With the growing focus on prevention in medicine, studies of how to describe risk have become increasing important. Recently, some researchers have argued against giving patients “comparative risk information,” such as data about whether their baseline risk of developing a particular disease is above or below average. The concern is that giving patients this information will interfere with their consideration of more relevant data, such as the specific chance of getting the disease (the “personal risk”), the risk reduction the (...) treatment provides, and any possible side effects. I explore this view and the theories of rationality that ground it, and I argue instead that comparative risk information can play a positive role in decision-making. The criticism of disclosing this sort of information to patients, I conclude, rests on a mistakenly narrow account of the goals of prevention and the nature of rational choice in medicine. (shrink)

The issue as to whether an atomistic or holistic viewof knowledge and meaning is correct relies on the way part/whole relationships is analysed,exactly as the issue as to whether a constructive or realistic view of knowledge and meaningis correct relies on the way internal/external relationships is analysed. Both theprinciple of compositionality and the context principle depend on how finely the constituents,the nature and the size of the context are identified; both the notion of meaning andthe notion of truth depend on (...) the resources of internalisation/externalisation. Thus thespectrum of semantic and epistemological theories varies from (global) atomismto (global) holism, and from minimal to maximal internalisation. Are compositionaltheories necessarily extensional? Does formal semantics necessarily rely on set theory?Does the domain-specific character of the notions of element, part and whole prevent anygeneral, non-trivial account? The aim of the present paper is to provide a negative answerto these questions by exploring some of the features a theory covering the phenomenologyof part and whole should have. This phenomenology will only be sketched through a fewparadigmatic examples, showing how the reference of notions of part and wholevaries and which are the constraints inherentin such variation. Categorytheory provides the tools for fashioning this framework, since it allows describing any coherentcollection of objects (with actions defined over them) and (action preserving) maps betweenthe objects, as well as the variation of such collections in terms of suitablefunctors, coding the ways parts and wholes undergo co-variation. The main thesis is thatthere are interference patterns between the two pairs Local/Global and Internal/External,only in terms of which the above phenomenology can be properly described.Se mai tu diventeraimetá di te stesso, e te l''auguro, ragazzo, capirai cose al di lá della comune intelligenza dei cervelli interi.Avrai perso metá di te e del mondo, ma la realtá rimasta sará mille volte piú profonda e preziosa. E tupure vorrai che tutto sia dimezzato e straziato a tua immagine, perchè bellezza e sapienza e giustizia ci sono soloin ció che é fatto a brani. (shrink)

Recent data indicate that under a specific posthypnotic suggestion to circumvent reading, highly suggestible subjects successfully eliminated the Stroop interference effect. The present study examined whether an optical explanation could account for this finding. Using cyclopentolate hydrochloride eye drops to pharmacologically prevent visual accommodation in all subjects, behavioral Stroop data were collected from six highly hypnotizables and six less suggestibles using an optical setup that guaranteed either sharply focused or blurred vision. The highly suggestibles performed the Stroop task when (...) naturally vigilant, under posthypnotic suggestion not to read, and while visually blurred; the less suggestibles ran naturally vigilant, while looking away, and while visually blurred. Although visual accommodation was precluded for all subjects, posthypnotic suggestion effectively eliminated Stroop interference and was comparable to looking away in controls. These data strengthen the view that Stroop interference is neither robust nor inevitable and support the hypothesis that posthypnotic suggestion may exert a top-down influence on neural processing. (shrink)

The chapter focuses on cases of assisted suicide and voluntary euthanasia in relation to the rarely discussed notion of indirect paternalism. Indirect paternalism involves not just a paternalistic intervener and a person whose welfare is supposed to be protected, but also another party, whom I call “assistant.” Indirect paternalism interferes with an assistant in order to prevent harm to another person. I will introduce a strategy that paternalists can pursue to justify indirect paternalism. It specifically targets an element of assistance (...) cases, namely the fact that people do not necessarily have a justified claim or entitlement to demand such assistance. To prevent people from providing assistance seems normatively different from preventing a person to do something to herself by her own means. I critically discuss arguments from the goals of medicine and from the conscientious objection. These aspects are not deemed decisive when considering the case of indirect paternalistic intervention. Finally, I argue against the rationale of indirect paternalism by showing that there are at least two situations where it does not succeed. One such situation that undermines the justification of indirect paternalism is present when the offered service is itself harmless, another pertinent situation consists of a person necessarily requiring assistance to be really free. At least in some cases, these very conditions are given when contemplating assistance to die. (shrink)

Recent data indicate that under a specific posthypnotic suggestion to circumvent reading, highly suggestible subjects successfully eliminated the Stroop interference effect. The present study examined whether an optical explanation could account for this finding. Using cyclopentolate hydrochloride eye drops to pharmacologically prevent visual accommodation in all subjects, behavioral Stroop data were collected from six highly hypnotizables and six less suggestibles using an optical setup that guaranteed either sharply focused or blurred vision. The highly suggestibles performed the Stroop task when (...) naturally vigilant, under posthypnotic suggestion not to read, and while visually blurred; the less suggestibles ran naturally vigilant, while looking away, and while visually blurred. Although visual accommodation was precluded for all subjects, posthypnotic suggestion effectively eliminated Stroop interference and was comparable to looking away in controls. These data strengthen the view that Stroop interference is neither robust nor inevitable and support the hypothesis that posthypnotic suggestion may exert a top-down influence on neural processing. (shrink)

In the midst of only the 6th mass extinction in the Earth's history, we must rethink how we teach evolution to prevent natural selection from being incorrectly used as a biological justification for inaction in the face of today's human‐caused mass extinction crisis. Pundits, policy makers, and the general public regularly identify the extinction of endangered species as natural selection at work, rather than attributing modern‐day extinction to the sudden catastrophic bad luck of human caused environmental change, a phenomenon distinct (...) from natural selection. In this natural selection framing, the inability of species to survive in human altered environments is the normal progression of “survival of the fittest” and conservation measures designed to protect species is human interference with natural selection. Paradoxically, this erroneous framing of extinction as the normal course of natural selection ignores humanity's exceptional role in causing today's mass extinction crisis. Our examination of this issue in U.S. college students indicates that it arises from misunderstanding the role of extinction in the history of life, leading us to recommend a greater teaching emphasis on the distinction between extinction and natural selection, and on past mass extinction events. Also see the video abstract here https://youtu.be/29VRyirMdiw. (shrink)

