Our aim in this paper is to present the distinct ways in which Wolff, Baumgarten, and Kant understand the relationship between necessitation, constraint, and reluctant action in an effort to illustrate the subtle ways in which their conceptions of obligation differ from each another. Whereas Wolff conceives of natural or moral obligation as incompatible with constraint, Baumgarten holds that constraint and reluctant action are, in some instances, compatible with natural obligation. Kant departs from Baumgarten by conceiving of obligation as necessarily (...) involving constraint: as Kant’s reply to Schiller’s famous objection reveals, obligation must take on the character of constraint to reluctant action on account of the fact that human beings possess inclinations that always threaten to impel them in directions that oppose morality. (shrink)

Founder of GotQuestions.org, the most popular online biblical resource, S. Michael Houdmann answers 100 of the most-asked questions on the site in a compassionate, accessible, and straightforward manner. Cutting through the confusion on even the hardest of topics, he offers the biblical truth we all need to understand God's Word and apply it to our lives.

Transformation of the sparrow and the butterfly -- Meeting the gods of poverty in a dream -- The greatest joys of the cicada and its cast-off shell -- The owl's understanding -- The centipede questions the snake -- The toad's way of the gods -- The mysterious technique of the cat -- Afterword by William Scott Wilson.

Should the recreational use of drugs such as marijuana, cocaine, heroin, and LSD, be prohibited by law? Prohibitionists answer yes. They usually argue that drug use is extremely harmful both to drug users and to society in general, and possibly even immoral, and they believe that these facts provide sufficient reasons for prohibition. Legalizers answer no. They usually give one or more of three arguments: First, some argue that drug use is not as harmful as prohibitionists believe, and even that (...) it is sometimes beneficial. Second, some argue that drug prohibition “does not work”, i.e., is not very successful in preventing drug use and/or has a number of very bad consequences. Lastly, some argue that drug prohibition is unjust or violates rights. I won’t attempt to discuss all these arguments here. Instead, I will focus on what seem to me the three most prominent arguments in the drug legalization debate: first, the argument that drugs should be outlawed because of the harm they cause to drug users; second, the argument that they should be outlawed because they harm people other than the user; and third, the argument that drugs should be legalized because drug prohibition violates rights. I shall focus on the moral/philosophical issues that these [134] arguments raise, rather than medical or sociological issues. I shall show that the two arguments for prohibition fail, while the third argument, for legalization, succeeds. (shrink)

Using William Shakespeare’s Hamlet and the play-within-the play, The Murder of Gonzago, as a case study, this essay argues that theatrical utterances constitute a special case of language usage not previously elucidated: the utterance of a statement with propositional content in theatre functions as an event. In short, the propositional content of a particular p (e.g. p1, p2, p3 …), whether or not it is true, is only understood—and understood to be true—if p1 is uttered in a particular time, place, (...) and situation (i.e. during a theatrical event); otherwise, the propositional content in those theatrical utterances can either be false or contingently true. (shrink)

Concepts and Cases in Nursing Ethics maps the ethical landscape of contemporary nursing. The book is the product of a collaboration between philosopher-ethicist Michael Yeo, nurse-ethicist Anne Moorhouse, and six representatives of various areas of professional nursing. It thus combines philosophical and ethical analysis with nursing knowledge and experience in a manner that is both understandable and relevant. The book is organized around six main concepts in nursing ethics: beneficence, autonomy, confidentiality, truth-telling, justice, and integrity. A chapter is devoted (...) to the elucidation of each of these concepts. In each chapter, historical background and conceptual analysis are supplemented by case studies that exemplify issues and show how the concept applies in nursing practice. In this new edition, the materials in each chapter have been updated to reflect recent developments in nursing and more generally in health care. In addition, a totally new chapter on ethical theory has been added. Complete with bibliographies and study questions for further analysis of cases, this book is ideally suited for textbook use. It will help both practitioners and students to deal better with the clinical problems and issues that are encountered in the field. However, it's simple prose and clear exposition of complex issues will make Concepts and Cases in Nursing Ethics attractive to anyone concerned about health care. (shrink)

