Aphids display an abundance of adaptations that are not easily studied in existing model systems. Here we review the biology of a new genomic model system, the pea aphid, Acyrthosiphon pisum. We then discuss several phenomena that are particularly accessible to study in the pea aphid: the developmental genetic basis of polyphenisms, aphid–bacterial symbioses, the genetics of adaptation and mechanisms of virus transmission. The pea aphid can be maintained in the laboratory and natural populations can be studied in the field. (...) These properties allow controlled experiments to be performed on problems of direct relevance to natural aphid populations. Combined with new genomic approaches, the pea aphid is poised to become an important model system for understanding the molecular and developmental basis of many ecologically and evolutionarily relevant problems. BioEssays 28: 747–755, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

La discussion sur le langage privé que l’on trouve dans les Recherchesphilosophiques a été écrite entre 1937 et 1945, après que les 190 premières remarques de la partie I du livre eurent presque atteint leur forme finale. Les textes post-1936 sur le langage privé constituent un nouveau départ, dans sa lettre et son esprit, par rapport au matériau d’avant 1936.Néanmoins, entre 1929 et 1936, Wittgenstein s’est penché à plusieurs reprises sur l’idée d’un langage « que moi seul peux comprendre ». (...) Un volet de cette question qui, lui, est abordé directement dans les Recherches, c’est l’idée que « si j’appliquais le mot “douleur” uniquement à ce que j’ai nommé jusqu’ici “ma douleur”, et les autres “la douleur de L.W.”, je ne ferais ainsi aucun tort aux autres, si toutefois l’on avait prévu une notation qui d’une façon ou d’une autre, permettrait de pallier l’absence du mot “douleur” dans d’autres combinaisons ». Cependant, la discussion de cette question dans les Recherches est beaucoup plus brève que dans les textes d’avant 1936. J’examine le rapport entre ce § 403 des Recherches d’un côté, et de l’autre côté les textes des cahiers de 1929 et les Remarques philosophiques , en retraçant le développement initial de cette argumentation et en explorant les principales lignes de continuité et de discontinuité dans le traitement que Wittgenstein réserve à la question du langage privé.The discussion of private language in the Investigations was written between 1937 and 1945, after the first 190 remarks of Part I of the book had almost reached their final form. The post-1936 writing on private language represents a fresh start, both in wording and in conception, on the pre-1936 material.Nevertheless, Wittgenstein did repeatedly discuss the idea of a language which “only I myself can understand” during 1929-36. One strand in this discussion that is directly taken up in the Investigations is the idea that “If I were to reserve the word ‘pain’ solely for what I had hitherto called ‘my pain”, and others “L.W.’s pain,” I should do other people no injustice, so long as a notation were provided in which the loss of the word ‘pain’ in other connexions were somehow supplied.” However, the discussion of this topic in the Investigations is much briefer than in the pre-1936 writing. I look at the relationship between §403 and texts from the 1929 notebooks and the Philosophical Remarks, assembled in the spring of 1930, mapping out the earlier development of this line of argument and exploring the principal continuities and discontinuities in Wittgenstein’s treatment of private language. (shrink)

The nonlinear differential equation governing the periodic motion of the one-dimensional, undamped, and unforced cubic-quintic Duffing oscillator is solved exactly by obtaining the period and the solution. The period is given in terms of the complete elliptic integral of the first kind and the solution involves Jacobian elliptic functions. We solve the cubic-quintic Duffing equation under arbitrary initial conditions. Physical applications are provided. The solution to the mixed parity Duffing oscillator is also formally derived. We illustrate the obtained results with (...) concrete examples. We give high accurate trigonometric approximations to the Jacobian function cn. (shrink)