This study examined whether worktime control buffered the impact of worktime demands on work-family interference (WFI), using data from 2,377 workers from various sectors of industry in The Netherlands. We distinguished among three types of worktime demands: time spent on work according to one's contract (contractual hours), the number of hours spent on overtime work (overtime hours), and the number of hours spent on commuting (commuting hours). Regarding worktime control, a distinction was made between having control over days off (...) and vacations (leave control) and having control over starting and finishing times (flextime). These three worktime demands were expected to have separate as well as joint effects on WFI, whereas worktime control should buffer these adverse effects of worktime demands on WFI. Stepwise regression analyses showed that working high numbers of contractual and overtime hours was indeed associated with high WFI. Further, worktime control indeed made a difference in terms of WFI: whereas leave control contributed directly to lower WFI, flextime buffered the adverse effects of long contractual workhours. Our results suggest that very long working days should be prevented, and that worktime control may be a powerful tool to help workers maintaining a good work-family balance. (shrink)

The traditional problem of evil sets theists the task of reconciling two things: God and evil. I argue that theists face the more difficult task of reconciling God and evils that God is specially obligated to prevent. Because of His authority, God's obligation to curtail evil goes far beyond our Samaritan duty to prevent evil when doing so isn't overly hard. Authorities owe their subjects a positive obligation to prevent certain evils; we have a right against our authorities that they (...) protect us. God's apparent mistake is not merely the impersonal wrong of failing to do enough good — though it is that too. It is the highly personal wrong of failing to live up to a moral requirement that comes bundled with authority over persons. To make my argument, I use the resources of political philosophy and defend a novel change to the orthodox account of authority. (shrink)

Most advocates of biogenetic modification hope to amplify existing human traits in humans in order to increase the value of such traits as intelligence and resistance to disease. These advocates defend such enhancements as beneficial for the affected parties. By contrast, some commentators recommend certain biogenetic modifications to serve social goals. As Ingmar Persson and Julian Savulescu see things, human moral psychology is deficient relative to the most important risks facing humanity as a whole, including the prospect of Ultimate Harm, (...) the point at which worthwhile life is forever impossible on the planet. These risks can be mitigated, they say, by enhancing moral psychology in novel ways. Persson and Savulescu argue that some parents should modify the underlying biogenetics of their children's moral psychology, if such measures were safe and effective, but they admit these interventions may not decouple humanity from Ultimate Harm. Neither are these modifications the only options, they concede, for addressing risks to humanity. Even with these concessions, saving humanity from itself is a fairly poor reason to modify the moral psychology of children. In most ways, adults would be better candidates, morally speaking, for modifications of psychology. Even then, there is no direct link between morally enhanced human beings and the hoped-for effect of better protection from Ultimate Harm. Asserting a general duty of all to contribute to the avoidance of Ultimate Harm is a better moral strategy than intervening in the moral psychology of some, even though meeting that duty may involve substantial interference with the free exercise of one's interests. (shrink)

The pre-trial detention of individuals charged with crimes is viewed by many legal scholars as problematic. Standard arguments against it are that it constitutes legal punishment of individuals not yet convicted of crimes, violates the presumption of innocence, and rests on dubious predictions of future crime. I defend modified and restrained forms of pre-trial detention. I argue that pre-trial detention could be made very different than imprisonment, should be governed by strict criteria, and is warranted, when the evidence of danger (...) is convincing. I contend that the presumption of innocence does not preclude us from doing many other things to criminal suspects and defendants that imply their guilt. Finally, I dispute arguments designed to show that pre-trial detention can be justified to prevent absconding or interferences with the course of justice, but not to prevent other, and sometimes much more serious, offenses. (shrink)

The purpose of this study is to examine the relationship between contextual work-related factors on the one hand, in terms of job demands (i.e., risk factors) and job resources (i.e., protective factors), and work-family conflict in teachers on the other. Building on the Job Demands-Resources (JD-R) model, we hypothesized that job demands, namely qualitative and quantitative workload, are positively associated with work-family conflict in teachers. Moreover, in line with the buffer hypothesis of the JD-R, we expected job resources, in terms (...) of support from supervisor, job autonomy, and participation in decision making, to affect this association, which is expected to be stronger when job resources are low. The study was conducted in an Italian secondary school. Overall, 122 teachers completed a self-report questionnaire aimed at determining work-family conflict, as well as job demands and resources. The hypothesized relationships were tested using moderated multiple regression. The results of this study largely support our predictions. First, both aspects of workload were positively associated with work-family conflict. Secondly, job resources, including support from supervisor and participation in decision making, buffered this association, which was stronger when resources were low. On the contrary, job autonomy did not buffer the association between workload and work-family conflict. Overall, the results of this study are consistent with the Job Demands-Resources model and contribute to to the understanding of work–family conflict among teachers. More specifically, our study suggests that teachers with high levels of job resources, namely support from supervisor and participation in decision making, can effectively cope with job demands, in terms of both qualitative and quantitative workload, thus preventing negative consequences such as conflict between work and family domains. Interventions aimed at preventing work-family conflict among teachers should encourage organizations to optimize the balance between job demands and resources, as well as the identification and training of the workers at risk of work-family conflict. (shrink)

