The tale of Gyges' ring narrated by Cicero atDe officiis3.38 is of course originally found, and acknowledged as such by Cicero, in Plato (Resp.359c–360b). I would like in this paper to address two questions about Cicero's handling of the tale – one historical, one philosophical. The purpose of the historical question is to evaluate, with respect to the Gyges narration, Cicero's quality as a reader of Plato. How well does Cicero understand the role of the story in its original Platonic (...) context? The motivation for the question is that, at first blush, Cicero seems to have badly misunderstood it. I shall argue that the appearance is illusory, and that Cicero understands the tale's Platonic provenance perfectly well. Now it should be noted that the question of Cicero's grasp of the tale's purpose in Plato is distinct from the question whether Cicero himself puts the story to the same or a different use than Plato did. I shall suggest that while there are striking points of contact between the two treatments, on one crucial feature – namely the tale's ostentatiously far-fetched nature – Cicero is instructively more explicit than Plato. (shrink)

Ao introduzir o estudo da substância em Metafísica Z1, Aristóteles apresenta um argumento cujo ponto inicial corresponde a uma questão acerca do estatuto ontológico de certos itens não-substanciais. Normalmente, entende-se que o objetivo desse argumento é estabelecer a compreensão da substância como ser primeiro. Pretende-se, aqui, propor uma interpretação alternativa para tal argumento. A questão acerca do estatuto ontológico de certos itens não-substanciais não teria o papel de estabelecer a compreensão da substância como ser primeiro, mas dirigir a investigação para (...) a razão pela qual a substância é tomada como ser primeiro. (shrink)

No início de Ética Eudêmia I 5, Aristóteles pretende mostrar que a questão “o que é a felicidade?” não é tão facilmente respondida como se crê usualmente. O modo como ele procura fazê-lo, no entanto, é intrigante, uma vez que ele recorre ao exame de diferentes situações nas quais não viver seria mais vantajoso do que viver. Não é claro como ele espera que estejam relacionadas entre si as diferentes situações que levam a essa conclusão nem como ele pretende que (...) essa linha de argumentação esclareça a dificuldade que é normalmente ignorada com relação à questão “o que é a felicidade?”. Neste artigo, discutimos esses pontos com o objetivo de determinar a contribuição da porção inicial de EE I 5 para a investigação eudêmia da felicidade. (shrink)

In recent years, the scientific study of meditation and psychedelic drugs has seen remarkable developments. The increased focus on meditation in cognitive neuroscience has led to a cross-cultural classification of standard meditation styles validated by functional and structural neuroanatomical data. Meanwhile, the renaissance of psychedelic research has shed light on the neurophysiology of altered states of consciousness induced by classical psychedelics, such as psilocybin and LSD, whose effects are mainly mediated by agonism of serotonin receptors. Few attempts have been made (...) at bridging these two domains of inquiry, despite intriguing evidence of overlap between the phenomenology and neurophysiology of meditation practice and psychedelic states. In particular, many contemplative traditions explicitly aim at dissolving the sense of self by eliciting altered states of consciousness through meditation, while classical psychedelics are known to produce significant disruptions of self-consciousness, a phenomenon known as drug-induced ego dissolution. In this article, we discuss available evidence regarding convergences and differences between phenomenological and neurophysiological data on meditation practice and psychedelic drug-induced states, with a particular emphasis on alterations of self-experience. While both meditation and psychedelics may disrupt self-consciousness and underlying neural processes, we emphasize that neither meditation nor psychedelic states can be conceived as simple, uniform categories. Moreover, we suggest that there are important phenomenological differences even between conscious states described as experiences of self-loss. As a result, we propose that self-consciousness may be best construed as a multidimensional construct, and that “self-loss,” far from being an unequivocal phenomenon, can take several forms. Indeed, various aspects of self-consciousness, including narrative aspects linked to autobiographical memory, self-related thoughts and mental time travel, and embodied aspects rooted in multisensory processes, may be differently affected by psychedelics and meditation practices. Finally, we consider long-term outcomes of experiences of self-loss induced by meditation and psychedelics on individual traits and prosocial behavior. We call for caution regarding the problematic conflation of temporary states of self-loss with “selflessness” as a behavioral or social trait, although there is preliminary evidence that correlations between short-term experiences of self-loss and long-term trait alterations may exist. (shrink)

In recent decades, societal perceptions about sexuality have undergone immense changes, which in turn led to substantial reform of states’ criminal regulation of sexual misconduct. Traditional Angl...

