In many cases, the “therapeutic misconception” may be an unavoidable part of the imperfect process of recruitment and consent in medical researchPaul Appelbaum, Loren Roth, and Charles Lidz coined the term “therapeutic misconception” in 1982.1 They described it as the misconception that participating in research is the same as receiving individualised treatment from a physician. It referred to the research subject’s failure to appreciate that the aim of research is to obtain scientific knowledge, and that any benefit to the subject (...) is a by-product of that knowledge. More recent studies by Appelbaum and Lidz have shown that this phenomenon is just as pervasive now as it was twenty four years ago.2 The problem pertains not to any duty of care for researchers but to participants’ unfounded belief in the therapeutic potential of research.3 It is especially acute in phase I oncology trials, which aim to test the toxicity and highest tolerable dose of anticancer drugs.To remedy this situation, many have argued that both clinicians and researchers need to do more in explaining to subjects the differences between experimental research and standard care. Clinicians and researchers recruiting potential subjects for research must present information about the expected risks and benefits of participation in research in a more realistic and straightforward way.4 In one recent examination of consent forms for phase I oncology trials, Sam Horng et al found that, in the section on “benefit”, only one of 272 forms stated that the subjects were expected to benefit. They also found that 11 consent forms stated clearly that subjects would not benefit, 25 forms communicated uncertainty about benefit, and 5 forms said nothing about the chance of benefit. Interestingly, 139 forms alluded to the …. (shrink)

Summary This article seeks to address the question how the Tetrarchic system of four rulers could be presented as legitimate in a society that had never seen this political constellation before. What were the different modes of presenting Tetrarchic rule and how did they help in making the new system acceptable? The article argues that new power structures needed to be formulated in familiar terms, not only for the rulers to legitimate their position, but also for the ruled to understand (...) such new systems. As a result, imperial messages during the Tetrarchic period were strongly influenced by traditional modes of representation from earlier periods. Traditions which were inherent in specific media and locations were determining factors for the way in which a new political system could be presented. The result was a much less coherent ideological Tetrarchic message than is often assumed. The image of group identity was regularly lost in a more complex and messy mode of formulating power. The new and innovative aspects of a collegiate rule by four emperors was less important than linking the power of those rulers to what was traditionally expected of the portrayal of Roman emperorship. (shrink)

Intellectual humility, which entails openness to other views and a willingness to listen and engage with them, is crucial for facilitating civil dialogue and progress in debate between opposing sides. In the present research, we tested whether intellectual humility can be reliably detected in discourse and experimentally increased by a prior self-affirmation task. Three-hundred and three participants took part in 116 audio and video-recorded group discussions. Blind to condition, linguists coded participants’ discourse to create an intellectual humility score. As expected, (...) the self-affirmation task increased the coded intellectual humility, as well as participants’ self-rated prosocial affect (e.g., empathy). Unexpectedly, the effect on prosocial affect did not mediate the link between experimental condition and intellectual humility in debate. Self-reported intellectual humility and other personality variables were uncorrelated with expert-coded intellectual humility. Implications of these findings for understanding the social psychological mechanisms underpinning intellectual humility are considered. (shrink)

This research explores temporal concept drift and temporal alignment in knowledge organization systems. A comparative analysis is pursued using the 1910 Library of Congress Subject Headings, 2020 FAST Topical, and automatic indexing. The use case involves a sample of 90 nineteenth-century Encyclopedia Britannica entries. The entries were indexed using two approaches: 1) full-text indexing; 2) Named Entity Recognition was performed upon the entries with Stanza, Stanford’s NLP toolkit, and entities were automatically indexed with the Helping Interdisciplinary Vocabulary application, using both (...) 1910 LCSH and FAST Topical. The analysis focused on three goals: 1) identifying results that were exclusive to the 1910 LCSH output; 2) identifying terms in the exclusive set that have been deprecated from the contemporary LCSH, demonstrating temporal concept drift; and 3) exploring the historical significance of these deprecated terms. Results confirm that historical vocabularies can be used to generate anachronistic subject headings representing conceptual drift across time in KOS and historical resources. A methodological contribution is made demonstrating how to study changes in KOS over time and improve the contextualization historical humanities resources. (shrink)