Michael Dummett's three John Dewey Lectures--"The Concept of Truth," "Statements About the Past," and "The Metaphysics of Time"--were delivered at Columbia University in the spring of 2002. Revised and expanded, the lectures are presented here along with two new essays by Dummett, "Truth: Deniers and Defenders" and "The Indispensability of the Concept of Truth." In _Truth and the Past,_ Dummett clarifies his current positions on the metaphysical issue of realism and the philosophy of language. He is best known as (...) a proponent of antirealism, which loosely characterizes truth as what we are capable of knowing. The events of the past and statements about them are critical tests of an antirealist position. These essays continue and significantly contribute to Dummett's work. (shrink)

Meta-ethical non-cognitivism makes two claims—a negative one and a positive one. The negative claim is that moral utterances do not express beliefs which provide the truth-conditions for those utterances. The positive claim is that the primary function of such utterances is to express certain of the speaker's desire-like states of mind. Non-cognitivism is officially a theory about the meanings of moral words, but non-cognitivists also maintain that moral states of mind are themselves at least partially constituted by desire-like states to (...) which moral utterances give voice. Non-cognitivists need a plausible account of what distinguishes whims, addictions and cravings from genuinely moral judgments. For while non-cognitivists maintain that in a suitably broad sense moral judgments just are constituted by desire-like states they also insist that not any old desire constitutes a genuinely moral judgment. Since the challenge is to demarcate what is distinctive about moral attitudes we might usefully call this the demarcation challenge. (shrink)

_A portion of the revenue from this book’s sales will be donated to Doctors Without Borders to assist the humanitarian work of nurses, doctors, and other health care providers in the fight against COVID-19 and beyond._ _Concepts and Cases in Nursing Ethics_ is an introduction to contemporary ethical issues in health care, designed especially for Canadian audiences. The book is organized around six key concepts: beneficence, autonomy, truth-telling, confidentiality, justice, and integrity. Each of these concepts is explained and discussed with (...) reference to professional and legal norms. The discussion is then supplemented by case studies that exemplify the relevant concepts and show how each applies in health care and nursing practice. This new fourth edition includes an added chapter on end-of-life issues, and it is revised throughout to reflect the latest developments on topics such as global health ethics, cultural competence, social media, and palliative sedation, as well as ethical issues relating to COVID-19. (shrink)

This paper discusses the notion of epistemic circularity, supposedly different from logical circularity, and evaluates Ernest Sosa’s claim that this specific kind of circular reasoning is virtuous rather than vicious. I attempt to determine whether or not the conditions said to make epistemic circularity a permissible instance of begging the question could make other instances of circular reasoning equally permissible.

A paradigm-shifting work that revolutionizes our understanding of the origins and structure of science. Captivatingly written, interwoven with tantalizing illustrations and historical vignettes ranging from Newton's alchemy to quantum mechanics to the storm surge of Hurricane Sandy, Michael Strevens's wholly original investigation of science asks two fundamental questions: Why is science so powerful? And why did it take so long, two thousand years after the invention of philosophy and mathematics, for the human race to start using science to learn (...) the secrets of nature? The Knowledge Machine's radical answer is that science calls on its practitioners to do something irrational: by willfully ignoring religion, theoretical beauty, and, especially, philosophy-essentially stripping away all previous knowledge-scientists embrace an unnaturally narrow method of inquiry, channeling unprecedented energy into observation and experimentation. Like Yuval Harari's Sapiens or Thomas Kuhn's 1962 classic, The Structure of Scientific Revolutions, The Knowledge Machine overturns much of what we thought we knew about the origins of the modern world. (shrink)