Cet article propose de retracer dans l’œuvre de Foucault la présence d’un engagement critique discret mais continu avec la catégorie aristotélicienne de la phronesis. Au cours des années 1970, Foucault consacre ses recherches à de nombreuses instances de la techné, savoir pratique proche mais distinct de la phronesis. S’il ne mentionne pratiquement pas cette dernière, nous montrerons cependant que ce non-dit est tout sauf un impensé. C’est par un travail de et sur la phronesis que Foucault pensera la complexité des (...) savoirs pratiques et négociera la distinction entre sa propre méthode, dite « généalogique », et les méthodes qu’il prend pour objet. Nous verrons que cette distinction s’articule autour d’un second doublet, celui du cas et de la singularité – une distinction qui prend tout son sens lorsqu’elle est passée au crible de la triade aristotélicienne du savoir : épistémè, techné et phronesis. Nous verrons que la notion foucaldienne de singularité, loin d’être identique au cas particulier, en constitue plutôt le principe de différence interne. En substituant une herméneutique de la singularité à une herméneutique du particulier, Foucault s’autorise à penser une phronesis renouvelée pour les temps présents. (shrink)

There is converging evidence that high doses of hallucinogenic drugs can produce significant alterations of self-experience, described as the dissolution of the sense of self and the loss of boundaries between self and world. This article discusses the relevance of this phenomenon, known as “drug-induced ego dissolution (DIED)”, for cognitive neuroscience, psychology and philosophy of mind. Data from self-report questionnaires suggest that three neuropharmacological classes of drugs can induce ego dissolution: classical psychedelics, dissociative anesthetics and agonists of the kappa opioid (...) receptor (KOR). While these substances act on different neurotransmitter receptors, they all produce strong subjective effects that can be compared to the symptoms of acute psychosis, including ego dissolution. It has been suggested that neuroimaging of DIED can indirectly shed light on the neural correlates of the self. While this line of inquiry is promising, its results must be interpreted with caution. First, neural correlates of ego dissolution might reveal the necessary neurophysiological conditions for the maintenance of the sense of self, but it is more doubtful that this method can reveal its minimally sufficient conditions. Second, it is necessary to define the relevant notion of self at play in the phenomenon of DIED. This article suggests that DIED consists in the disruption of subpersonal processes underlying the “minimal” or “embodied” self, i.e., the basic experience of being a self rooted in multimodal integration of self-related stimuli. This hypothesis is consistent with Bayesian models of phenomenal selfhood, according to which the subjective structure of conscious experience ultimately results from the optimization of predictions in perception and action. Finally, it is argued that DIED is also of particular interest for philosophy of mind. On the one hand, it challenges theories according to which consciousness always involves self-awareness. On the other hand, it suggests that ordinary conscious experience might involve a minimal kind of self-awareness rooted in multisensory processing, which is what appears to fade away during DIED. (shrink)

Many authors argue that conscious experience involves a sense of self or self-consciousness. According to the strongest version of this claim, there can be no selfless states of consciousness, namely states of consciousness that lack self-consciousness altogether. Disagreements about this claim are likely to remain merely verbal as long as the target notion of self-consciousness is not adequately specified. After distinguishing six notions of self-consciousness commonly discussed in the literature, I argue that none of the corresponding features is necessary for (...) consciousness, because there are states of consciousness in which each of them is plausibly missing. Such states can be said to be at least partially selfless, since they lack at least one of the ways in which one could be self-conscious. Furthermore, I argue that there is also preliminary empirical evidence that some states of consciousness lack all of these six putative forms of self-consciousness. Such states might be totally selfless, insofar as they lack all the ways in which one could be self-conscious. I conclude by addressing four objections to the possibility and reportability of totally selfless states of consciousness. (shrink)

