having a justified belief,” arguing that the former is conceptually more fundamental. Fumerton then addresses the possibility that justification is a normative matter, suggesting that this possibility has little to offer as a concept of epistemic justification. He also critically examines more specific attempts to (...) capture the structure and content of epistemic justification. These include traditional foundationalism and variants thereof, externalist versions of foundationalism, contextualism, coherentism, and “mixed” theories which combine aspects of coherentism and foundationalism. (shrink)

Richard Tieszen presents an analysis, development, and defense of a number of central ideas in Kurt Gödel's writings on the philosophy and foundations of mathematics and logic. Tieszen structures the argument around Gödel's three philosophical heroes - Plato, Leibniz, and Husserl - and his engagement with Kant, and supplements close readings of Gödel's texts on foundations with materials from Gödel's Nachlass and from Hao Wang's discussions with Gödel. He provides discussions of Gödel's views, and develops a new type of (...) platonic rationalism that requires rational intuition, called 'constituted platonism'. (shrink)

Richard Sorabji presents a brilliant exploration of the history of our understanding of the self, which has remained elusive and mysterious throughout the spectacular development of human knowledge of the outside world. He ranges from ancient to contemporary thought, Western and Eastern, to reveal and assess the insights of a remarkable variety of thinkers. On this basis he rejects the common idea that the self is an illusion, and develops his own original conception of the self as essential to (...) our ownership of our experience and our apprehension of the world. (shrink)

In a wide-ranging inquiry Richard W. Miller provides new resources for coping with the most troubling types of moral conflict: disagreements in moral conviction, conflicting interests, and the tension between conscience and desires. Drawing on most fields in philosophy and the social sciences, including his previous work in the philosophy of science, he presents an account of our access to moral truth, and, within this framework, develops a theory of justice and an assessment of the role of morality in (...) rational choice. In Miller's view, we are often in a position to claim that our moral judgments are true descriptions of moral facts. But others, relying on contrary ways of moral learning, would reject truths that we are in a position to assert, in dissent that does not depend on irrationality or ignorance of relevant evidence or arguments. With this mixed verdict on moral realism, Miller challenges many received views of rationality, scientific method, and the relation between moral belief and moral choice. In his discussion of justice, Miller defends the adequacy, for modern political choices, of a widely shared demand that institutions be freely and rationally acceptable to all. Drawing on social research and economic theories, he argues that this demand has dramatically egalitarian consequences, even though it is a premise of liberals and conservatives alike. In the final chapters, Miller investigates the role and limits of morality in the choice of conduct, arguing for new perspectives on reason and impartiality. (shrink)

As its subtitle 'Skepticism, Individuality and Chastened Politics' indicates, this book is an exploration of and a largely favorable engagement with salient elements in the thinking of a theorist who is widely regarded as the greatest Anglophone political thinker and among the top rank of philosophical writers generally. In emphazing Hobbes's skepticism, Richard Flathman goes against the grain of much of the literature concerning Hobbes. The theme of individuality is more familiar, particularly from the celebrated writings on Hobbes by (...) Michael Oakeshott, but the idea of a chastened politics challenges the widely influential view that Hobbes was not only an authoritarian but an incipient or proto-totalitarian. (shrink)

humanism /'hju:menizm/ n. an outlook or system of thought concerned with human rather than divine or supernatural matters. Albert Einstein, Isaac Asimov, E.M. Forster, Bertrand Russell, and Gloria Steinem all declared themselves humanists. What is humanism and why does it matter? Is there any doctrine every humanist must hold? If it rejects religion, what does it offer in its place? Have the twentieth century's crimes against humanity spelled the end for humanism? On Humanism is a timely and powerfully argued philosophical (...) defence of humanism. It is also an impassioned plea that we turn to ourselves, not religion, if we want to answer Socrates' age-old question: what is the best kind of life to lead? Although humanism has much in common with science, Richard Norman shows that it is far from a denial of the more mysterious, fragile side of being human. He deals with big questions such as the environment, Darwinism and 'creation science', euthanasia and abortion, and then argues that it is ultimately through the human capacity for art, literature and the imagination that humanism is a powerful alternative to religious belief. Drawing on a varied range of examples from Aristotle to Primo Levi and the novels of Virginia Woolf and Graham Swift, On Humanism is a lucid and much needed reflection on this much talked about but little understood phenomenon. (shrink)

An investigation of Frege’s various contributions to the study of language, focusing on three of his most famous doctrines: that concepts are unsaturated, that sentences refer to truth-values, and that sense must be distinguished from reference.

Richard Jeffrey regarded the version of Bayesian decision theory he floated in ‘The Logic of Decision’ and the idea of a probability kinematics—a generalisation of Bayesian conditioning to contexts in which the evidence is ‘uncertain’—as his two most important contributions to philosophy. This paper aims to connect them by developing kinematical models for the study of preference change and practical deliberation. Preference change is treated in a manner analogous to Jeffrey’s handling of belief change: not as mechanical outputs of (...) combinations of intrinsic desires plus information, but as a matter of judgement and of making up one’s mind. In the first section Jeffrey’s probability kinematics is motivated and extended to the treatment of changes in conditional belief. In the second, analogous kinematical models are developed for preference change and in particular belief-induced change that depends on an invariance condition for conditional preference. The two are the brought together in the last section in a tentative model of pratical deliberation. (shrink)