Online social networks (OSN) have become a part of our daily lives whether they are used for socialization and communication or to promote business interests. OSN have become an important tool for businesses to advertise, create brand awareness, and promote their products and services. Business use of OSN for advertising purposes is highly reliant on targeted ads which display advertisements to OSN users based on their demographics and use of OSN, apps, and websites. Thus, one of the most valuable commodities (...) of OSN is the population of users and the information they share. To investigate the relationship between OSN site use, use of privacy settings, and how they relate to profile disclosure, a model is built based on the theory of reasoned action and the privacy calculus model. To validate the model, a survey is conducted and the results are analyzed with partial least squares. Risk and benefit were both shown to be significant antecedents of attitude. Both attitude and subjective norm, from the theory of reasoned action model, significantly affected OSN site use, while omitting intentions. OSN site use was significantly related to both profile disclosure and use of privacy settings. Last, use of privacy settings significantly affected profile disclosure. These results imply that use of privacy settings does not decrease the rate of disclosure. Giving users tools to protect their private information is important in protecting the privacy of OSN users, and it will lead to increases in safe disclosure of information helping OSN target ads effectively. (shrink)

Criticized as a nostalgic anachronism by those who oppose her version of political theory and lauded as symbol of direct democratic participation by those who favor it, the Athenian polis features prominently in Hannah Arendt's account of politics. This essay traces the origin and development of Arendt's conception of the polis as a space of appearance from the early 1950s onward. It makes particular use of the Denktagebuch, Arendt's intellectual diary, in order to shed new light on the historicity of (...) one of her central concepts. The article contends that both critics and partisans of Arendt's use of the polis have made the same mistake: they have presumed that the polis represents a space of face-to-face immediacy. In fact, Arendt compared the polis to a series of analogues, many of which are not centered on direct exchanges between political actors and spectators. As a result, Arendt's early work on the polis turns out to anticipate many of the concerns of her later work on judgment, and her theory of the polis becomes a theory of topics. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Theology of Play and the Play of Theology in Thomas AquinasDavid L. Whidden IIISTUDENTS OF THOMAS AQUINAS have argued over many issues in the last 150 years or so; in fact, it is nearly impossible to get out of the very first question of the Summa Theologiae without entering into a century-long debate about the status of sacred doctrine as an Aristotelian science. We ponder whether theology meets (...) the requirements of a scientia and argue about just how to understand the task of theology in the face of Aquinas’s concern about theology as a scientia. Part of this ongoing argument is shaped by the philosophical and epistemological needs of theologians attempting to justify their positions in an academic world driven by the secular and scientific norms of the Enlightenment. Additionally, some interest in theology as a scientia is driven by the desire to provide a philosophically acceptable alternative to secular forms of reason—thus Leo’s XIII’s promotion of Thomistic philosophy.The interest in theology as a science was shaped by the historical work of Chenu in his influential articles on the topic and then by almost every other important Thomist in the last fifty years.1 Theology as a scientia is such a pressing topic that it would almost be fair to say that Thomists have developed their own scientia of theology as a scientia. [End Page 273]Beyond the modern and, perhaps, postmodern concerns driving this interest, there are good reasons to pay attention to Aquinas on the status of theology. If we focus on theology as a scientia, it is because Aquinas invites us to do so by taking up this question in one form or another at the beginning of his major theological syntheses. We are, after all, only following his lead and pondering with him just what we are thinking about, and how we are thinking, when we think about God.Within the Thomistic corpus there is, however, a minority report with regard to the status of theology. In his prologue to his commentary on Boethius’s Hebdomads, Aquinas looks at theology in a very different way, one that can supplement our understanding of sacred doctrine in its role as both an intellectual and an affective enterprise. In this commentary Aquinas journeys into a different territory and explores theology, not as a scientia, but as a kind of play—a play that evokes delight and pleasure in the one who pursues wisdom.My approach will be first to describe Aquinas’s theology with regard to regular play—the kind of recreational activities we all engage in, whether they are physical or verbal. He takes up the question of the morality of play in several places and in a way that will inform our understanding of what he means when he describes theology as play. With this understanding of regular play in place, we will then explore theology as play, based on the supposition that there is something analogical between regular play and theology as play. I will finish with some reflections on how this might contribute to our present understanding of theological work.IWhile he scatters comments about play across his corpus and mentions it in all of his theological syntheses, Aquinas gives sustained attention to play in two places: first, in his commentary on Aristotle’s Ethics, and second, in question 168 of the Secunda secundae (in the treatise on temperance) of the Summa theologiae. From the outset one will notice that one of [End Page 274] the difficulties in thinking about play with Aquinas is that the Latin word for play, ludo, is multivalent, difficult to translate, and so can sometimes mean recreational games, sometimes word play, and sometimes making fun of or deriding someone.2 Even the context does not always make it clear exactly how Aquinas is talking about play.In these two sustained treatments of play Aquinas is concerned with two main issues: first, the purpose of play; second, the morality of games and how they can be approached virtuously—with proper order. That is, he is concerned with the why and the how of games.Aquinas pursues these issues in his commentary... (shrink)

