Results for 'Alfred Pagel'

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  1.  26
    Gene replacement therapy in the central nervous system: Viral vector-mediated therapy of global neurodegenerative disease.Edward A. Neuwelt, Michael A. Pagel, Alfred Geller & Leslie L. Muldoon - 1995 - Behavioral and Brain Sciences 18 (1):1-9.
    For focal neurodegenerative diseases or brain tumors, localized delivery of protein or genetic vectors may be sufficient to alleviate symptoms, halt disease progression, or even cure the disease. One may circumvent the limitation imposed by the blood-brain barrier by transplantation of genetically altered cell grafts or focal inoculation of virus or protein. However, permanent gene replacement therapy for diseases affecting the entire brain will require global delivery of genetic vectors. The neurotoxicity of currently available viral vectors and the transient nature (...)
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  2.  46
    Logic, semantics, metamathematics.Alfred Tarski - 1956 - Oxford,: Clarendon Press. Edited by John Corcoran & J. H. Woodger.
    I ON THE PRIMITIVE TERM OF LOGISTICf IN this article I propose to establish a theorem belonging to logistic concerning some connexions, not widely known, ...
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  3.  10
    Effective intentions: the power of conscious will.Alfred R. Mele - 2009 - New York: Oxford University Press.
    Each of the following claims has been defended in the scientific literature on free will and consciousness: your brain routinely decides what you will do before you become conscious of its decision; there is only a 100 millisecond window of opportunity for free will, and all it can do is veto conscious decisions, intentions, or urges; intentions never play a role in producing corresponding actions; and free will is an illusion. In Effective Intentions Alfred Mele shows that the evidence (...)
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  4.  12
    Springs of action: understanding intentional behavior.Alfred R. Mele - 1992 - New York: Oxford University Press.
    Tackling some central problems in the philosophy of action, Mele constructs an explanatory model for intentional behavior, locating the place and significance of such mental phenomena as beliefs, desires, reason, and intentions in the etiology of intentional action. Part One comprises a comprehensive examination of the standard treatments of the relations between desires, beliefs, and actions. In Part Two, Mele goes on to develop a subtle and well-defended view that the motivational role of intentions is of a different sort from (...)
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  5. Irrationality: an essay on akrasia, self-deception, and self-control.Alfred R. Mele - 1987 - Oxford: Oxford University Press.
    The author demonstrates that certain forms of irrationality - incontinent action and self-deception - which many philosophers have rejected as being logically or psychologically impossible, are indeed possible.
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  6.  60
    Springs of Action: Understanding Intentional Behavior.Alfred R. Mele - 2002 - New York: Oxford University Press.
    Tackling some central problems in the philosophy of action, Mele constructs an explanatory model for intentional behavior, locating the place and significance of such mental phenomena as beliefs, desires, reasons, and intentions in the etiology of intentional action. In the first part, Mele illuminates the connection between desire and action and defends detailed characterizations of irresistible desires and reasons for action. Mele argues for the viability of a causal approach to the explanation of intentional action in terms of psychological states (...)
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  7. Free: Why Science Hasn't Disproved Free Will.Alfred R. Mele - 2014 - New York: Oxford University Press USA.
    Does free will exist? The question has fueled heated debates spanning from philosophy to psychology and religion. The answer has major implications, and the stakes are high. To put it in the simple terms that have come to dominate these debates, if we are free to make our own decisions, we are accountable for what we do, and if we aren't free, we're off the hook.There are neuroscientists who claim that our decisions are made unconsciously and are therefore outside of (...)
  8.  31
    Real Self-Deception.Alfred R. Mele - 1997 - Behavioral and Brain Sciences 20 (1):91-102.
    Self-deception poses tantalizing conceptual conundrums and provides fertile ground for empirical research. Recent interdisciplinary volumes on the topic feature essays by biologists, philosophers, psychiatrists, and psychologists (Lockard & Paulhus 1988, Martin 1985). Self-deception's location at the intersection of these disciplines is explained by its significance for questions of abiding interdisciplinary interest. To what extent is our mental life present--or even accessible--to consciousness? How rational are we? How is motivated irrationality to be explained? To what extent are our beliefs subject to (...)
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  9. On the Concept of Following Logically.Alfred Tarski - 2002 - History and Philosophy of Logic 23 (3):155-196.
    We provide for the first time an exact translation into English of the Polish version of Alfred Tarski's classic 1936 paper, whose title we translate as ?On the Concept of Following Logically?. We also provide in footnotes an exact translation of all respects in which the German version, used as the basis of the previously published and rather inexact English translation, differs from the Polish. Although the two versions are basically identical, to an extent that is even uncanny, we (...)