In his remarkable paper Formalism 64, Robinson defends his eponymous position concerning the foundations of mathematics, as follows:Any mention of infinite totalities is literally meaningless.We should act as if infinite totalities really existed. Being the originator of Nonstandard Analysis, it stands to reason that Robinson would have often been faced with the opposing position that ‘some infinite totalities are more meaningful than others’, the textbook example being that of infinitesimals. For instance, Bishop and Connes have made such claims regarding infinitesimals, (...) and Nonstandard Analysis in general, going as far as calling the latter respectively a debasement of meaning and virtual, while accepting as meaningful other infinite totalities and the associated mathematical framework. We shall study the critique of Nonstandard Analysis by Bishop and Connes, and observe that these authors equate ‘meaning’ and ‘computational content’, though their interpretations of said content vary. As we will see, Bishop and Connes claim that the presence of ideal objects in Nonstandard Analysis yields the absence of meaning. We will debunk the Bishop–Connes critique by establishing the contrary, namely that the presence of ideal objects in Nonstandard Analysis yields the ubiquitous presence of computational content. In particular, infinitesimals provide an elegant shorthand for expressing computational content. To this end, we introduce a direct translation between a large class of theorems of Nonstandard Analysis and theorems rich in computational content, similar to the ‘reversals’ from the foundational program Reverse Mathematics. The latter also plays an important role in gauging the scope of this translation. (shrink)

This paper examines the importance of aspirations as reference points in a multi-period decision-making context. After stating their personal aspiration level, 172 individuals made six sequential decisions among risky prospects as part of a choice experiment. The results show that individuals make different risky-choices in a multi-period compared to a single-period setting. In particular, individuals’ aspiration level is their main reference point during the early stages of decision-making, while their starting status (wealth level at the start of the experiment) becomes (...) the central reference point during the later stages of their multi-period decision-making. (shrink)

Bestselling author Sam Harris dismantles the most common justification for religious faith-that a moral system cannot be based on science.

In this enlightening book, Sam Harris argues that free will is an illusion but that this truth should not undermine morality or diminish the importance of social and political freedom; indeed, this truth can and should change the way we think about some of the most important questions in life.

Sam Gillespie's The Mathematics of Novelty presents a new account of Alain Badiou and Gilles Deleuze, identifying conceptual impasses in their philosophical ...

This article explores the interplay between the globalization process and the nation/nation-state by examining the case of contemporary Taiwan. Globalization is analyzed along four dimensions: flows of people, flows of culture, economic globalization and international/transnational institutions. Along each dimension, it is found that globalization has had a profound impact upon how cultural and political elites imagine their nation, leading to rising aspirations for nationhood and nation-stateness. Meanwhile, nation-building efforts have deepened Taiwan's embeddedness in globalization, where globalization itself is being employed, (...) both by the state and non-state elites, as a strategy to construct the nation. Three implications suggest that the relationship between `the global' and `the national' be reconceptualized. First, nations and nationalism can be better comprehended against a global/international backdrop, as national identity to a large extent depends upon the imagined or real approval of other nations. Second, there emerges a new strategic alliance between the global and the national, in the sense that globalization gives new ground upon which the nation can be formulated. And finally, by reinforcing certain institutional prerogatives of nations and nation-states, globalization may also lead to an increased desire for nationhood and nation-stateness in cases where the latter two have not been fully realized. (shrink)

Sam Harris dismantles the most common justification for religious faith--that a moral system cannot be based on science.

Some critics argue that the types of psychiatric diagnosis found in the Diagnostic and Statistical Manual of Mental Disorders and International Classification of Disease are superfluous and should be abandoned. These are known as categorical polythetic psychiatric diagnoses. To receive a categorical polythetic psychiatric diagnosis an individual need only exhibit some, rather than all, of the symptoms on the diagnostic criteria. Consequently, categorical polythetic psychiatric diagnoses only associate an individual with a range of symptoms rather than specify which symptoms they (...) have. Drawing on Giere’s account of scientific models, I portray categorical polythetic psychiatric diagnoses as abstract models that guide the building of less abstract models. These models can specify which symptoms a particular individual has. Additionally, categorical polythetic psychiatric diagnoses can guide investigation of symptoms towards difficult to spot symptoms, guide investigation towards changing symptoms, and guide investigation towards how symptoms manifest. These important roles mean categorical polythetic psychiatric diagnoses should not be abandoned. (shrink)

Since Aristotle, many writers have treated metaphors and similes as equals: any metaphor can be paraphrased as a simile, and vice-versa. This property of metaphors is the basis for psycholinguistic comparison theories of metaphor comprehension. However, if metaphors cannot always be paraphrased as similes, then comparison theories must be abandoned. The different forms of a metaphor—the comparison and categorical forms—have different referents. In comparison form, the metaphor vehicle refers to the literal concept, e.g. 'in my lawyer is like a shark', (...) the term 'shark' refers to the literal fish. In categorical form, 'my lawyer is a shark', 'shark' refers to an abstract (metaphorical) category of predatory creatures. This difference in reference makes it possible for a metaphor and its corresponding simile to differ (a) in interpretability and (b) in meaning. Because a metaphor cannot always be understood in terms of its corresponding simile, we conclude that comparison theories of metaphor are fundamentally flawed. (shrink)