The essay begins by briefly reviewing the complex history of the collaborative long-distance editing work that led to the publication of Wittgenstein: Lectures, Cambridge 1930-1933 (Cambridge UP, 2016). It then turns to a discussion of the rationale for the innovative editorial policies we ultimately developed and implemented, and some of the broader methodological issues that they raise.

"Legend is overdue for replacement, and an adequate replacement must attend to the process of science as carefully as Hull has done. I share his vision of a serious account of the social and intellectual dynamics of science that will avoid both the rosy blur of Legend and the facile charms of relativism.... Because of [Hull's] deep concern with the ways in which research is actually done, Science as a Process begins an important project in the study of science. It (...) is one of a distinguished series of books, which Hull himself edits."—Philip Kitcher, Nature "In Science as a Process, [David Hull] argues that the tension between cooperation and competition is exactly what makes science so successful.... Hull takes an unusual approach to his subject. He applies the rules of evolution in nature to the evolution of science, arguing that the same kinds of forces responsible for shaping the rise and demise of species also act on the development of scientific ideas."—Natalie Angier, New York Times Book Review "By far the most professional and thorough case in favour of an evolutionary philosophy of science ever to have been made. It contains excellent short histories of evolutionary biology and of systematics (the science of classifying living things); an important and original account of modern systematic controversy; a counter-attack against the philosophical critics of evolutionary philosophy; social-psychological evidence, collected by Hull himself, to show that science does have the character demanded by his philosophy; and a philosophical analysis of evolution which is general enough to apply to both biological and historical change."—Mark Ridley, Times Literary Supplement "Hull is primarily interested in how social interactions within the scientific community can help or hinder the process by which new theories and techniques get accepted.... The claim that science is a process for selecting out the best new ideas is not a new one, but Hull tells us exactly how scientists go about it, and he is prepared to accept that at least to some extent, the social activities of the scientists promoting a new idea can affect its chances of being accepted."—Peter J. Bowler, Archives of Natural History "I have been doing philosophy of science now for twenty-five years, and whilst I would never have claimed that I knew everything, I felt that I had a really good handle on the nature of science, Again and again, Hull was able to show me just how incomplete my understanding was.... Moreover, [Science as a Process] is one of the most compulsively readable books that I have ever encountered."—Michael Ruse, Biology and Philosophy. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS The Immutability of God in the Theology of Hans Urs von Balthasar. By GERARD F. O'HANLON, S.J. Cambridge: Cambridge University Press, 1990. Pp. 246. $59.95 (cloth). O'Hanlon unfolds Balthasar's theology in four main chapters, which treat the question of immutability in terms, respectively, of Christ· ology; creation; time and eternity; and inner trinitarian life in God. In Chapter 5, O'Hanlon compares Balthasar's approach with some English-speaking authors (...) (B. Davies, A. Kenny, E. Stump, Kretzmann, P. Geach, J. Kvanvig, D. H. Mellor, A. E. Williams). Finally, in Chapter 6, O'Hanlon ofiers a summary and assessment of Balthasar's proposals. (1) Regarding his treatment of Christology in Chapter 1, O'Hanlon discusses how Balthasar's attempt to find a "middle way" between simple mutability and a traditional sense of immutability in God lies in uncovering the trinitarian presuppositions of Christology. Whether God is open to being afiected by dialogue with creatures hinges decisively on how we understand Jesus Christ or, more precisely, on how we understand the humanity of Jesus to reveal what God is like (9-10). This is an approach difierent from.that of those who would criticize the traditional axiom of divine immutability on the basis of certain philosophical assumptions regarding the priority of becoming over being (10-11). Balthasar's approach is first theological: when we con· sider the soteriological and eschatological dimensions of Christ's work for us, we are forced to ask the question about the nature of God: "does he too not sufier, is he not afiected by sin, can he he simply apathetic to the prospect of any final loss of his creatures to hell? " (9). At the heart of Ba1thasar's position, then, lies an affirmation of a kenosis within the inner life of God, which already provides a foundation for the possibility of the (second) kenosis revealed in the incarnation and the cross (11-14). That is, the "kind of emptying and self. giving we see in the incarnation is both the image and the effect of the eternal ' externalization ' of God that is involved in the intra-trinitarian life" (14). It is imperative that one see the nuances of this affirmation. On the one hand, Balthasar is careful to avoid a simple identification of the second with the first kenosis: this would make the incarna· 335 336 BOOK REVIEWS tion and cross natural and necessary to God, thus entailing theopaschism (14-15). On the other hand, the suffering love of Christ does truly reveal God's sovereign power to be absolute love and self-giving, because there " is a certain analogy between the divine and human natures of Christ which is due to the identity of the person, the pre-existent Logos" (14). Thus Balthasar is led to qualify the traditional understanding of divine immutability (15) : there is " some real kenosis within God which has ontological status and is not merely functional, soteriological, or a simple addition which does not affect God" {16). O'Hanlon makes clear how Balthasar is at pains always to respect the mysterious nature of the issue, as well as the limits set by the great Christian tradition. At the heart of the matter lies a return to the person -nature distinction as set by Chalcedon. Traditionally, the affirmation has been of a divine nature in Christ which remains immutable and a human nature which changes and suffers. Balthasar goes beyond this affirmation. On the basis of Philippians 2:5-11, he arrives at the necessity of positing a real kenosis in God ; and from his recognition of the ontological, personal identity of the Logos as the subject who unites the two distinct natures in Christ, he refuses to limit the change and suffering which Christ experiences to his human nature alone. In fact, the tendency to understand the human nature of Christ as an instrumentum conjunctum which does not affect the divine person he considers as Nestorian in character. Yet, at the same time, Balthasar affirms the incommensurable difference between God and the world, between the divine and human " unmixed " natures of Christ. The relation between the two natures is precisely analogous (after the manner... (shrink)

