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In eukaryotic cells terminally misfolded proteins of the secretory pathway are retarded in the endoplasmic reticulum (ER) and subsequently degraded in a ubiquitin‐proteasome‐dependent manner. This highly conserved process termed ER‐associated protein degradation (ERAD) ensures homeostasis in the secretory pathway by disposing faulty polypeptides and preventing their deleterious accumulation and eventual aggregation in the cell. The focus of this paper is the functional description of membrane‐bound ubiquitin ligases, which are involved in all critical steps of ERAD. In the end we want (...) to speculate on how the modular architecture of these entities ensures the specificity of substrate selection and possibly accomplishes the transport of misfolded polypeptides from the ER into the cytoplasm. (shrink)

Peer review is a widely accepted instrument for raising the quality of science. Peer review limits the enormous unstructured influx of information and the sheer amount of dubious data, which in its absence would plunge science into chaos. In particular, peer review offers the benefit of eliminating papers that suffer from poor craftsmanship or methodological shortcomings, especially in the experimental sciences. However, we believe that peer review is not always appropriate for the evaluation of controversial hypothetical science. We argue that (...) the process of peer review can be prone to bias towards ideas that affirm the prior convictions of reviewers and against innovation and radical new ideas. Innovative hypotheses are thus highly vulnerable to being “filtered out” or made to accord with conventional wisdom by the peer review process. Consequently, having introduced peer review, the Elsevier journal Medical Hypotheses may be unable to continue its tradition as a radical journal allowing discussion of improbable or unconventional ideas. Hence we conclude by asking the publisher to consider re-introducing the system of editorial review to Medical Hypotheses. (shrink)

This topically organized, interdisciplinary anthology provides competing perspective on the claim that western culture faces a moral crisis. Using clearly written, accessible essays by well-known authors in philosophy, the social sciences, and the humanities, the book introduces students to a variety of perspectives on the current cultural debate about values that percolates beneath the surface of most of our social and political controversies.

This book collects several excerpts from the work of each of nine 18th and 19th century Scottish thinkers: Francis Hutcheson, David Hume, Adam Smith, Thomas Reid, Dugald Stewart, Thomas Brown, Sir William Hamilton, James Frederick Foster, and James McCosh. A brief account of each man's life and work accompanies the selections.

This book collects several excerpts from the work of each of nine 18th and 19th century Scottish thinkers: Francis Hutcheson, David Hume, Adam Smith, Thomas Reid, Dugald Stewart, Thomas Brown, Sir William Hamilton, James Frederick Foster, and James McCosh. A brief account of each man's life and work accompanies the selections.

To the best of my knowledge, with the exception of Galton's original work (1880, 1883), Sommer's brief case study (1978), and Faw's (1997, 2009) articles, this is the only really substantial discussion of the phenomenon of non-brain-damaged "non-imagers" available anywhere.

This introductory chapter discusses the philosophical and scientific arguments for free will skepticism and their implications--including the debate between Saul Smilansky's "illusionism," Thomas Nadelhoffer's "disillusionism," Shaun Nichols' "anti-revolution," and the "optimistic skepticism" of Derk Pereboom, Bruce Waller, Tamler Sommers, and others.

The problem of the relation between mind and brain has been among the most persistent in modern Western thought, one that even recent advances in neuroscience haven't been able to put to rest. Historian Larry McGrath's Making Spirit Matter is about how a particularly productive and influential generation of late nineteenth- and early twentieth-century French thinkers attempted to answer this puzzle by showing the mutual dependence of spirit and matter. The veritable revolution taking place across disciplines, from philosophy to psychology, (...) located our spiritual powers in the brain and offered a radical reformulation of the meaning of science, spirit, and the self. Pulling out connections between thinkers such as Bergson, Blondel, and Fouille̹e, among others, McGrath plots the intellectual movements that brought back to life themes of agency, time, and experience by putting into action the very sciences that seemed to undermine metaphysics and theology. In so doing, Making Spirit Matter lays bare the long legacy of this moment in the history of ideas and how it might renew our understanding of the relationship between mind and brain. (shrink)

Immunology is central to contemporary biology and medicine, but it also provides novel philosophical insights. Its most significant contribution to philosophy concerns the understanding of biological individuality: what a biological individual is, what makes it unique, how its boundaries are established and what ensures its identity through time. Immunology also offers answers to some of the most interesting philosophical questions. What is the definition of life? How are bodily systems delineated? How do the mind and the body interact? In this (...) Element, Thomas Pradeu considers the ways in which immunology can shed light on these and other important philosophical issues. This title is also available as Open Access on Cambridge Core. (shrink)

The Scottish philosopher Thomas Reid first published Essays on Active Powers of Man in 1788 while he was Professor of Philosophy at King's College, Aberdeen. The work contains a set of essays on active power, the will, principles of action, the liberty of moral agents, and morals. Reid was a key figure in the Scottish Enlightenment and one of the founders of the 'common sense' school of philosophy. In Active Powers Reid gives his fullest exploration of sensus communis as (...) the basis of all philosophical inquiry. He uses common sense realism to argue for the existence of a stable external world, the existence of other minds, and to offer a powerful challenge to versions of the Theory of Ideas advocated by Hume and Locke . This is a key work of the Scottish Enlightenment that made important contributions to fundamental debates about the basis of philosophical inquiry. (shrink)