The principle that we should not interfere with nature plays a prominent role in both popular and academic accounts of environmental ethics. For example, it is often cited to justify the claims that we should not actively manage wilderness areas and that we should not extinguish naturally occurring fires in those areas. It is far from clear, however, exactly what that principle entails for our treatment of species and ecosystems. Does all human interaction with nature amount to interference? If (...) there are different kinds of interference, are they all wrong? Might not there be such a thing as beneficial interference? Can one part of nature interfere with another, and if so, is it morally permissible or forbidden for humans to prevent this kind of interference? These questions can be answered only if we have a clear notion of interference. First, I examine one initially plausible account which takes it to be a kind of cause. One interferes with a species or ecosystem when one alters or redirects it. Second, I answer a crucial question that must be faced with regard to any theory that takes interference to be a kind of cause. If interference involves nothing more than having an effect on an ecosystem, then the activities of practically every species in an ecosystem interfere with it. However, these activities are usually thought of as legitimate or normal ecosystemic change, as essential components of the ecosystem, rather than as interference.Thus, some criterion must be proposed to distinguish between interference and the actions of other species which have an effect on an ecosystem but do not interfere with it. I look at a number of proposals and conclude that no one of them is uniquely correct. Rather, the criterion one employs to understand interference must be determined by one’s projects and goals. (shrink)

The principle that we should not interfere with nature plays a prominent role in both popular and academic accounts of environmental ethics. For example, it is often cited to justify the claims that we should not actively manage wilderness areas and that we should not extinguish naturally occurring fires in those areas. It is far from clear, however, exactly what that principle entails for our treatment of species and ecosystems. Does all human interaction with nature amount to interference? If (...) there are different kinds of interference, are they all wrong? Might not there be such a thing as beneficial interference? Can one part of nature interfere with another, and if so, is it morally permissible or forbidden for humans to prevent this kind of interference? These questions can be answered only if we have a clear notion of interference. First, I examine one initially plausible account which takes it to be a kind of cause. One interferes with a species or ecosystem when one alters or redirects it. Second, I answer a crucial question that must be faced with regard to any theory that takes interference to be a kind of cause. If interference involves nothing more than having an effect on an ecosystem, then the activities of practically every species in an ecosystem interfere with it. However, these activities are usually thought of as legitimate or normal ecosystemic change, as essential components of the ecosystem, rather than as interference.Thus, some criterion must be proposed to distinguish between interference and the actions of other species which have an effect on an ecosystem but do not interfere with it. I look at a number of proposals and conclude that no one of them is uniquely correct. Rather, the criterion one employs to understand interference must be determined by one’s projects and goals. (shrink)

Since causal processes can be prevented and interfered with, law-governed causation is a challenge for necessitarian theories of laws of nature. To show that there is a problematic friction between necessity and interference, I focus on David Armstrong's theory; with one proviso, his lawmaker, nomological necessity, is supposed to be instantiated as the causation of the law's second relatum whenever its first relatum is instantiated. His proviso is supposed to handle interference cases, but fails to do so. In (...) order to be able to handle interferences, any theory which utilizes a kind of necessitation as lawmaker has to downgrade what it treats as necessity to something more akin to (Newtonian) forces. (shrink)

It has become apparent that difficulties to replicate telomeres concern not only the very ends of eukaryotic chromosomes. The challenges already start when the replication fork enters the telomeric repeats. The obstacles encountered consist mainly of noncanonical nucleic acid structures that interfere with replication if not resolved. Replication stress at telomeres promotes the formation of so‐called fragile telomeres displaying an abnormal appearance in metaphase chromosomes though their exact molecular nature remains to be elucidated. A substantial number of factors is required (...) to counteract fragility. In this review we promote the hypothesis that telomere fragility is not caused directly by an initial insult during replication but it results as a secondary consequence of DNA repair of damaged replication forks by the homologous DNA recombination machinery. Incomplete DNA synthesis at repair sites or partial chromatin condensation may become apparent as telomere fragility. Fragility and DNA repair during telomere replication emerges as a common phenomenon which exacerbates in multiple disease conditions. (shrink)

Immigration is often associated with a situation in which would-be migrants and their countries of origin are put at the mercy of others’ decisions. The main objective of this article is to theorize this ‘being at the mercy’ in light of a republican definition of what freedom is about: the absence of domination. Immigration policy represents instances of domination on a wide spectrum of individuals and political communities. This article focuses on the procedural discretion claimed by states of destination in (...) their relations with would-be migrants. On the basis of a definition of the concept of ‘jurisdiction’, the article distinguishes 4 paradigmatic situations of immigration, which all display situations of domination. In each situation, the state of destination arbitrarily interferes with important interests of individuals and political communities. In light of this argument, existing mechanisms in national, transnational and international settings can be identified and justified as anti-domination measures. The argument offers a blueprint on how to further develop them in preventing domination in immigration. (shrink)