According to the somatic mutation theory (SMT), cancer begins with a genetic change in a single cell that passes it on to its progeny, thereby generating a clone of malignant cells. It is strongly supported by observations of leukemias that bear specific chromosome translocations, such as Burkitt's lymphoma, in which a translocation activates the c‐myc gene, and chronic myeloid leukemia (CML), in which the Philadelphia chromosome causes production of the BCR‐ABL oncoprotein. Although the SMT has been modified and extended to (...) encompass tumor suppressor genes, epigenetic inheritance, and tumor progression through accumulation of further mutations, perhaps the strongest validation comes from the successful treatment of certain malignancies with drugs that directly target the product of the mutant gene.magnified imageDavid Vaux is at the Walter and Eliza Hall Institute and La Trobe Institute for Molecular Science, Melbourne, Australia. (shrink)

To many it seems obvious that any reduction of the nature of man to purely physical components involves an indirect attack on the doctrine of human immortality. To so reduce human nature, it may be argued, is to eliminate the soul and it is this essential component of man, rather than his body, which is the foundation of his immortality. This seems to me an altogether mistaken notion. My purpose in this paper, therefore, is to clarify the relation of physicalism (...) and immortality and thereby to reveal the error in this alleged incompatibility. (shrink)

Compares classic and contemporary theories of genetics and evolution and explores the role of teleological thought in biology.