Many authors claim that being conscious constitutively involves being self-conscious, or conscious of oneself. This claim appears to be threatened by reports of `selfless' episodes, or conscious episodes lacking self-consciousness, recently described in a number of pathological and nonpathological conditions. However, the credibility of these reports has in turn been challenged on the following grounds: remembering and reporting a past conscious episode as an episode that one went through is only possible if one was conscious of oneself while undergoing it. (...) Call this the Memory Challenge. This paper argues that the Memory Challenge fails to undermine the credibility to reports of selfless episodes, because it rests on problematic assumptions about episodic memory. The paper further argues that we should distinguish between several kinds of self-representation that may be involved in the process of episodic remembering, and that once we do so, it is no longer mysterious how one could accurately remember and report a selfless episode as an episode that one went through. Thus, we should take reports of this kind seriously, and view them as credible counter-examples to the claim that consciousness constitutively involves self-consciousness. (shrink)

The influence of eastern thought on the culture of the United States and Western Europe is now seen in the spread of Buddhism, meditation, martial arts, yoga, oriental art, and hundreds of other Asian imports. Written during World War II, this classic work correctly anticipated the clash of eastern and western ideologies which has dominated the post-war landscape.

This special issue is about something most of us might find very hard to conceive: states of consciousness in which self-consciousness is radically disrupted or altogether missing.

This volume collects reflections on the role of philosophy in case studies in the history of science. Case studies have played a prominent role in recent history and philosophy of science. They have been used to illustrate, question, explore, or explicate philosophical points of view. Even if not explicitly so, historical narratives are always guided by philosophical background assumptions. But what happens if different philosophies lead to different narratives of the same historical episodes? Can historical case studies decide between competing (...) philosophical viewpoints? What are the criteria that a case study has to fulfill in order to be philosophically relevant? Bringing together leading practitioners in the fields of history and philosophy of the physical and the life sciences, this volume addresses this methodological problem and proposes ways of rendering explicit philosophical assumptions of historical work. (shrink)

Kyle Stanford has recently given substance to the problem of unconceived alternatives, which challenges the reliability of inference to the best explanation (IBE) in remote domains of nature. Conjoined with the view that IBE is the central inferential tool at our disposal in investigating these domains, the problem of unconceived alternatives leads to scientific anti-realism. We argue that, at least within the biological community, scientists are now and have long been aware of the dangers of IBE. We re-analyse the nineteenth-century (...) study of inheritance and development (Stanford’s case study) and extend it into the twentieth century, focusing in particular on both classical Mendelian genetics and the studies by Avery et al. on the chemical nature of the hereditary substance. Our extended case studies show the preference of the biological community for a different methodological standard: the vera causa ideal, which requires that purported causes be shown on non-explanatory grounds to exist and be competent to produce their effects. On this basis, we defend a prospective realism about the biological sciences. 1 Introduction2 Stanford on Unconceived Alternatives3 Pangenesis: A Re-analysis4 The Vera Causa Ideal I: Negative Aspect5 Rendering Heredity Accessible6 The Vera Causa Ideal II: Positive Aspect7 Implications for Scientific Realism8 Conclusion. (shrink)

Deep learning algorithms are rapidly changing the way in which audiovisual media can be produced. Synthetic audiovisual media generated with deep learning—often subsumed colloquially under the label “deepfakes”—have a number of impressive characteristics; they are increasingly trivial to produce, and can be indistinguishable from real sounds and images recorded with a sensor. Much attention has been dedicated to ethical concerns raised by this technological development. Here, I focus instead on a set of issues related to the notion of synthetic audiovisual (...) media, its place within a broader taxonomy of audiovisual media, and how deep learning techniques differ from more traditional approaches to media synthesis. After reviewing important etiological features of deep learning pipelines for media manipulation and generation, I argue that “deepfakes” and related synthetic media produced with such pipelines do not merely offer incremental improvements over previous methods, but challenge traditional taxonomical distinctions, and pave the way for genuinely novel kinds of audiovisual media. (shrink)

The claim that consciousness constitutively involves self-consciousness has a long philosophical history, and has received renewed support in recent years. My aim in this paper is to argue that this surprisingly enduring idea is misleading at best, and insufficiently supported at worst. I start by offering an elucidatory account of consciousness, and outlining a number of foundational claims that plausibly follow from it. I subsequently distinguish two notions of self-consciousness: consciousness of oneself and consciousness of one’s experience. While “self-consciousness” is (...) often taken to refer to the former notion, the most common variant of the constitutive claim, on which I focus here, targets the latter. This claim can be further interpreted in two ways: on a deflationary reading, it falls within the scope of foundational claims about consciousness, while on an inflationary reading, it points to determinate aspects of phenomenology that are not acknowledged by the foundational claims as being aspects of all conscious mental states. I argue that the deflationary reading of the constitutive claim is plausible, but should be formulated without using a term as polysemous and suggestive as “self-consciousness”; by contrast, the inflationary reading is not adequately supported, and ultimately rests on contentious intuitions about phenomenology. I conclude that we should abandon the idea that self-consciousness is constitutive of consciousness. (shrink)