Immigration is often associated with a situation in which would-be migrants and their countries of origin are put at the mercy of others’ decisions. The main objective of this article is to theorize this ‘being at the mercy’ in light of a republican definition of what freedom is about: the absence of domination. Immigration policy represents instances of domination on a wide spectrum of individuals and political communities. This article focuses on the procedural discretion claimed by states of destination in (...) their relations with would-be migrants. On the basis of a definition of the concept of ‘jurisdiction’, the article distinguishes 4 paradigmatic situations of immigration, which all display situations of domination. In each situation, the state of destination arbitrarily interferes with important interests of individuals and political communities. In light of this argument, existing mechanisms in national, transnational and international settings can be identified and justified as anti-domination measures. The argument offers a blueprint on how to further develop them in preventing domination in immigration. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy, Psychiatry, & Psychology 9.3 (2002) 265-269 [Access article in PDF] The Psychology and Physiology of Depression Walter Glannon Trauma and stressful events can disrupt the physiologic homeostasis of our bodies and brains. The physiologic stress response consists of neural and endocrine mechanisms whose function is to reestablish homeostasis. These mechanisms include the secretion of glucocorticoids (cortisol) and catecholemines (epinephrine and norepinephrine). Once an external event has ceased to (...) be a stressor or threat to a human organism, an integrated system of negative feedback loops inhibits the continued production of these hormones and effectively shuts down the stress response. These mechanisms are adaptive in the sense that they ensure the survival of the organism by reestablishing homeostasis. But prolonged exposure to real or perceived stressors can trigger prolonged secretion of stress hormones, thereby disrupting the feedback systems and causing a cascade of pathogenic events. The stress response is a double-edged sword. An acute stress response can protect an organism from external threats and reestablish homeostasis. But a chronic stress response can cause the body's defenses to become damaging rather than protective and to result in various disorders. Acute stress responses are adaptive. Chronic stress responses are often maladaptive and pathogenic.In "Depression as a Mind-Body Problem," I characterized major clinical depression as a disorder resulting from a maladaptive chronic stress response (Glannon 2003). Specifically, I argued that depression often results when our beliefs and emotions are out of proportion to the true nature of external events. The mind prolongs rather than constrains the physiologic stress response. Depression is not a disorder of the brain alone or the mind alone, however. Endocrine and immune dysfunction can contribute to the dysfunction in the brain and central nervous system that are involved in depression. Moreover, the contents of the mental states that initiate the sequence of events leading to depression are reflections of the person's natural and social environment. Thus, a satisfactory account of depression requires an analysis of the interconnections among the central nervous, endocrine, and immune systems, as well as the mind and the environment. All of these factors support the description of depression as a psychoneuroimmunologic disorder.Mike Martin (Martin 2003) and Thomas Fuchs (Fuchs 2003) discuss important aspects of depression that I did not elaborate in my paper. Martin argues that I fail to distinguish between depression as a mood and depression as a disorder. This is pertinent to the distinction evolutionary psychiatrists draw between moods that are adaptive and moods that are maladaptive. In contrast to my negative characterization of depression, Martin also makes a case for the positive [End Page 265] contributions of depression to meaningful life. Fuchs explores the notion of the brain as an organ of translation enabling patients to have meaningful subjective experience. The emphasis on subjectivity has important implications for potential preventive and therapeutic interventions for depression. For whether a person perceives an external event as a stressor may play a crucial role in the physiologic stress response. I will address the main points of these two authors in turn.Contrary to what Martin claims, I explicitly defined chronic depression as an affective (mood) disorder. My focus was on the clinical definition of major depression as a moderately severe to severe chronic disorder. It consists of affective, cognitive, and even physical dysfunction that interferes with a person's ability to carry out the normal tasks of daily life. This characterization of major chronic depression distinguishes it from milder forms of depression, such as dysthymia. Because these milder forms do not involve the same type or degree of dysfunction as more severe forms, they are not appropriately characterized as pathologies. For this reason, I focused on Nesse's (2000) discussion of depression rather than on his discussion of low mood. In fairness to Nesse and Stevens and Price (2000), not all forms of depression are pathologic according to the evolutionary view they defend. Some passive aspects of mild depression may be useful in alerting us to dangerous or wasteful behavior. It does seem plausible to describe depressed moods as falling along a continuum from those that... (shrink)

Various aspects of prepositions translation have been primarily investigated in the framework of translation theory. Applied research is mostly focused on translating particular groups of prepositions against the background of plain language. Legal translation researchers have not yet comprehensively analysed peculiarities of translating Russian prepositions used in legal texts into English. The paper is an attempt to investigate the difficulties which Russian learners can encounter when translating prepositions from Russian commercial contracts into English. Methods employed include language typology comparison, continuous (...) sampling technique, language corpus data analysis as applied to language error forecast and prevention. The material selected for analysis – Russian commercial contracts – is chosen in accordance with the principles of professionalism, globalization, specialisation as well as graduates’ employment opportunities. The author develops a classification of prepositions drawing upon their structural, grammar and semantic functions in the texts of Russian commercial contracts. The findings reveal negative interference zones that can potentially cause preposition errors. Feasibility of the forecast is confirmed by the analysis of real learners’ errors. The research concludes that modelling legal translation teaching which takes into account potential interference zones for students can contribute to shifting focus to problem zones while teaching, raising students’ awareness, and therefore acting as propedeutics of the corresponding errors. (shrink)

Transplantation programs commonly rely on clinicians’ judgments about patients’ social support (care from friends or family) when deciding whether to list them for organ transplantation. We examine whether using social support to make listing decisions for adults seeking transplantation is morally legitimate, drawing on recent data about the evidence-base, implementation, and potential impacts of the criterion on underserved and diverse populations. We demonstrate that the rationale for the social support criterion, based in the principle of utility, is undermined by its (...) reliance on tenuous evidence. Moreover, social support requirements may reinforce transplant inequities, interfere in patients’ personal relationships, and contribute to biased and inconsistent listing procedures. As such, accommodating the needs of patients with limited social support would better balance ethical commitments to equity, utility, and respect for persons in transplantation. We suggest steps for researchers, transplantation programs, and policymakers to improve fair use of social support in transplantation. (shrink)

According to Libertarians, the freedom of individuals to make crucial lifeshaping choices is effectively and adequately protected if other individuals and agenciesrefrain from interfering with their freedom and if the state takes steps to ensure that such interference is either prevented or punished. This paper presents a “Liberal” critique of this position, in three stages. First, prevention of interference is only one of several conditions that must be fulfilled if an individual’s lot in life is to be (...) legitimately traceable to his or her choices. Second, the additional conditions resemble prevention of interference in that their fulfillment cannot be secured by the unaided efforts of individuals. Third, these further conditions resemble prevention of interference in that their fulfillment cannot be secured on an equitable basis for all if the state does not assume responsibility for trying to ensure their fulfillment. The argument (of non-anarchist Libertarians) that the state has a role to play in securing the fulfillment of the non-interference condition ought consequently to be extended to support the view that securing the fulfillment of the otherconditions of freedom of choice is also a legitimate function of the state. (shrink)

According to Libertarians, the freedom of individuals to make crucial lifeshaping choices is effectively and adequately protected if other individuals and agenciesrefrain from interfering with their freedom and if the state takes steps to ensure that such interference is either prevented or punished. This paper presents a “Liberal” critique of this position, in three stages. First, prevention of interference is only one of several conditions that must be fulfilled if an individual’s lot in life is to be (...) legitimately traceable to his or her choices. Second, the additional conditions resemble prevention of interference in that their fulfillment cannot be secured by the unaided efforts of individuals. Third, these further conditions resemble prevention of interference in that their fulfillment cannot be secured on an equitable basis for all if the state does not assume responsibility for trying to ensure their fulfillment. The argument that the state has a role to play in securing the fulfillment of the non-interference condition ought consequently to be extended to support the view that securing the fulfillment of the otherconditions of freedom of choice is also a legitimate function of the state. (shrink)