The fact that Gilbert Ryle and J.L. Austin seem to disagree about the ordinary use of words such as ‘voluntary’, ‘involuntary’, ‘voluntarily’, and ‘involuntarily’ has been taken to cast doubt on the methods of ordinary language philosophy. As Benson Mates puts the worry, ‘if agreement about usage cannot be reached within so restricted a sample as the class of Oxford Professors of Philosophy, what are the prospects when the sample is enlarged?’ (Mates, Inquiry 1:161–171, 1958, p. 165). In this chapter, (...) we evaluate Mates’s criticism alongside Ryle’s and Austin’s specific claims about the ordinary use of these words, assessing these claims against actual examples of ordinary use drawn from the British National Corpus (BNC). Our evaluation consists in applying a combination of methods: first aggregating judgments about a large set of samples drawn from the corpus, and then using a clustering algorithm to uncover connections between different types of use. In applying these methods, we show where and to what extent Ryle’s and Austin’s accounts of the use of the target terms are accurate as well as where they miss important aspects of ordinary use, and we demonstrate the usefulness of this new combination of methods. At the heart of our approach is a commitment to the idea that systematically looking at actual uses of expressions is an essential component of any approach to ordinary language philosophy. (shrink)

Shaftesbury believed that the height of virtue was impartial love for all of humanity. But Shaftesbury also harboured grave doubts about our ability to develop such an expansive love. In The Moralists, Shaftesbury addressed this problem. I show that while it may appear on the surface that The Moralists solves the difficulty, it in fact remains unresolved. Shaftesbury may not have been able to reconcile his view of the content of virtue with his view of our motivational psychology.

Originally published in 1979, The Darwinian Revolution was the first comprehensive and readable synthesis of the history of evolutionary thought. Though the years since have seen an enormous flowering of research on Darwin and other nineteenth-century scientists concerned with evolution, as well as the larger social and cultural responses to their work, The Darwinian Revolution remains remarkably current and stimulating. For this edition Michael Ruse has written a new afterword that takes into account the research published since his book's (...) first appearance. "It is difficult to believe that yet another book on Darwin and the Darwinian Revolution could add anything new or contain any surprises. Ruse's book is an exception on all counts. Darwin scholars and the general reader alike can learn from it."--David L. Hull, Nature "No other account of the Darwinian Revolution provides so detailed and sympathetic an account of the framework within which the scientific debates took place."--Peter J. Bowler, Canadian Journal of History "A useful and highly readable synthesis...skillfully organized and written with verve, imagination, and welcome touches of humor."--John C. Greene, Science. (shrink)

It is time to transcend the arid debate between rationality and ir-, a-, or non-rationality as our basic assumption about human agency.1 There are powerful arguments and extensive evidence both for and against the rationality assumption, with heavily defended entrenchments on both sides. Managers and management scholars continually make at least tacit assumptions about how they expect others to behave. If only we could have in both theory and practice the coherence and precision of rational models as well as the (...) descriptive richness of ‘behavioural’ approaches. The message of this paper is that perhaps we can. The advent of consciousness studies and, more recently, neuroeconomics would seem to indicate the way forward to transcend the opposition in some kind of synthesis. This paper investigates rationality in the light of Daniel Dennett’s thesis that it is at the core of all intentionality that is the defining characteristic of mental phenomena. Neuroeconomics seeks to enhance understanding of agency by investigating new insights on the materialist basis of mental phenomenology in the neurophysiology of the brain and nervous system. Experimental evidence mapping intentional states onto neurophysiological states is emerging, some researchers even claiming to have found a ‘neurophysiological utility function’. Dennett closes the circuit by locating the existence of brain-hardware supporting satisficing intentional choice and action as the output of evolutionary ‘design’. The dichotomy is transcended: satisficing models (of which normative optimising rational choice models are a reasonable abstraction) are a good basis both for statistical prediction of the behaviour of large numbers, and as the first base on which to construct and refine a model of expectation-formation about particular types of agent and then of individual agents. Using both the old (‘external’) and the new (sub-individual) behaviourism as well as work on unpacking the abstract notion of rationality, we can concretise optimising rational choice both generally, for epistemic theory-building purposes, and specifically for understanding and deploying models of managerial agency. Such models will need to incorporate emotion with cognition in an integrated approach. (shrink)