According to the "confrontation model," integrated history and philosophy of science operates like an empirical science. It tests philosophical accounts of science against historical case studies much like other sciences test theory against data. However, the confrontation model's critics object that historical facts can neither support generalizations nor genuinely test philosophical theories. Here I argue that most of the model's defects trace to its usual framing in terms of two problematic accounts of empirical inference: the hypothetico-deductive method and enumerative induction. (...) This framing can be taken to suggest an unprofitable one-off confrontation between particular historical facts and general philosophical theories. I outline more recent accounts of empirical inquiry, which describe an iterative back-and-forth movement between concrete empirical exemplars to their abstract descriptions. Reframed along similar lines, the confrontation model continues to offer both conceptual insight and practical guidance for a naturalized philosophy of science. (shrink)

P. M. Asaro: What should We Want from a Robot Ethic? G. Tamburrini: Robot Ethics: A View from the Philosophy of Science B. Becker: Social Robots - Emotional Agents: Some Remarks on Naturalizing Man-machine Interaction E. Datteri, G. Tamburrini: Ethical Reflections on Health Care Robotics P. Lin, G. Bekey, K. Abney: Robots in War: Issues of Risk and Ethics J. Altmann: Preventive Arms Control for Uninhabited Military Vehicles J. Weber: Robotic warfare, Human Rights & The Rhetorics of Ethical Machines T. (...) Nishida: Towards Robots with Good Will R. Capurro: Ethics and Robotics. (shrink)

Cicero's philosophical works introduced Latin audiences to the ideas of the Stoics, Epicureans and other schools and figures of the post-Aristotelian period, thus influencing the transmission of those ideas through later history. While Cicero's value as documentary evidence for the Hellenistic schools is unquestioned, Cicero: The Philosophy of a Roman Sceptic explores his writings as works of philosophy that do more than simply synthesize the thought of others, but instead offer a unique viewpoint of their own. In this volume (...) class='Hi'>Raphael Woolf describes and evaluates Cicero's philosophical achievements, paying particular attention to his relation to those philosophers he draws upon in his works, his Romanizing of Greek philosophy, and his own sceptical and dialectical outlook. The volume aims, using the best tools of philosophical, philological and historical analysis, to do Cicero justice as a distinctive philosophical voice. Situating Cicero's work in its historical and political context, this volume provides a detailed analysis of the thought of one of the finest orators and writers of the Roman period. Written in an accessible and engaging style, Cicero: The Philosophy of a Roman Sceptic is a key resource for those interested in Cicero's role in shaping Classical philosophy. (shrink)

ABSTRACT This study focuses on the notions of ‘ruins’, ‘savage knowledge’, and ‘American race’ in the works of the German naturalist Carl Friedrich Philipp von Martius (1794–1868). A somewhat neglected figure in the history of anthropology and of natural history, Martius was regarded by scholars from Europe and the Americas as a leading figure in botany and ethnology in the nineteenth century. In this article, I discuss how Martius articulated: (1) the notion of American race, that is, a broad characterization (...) of the native peoples of the Americas rooted in a complex natural history which brought together seemingly disparate fields of knowledge, such as medicine, botany, theology, philology, and mythology; (2) having ruins as a guiding concept, which helped him to make sense of American natives; and (3) savage knowledge – a concept semantically aligned to that of ruins, and among whose principal modes of expression was shamanic practice. (shrink)