According to Libertarians, the freedom of individuals to make crucial lifeshaping choices is effectively and adequately protected if other individuals and agenciesrefrain from interfering with their freedom and if the state takes steps to ensure that such interference is either prevented or punished. This paper presents a “Liberal” critique of this position, in three stages. First, prevention of interference is only one of several conditions that must be fulfilled if an individual’s lot in life is to be (...) legitimately traceable to his or her choices. Second, the additional conditions resemble prevention of interference in that their fulfillment cannot be secured by the unaided efforts of individuals. Third, these further conditions resemble prevention of interference in that their fulfillment cannot be secured on an equitable basis for all if the state does not assume responsibility for trying to ensure their fulfillment. The argument that the state has a role to play in securing the fulfillment of the non-interference condition ought consequently to be extended to support the view that securing the fulfillment of the otherconditions of freedom of choice is also a legitimate function of the state. (shrink)

In this paper we argue that the responsibility for systematic community-based preventive medicine should not be made part of the role of the general practitioner (GP). Preventive medicine cannot be shown to be more effective than curative or supportive medicine. Therefore, the allocation of the large amount of general practice staff time and resources required for systematic preventive medicine should not come at the expense of the care of the sick and the suffering. The traditional healing role of the GP (...) requires a cooperative patient-centred approach, whereas systematic preventive medicine is driven by rigid pre-set protocols and is intrinsically paternalistic. Trying to merge the two approaches is detrimental to the doctor-patient relationship. Furthermore, a number of potential pitfalls are identified that may be encountered in the implementation of preventive medicine programmes in general practice: interference with the course of the consultation; inadequate explanation and consent; distortion of practice priorities as reflected in quality indicators; temptation to record inaccurate data; conflict of interests where the doctor is rewarded for performance; patient blaming; exacerbation of the health gap. We suggest that a more justifiable strategy would be for GPs to identify patients at high risk and offer them specific preventive advice when the opportunity presents itself and at a time when the patient is likely to be most amenable to cooperate. Opportunistic health promotion offers higher expectations of benefit, as well as a more equitable allocation of the risks associated with preventive medicine, than a systematic community-based approach. (shrink)

Globalization and the Posthuman argues that by globalizing posthumanism through biotechnology, particularly through the invasive interface of humans and machines, we may well interfere with and even undermine the innate quality of human psycho-physiology and the experience of the internal observer, the non-socially constructed self or pure consciousness. Furthermore, many features of globalization in-and-of itselfâ "such as the fall of public man, the exterritorialization of capital, the loss of an impersonal public world to localized communities based on emotively shared interestsâ (...) "combined with the posthuman expansion of biotechnology will diminish our natural capacity to experience the self as knower and lead to an increase in global crime, sickness, accident rates and overall lack of harmony. The experience of the self comprises the unsayable secret of modern and postmodern literature and art, a secret that may soon become inaccessible if the world continues down the road of globalized infomania. The analysis of the consequences of globalization and the posthuman in this book is unique in that it will be the first to examine the interrelation between globalization, posthumanism and pure consciousness. Posthumanists define consciousness in a way that promotes the globalization of biotechnology without regard for its potential risks. This book explores the implications of the globalization of the posthuman model of consciousness. On the one hand, cognitive scientists tend to equate consciousness with subjectivity, which they associate with the thinking mind as an extension of the body, nature and culture; Eastern philosophy, on the other hand, distinguishes mind from consciousness, with mind defined as the content of consciousness. Bionic technology will have the effect of raising human metabolism and preventing the mind from settling down to the state of least excitation of consciousness. This book suggests that while conscious content is an indispensable aspect of both the human and posthuman condition, the thoughts, memories, feelings and perceptions of this content do not encompass a vital aspect of human nature attested to not only by the first-person experience of many millions of people around the world, but also by the records of both classical and modern contemplative traditions. (shrink)

Analysing cylindromatosis and the associated defects in the CYLD gene is providing novel insights into the molecular principles of epithelial growth control and carcinogenesis in, and beyond, the skin. In this review, we summarize the histopathology and histogenesis of cylindromas, and the available genetic information on patients with these skin appendage tumors. Focusing on recent data concerning the normal functions and signaling interactions of the CYLD gene product, we explain how CYLD interferes with TNF‐α or TLR‐mediated signaling as well as (...) with JNK or NF‐κB‐dependent p65/50 signaling to limit inflammation. In addition, we delineate how CYLD interferes with activation of the proto‐oncogene Bcl3 and with cyclin D1 expression to limit tumorigenesis, and chart how tumor growth‐promoting agents or UV light and inflammatory mediators can activate CYLD. We argue that these recent insights into CYLD function and cylindroma pathogenesis may lead to the development of novel molecular strategies for cancer prevention and treatment. BioEssays 29:1203–1214, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

In German-speaking countries, there have been concerted and successful attempts to prevent any discussion of euthanasia from taking place. Both the present writers have been invited to give lectures on this topic, and had these lectures cancelled at short notice because of this opposition. Against that background, we welcome Pauer-Studer’s airing of these issues, and her clear statement that attempts to prevent advocates of euthanasia from speaking are “definitely unacceptable.” Nevertheless, we find much that Pauer-Studer says to be in error.