What makes us persons? Is it our bodies, our minds, or our consciousness? For centuries, philosophers have sought to answer these questions. While some believe humans are physical or biological, others claim we have an immaterial soul. This book proposes a new alternative. Selves were formed in evolution through connections and commitments to others when early hominins lived in tribal groups and developed languages. As humans learned to fulfill these commitments, they not only cultivated relationships but also created their personal (...) identities. Their habits of responsibility established their characters and therefore their reputations within their communities. This naturalistic approach proposes that a self is defined by the history of its commitments to cultural and personal norms. While brain processes are required, the self is not some internal, private mind but primarily a role within its community. As technology advances, selfhood could in the future be enabled by electronic, quantum, or other non-biological means. So if a self is formed through norms, could artificial intelligence evolve to have self-identity? (shrink)

Drawing on work of the past decade, this volume brings together articles from the philosophy, history, and sociology of science, and many other branches of the biological sciences. The volume delves into the latest theoretical controversies as well as burning questions of contemporary social importance. The issues considered include the nature of evolutionary theory, biology and ethics, the challenge from religion, and the social implications of biology today (in particular the Human Genome Project).

Intentionality, as Brentano originally introduced the term in modern philosophy, was meant to provide a distinctive characteristic definitively separating the mental from the physical.(1) Mental states have an intrinsic relationship to an object, to that which they are "about." Physical entities just are what they are, they cannot, by their very essence, refer to anything, they have no "outreach", as one might put it. Mental states have, as it were, an incomplete essence, they cannot exist at all unless they are (...) completed by something other than themselves, their object. Brentano's position is opposed to all theories which represent the mental as only extrinsically related to the world, that is, to all theories in which mental states are themselves self-sufficient for their own existence and only secondarily relate to the world by means of something external to their nature, e.g., neurological causation, divine intervention, or pre-established harmony. In these later cases, any mental act whatsoever could be related to any object, or indeed to none, for the relation is external to the nature of the act, it is superimposed on it by outside forces. Brentano's point is that a mental act has, by its very essence, an Intentional object without which it would not be a mental act. It would therefore appear that since causality is an external relationship which could in principle relate any two things regardless of their nature, the Intentional relation between an act and its object cannot be a causal relation. (shrink)

The Human Genome Project has raised many issues regarding the contributions of genetics to a variety of diseases and societal conditions. With genetic testing now easily conducted with lowered costs in nonmedical domains, a variety of privacy issues must be considered. Such testing will result in the loss of significant privacy rights for the individual. Society must now consider such issues as the ownership of genetic data, confidentiality rights to such information, limits placed on genetic screening, and legislation to control (...) genetic testing and its applications. There is often a conflict between individual rights to privacy and the need for societal protection. (shrink)

Biological species have been treated traditionally as spatiotemporally unrestricted classes. If they are to perform the function which they do in the evolutionary process, they must be spatiotemporally localized individuals, historical entities. Reinterpreting biological species as historical entities solves several important anomalies in biology, in philosophy of biology, and within philosophy itself. It also has important implications for any attempt to present an "evolutionary" analysis of science and for sciences such as anthropology which are devoted to the study of single (...) species. (shrink)

Thought is not based on an image that is isomorphic to the object. Descartes, Husserl, Frege, Wittgenstein and Brandom progressively overcome this Aristotelian misconception of the intentionality of thinking.

The headlines at the outset of 1987 told of Howard Beach, where a group of blacks had been chased, and one killed, because they had unwittingly entered a white enclave in New York City. And they told of Forsythe County, Georgia, where the mere presence of civil rights marchers, in a place from which blacks had been driven three-quarters of a century earlier, brought out depths of antagonism unknown since an earlier era of civil rights marches. Behind both events – (...) indeed, behind almost every question of race to arise in recent years – was the specter of affirmative action. Even as, during the late 1960s, some blamed urban riots on the federal government's failure to achieve equal opportunity between the races by equalizing life outcomes, so in 1987 white antagonisms were regarded in some quarters as a crude reflection of the Reagan administration's hostility towards affirmative action. The rhetoric and the policies of that administration, it was said, contributed to a sentiment that blacks already had their share – indeed, more than their share. Official word and deed contributed also, it was argued, to a resentment against blacks who, because of quotas, had been unfairly advantaged. (shrink)

Kosgaard claims that selves/agents self-constitute during actions by relying on principles such as Kant’s Categorical Imperative. This intellectualist approach neglects the body. Merleau-Ponty considers the “lived body” and its perceptual world as the source of the unity of action, an approach that I extrapolate to all biological organisms.