Models for truth in fiction must be able to account for differing versions and interpretations of a given fiction in such a way that prevents contradictions from arising. I propose an analysis of truth in fiction designed to accommodate this. I examine both the interpretation of claims about truth in fiction (the ‘Interpretation Problem’) and the metaphysical nature of fictional worlds and entities (the ‘Metaphysical Problem’). My reply to the Interpretation Problem is a semantic contextualism influenced by Cameron (2012), while (...) my reply to the Metaphysical Problem involves an extension and generalisation of the counterpart-theoretic analysis put forth by Lewis (1978). The proposed analysis considers interpretive context as a counterpart relation corresponding to a set of worlds, W, and states that a sentence φ is true in interpretive context W iff φ is true at every world (w∈W). I consider the implications of this analysis for singular terms in fiction, concluding that their extensions are the members of sets of counterparts. In the case of pre-existing singular terms in fiction, familiar properties of the corresponding actual-world entities are salient in restricting the counterpart relation. I also explore interpretations of sentences concerning multiple fictions and those concerning both fictional and actual entities. This account tolerates a plurality of interpretive approaches, avoiding contradictions. (shrink)

There has been much written of late on the topic of panentheism. Dissatisfied with many contemporary descriptions of “panentheism” and the related “pantheism,” which we feel arise out of theistic presuppositions, we produce our own definition of sorts, rooted in and paying respect to the term’s etymology and the concept’s roots in Indian religion and western philosophy. Furthermore, we consider and comment on the arguments and comments concerning panentheism’s definition and plausibility put forth by Göcke, Mullins, and Nickel.

It is widely assumed that ordinary conscious experience involves some form of sense of self or consciousness of oneself. Moreover, this claim is often restricted to a ‘thin’ or ‘minimal’ notion of self-consciousness, or even ‘the simplest form of self-consciousness’, as opposed to more sophisticated forms of self-consciousness which are not deemed ubiquitous in ordinary experience. These formulations suggest that self-consciousness comes in degrees, and that individual subjects may differ with respect to the degree of self-consciousness they exhibit at a (...) given time. In this article, I critically examine this assumption. I consider what the claim that self-consciousness comes in degrees may mean, raise some challenges against the different versions of the claim, and conclude that none of them is both coherent and particularly plausible. (shrink)

Even though anthropogenic climate change is largely caused by industrialized nations, its burden is distributed unevenly with poor developing countries suffering the most. A common response to livelihood insecurities and destruction is migration. Using Peter Singer's ‘historical principle’, this paper argues that a morally just evaluation requires taking causality between climate change and migration under consideration. The historical principle is employed to emphasize shortcomings in commonly made philosophical arguments to oppose immigration. The article concludes that none of these arguments is (...) able to override the moral responsibility of industrialized countries to compensate for harms that their actions have caused. (shrink)

Since the 1980s, there have been many attempts to bring together Critical Theory of Frankfurtian strain and French theories generally referred to as poststructuralist. The present text seeks to readdress the problem of their tricky articulation by taking a look at some vicissitudes those two currents of thought underwent in Brazil. In addition to the risk – embedded in the Parisian passion for dissolution – of positivizing atrocious aspects of Brazilian society related to the country’s multi-secular informality and backwardness, what (...) is at stake is the adequate understanding of the meaning and relevance of dialectical criticism in a peripheral country, in other words, the capacity to weigh the influx and gravitation of foreign ideas and forms in a society of inorganic culture, the possibility, finally, of critically verifying the supposed universality of hegemonic theories and categories in light of a cultural experience amassed under a heterodox modernization. (shrink)

This paper takes part in the ongoing debate on how emotions can be dealt with by argumentation theory. Its main goal is to formulate a relationship between emotion and argumentation which differs from that usually found in most of the literature on the subject. In the “standard” conception, emotions are seen as the objects of appeals which function as adjuvants to argumentation: speakers appeal to pity, fear, shame and the like in order to enhance the cogency of an argument which (...) bears on something else—whether it be the validity of a disputable opinion or the opportunity of a course of action. According to the “alternative” conception which I propose to consider, emotions themselves may be viewed, in some cases, as the very objects of argumentation. This conception lays emphasis on the arguability of emotions. Drawing on insights from current psychological and philosophical theories, it involves a reassessment of the Aristotelian concept of pathos, as well as an in-depth critical discussion of normative and descriptive approaches to emotional appeals. (shrink)