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  10.  87
    Critical Elitism: Deliberation, Democracy, and the Problem of Expertise.Alfred Moore - 2017 - Cambridge: Cambridge University Press.
    Democracies have a problem with expertise. Expert knowledge both mediates and facilitates public apprehension of problems, yet it also threatens to exclude the public from consequential judgments and decisions located in technical domains. This book asks: how can we have inclusion without collapsing the very concept of expertise? How can public judgment be engaged in expert practices in a way that does not reduce to populism? Drawing on deliberative democratic theory and social studies of science, Critical Elitism argues that expert (...)
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  11.  82
    Self-deception and selectivity.Alfred R. Mele - 2020 - Philosophical Studies 177 (9):2697-2711.
    This article explores the alleged “selectivity problem” for Alfred Mele’s deflationary position on self-deception, a problem that can allegedly be solved only by appealing to intentions to bring it about that one acquires certain beliefs, or to make it easier for oneself to acquire certain beliefs, or to deceive oneself into believing that p. This article argues for the following thesis: the selectivity problem does not undermine this deflationary position on self-deception, and anyone who takes it to be a (...)
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  12. Patient Autonomy and the Ethics of Responsibility.Alfred I. Tauber - 2005 - MIT Press.
    The principle of patient autonomy dominates the contemporary debate over medical ethics. In this examination of the doctor-patient relationship, physician and philosopher Alfred Tauber argues that the idea of patient autonomy -- which was inspired by other rights-based movements of the 1960s -- was an extrapolation from political and social philosophy that fails to ground medicine's moral philosophy. He proposes instead a reconfiguration of personal autonomy and a renewed commitment to an ethics of care. In this formulation, physician beneficence (...)
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  13.  10
    Immunity: The Evolution of an Idea.Alfred I. Tauber - 2017 - New York, US: Oup Usa.
    In Immunity, Alfred Tauber sets forth a new theory of immunology that rejects the common principle of self and non-self, and the immune system's role as a protector of the self from external threats. Rather than serving to defend an independent entity, he argues, immunity participates in a large, complex eco-system of porous and flexible boundaries. Tauber's new approach to immunology necessitates a new biology in which symbiosis is the rule, not the exception.
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  14.  33
    Free will: an opinionated guide.Alfred R. Mele - 2022 - New York, NY: Oxford University Press.
    What did you do a moment ago? What will you do after you read this? Are you deciding as we speak, or is something else going on in your brain or elsewhere in your body that is determining your actions? Stopping to think this way can freeze us in our tracks. A lot in the world feels far beyond our control--the last thing we need is to question whether we make our own choices in the way we usually assume we (...)
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  15.  68
    Moral responsibility and manipulation: on a novel argument against historicism.Alfred R. Mele - 2020 - Philosophical Studies 177 (10):3143-3154.
    Taylor Cyr offers a novel argument against, as he puts it, “all versions of historicism” about direct moral responsibility. The argument features constitutive luck and a comparison of manipulated agents and young agents performing the first actions for which they are morally responsible. Here it is argued that Cyr’s argument misses its mark. Alfred Mele’s historicism is highlighted.
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  16.  14
    Freud, the Reluctant Philosopher.Alfred I. Tauber - 2010 - Princeton University Press.
    Freud began university intending to study both medicine and philosophy. But he was ambivalent about philosophy, regarding it as metaphysical, too limited to the conscious mind, and ignorant of empirical knowledge. Yet his private correspondence and his writings on culture and history reveal that he never forsook his original philosophical ambitions. Indeed, while Freud remained firmly committed to positivist ideals, his thought was permeated with other aspects of German philosophy. Placed in dialogue with his intellectual contemporaries, Freud appears as a (...)
  17. Science Transformed?: Debating Claims of an Epochal Break.Alfred Nordmann, Hans Radder & Gregor Schiemann (eds.) - 2011 - University of Pittsburgh Press.
    Advancements in computing, instrumentation, robotics, digital imaging, and simulation modeling have changed science into a technology-driven institution. Government, industry, and society increasingly exert their influence over science, raising questions of values and objectivity. These and other profound changes have led many to speculate that we are in the midst of an epochal break in scientific history. -/- This edited volume presents an in-depth examination of these issues from philosophical, historical, social, and cultural perspectives. It offers arguments both for and against (...)
  18. Should We Aim for Consensus?Alfred Moore & John Beatty - 2010 - Episteme 7 (3):198-214.
    There can be good reasons to doubt the authority of a group of scientists. But those reasons do not include lack of unanimity among them. Indeed, holding science to a unanimity or near-unanimity standard has a pernicious effect on scientific deliberation, and on the transparency that is so crucial to the authority of science in a democracy. What authorizes a conclusion is the quality of the deliberation that produced it, which is enhanced by the presence of a non-dismissible minority. Scientists (...)