This essay argues that Kant’s conception of regulative ideas of practical reason introduced in the Critique of Pure Reason serves an important twofold function in his political philosophy. First, Kant’s version of the ideal, Platonic republic acts as the a priori paradigm of a rightful state to which existing regimes can and should conform. Second, Kant frames the regulative status of such practical ideas as a resolution of the conflict between the extremes of dogmatism and skepticism. In his principal political (...) writings from the 1790s—i. e., “Theory and Practice,” “Perpetual Peace,” and the Doctrine of Right—Kant draws on his account of practical ideas in the Critique to articulate a counterfactual norm of popular sovereignty that distinguishes his political standpoint from opponents on the left and the right. Radicals repeat the error of the dogmatists by affirming that the norm of collective self-legislation is completely attainable in experience. By contrast, conservatives make the mistake of the skeptics by denying that rational political standards can be applied to reality at all. I show that Kant reconciles these extremes through his model of gradual, non-violent political reform guided by the regulative ideal of a perfectly self-legislating state. (shrink)

Michael J. Loux here presents a fresh reading of two of the most important books of the Metaphysics, Books Z and H, in which Aristotle presents his mature ...

This essay explores a creative argument that Cicero offers to answer a fundamental question: how are we to judge among different ways of life? Is there a natural hierarchy of human types? In response to this problem, Cicero gives an account of a person’s possessing two natures. All of us participate in a general human nature, the characteristics of which provide us with certain universal duties and a natural moral hierarchy. But, we also each possess an individual nature, qualities that (...) make us unique and which we have an obligation to cultivate. By employing different concepts of natura to refer either to common human nature or to particular individual nature, Cicero establishes a basis for a normative standard that manages to affirm the superiority of certain especially valuable types of life, such as the philosopher and the statesman. At the same time, he advances a coherent account of individuality that places high value on natural human diversity. (shrink)

The problem with authenticity—the idea of being “true to one’s self”—is that its somewhat checkered reputation garners a complete range of favorable and unfavorable reactions. In educational settings, authenticity is lauded as one of the top two traits students desire in their teachers. Yet, authenticity is criticized for its tendency towards narcissism and self-entitlement. So, is authenticity a good or a bad thing? The purpose of this article is to develop an intimate understanding of authenticity by investigating its current interpretation (...) and criticisms, its struggle with narcissism and relation to freedom. Examining authenticity as multilayered self-exploration reveals a composite of understanding, care, and acceptance. While a side current of acceptable tension shifts our understanding of authenticity from the security of self-determination to the messy interplay involved in being “true to one’s self” and being “in-the-world”. (shrink)

Editorial NoteThis paper was read by Michael Dummett at Leiden University on September 26, 1992 at the invitation by Göran Sundholm to address the topic mentioned in the title. Dummett’s lecture was part of a workshop, Meaning Theory and Intuitionism, with 12 invited speakers over three days. After the workshop, Dummett gave a copy of the manuscript to Sundholm together with permission to publish it. At the time, nothing came of the publication plans, nor did Dummett publish it in (...) any other form. The text has remained virtually unknown, and apart from a lecture of Per Martin-Löf, also at Leiden, on the same topic, it has received no scholarly attention. We are indebted to Dummett’s literary executor, Professor Ian Rumfitt, of All Souls College, Oxford, who after nearly three decades confirmed the earlier permission to publish.Göran SundholmAnsten Klev. (shrink)

Biologists are remarkably visual people. Yet, the classics of logical empiricism never raised the general question of scientific illustration. Moreover, one suspects that the silence was, if anything, actively hostile. People did not talk about biological illustration, because they did not judge it to be part of “real science”. This enterprise produces statements or propositions, ideally embedded in a formal system. It may beaboutthe real world, but it is not in any senseofthe real world, in being a copy or mirror (...) image. Philosophers recognized that regretfully human weakness demanded the visual. But it was judged at best a prop. (See, for instance, Braithwaite 1953, Hempel 1965, and Bunge 1967; although see also Achinstein 1968. The best discussion of scientific illustration that I know is Rudwick 1976.). (shrink)

Dewey scholar Michael Eldridge provides a thorough and well-researched interpretation of Dewey's philosophy that focuses on the role of intelligence in human ...