If we consider the field of argumentation studies, we notice that many approaches consider argumentation in a pragmatic manner and define it as a verbal activity oriented towards the realization of a goal . The idea that subtends—in an explicit or implicit way—most of these approaches is that argumentation fundamentally aims to produce an effect upon an addressee, and that this effect consists in a change of attitude with respect to a viewpoint : argumentation theories inevitably confront the issue of (...) persuasion. In this article, I defend, on the contrary, the hypothesis that it is not necessary to have recourse to the notion of persuasion, nor even to speak of an attempt to provoke a change of attitude in the addressee , in order to develop a general definition of argumentation. It seems to me that there are serious reasons to uncouple, insofar as a definition is concerned, argumentation and persuasion. I will look to identify these reasons, to formulate them and to evaluate their strength. In the same vein as recent works by Christian Plantin and Marc Angenot, I will try to contribute to the development of a non - persuasive conception of argumentation. Such a conception bases the definition of argumentation on the pragmatic aims of “justification” and “positioning”, as well as on the articulation of a discourse and a counter-discourse. I argue that such a conception might offer a better empirical adequacy than those that link, insofar as a definition, the argumentative activity and the persuasive aim. (shrink)

We show that, assuming the Axiom of Determinacy, every non-selfdual Wadge class can be constructed by starting with those of level $\omega _1$ and iteratively applying the operations of expansion and separated differences. The proof is essentially due to Louveau, and it yields at the same time a new proof of a theorem of Van Wesep. The exposition is self-contained, except for facts from classical descriptive set theory.

All spaces are assumed to be separable and metrizable. We show that, assuming the Axiom of Determinacy, every zero-dimensional homogeneous space is strongly homogeneous (i.e. all its non-empty clopen subspaces are homeomorphic), with the trivial exception of locally compact spaces. In fact, we obtain a more general result on the uniqueness of zero-dimensional homogeneous spaces which generate a given Wadge class. This extends work of van Engelen (who obtained the corresponding results for Borel spaces), complements a result of van Douwen, (...) and gives partial answers to questions of Terada and Medvedev. (shrink)

The article focuses on a chapter of the biography of Angela Davis which, unless mistaken, has not yet received due attention: the training and intellectual experience with her German professors, Herbert Marcuse and Theodor W. Adorno. From the philosophical studies in Frankfurt in the 1960s to the more recent reflections on movements such as Black Lives Matter, there seems to be a continuity in the way she approaches contemporary social reality, a démarche that draws its strength from the original combination (...) of two traditions of radical critical thinking: Frankfurtian and Afro-American. (shrink)

The article addresses the treatment given to the notion of subject in Slavoj Žižek and Robert Kurz. Without aiming at a synthesis between the two radically opposed positions, they are played against one another in order to reveal the unidimensional stances and false steps in the field of the constitution of the struggle for a concrete negation of capitalist society.

Existe-il une corrélation entre le pouvoir d’un organe et le rang hiérarchique de ses normes ? La théorie réaliste de l’interprétation pourrait sembler indiquer le contraire. En effet, si, comme elle l’enseigne, c’est l’interprète d’un énoncé qui en détermine la signification, les agents de l’administration qui mettent en œuvre les politiques publiques devraient exercer un pouvoir plus important que le législateur qui les élabore. L’auteur de l’article soutient toutefois qu’une semblable conclusion serait erronée car les organes qui produisent les énoncés (...) juridiques généraux et abstraits peuvent généralement mobiliser des ressources qui leur permettent de contraindre les organes de concrétisation à prendre leurs préférences en considération. La représentation du droit comme étant constitué d’un ensemble de normes hiérarchisées confère certaines des ressources dont ils disposent. Celles-ci doivent être identifiées et leur efficacité évaluée afin de déterminer dans quels cas il existe.. (shrink)

G protein‐coupled receptors (GPCRs) constitute the largest family of transmembrane proteins and play a crucial role in regulating diverse cellular functions. They transmit their signaling via binding to intracellular signal transducers and effectors, such as G proteins, GPCR kinases, and β‐arrestins. To influence specific GPCR signaling behaviors, β‐arrestins recruit effectors to form larger signaling complexes. Intriguingly, they facilitate divergent functions for the binding to different receptors. Recent studies relying on advanced structural approaches, novel biosensors and interactome analyses bring us closer (...) to understanding how this specificity is achieved. In this article, we share our hypothesis of how active GPCRs induce specific conformational rearrangements within β‐arrestins to reveal distinct binding interfaces, enabling the recruitment of a subset of effectors to foster specialized signaling complexes. Furthermore, we discuss methods of how to comprehensively assess β‐arrestin conformational states and present the current state of research regarding the functionality of these multifaceted scaffolding proteins. (shrink)