It is commonplace among friends of irreducible causal powers to depict powers as producing their characteristic manifestations as a matter of metaphysical necessity. That is to say that when a power finds itself in those circumstances that stimulate it, it cannot help but be exercised: its effects must occur. The result is a metaphysic that depicts the world not as loose and separate but as united by the strongest glue; this is but one way in which the world as understood (...) by friends of powers differs from that of their Humean adversaries. However, this typical understanding of powers has recently come under attack. Schrenk and Mumford and Anjum have independently argued that metaphysical necessity is not up to the task of connecting a stimulated power with its manifestation. Employing the same devices friends of powers use in rejecting attempts to analyze power ascriptions in terms of counterfactual conditionals, Schrenk and Mumford and Anjum argue that any process a power elicits could be frustrated by way of interference or prevention, and thereby blocked. For example, striking a dry match against a rough surface will generally lead to its lighting, but as anyone who has attempted to do this can attest, a strong gust of wind can prevent the match from lighting, despite the striking having taken place. Hence, even in the presence of its stimulus, the power's manifestation is not ensured, and so the claim that powers necessarily bring about their manifestations is undermined. (shrink)

The Simple Counterfactual Analysis (SCA) was once considered the most promising analysis of disposition ascriptions. According to SCA, disposition ascriptions are to be analyzed in terms of counterfactual conditionals. In the last few decades, however, SCA has become the target of a battery of counterexamples. In all counterexamples, something seems to be interfering with a certain object’s having or not having a certain disposition thus making the truth-values of the disposition ascription and of its associated counterfactual come apart. Intuitively, however, (...) it would seem that, if all interferences were absent, the disposition ascription and its associated conditional would have the same truth-value. Although this idea may seem obvious, it is far from obvious how to implement it. In fact, it has become widely assumed that the content of qualifying ceteris paribus clauses (such as ‘if all interferences were absent’) cannot be specified in a clear and non-circular manner. In this paper, I will argue that this assumption is wrong. I will develop an analysis of disposition ascriptions, the Interference-Free Counterfactual Analysis, which relies on a clear and non-circular definition of the notion of interference and avoids the standard counterexamples to SCA while vindicating the intuition that disposition ascriptions and counterfactual conditionals are intimately related. (Please note that an erratum has been issued for the published version of this paper. It is recommended to read the self-archived version of the paper.). (shrink)

Sometimes it is not us but those to whom we stand in special relations that face transformative choices: our friends, family or beloved. A focus upon first-personal rational choice and agency has left crucial ethical questions regarding what we owe to those who face transformative choices largely unexplored. In this paper I ask: under what conditions, if any, is it morally permissible to interfere to try to prevent another from making a transformative choice? Some seemingly plausible answers to this question (...) fail precisely because they concern transformative experiences. I argue that we have a distinctive moral right to revelatory autonomy grounded in the value of autonomous self-making. If this right is outweighed then, I argue, interfering to prevent another making a transformative choice is permissible. This conditional answer lays the groundwork for a promising ethics of transformative experience. (shrink)

In this thesis I investigate the question of whether or not dispositional properties are able to necessitate their manifestations. I provide three main discussions that reflect three aspects of my question. The first and second discussions concern different aspects of the 'problem of prevention'. This is the premise that causal interactions can be subject to interference/prevention, generally construed. A number of philosophers have argued that the problem of prevention undercuts the necessitation of lawful regularities in the (...) context of dispositional essentialism. We can term this issue the 'necessitation issue'. In the first discussion I examine whether or not antidotes qua preventative entities are metaphysically possible within the context of Alexander Bird's dispositional monism. I argue that Bird's theory raises a problem of ontological representation re antidotes. The line of thought in this discussion is that it is difficult for Bird to say what antidotes are and how they operate; nevertheless, in this discussion I provide a solution to my problem that stays within the confines of Bird's dispositional monism. In this section of the thesis I remain neutral on the necessitation issue, but I take myself to clarify the question of whether or not dispositional properties are able to necessitate their manifestations by criticising Bird's model of antidotes/prevention and setting out a replacement. In the second discussion I examine Stephen Mumford and Rani Lill Anjum's anti-necessitarian strategies. Mumford and Anjum's 'causal dispositionalism' encompasses a theory of dispositional properties, antidotes, and prevention. Mumford and Anjum's causal dispositionalism is not subject to the problem of ontological representation that Bird's theory raises; nevertheless, I argue that their theory is multiply problematic. The purpose of this discussion, taken as a whole, is to show that a recent strategy for attacking the necessitarian claim of dispositional essentialism is weaker than it has appeared to a number of philosophers. In this section of the thesis I move from a neutral stance on necessitation to a defensive stance. In the first two stages of the thesis, which concern the problem of prevention, I work with the background assumption that dispositional essentialism is a tenable position. In the third section of this thesis, however, I begin by endorsing Stephen Barker's essay The Emperor's New Metaphysics of Powers, which argues that the main articulations of dispositional essentialism are either internally inconsistent or otherwise disguised versions of brute modalism, where brute modalism focuses upon possible worlds as oppose to properties. In response, I develop a replacement position for dispositional essentialism that I term 'temporal essentialism'. I advance temporal essentialism as a prototype position in the properties and laws debate. It aims to provide a metaphysical explanation for lawful regularities by drawing upon the passage of time. In short, temporal essentialism is the position that it is built into a system of ontology that it dynamically adds new entities to its ontological categories and constructs states of affairs in a rule-following way. (shrink)

The Term ‘liberty’ invokes such universal respect that most modern political economists and moralists endeavour to find a conspicuous place for it somewhere in their systems or prescriptions. But in view of the innumerable senses of this term an insistence on some kind of definition prior to any discussion seems to be justified. For our present purposes attention to two particularly conflicting interpretations will be sufficient. These are sometimes called the ‘negative’ and the ‘positive’ notions of Liberty. According to the (...) ‘negative’ notion, my own liberty implies the reduction to a minimum of the deliberate interference of other human beings within the area in which I wish to act. Conversely the absence of liberty, or coercion, is regarded as undesirable because it amounts to the prevention by other persons of my doing what I want. On the other hand, the ‘positive’ sense of the word ‘liberty’ consists in the attainment of self-mastery, or, in other words, the release from the domination of ‘adverse’ influences. This ‘slavery’ from which men ‘liberate’ themselves is variously described to include slavery to ‘nature’, to ‘unbridled passions’, to ‘irrational impulses’, or simply slavery to one's ‘lower nature’. ‘Positive’ liberty is then identified with ‘self-realisation’ or an awakening into a conscious state of rationality. The fact that it is contended that such a state can often be attained only by the interference of other ‘rational’ persons who ‘liberate’ their fellow beings from their ‘irrationality’, brings this interpretation of liberty into open and striking conflict with liberty in the ‘negative’ sense. (shrink)