Preface -/- Introduction -/- PART I -/- 1 Kant’s pursuit of the Supreme Principle of Morality -/- 2 The Categorical Imperative and the Kantian theory of value, part I -/- 3 The Categorical Imperative and the Kantian theory of value, part II -/- 4 Dignity -/- 5 Freedom, reason, and the possibility of the Categorical Imperative -/- PART II -/- 6 Objections to the Formula of Universal Law -/- 7 Three problems in Kant’s practical ethics -/- 8 Reason and sentiment: (...) Kantian ethics in a good human life -/- Conclusion -/- Index . (shrink)

There is a non-trivial chance that sometime in the future, someone will build an artificial general intelligence that will surpass human-level cognitive proficiency and go on to become “superintelligent”, vastly outperforming humans. The advent of superintelligent AI has great potential, for good or ill. It is therefore imperative that we find a way to ensure—long before one arrives—that any superintelligence we build will consistently act in ways congenial to our interests. This is a very difficult challenge in part because most (...) of the final goals we could give an AI admit of so-called “perverse instantiations”. I propose a novel solution to this puzzle: instruct the AI to love humanity. The proposal is compared with Yudkowsky’s Coherent Extrapolated Volition, and Bostrom’s Moral Modeling proposals. (shrink)

It argues that states forge a relationship due to strategic needs such as economic or security needs. Slobodchikoff has developed a database composed of the whole population of bilateral treaties between Russia and each of the former Soviet republics, and examines all of these bilateral relationships. He finds that Russia indeed forged relationships with the former republics based on its strategic interests. However, despite Russia's strategic interests, it had to build a bilateral relationship that would address the issues of mistrust (...) and power asymmetry between the states. To achieve this, Russia and the former Soviet republics created treaty networks, which served to legitimize as well as legalize the independent status of each of the former republics while also increasing the cost to Russia of violating any of the treaties. (shrink)

Austin is not much in fashion these days. In Austin’s Way with Skepticism, Mark Kaplan swims against the current, arguing that Austin still has much to teach us about how to do epistemology. Methodologically, Austin’s insistence on fidelity to ordinary ways of talking about knowledge is a non-negotiable constraint on epistemological theorizing. Substantively, Austin has important things to say about knowledge. But while I am fully in accord with the spirit of Kaplan’s enterprise, I take Austin to occupy a more (...) radical position: that getting the linguistic facts straight should lead us to call into question the very idea of a theory of knowledge, at least as ‘theory of knowledge’ has traditionally been understood. (shrink)

A moral theory T is esoteric if and only if T is true but there are some individuals who, by the lights of T itself, ought not to embrace T, where to embrace T is to believe T and rely upon it in practical deliberation. Some philosophers hold that esotericism is a strong, perhaps even decisive, reason to reject a moral theory. However, proponents of this objection have often supposed its force is obvious and have said little to articulate it. (...) I defend a version of this objection—namely, that, in light of the strongly first-personal epistemology of benefit and burden, esoteric theories fail to justify the allocation of benefits and burdens to which moral agents would be subject under such theories. Because of the holistic nature of moral-theory justification, this conclusion in turn implies that the entirety of a moral theory must be open to public scrutiny in order for the theory to be justified. I conclude by answering several objections to my account of the esotericism objection. (shrink)

The earlier volume in this series dealt with two religions of Indian origin, namely, Buddhism and Jainism. The Indian religious scene, however, is characterized by not only religions which originated in India but also by religions which entered India from outside India and made their home here. Thus religious life in India has been enlivened throughout its history by the presence of religions of foreign origin on its soil almost from the very time they came into existence. This volume covers (...) three such religions—Zoraoastrianism, Judaism, and Islam. In the case of Zoraostianism, even its very beginnings are intertwined with India, as Zoroastrianism reformed a preexisting religion which had strong links to the Vedic heritage of India. This relationship took on a new dimension when a Zoroastrian community, fearing persecution in Persia after its Arab conquest, sought shelter in western India and ultimately went on to produce India’s pioneering nationalist in the figure of Dadabhai Naoroji ( 1825-1917), also known as the Grand Old Man of India. Jews found refuge in south India after the destruction of the Temple by the Romans in 70 C.E. and have remained a part of the Indian religious scene since then, some even returning to Israel after it was founded in 1948. Islam arrived in Kerala as soon as it was founded and one of the earliest mosques in the history of Islam is found in India. Islam differs from the previously mentioned religions inasmuch as it went on to gain political hegemony over parts of the country for considerable periods of time, which meant that its impact on the religious life of the subcontinent has been greater compared to the other religions. It has also meant that Islam has existed in a religiously plural environment in India for a longer period than elsewhere in the world so that not only has Islam left a mark on India, India has also left its mark on it. Indeed all the three religions covered in this volume share this dual feature, that they have profoundly influenced Indian religious life and have also in turn been profoundly influenced by their presence in India. (shrink)