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  19.  12
    Intentional action, folk judgments, and stories: Sorting things out.Alfred R. Mele & Fiery Cushman - 2007 - Midwest Studies in Philosophy 31 (1):184–201.
    How are our actions sorted into those that are intentional and those that are not? The philosophical and psychological literature on this topic is livelier now than ever, and we seek to make a contribution to it here. Our guiding question in this article is easy to state and hard to answer: How do various factors— specifically, features of vignettes—that contribute to majority folk judgments that an action is or is not intentional interact in producing the judgment? In pursuing this (...)
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  20.  15
    Internalist moral cognitivism and listlessness.Alfred R. Mele - 1996 - Ethics 106 (4):727-753.
    This paper criticizes the conjunction of two theses: 1) cognitivism about first-person moral ought-beliefs, the thesis (roughly) that such beliefs are attitudes with truth-valued contents; 2) robust internalism about these beliefs, the thesis that, necessarily, agents' beliefs that they ought, morally, to A constitute motivation to A. It is argued that the conjunction of these two theses places our moral agency at serious risk. The argument, which centrally involves attention to clinical depression, is extended to a less demanding, recent brand (...)
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  21. Self-Deception and Delusions.Alfred Mele - 2006 - European Journal of Analytic Philosophy 2 (1):109-124.
    My central question in this paper is how delusional beliefs are related to self-deception. In section 1, I summarize my position on what self-deception is and how representative instances of it are to be explained. I turn to delusions in section 2, where I focus on the Capgras delusion, delusional jealousy (or the Othello syndrome), and the reverse Othello syndrome.
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  22. Situationism and Agency.Alfred R. Mele & Joshua Shepherd - 2013 - Journal of Practical Ethics 1 (1):62-83.
    Research in psychology indicates that situations powerfully impact human behavior. Often, it seems, features of situations drive our behavior even when we remain unaware of these features or their influence. One response to this research is pessimism about human agency: human agents have little conscious control over their own behavior, and little insight into why they do what they do. In this paper we review classic and more recent studies indicating “the power of the situation,” and argue for a more (...)
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  23. Self-control, motivational strength, and exposure therapy.Alfred R. Mele - 2014 - Philosophical Studies 170 (2):359-375.
    Do people sometimes exercise self-control in such a way as to bring it about that they do not act on present-directed motivation that continues to be motivationally strongest for a significant stretch of time (even though they are able to act on that motivation at the time) and intentionally act otherwise during that stretch of time? This paper explores the relative merits of two different theories about synchronic self-control that provide different answers to this question. One is due to Sripada (...)
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  24.  17
    Persisting intentions.Alfred R. Mele - 2007 - Noûs 41 (4):735–757.
    Al is nearly finished sweeping his kitchen floor when he notices, on a counter, a corkscrew that should be put in a drawer. He intends to put the corkscrew away as soon as he is finished with the floor; but by the time he returns the broom and dustpan to the closet, he has forgotten what he intended to do. Al knows (or has a true belief) that there is something he intended to do now in the kitchen. He gazes (...)
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  25.  19
    Collapse of Distance: Epistemic Strategies of Science and Technoscience.Alfred Nordmann - 2006 - Danish Yearbook of Philosophy 41 (1):7-34.
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  26.  15
    Intentional action: Controversies, data, and core hypotheses.Alfred R. Mele - 2003 - Philosophical Psychology 16 (2):325-340.
    This article reviews some recent empirical work on lay judgments about what agents do intentionally and what they intend in various stories and explores its bearing on the philosophical project of providing a conceptual analysis of intentional action. The article is a case study of the potential bearing of empirical studies of a variety of folk concepts on philosophical efforts to analyze those concepts and vice versa. Topics examined include double effect; the influence of moral considerations on judgments about what (...)
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  27. Moral Responsibility, Manipulation, and Minutelings.Alfred R. Mele - 2013 - The Journal of Ethics 17 (3):153-166.
    This article explores the significance of agents’ histories for directly free actions and actions for which agents are directly morally responsible. Candidates for relevant compatibilist historical constraints discussed by Michael McKenna and Alfred Mele are assessed, as is the bearing of manipulation on free action and moral responsibility.
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  28. When Are We Self-Deceived?Alfred Mele - 2012 - Humana Mente Journal of Philosophical Studies (20).