Sometimes it is not us but those to whom we stand in special relations that face transformative choices: our friends, family, or beloved. A focus upon first-personal rational choice and agency has left crucial ethical questions regarding what we owe to those who face transformative choices largely unexplored. In this paper, I ask: under what conditions, if any, is it morally permissible to interfere with to try to prevent another from making a transformative choice? Some seemingly plausible answers to this (...) question fail precisely because they concern transformative experiences. I argue that we have a distinctive moral right to revelatory autonomy grounded in the value of autonomous self-making. If this right is outweighed then, I argue, interfering to prevent another making a transformative choice is permissible. This conditional answer lays the groundwork for a promising ethics of transformative experience. (shrink)

Does A cause B simply if A prevents what would have prevented B? Such a case is known as double prevention: where we have the prevention of a prevention. One theory of causation is that A causes B when B counterfactually depends on A and, as there is such a dependence, proponents of the view must rule that double prevention is causation.<br><br>However, if double prevention is causation, it means that causation can be an extrinsic matter, (...) that the cause and effect need not be connected by a continuous chain of events, that there can be causation by absence, and that there can be causation at a distance. All of these implications jar with strong intuitions we have about the nature of causation. There is, on the other hand, a theory of causation based on an ontology of real dispositions, where causation involves the passing around of powers. This theory in contrast entails that double prevention is not causation and, on this issue, it can claim a victory over the counterfactual dependence account. (shrink)

In many or most instances of paternalism, more than one person acts paternalistically, or more than one person is treated paternalistically. This chapter discusses some complications that arise in such group cases, which are largely ignored in the conceptual debate. First, a group of people who together perform an action may do so for different reasons, which makes it more challenging to determine whether the action is paternalistic. This gives us some reason not to pin the property of being paternalistic (...) on actions, since we may alternatively pin it on reasons for actions and allow that these differ between members in the group. Second, the prevention of harmful consensual interactions is sometimes paternalism towards both or all involved, but only if all benefit from interference with themselves rather than with other members in the group, or if all want the harm or risk (more or less) for its own sake. Third, interrelations between three components of paternalism - interference, benevolence and consent - gives us reason to allow that an action can be paternalistic towards some but not others of those affected. This makes it even more difficult, and less relevant, to determine whether or not actions are paternalistic. (shrink)

The “therapeutic misconception” describes a process whereby research volunteers misinterpret the intentions of researchers and the nature of clinical research. This misinterpretation leads research volunteers to falsely attribute a therapeutic potential to clinical research, and compromises informed decision making, therefore compromising the ethical integrity of a clinical experiment. We review recent evidence from the neurobiology of social cognition to provide a novel framework for thinking about the therapeutic misconception. We argue that the neurobiology of social cognition should be considered in (...) any ethical analysis of how people make decisions about participating in clinical trials. The neurobiology of social cognition also suggests how the complicated dynamics of the doctor-patient relationship may unavoidably interfere with the process of obtaining informed consent. Following this argument we suggest new ways to prevent or at least mitigate the therapeutic misconception. (shrink)

Despite the widespread use of the notion of moral intuition, its psychological features remain a matter of debate and it is unclear why the capacity to experience moral intuitions evolved in humans. We first survey standard accounts of moral intuition, pointing out their interesting and problematic aspects. Drawing lessons from this analysis, we propose a novel account of moral intuitions which captures their phenomenological, mechanistic, and evolutionary features. Moral intuitions are composed of two elements: an evaluative mental state and a (...) feeling of rightness (FOR). We illustrate the phenomenology of the FOR with examples of non-moral and moral cases, and provide a biological and mechanistic account: the emergence of human reasoning capacities created a need for the co-evolution of a psychological system producing the feeling of rightness (the FORs). This system is triggered when we experience conflicting evaluations. The FORs renders evaluations resulting from rational deliberation less compelling than the evaluations produced by simple evolved systems. It thus facilitates optimal decision-making, preventing excessive interference by rational deliberation. Our account sheds light on why moral intuitions are so frequently experienced and why they are so compelling and resistant to argument. In addition, the account fuels interesting speculations about common metaethical intuitions. (shrink)

J s mill's principle of liberty is often thought to say that the only good reason for interfering with a person's conduct is that it is harmful to others. An alternative interpretation is defended: that the only good reason for interfering is to prevent harm to others. Harm-Prevention is the aim, But the latter principle allows that conduct affected not be harmful; interference must be calculated to prevent harm to others, Perhaps indirectly. This accords with mill's official statement (...) of his principle, Accommodates his own otherwise troublesome examples of cooperation and good samaritan requirements, And fits as well with the texts. (shrink)

Defends Kantian paternalism: Interference with an individual’s liberty for her own sake is justified absent her actual consent only to the extent that such interference stands a reasonable chance of preventing her from exercising her liberty irrationally in light of the rationally chosen ends that constitute her conception of the good. More specifically, interference with an individual’s liberty is permissible only if, by interfering, we stand a reasonable chance of preventing that agent from performing actions she chose (...) due to distorted reasoning and which would result in that agent’s rationally chosen ends not being as fully realized as they would have been had she so acted. -/- Applied to suicide intervention Kantian paternalism implies that such intervention is justified to the extent that it prevents a person from ending her life when, due to distorted reasoning, she engages in suicidal behavior that is at odds with her rationally chosen ends. (shrink)

This paper introduced the letter insertion and letter deletion tasks. In these tasks participants are presented with letter strings and are instructed to insert or delete a letter to create a word. Experiment 1 demonstrated facilitation priming and established these tasks as sensitive indirect measures of memory. Experiments 2 and 3 demonstrated interference priming effects. In Experiment 4 the process dissociation paradigm was applied to investigate the contributions of automatic and consciously controlled processes to performance on the letter insertion (...) task. In addition, performance in the exclusion condition demonstrated an interference effect caused by automatic retrieval. Potential applications for the letter insertion and letter deletion tasks are discussed. (shrink)