Michael Allen's latest work on the profoundly influential Florentine thinker of the fifteenth century, Marsilio Ficino, will be welcomed by philosophers, literary scholars, and historians of the Renaissance, as well as by classicists. Ficino was responsible for inaugurating, shaping, and disseminating the wide-ranging philosophico-cultural movement known as Renaissance Platonism, and his views on the _Sophist_, which he saw as Plato's preeminent ontological dialogue, are of signal interest. This dialogue also served Ficino as a vehicle for exploring a number of (...) other humanist, philosophical, and magical preoccupations, including the theme of man the artist and creator. (shrink)

Background: Treating medication-refractory freezing of gait in Parkinson’s disease remains challenging despite several trials reporting improvements in motor symptoms using subthalamic nucleus or globus pallidus internus deep brain stimulation. Pedunculopontine nucleus region DBS has been used for medication-refractory FoG, with mixed findings. FoG, as a paroxysmal phenomenon, provides an ideal framework for the possibility of closed-loop DBS.Methods: In this clinical trial, five subjects with medication-refractory FoG underwent bilateral GPi DBS implantation to address levodopa-responsive PD symptoms with open-loop stimulation. Additionally, PPN (...) DBS leads were implanted for CL-DBS to treat FoG. The primary outcome of the study was a 40% improvement in medication-refractory FoG in 60% of subjects at 6 months when “on” PPN CL-DBS. Secondary outcomes included device feasibility to gauge the recruitment potential of this four-lead DBS approach for a potentially larger clinical trial. Safety was judged based on adverse events and explantation rate.Findings: The feasibility of this approach was demonstrated as we recruited five subjects with both “on” and “off” medication freezing. The safety for this population of patients receiving four DBS leads was suboptimal and associated with a high explantation rate of 40%. The primary clinical outcome in three of the five subjects was achieved at 6 months. However, the group analysis of the primary clinical outcome did not reveal any benefit.Interpretation: This study of a human PPN CL-DBS trial in medication-refractory FoG showed feasibility in recruitment, suboptimal safety, and a heterogeneous clinical effect in FoG outcomes. (shrink)

The chapter presents a brief case study, in which we can observe the impact of Pierre Hadot's ideas on Martin O’Hagan, a person not far removed from us in terms of space, time, and aspirations. Hadot's concept of “Philosophy as a Way of Life (PWL)” could provide an option for a person who, excluded from and/or disillusioned by Academic philosophy, still felt the need to search for answers to a few centrally important questions that had direct impact on his life. (...) Even the characteristic that has returned like a Leitmotif throughout this chapter — analytic philosophy's tendency to ignore the so‐called Big Questions, such as that of the meaning of life — can be illuminated by means of Kuhn's theories. The author hopes that the interest in Hadot's concept of PWL will contribute to the rehabilitation of philosophy as it was before its takeover by Academic philosophy. (shrink)

Spinoza presents his ethics using a variety of terminologies. Propositions that are, or at least might be taken for, normative include only very few explicit guidelines for action. I will take this claim from Vp10s to be one such guideline:Vp10s: So that we may always have this rule of reason ready when it is needed, we should think and meditate often about common human wrongs and how and in what way they may best be driven away by nobility.