    This article‘s point of departure is a proto-analysis that I have suggested of entering self-deception in acquiring a belief and an associated set of jointly sufficient conditions for self-deception that I have proposed. Partly with the aim of fleshing out an important member of the proposed set of conditions, I provide a sketch of my view about how selfdeception happens. I then return to the proposed set of jointly sufficient conditions and offer a pair of amendments.
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  29.  6
    A short commentary on Kant's Critique of pure reason.Alfred Cyril Ewing - 1938 - Chicago: University of Chicago Press.
    This concise volume is at once an excellent introduction to Kant'sCritique of Pure Reasonand an original analysis of Kant's ideas.
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  30. Recent Work on Intentional Action.Alfred R. Mele - 1992 - American Philosophical Quarterly 29 (3):199 - 217.
    Central to the philosophy of action is a concern to understand intentional action. Two pertinent questions may be distinguished. What is it to do something intentionally? How is intentional behavior to be explained? Although, ideally, a review of recent work in the philosophy of action would attend equally to both questions, space does not permit my doing justice to both here. I shall focus on the definitional or conceptual issue and examine work on the explanatory issue only insofar as it (...)
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  31.  29
    Twisted Self Deception.Alfred R. Mele - 1999 - Philosophical Psychology 12 (2):117-137.
    In instances of "twisted" self-deception, people deceive themselves into believing things that they do not want to be true. In this, twisted self-deception differs markedly from the "straight" variety that has dominated the philosophical and psychological literature on self-deception. Drawing partly upon empirical literature, I develop a trio of approaches to explaining twisted self-deception: a motivation-centered approach; an emotion-centered approach; and a hybrid approach featuring both motivation and emotion. My aim is to display our resources for exploring and explaining twisted (...)
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  32.  59
    Deciding: how special is it?Alfred R. Mele - 2021 - Philosophical Explorations 24 (3):359-375.
    To decide to A, as I conceive of it, is to perform a momentary mental action of forming an intention to A. I argue that ordinary instances of practical deciding, so conceived, falsify the following...
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  33.  98
    Direct Versus Indirect: Control, Moral Responsibility, and Free Action.Alfred R. Mele - 2020 - Philosophy and Phenomenological Research 102 (3):559-573.
    Philosophy and Phenomenological Research, EarlyView.
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  34.  35
    Nature and Life.Alfred North Whitehead - 1934 - New York: Cambridge University Press.
    First published as part of the Cambridge Miscellany series in 1934, this book presents the content of two lectures delivered by Alfred North Whitehead at the University of Chicago in October 1933. The volume concerns itself chiefly with the complex relationship between nature, philosophy and science.
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  35.  13
    Deciding to act.Alfred R. Mele - 2000 - Philosophical Studies 100 (1):81–108.
    As this passage from a recent book on the psychology of decision-making indicates, deciding seems to be part of our daily lives. But what is it to decide to do something? It may be true, as some philosophers have claimed, that to decide to A is to perform a mental action of a certain kind – specifically, an action of forming an intention to A. (Henceforth, the verb ‘form’ in this context is to be understood as an action verb.) Even (...)
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  36.  60
    Surrounding Free Will: Philosophy, Psychology, Neuroscience.Alfred R. Mele (ed.) - 2014 - New York: Oup Usa.
    This cutting-edge volume showcases work supported by a four-year, 4.4 million dollar project on free will and science. In fourteen new articles and an introduction, contributors explore the subject of free will from the perspectives of neuroscience; social, cognitive, and developmental psychology; and philosophy.
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  37.  21
    Idealism : A Critical Survey.Alfred C. Ewing - 1934 - London, England: Routledge.
    First published in 1934, this book evaluates the characteristic doctrines of the idealism which dominated philosophy during the last century. It seeks to combine realism, as to epistemology and physical objects, with a greater appreciation of views which emphasize the unity and rationality of the universe. This work is not a history and does not try to compete with any histories of idealism but it instead reaches an independent conclusion on certain philosophical problems by criticising what others have said. The (...)
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  38.  48
    Wittgenstein's Tractatus: An Introduction.Alfred Nordmann - 2005 - New York: Cambridge University Press.
    Ludwig Wittgenstein's 'Tractatus Logico-Philosophicus' is one of the most important books of the twentieth century. It influenced philosophers and artists alike and it continues to fascinate readers today. It offers rigorous arguments but clothes them in enigmatic pronouncements. Wittgenstein himself said that his book is 'strictly philosophical and simultaneously literary, and yet there is no blathering in it'. This introduction, first published in 2005, considers both the philosophical and the literary aspects of the 'Tractatus' and shows how they are related. (...)
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  39.  78
    On snubbing proximal intentions.Alfred R. Mele - 2019 - Philosophical Studies 176 (11):2833-2853.