This paper critically analyses realist evaluation, focussing on its primary analytical concepts: mechanisms, contexts, and outcomes. Noting that nursing investigators have had difficulty in operationalizing the concepts of mechanism and context, it is argued that their confusion is at least partially the result of ambiguities, inconsistencies, and contradictions in the realist evaluation model. Problematic issues include the adoption of empiricist and idealist positions, oscillation between determinism and voluntarism, subsumption of agency under structure, and categorical confusion between context and mechanism. In (...) relation to outcomes, it is argued that realist evaluation's adoption of the fact/value distinction prevents it from taking into account the concerns of those affected by interventions. The aim of the paper is to use these immanent critiques of realist evaluation to construct an internally consistent realist approach to evaluation that is more amenable to being operationalized by nursing researchers. (shrink)

This article provides a non-technical overview of the conflict between the special theory of relativity and the dynamic theories of time. The chief argument against dynamic theories of time from relativistic mechanics is presented. The space of current responses to that argument is subsequently mapped.

Introduction : time, film, and the ethical vision of Emmanuel Levinas. American transcendence : Levinas and a short history of an American idea in film -- Frank Capra and James Stewart : time, transcendence, and the other -- The changing face of American redemption : Henry Fonda, Marilyn Monroe, Paul Newman, and Denzel Washington -- Sex, art, and Oedipus : The unbearable lightness of being -- Fellini and La dolce vita : documentary, decadence, and desire -- Antonioni and L'avventura : (...) transcendence, the body, and the feminine. (shrink)

Psychiatric researchers typically assume that the modelling of psychiatric symptoms is not influenced by psychiatric categories; symptoms are modelled and then grouped into a psychiatric category. I highlight this primarily through analysing research domain criteria. RDoC’s importance makes it worth scrutinizing, and this assessment also serves as a case study with relevance for other areas of psychiatry. RDoC takes inadequacies of existing psychiatric categories as holding back causal investigation. Consequently, RDoC aims to circumnavigate existing psychiatric categories by directly investigating the (...) causal basis of symptoms. The unique methodological approach of RDoC exploits the supposed lack of influence of psychiatric categories on symptom modelling, taking psychiatric symptoms as the same regardless of which psychiatric category is employed or if no psychiatric category is employed. But this supposition is not always true. I will show how psychiatric categories can influence symptom modelling, whereby identical behaviours can be considered as different symptoms based on an individual’s psychiatric diagnosis. If the modelling of symptoms is influenced by psychiatric categories, then psychiatric categories will still play a role, a situation which RDoC researchers explicitly aim to avoid. I discuss four ways RDoC could address this issue. This issue also has important implications for factor analysis, cluster analysis, modifying psychiatric categories, and symptom based approaches. (shrink)

It is commonly assumed that all propositions have modal profiles and therefore bear their truth-values either contingently or necessarily. I argue against this commonly assumed view and in defence of amodalism, according to which certain true propositions are neither necessarily nor contingently true, but only true simpliciter. I consider three arguments against ‘possible-worlds theories’, which hold that modal concepts are to be analysed in terms of possible worlds. Although each of these arguments targets a different version of possible-worlds theory, these (...) versions jointly exhaust the entire range of possible-worlds theories. After showing that each argument is naturally addressed by adopting amodalism, I argue that all defenders of possible-worlds theory ought to accept amodalism. (shrink)

We develop a new version of the causal theory of spacetime. Whereas traditional versions of the theory seek to identify spatiotemporal relations with causal relations, the version we develop takes causal relations to be the grounds for spatiotemporal relations. Causation is thus distinct from, and more basic than, spacetime. We argue that this non-identity theory, suitably developed, avoids the challenges facing the traditional identity theory.

The distinction between perception and cognition frames countless debates in philosophy and cognitive science. But what, if anything, does this distinction actually amount to? In this introductory article, we summarize recent work on this question. We first briefly consider the possibility that a perception-cognition border should be eliminated from our scientific ontology, and then introduce and critically examine five positive approaches to marking a perception–cognition border, framed in terms of phenomenology, revisability, modularity, format, and stimulus-dependence.

