Since Hilary Putnam offered multiple realization as an empirical hypothesis in the 1960s, philosophical consensus has turned against the idea that mental processes are identifiable with brain processes, and multiple realization has become the keystone of the 'antireductive consensus' across philosophy of science. Thomas W. Polger and Lawrence A. Shapiro offer the first book-length investigation of multiple realization, which serves as a starting point to a series of philosophically sophisticated and empirically informed arguments that cast doubt on the generality (...) of multiple realization in the cognitive sciences. They argue that mind-brain identities have played an important role in the growth and achievements of the cognitive sciences, and suggest that there is little prospect for multiple realization in an empirically-based theory of mind. This leads Polger and Shapiro to offer an alternative framework for understanding explanations in the cognitive sciences, as well as in chemistry, biology, and other non-basic sciences. (shrink)
In the pursuit of a quality and well-rounded education with philosophy, Shapiro conducts an introductory lesson to students and teachers alike in order to develop deeper, more philosophical questions from their students. Academically, the article expands detail on tutoring in philosophy, analytical practices, and metaphysical activities.
Written by Thomas Hobbes and first published in 1651, _Leviathan_ is widely considered the greatest work of political philosophy ever composed in the English language. Hobbes's central argument—that human beings are first and foremost concerned with their own fears and desires, and that they must relinquish basic freedoms in order to maintain a peaceful society—has found new adherents and critics in every generation. This new edition, which uses modern text and relies on large-sheet copies from the 1651 Head version, includes (...) interpretive essays by four leading Hobbes scholars: John Dunn, David Dyzenhaus, Elisabeth Ellis, and Bryan Garsten. Taken together with Ian Shapiro’s wide-ranging introduction, they provide fresh and varied interpretations of _Leviathan_ for our time. (shrink)
We have synthesized a 582,970-base pair Mycoplasma genitalium genome. This synthetic genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type M. genitalium G37 except MG408, which was disrupted by an antibiotic marker to block pathogenicity and to allow for selection. To identify the genome as synthetic, we inserted "watermarks" at intergenic sites known to tolerate transposon insertions. Overlapping "cassettes" of 5 to 7 kilobases (kb), assembled from chemically synthesized oligonucleotides, were joined by in vitro recombination to produce intermediate (...) assemblies of approximately 24 kb, 72 kb ("1/8 genome"), and 144 kb ("1/4 genome"), which were all cloned as bacterial artificial chromosomes in Escherichia coli. Most of these intermediate clones were sequenced, and clones of all four 1/4 genomes with the correct sequence were identified. The complete synthetic genome was assembled by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae, then isolated and sequenced. A clone with the correct sequence was identified. The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments. 10.1126/science.1151721. (shrink)
In his paper “The Catholic Church, the American Military, and Homosexual Reorientation Therapy,” David W. Lutz ultimately concludes that it is “appropriate, and highly ethical” for the American military to offer reorientation therapy to help homosexuals overcome “the vice of sodomy.” The major thrust of his paper, however, is to call for abandonment of the “Don't Ask/Don't Tell” policy currently in place in the military. Lutz's paper covers much ground, and this review begins by examining whether such a wide (...) view is necessary for the ultimate conclusions. It goes on to ask whether Lutz has omitted to mention important considerations bearing on this issue, and whether Lutz's call for the introduction of reorientation therapy is a serious call or a symbolic response to homosexual activities. Lutz fails to address essential issues such as the actual experiences of other nations having homosexuals in the military, and issues regarding what constitutes “reorientation therapy,” the latter leading to questions about how such a therapy would actually be implemented. (shrink)
Remarks to the effect that a correct answer depends upon a correct question —that from a misleading question there can result only a misleading answer—are common today. In fact, one might suspect that such common concentration on finding the right questions has something to do with what seems to be an uncommon lack of answers. This concentration on the importance of asking the right questions can be applied to the interpretation of biblical literature. For here, certainly, the questions asked are (...) often decisive. They guide the inquiry by setting the terms of the search and, in this sense, they determine at least the kind of answers that will be given. Further, they often disclose the presuppositions with which one is working. (shrink)