The sameness and difference of entities depend on context or horizon and these horizons may be either synchronous or diachronic. Money and qualia are examples of identity within synchronic contexts. Music, biological functions, and cultural roles are defined by their diachronic horizons. The diachronic cultural and narrative contexts of selves are what makes them distinctively different.

Jacobs, in Choosing Character, seems to assume that there are selves already capable of voluntary choice who then choose their character by developing habits. I argue that selves, choice, responsibility and character form a conceptual and practical hermeneutic circle, a whole without which selfhood makes no sense. There can be no selfhood prior to responsible character.

My aim is to give an overview of what minds are and how they came to be. Minds are a product of billions of years of evolution so it is a daunting task to summarize this history in 45 minutes. My attempt will involve vast oversimplifications, highly speculative and condensed “just so” stories, and a great amount of hand waving. In particular, I will presuppose the theory of evolution and will not attempt to either explain it or justify it.

Intuition. Originally an alleged direct relation, analogous to visual seeing, between the mind and something abstract and so not accessible to the senses. What are intuited (which can be derivatively called 'intuitions') may be abstract objects, like numbers or properties, or certain truths regarded as not accessible to investigation through the senses or calculation; the mere short circuiting of such processes in 'bank managers intuition' would not count as intuition for philosophy. Kant talks of our intuiting space and time, in (...) a way which is direct and entirely free from any mediation by the intellect - but this must be distinguished from an alleged pure reception of 'raw data' from the senses; the intuiting is presupposed by, and so cannot depend upon, sensory experience. (shrink)

“Hildebrand has constructed a well-paced and historically informative evaluation of neopragmatism. . . . This book makes an excellent companion for courses in both contemporary epistemology and American philosophy.” –Choice How faithful are the Neopragmatists' reformulations of Classical Pragmatism? Can their Neopragmatisms work? In examining the difficulties in Neopragmatism, David L. Hildebrand is able to propose some distinct directions for Pragmatism.

One way to understand science is as a selection process. David Hull, one of the dominant figures in contemporary philosophy of science, sets out in this 2001 volume a general analysis of this selection process that applies equally to biological evolution, the reaction of the immune system to antigens, operant learning, and social and conceptual change in science. Hull aims to distinguish between those characteristics that are contingent features of selection and those that are essential. Science and Selection brings (...) together many of David Hull's most important essays on selection in one accessible volume. (shrink)

Individuals with autistic spectrum disorder (ASD) display diverse deficits in social, cognitive and behavioral functioning. To date, there has been mixed findings on the profile of executive function deficits for high-functioning adults (IQ >70) with ASD. A conceptual distinction is commonly made between “cold” and “hot” executive functions. Cold executive functions refer to mechanistic higher-order cognitive operations (e.g., working memory), whereas hot executive functions entail cognitive abilities supported by emotional awareness and social perception (e.g., social cognition). This study aimed to (...) determine the independence of deficits in hot and cold executive functions for high-functioning adults with ASD. Forty-two adults with ASD (64% male, aged 18-66 years) and 40 age and gender matched controls were administered The Awareness of Social Inference Test (TASIT; emotion recognition and social inference), Letter Number Sequencing (working memory) and Hayling Sentence Completion Test (response initiation and suppression). Between-group analyses identified that the ASD group performed significantly worse than matched controls on all measures of cold and hot executive functions (d =.54-1.5). Hierarchical multiple regression analyses revealed that the ASD sample performed more poorly on emotion recognition and social inference tasks than matched controls after controlling for cold executive functions and employment status. The findings also indicated that the ability to recognise emotions and make social inferences was supported by working memory and response initiation and suppression processes. Overall, this study supports the distinction between hot and cold executive function impairments for adults with ASD. Moreover, it advances understanding of higher-order impairments underlying social interaction difficulties for this population which, in turn, may assist with diagnosis and inform intervention programs. (shrink)