Pettit endorses a ‘republican’ conception of social freedom of the person as consisting of a state of non-domination, and takes this to refute Mill’s ‘liberal’ claim that non-domineering but coercive interference can compromise social freedom of choice. This paper argues that Pettit’s interpretation is true to the extent that Mill believes that the legitimate, non-arbitrary and just coercion of would-be dominators, for the sake of preventing them from dominating others, can render them unfree to choose to do so without (...) rendering them socially unfree (qua dominated) persons in their own right. However, contra Pettit, Mill is correct to reject the ‘republican’ view for at least two reasons. Firstly, it enables him to avoid commitment to the implausible implication that would-be dominators who sincerely deny any interest in a shared system of basic liberties are automatically rendered unfree persons by the coercion necessary to uphold such a system. Secondly, it enables him to avoid begging the question against ‘immoralists’ like Nietzsche, whose opposition to systems of reciprocal non-domination is at least partly motivated by the losses of social freedom of choice they entail for those they deem to be worthy of dominating others. (shrink)

In these twelve papers notable ethicists use the resources of ethical theory to illuminate important theoretical and practical topics, including the nature of public health, notions of community, population bioethics, the legitimate role of law, the use of cost-effectiveness as a methodology, vaccinations, and the nature of infectious disease.

Several arguments suggest that motor planning may share embodied neural mechanisms with mental rotation (MR). However, it is not well established whether this overlap occurs regardless of the type of stimulus that is manipulated, in particular manipulable or non-manipulable objects and body parts. We here used high-density electroencephalography (EEG) to examine the cognitive similarity between MR of objects that do not afford specific hand actions (chairs) and bodily stimuli (hands). Participants had identical response options for both types of stimuli, and (...) they gave responses orally in order to prevent possible interference with motor imagery. MR of hands and chairs generated very similar behavioral responses, time-courses and neural sources of evoked-response potentials (ERPs). ERP segmentation analysis revealed distinct time windows during which differential effects of stimulus type and angular disparity were observed. An early period (90–160 ms) differentiated only between stimulus types, and was associated with occipito-temporal activity. A later period (290–330 ms) revealed strong effects of angular disparity, associated with electrical sources in the right angular gyrus and primary motor/somatosensory cortex. These data suggest that spatial transformation processes and motor planning are recruited simultaneously, supporting the involvement of motor emulation processes in MR. (shrink)

The adoption and reporting of CSR policies have important ethical and managerial implications that need scrutiny. This study answers the call of CSR scholars for further studies in controversial sectors by focusing on the voluntary reporting practices of companies that market products or services that generate addiction among consumers. It contributes to the debate on organizational legitimacy and corporate reporting by empirically analyzing whether and how corporations in the tobacco, alcohol and gambling industries disclose their CSR actions and what reactions (...) such disclosures generate in stakeholders. Drawing on legitimacy theory and organizational façades, we apply a consequent mixed-methods design (initiation approach) built on (i) a content analysis of reports prepared by a large set of companies listed on the European, British, US, Canadian, Australian and New Zealand stock exchanges and (ii) an experiment on how different actions taken by the companies (preventive vs. remedial) elicit different perceptions of company hypocrisy and action effectiveness. While previous analyses have focused on “sin” or “harm” industries, this is one of the first to assess how companies account for “addiction”, which is more difficult for them to report and legitimate due to long-term negative consequences. This study contributes to the literature on the instrumental use of CSR reporting by empirically investigating how addiction companies shape their organizational façades and manage organizational legitimacy through disclosure. Moreover, the experimental evidence advances the knowledge of how cognitive mechanisms influence stakeholders in terms of legitimacy assessment and the perceived hypocrisy/effectiveness of CSR disclosure. (shrink)

The ideal scalar Aharonov–Bohm (SAB) and Aharonov–Casher (AC) effect involve a magnetic dipole pointing in a certain fixed direction: along a purely time dependent magnetic field in the SAB case and perpendicular to a planar static electric field in the AC case. We extend these effects to arbitrary direction of the magnetic dipole. The precise conditions for having nondispersive precession and interference effects in these generalized set ups are delineated both classically and quantally. Under these conditions the dipole is (...) affected by a nonvanishing torque that causes pure precession around the directions defined by the ideal set ups. It is shown that the precession angles are in the quantal case linearly related to the ideal phase differences, and that the nonideal phase differences are nonlinearly related to the ideal phase differences. It is argued that the latter nonlinearity is due to the appearance of a geometric phase associated with the nontrivial spin path. It is further demonstrated that the spatial force vanishes in all cases except in the classical treatment of the nonideal AC set up, where the occurring force has to be compensated by the experimental arrangement. Finally, for a closed space-time loop the local precession effects can be inferred from the interference pattern characterized by the nonideal phase differences and the visibilities. It is argued that this makes it natural to regard SAB and AC as essentially local and nontopological effects. (shrink)

Adaptive preferences give rise to puzzles in ethics, political philosophy, decision theory, and the theory of action. Like our other preferences, adaptive preferences lead us to make choices, take action, and give consent. In 'False Consciousness for Liberals', recently published in The Philosophical Review, David Enoch (2020) proposes a criterion by which to identify when these choices, actions, and acts of consent are less than fully autonomous; that is, when they suffer from what Natalie Stoljar (2014) calls an 'autonomy deficit'. (...) According to Enoch, such actions are not protected in the usual way against interference by others; there is not the same prohibition against trying to prevent someone from acting in a particular way when that action is motivated by such adaptive preferences and is an attempt to satisfy them. In this note, I raise two concerns about Enoch's criterion. (shrink)

The Bush doctrine of preventive and pre-emptive strikes triggered a debate in academic and governmental circles about the possible legitimization of those concepts in international politics and possibly international law. This essay gives an overview of the practice of preventive and pre-emptive strikes, both before and after the Cold War. Further, it sketches the above-mentioned debate and the underlying trends explaining it. Finally, it assesses the new doctrine in light of a possible future incorporation of the concepts of preventive and (...) pre-emptive strikes into international law. A distinction will be made between three kind of preventive strikes: counter-terrorist, counter-proliferation, and preventing humanitarian disasters. (shrink)