We provide a new interpretation of Zeno’s Paradox of Measure that begins by giving a substantive account, drawn from Aristotle’s text, of the fact that points lack magnitude. The main elements of this account are (1) the Axiom of Archimedes which states that there are no infinitesimal magnitudes, and (2) the principle that all assignments of magnitude, or lack thereof, must be grounded in the magnitude of line segments, the primary objects to which the notion of linear magnitude applies. Armed (...) with this account, we are ineluctably driven to introduce a highly constructive notion of (outer) measure based exclusively on the total magnitude of potentially infinite collections of line segments. The Paradox of Measure then consists in the proof that every finite or potentially infinite collection of points lacks magnitude with respect to this notion of measure. We observe that the Paradox of Measure, thus understood, troubled analysts into the 1880’s, despite their knowledge that the linear continuum is uncountable. The Paradox was ultimately resolved by Borel in his thesis of 1893, as a corollary to his celebrated result that every countable open cover of a closed line segment has a finite sub-cover, a result he later called the “First Fundamental Theorem of Measure Theory.” This achievement of Borel has not been sufficiently appreciated. We conclude with a metamathematical analysis of the resolution of the paradox made possible by recent results in reverse mathematics. (shrink)

IntroductionCognitive impairment is a highly prevalent non-motor feature of Parkinson’s disease. A better understanding of the underlying pathophysiology may help in identifying therapeutic targets to prevent or treat dementia. This study sought to identify metabolic alterations in the prefrontal cortex, a key region for cognitive functioning that has been implicated in cognitive dysfunction in PD.MethodsProton Magnetic Resonance Spectroscopy was used to investigate metabolic changes in the PFC of a cohort of cognitively normal individuals without PD, as well as PD participants (...) with either normal cognition, mild cognitive impairment, or dementia. Ratios to Creatine resonance were obtained for glutamate, glutamine and glutamate combined, N-acetylaspartate, myoinositol, and total choline, and correlated with cognitive scores across multiple domains administered to the PD participants only.ResultsWhen individuals retain cognitive capabilities, the presence of Parkinson’s disease does not create metabolic disturbances in the PFC. However, when cognitive symptoms are present, PFC Glu/Cre ratios decrease with significant differences between the PD-NC and PPD groups. In addition, Glu/Cre ratios and memory scores were marginally associated, but not after Bonferroni correction.ConclusionThese preliminary findings indicate that fluctuations in prefrontal glutamate may constitute a biomarker for the progression of cognitive impairments in PD. We caution for larger MRS investigations of carefully defined PD groups. (shrink)

De Neys argues against assigning exclusive capacities to automatic versus controlled processes. The dual implicit process model provides a theoretical rationale for the exclusivity of automatic threat processing, and corresponding data provide empirical evidence of such exclusivity. De Neys's dismissal of exclusivity is premature and based on a limited sampling of psychological research.

ARISTOTLE’S THEORY OF PERCEPTION AND THOUGHT in books 2 and 3 of de Anima is usually interpreted in terms of representationalism: in perception and thought, we receive sensible or intelligible forms. These forms are representations of qualities, things, or events in the world. We gain epistemic access to the world by means of these representations. In this paper I argue that contrary to received opinion, Aristotle’s text can also be read in terms of direct realism: we have epistemic access to (...) the world in perception and thought without representations intervening as epistemic intermediaries. (shrink)

Elizabeth Anscombe is well-known for her insistence that there are absolutely prohibited actions, though she is somewhat obscure about why this is so. Nonetheless, I contend in this paper that Anscombe is more concerned with the epistemology of absolute prohibitions, and that her thought on connatural moral knowledge – which resembles moral intuition – is key to understanding her thought on moral prohibitions. I shall identify key features of Anscombe’s moral epistemology before turning to investigate its sources, examining the roots (...) of connaturality in Aquinas and comparing it with rationalist ethical intuitionism, which Anscombe differs from in rejecting “good” as a simple, non-natural property. I then develop a two-stage argument about absolute prohibition: The first will be loosely Thomistic, while the second will suggest how Anscombe’s absolute prohibitions can be seen as a continuation of Wittgenstein’s anti-scepticism in On Certainty. I develop an account of absolute prohibitions as a form of Wittgensteinian hinge proposition – they are not the conclusions of deductive arguments, but the foundations for intelligibility in action. (shrink)