According to the KK-principle, knowledge iterates freely. It has been argued, notably in Greco, that accounts of knowledge which involve essential appeal to normality are particularly conducive to defence of the KK-principle. The present article evaluates the prospects for employing normality in this role. First, it is argued that the defence of the KK-principle depends upon an implausible assumption about the logical principles governing iterated normality claims. Once this assumption is dropped, counter-instances to the principle can be expected to arise. (...) Second, it is argued that even if the assumption is maintained, there are other logical properties of normality which can be expected to lead to failures of KK. Such failures are noteworthy, since they do not depend on either a margins-for-error principle or safety condition of the kinds Williamson appeals to in motivating rejection KK. “Introduction: KK and Being in a Position to Know” Section formulates two versions of the KK-Principle; “Inexact Knowledge and Margins for Error” Section presents a version of Williamson’s margins-for-error argument against it; “Knowledge and Normality” and “Iterated Normality” Sections discuss the defence of the KK-Principle due to Greco and show that it is dependent upon the implausible assumption that the logic of normality ascriptions is at least as strong as K4; finally, “Knowledge in Abnormal Conditions” and “Higher-Order Ignorance Inside the Margins” Sections argue that a weakened version of Greco’s constraint on knowledge is plausible and demonstrate that this weakened constraint will, given uncontentious assumptions, systematically generate counter-instances to the KK-principle of a novel kind. (shrink)

Philosophy and Phenomenological Research, Volume 104, Issue 1, Page 19-49, January 2022.

Volume 20, Issue 4, May 2020, Page 44-45.

Offers a conciliatory solution to one of the central contemporary debates in the theory of rationality, the debate about the proper formulation of rational requirements. Introduces a novel conception of the “symmetry problem” for wide scope rational requirements, and sketches a theory of rational commitment as a response.

Many prominent critiques of philosophical methods proceed by suggesting that some method is unreliable, especially in comparison to some alternative method. In light of this, it may seem natural to conclude that these (comparatively) unreliable methods should be abandoned. Drawing upon work on the division of cognitive labour in science, we argue things are not so straightforward. Rather, whether an unreliable method should be abandoned depends heavily on the crucial question of how we should divide philosophers’ time and effort between (...) different methods, in order to maximise our prospects of achieving epistemic success. We show that, in a range of cases, even a (comparatively) unreliable method deserves to be allocated some of these resources. (shrink)

The curriculum design, faculty characteristics, and experience of implementing masters' level international research ethics training programs supported by the Fogarty International Center was investigated. Multiple pedagogical approaches were employed to adapt to the learning needs of the trainees. While no generally agreed set of core competencies exists for advanced research ethics training, more than 75% of the curricula examined included international issues in research ethics, responsible conduct of research, human rights, philosophical foundations of research ethics, and research regulation and ethical (...) review process. Common skills taught included critical thinking, research methodology and statistics, writing, and presentation proficiency. Curricula also addressed the cultural, social, and religious context of the trainees related to research ethics. Programs surveyed noted trainee interest in Western concepts of research ethics and the value of the transnational exchange of ideas. Similar faculty expertise profiles existed in all programs. Approximately 40% of faculty were female. Collaboration between faculty from low- and middleincome countries (LMICs) and high-income countries (HICs) occurred in most programs and at least 50% of HIC faculty had previous LMIC experience. This paper is part of a collection of papers analyzing the Fogarty International Research Ethics Education and Curriculum Development program. (shrink)

Inquiry aims at knowledge. Your inquiry into a question succeeds just in case you come to know the answer. However, combined with a common picture on which misleading evidence can lead knowledge to be lost, this view threatens to recommend a novel form of dogmatism. At least in some cases, individuals who know the answer to a question appear required to avoid evidence bearing on it. In this paper, we’ll aim to do two things. First, we’ll present an argument for (...) this novel form of dogmatism and show that it presents a substantive challenge. Second, we’ll consider a way those who take knowledge to be the aim of inquiry can mount a response. In the course of doing so, we’ll try to get clearer on the normative connections between inquiry, knowledge and evidence gathering. (shrink)

Identifying patterns in the world requires noticing not only unusual occurrences, but also unusual absences. We examined how people learn from absences, manipulating the extent to which an absence is expected. People can make two types of inferences from the absence of an event: either the event is possible but has not yet occurred, or the event never occurs. A rational analysis using Bayesian inference predicts that inferences from absent data should depend on how much the absence is expected to (...) occur, with less probable absences being more salient. We tested this prediction in two experiments in which we elicited people's judgments about patterns in the data as a function of absence salience. We found that people were able to decide that absences either were mere coincidences or were indicative of a significant pattern in the data in a manner that was consistent with predictions of a simple Bayesian model. (shrink)

ABSTRACTPresentism and endurantism are natural bedfellows: arguments have been mounted from endurantism to presentism and vice versa. I generalise an argument against the compatibility between presentism and endurantism offered recently by Tallant. I then show how to reformulate endurantism so that it is compatible with presentism. I demonstrate that this reformulated version of endurantism can do the same work with respect to the problem of temporary intrinsics as can standard definitions.