    In the simplest case, a proximal intention is an intention one has now to do something now. Recently, some philosophers have argued that proximal intentions do much less work than they are sometimes regarded as doing. This article rebuts these arguments, explains why the concept of proximal intentions is important for some scientific work on intentional action, and sketches an empirical approach to identifying proximal intentions. Ordinary usage of “intend” and the place of intention in folk psychology and scientific psychology (...)
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  40.  44
    Anonymity, Pseudonymity, and Deliberation: Why Not Everything Should Be Connected.Alfred Moore - 2018 - Journal of Political Philosophy 26 (2):169-192.
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  41.  15
    Noumenal Technology.Alfred Nordmann - 2005 - Techné: Research in Philosophy and Technology 8 (3):3-23.
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  42. Unconscious decisions and free will.Alfred Mele - 2013 - Philosophical Psychology 26 (6):777-789.
    It is sometimes claimed that certain experiments show that free will is an illusion by showing that all decisions are made unconsciously. I have argued elsewhere that these experiments do not show that any decisions are made unconsciously. But suppose I am wrong about that. Even then, I argue, these experiments do not pose a serious threat to free will. First, one is not warranted in generalizing from findings about the decisions allegedly made in these experiments to the claim that (...)
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  43.  45
    Noumenal Technology.Alfred Nordmann - 2005 - Techné: Research in Philosophy and Technology 8 (3):3-23.
  44. Another Scientific Threat to Free Will?Alfred Mele - 2012 - The Monist 95 (3):422-440.
    In Effective Intentions: The Power of Conscious Will (Mele 2009), I argue that scientists—neuroscientists and others—have not proved that free will is an illusion and have not produced powerful evidence for that claim. Manuel Vargas has suggested that in that book I ignore a serious scientific threat to free will (2009). The alleged threat is identified in section 1. It is the topic of this article.
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  45.  13
    Akrasia, self-control, and second-order desires.Alfred R. Mele - 1992 - Noûs 26 (3):281-302.
    Pristine belief/desire psychology has its limitations. Recognizing this, some have attempted to fill various gaps by adding more of the same, but at higher levels. Thus, for example, second-order desires have been imported into a more stream- lined view to explicate such important notions as freedom of the will, personhood, and valuing. I believe that we need to branch out as well as up, augmenting a familiar 'philosophical psychology' with psychological items that are irreducible to beliefs and desires (for support, (...)
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  46.  74
    Libertarianism, Compatibilism, and Luck.Alfred R. Mele - 2015 - The Journal of Ethics 19 (1):1-21.
    The “problem of present luck” targets a standard libertarian thesis about free will. It has been argued that there is an analogous problem about luck for compatibilists. This article explores similarities and differences between the alleged problems.
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  47.  12
    Henry David Thoreau and the Moral Agency of Knowing.Alfred I. Tauber - 2001 - University of California Press.
    In his graceful philosophical account, Alfred I. Tauber shows why Thoreau still seems so relevant today—more relevant in many respects than he seemed to his contemporaries. Although Thoreau has been skillfully and thoroughly examined as a writer, naturalist, mystic, historian, social thinker, Transcendentalist, and lifelong student, we may find in Tauber's portrait of Thoreau the moralist a characterization that binds all these aspects of his career together. Thoreau was caught at a critical turn in the history of science, between (...)
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  48.  22
    Democratic Reason, Democratic Faith, and the Problem of Expertise.Alfred Moore - 2014 - Critical Review: A Journal of Politics and Society 26 (1-2):101-114.
    ABSTRACTHélène Landemore's Democratic Reason develops one important line of research in political epistemology, which we can define as the study of the ways in which distributed knowledge is put together for the purposes of making political decisions. Landemore argues for the epistemic benefits of cognitive diversity in political decision procedures in a condition of epistemic equality—where there are no experts. Given this omission, her approach has undeveloped potential for a second line of research in political epistemology, on the problem of (...)
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  49.  68
    Another New Wittgenstein: The Scientific and Engineering Background of the Tractatus.Alfred Nordmann - 2002 - Perspectives on Science 10 (3):356-384.
  50.  15
    When Are We Self-Deceived?Alfred R. Mele - 2012 - Humana Mente 5 (20).
    This article’s point of departure is a proto-analysis that I have suggested of entering self-deception in acquiring a belief and an associated set of jointly sufficient conditions for self-deception that I have proposed. Partly with the aim of fleshing out an important member of the proposed set of conditions, I provide a sketch of my view about how self-deception happens. I then return to the proposed set of jointly sufficient conditions and offer a pair of amendments.
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