Der Gedanke, der sich in der modernen Idee der Autonomie verdichtet, ist ein doppelter: Die Figur der Autonomie enthält zugleich eine neue Auffassung von Normativität und eine eigene Konzeption von Freiheit. Dem Gedanken der Autonomie zufolge ist ein Gesetz, das wahrhaft normativ ist, eines, als dessen Urheber wir uns selbst betrachten können; und eine Freiheit, die im vollen Sinne wirklich ist, drückt sich in Gestalt eben solcher selbstgegebener Gesetze aus. Die Idee der Autonomie artikuliert so die Einsicht, dass man Freiheit (...) und Gesetz nicht durch ihre Entgegensetzung bestimmen kann, sondern durcheinander erläutern muss. Wirkliche Freiheit ist nicht Freiheit von Gesetzen, sondern Freiheit in Gesetzen; verbindliche Normen sind nicht das, was Freiheit äußerlich beschränkt, sondern das, was Freiheit innerlich verwirklicht. Die Idee der Autonomie, die für die moderne praktische Philosophie seit Rousseau und Kant grundlegend ist, zielt so darauf, Freiheit und Verbindlichkeit in einem Zuge zu artikulieren: durch die Form selbstgegebener Gesetze. Mit Beiträgen von Robert Brandom, Judith Butler, Thomas Khurana, Christoph Menke, Terry Pinkard und Sebastian Rödl. (shrink)

Nicht erst seit dem Erscheinen der Schwarzen Hefte wird Martin Heideggers personliche wie denkerische Verstrickung in den Nationalsozialismus diskutiert. Die Debatte, ob er sich aus dieser Verstrickung jemals entschieden gelost hat, begleitet die Auseinandersetzung mit Heideggers Denken seit Jahrzehnten. Die Tagung Heideggers Schwarze Hefte. Ideologieanfalligkeit der Intellektuellen, die im Dezember 2015 an der Universitat Freiburg i.Br. stattfand, wendete sich im Blick auf Heidegger und daruber hinaus der Frage zu, wie es dazu kommen konnte, dass sich Intellektuelle in der Weimarer Republik (...) wenigstens zeitweise fur die NS-Bewegung begeisterten. Immanent-kritisches Weiterdenken mit Heidegger gegen Heidegger (NZZ) zeichnet die aus Anlass der Tagung gehaltenen Vortrage in ihrer Gesamtheit aus. Der Band enthalt die Beitrage von Wolfgang Essbach, Andreas Urs Sommer, Claus Arnold, Lore Huhn, Christian Bermes, Jeff Malpas, Emil Angehrn, Peter Trawny, Christoph Demmerling, Oliver Muller, Georg Essen, Rainer Marten und Dieter Thoma. (shrink)

These lucid studies of Derrida, Foucault, Habermas, and Rorty analyze majorcontributions to recent critical theory and forge a distinct position in the current philosophicaldebate.Thomas McCarthy is John Schaffer Professor in the Humanities ...

Thomas Erne entfaltet im Anschluss an Schleiermachers Ästhetik das Verhältnis von Kunst und Religion. Dabei nimmt er über Schleiermacher hinaus auch die moderne, autonome Kunst in Blick. Im Dialog mit exemplarischen Kunstwerken der Gegenwart fragt er nach Transzendenzerfahrungen in der Gegenwartskunst, in der die Kunstwerke selbst zu,,autonomen Sinndomänen" werden. Der Band dokumentiert die Schleiermacher-Lecture 2019 an der Theologischen Fakultät der Humboldt-Universität zu Berlin. Im Rahmen dieser Reihe sollen ausgewählte Aspekte von Schleiermachers Werk mit Fragen und Problemkonstellationen der Gegenwart in (...) Beziehung gesetzt werden. (shrink)

Les Beiträge zur Philosophie (1936-1938) ont été présentées, lors de leur publication en 1989, par l'éditeur F. -W. von Herrmann comme le "second chef-d'oeuvre" de M. Heidegger. Le présent volume rassemble des contributions parmi les plus grands spécialistes des recherches heideggériennes de la France et de l'étranger, qui permet de statuer sur la réception de cet ouvrage aussi fascinant que troublant. Il s'agit, d'une part, de préciser l'objet du texte, d'en exposer la structure, les concepts fondamentaux et son rapport avec (...) Etre et temps (1927), ainsi qu'avec certaines élaborations ultérieures ; d'autre part, des problèmes ciblés, parfois plus techniques, sont abordés, qui permettent d'introduire à ce texte, sans doute le plus difficile de Heidegger, et d'en approfondir la lecture. (shrink)

[Thomas Hurka] Using Bernard Suits's brilliant analysis of playing a game, this paper examines the intrinsic value of game-playing. It argues that two elements in Suits's analysis make success in games difficult, which is one ground of value, while a third involves choosing a good activity for the property that makes it good, which is a further ground. The paper concludes by arguing that game-playing is the paradigm modern as against classical value: since its goal is intrinsically trivial, its (...) value is entirely one of process rather than product, journey rather than destination. /// [John Tasioulas] This paper contends that play, not achievement, is the primary intrinsic good internal to game-playing, and supports a relational, as opposed to formal, conception of achievement. (shrink)

In this paper, I argue that the two most common views of how to respond rationally to peer disagreement–the Total Evidence View (TEV) and the Equal Weight View (EWV)–are both inadequate for substantial reasons. TEV does not issue the correct intuitive verdicts about a number of hypothetical cases of peer disagreement. The same is true for EWV. In addition, EWV does not give any explanation of what is rationally required of agents on the basis of sufficiently general epistemic principles. I (...) will then argue that there is a genuine alternative to both views–the Preemption View (PV)–that fares substantially better in both respects. I will give an outline and a detailed defense of PV in the paper. (shrink)

There is much to learn from Durán and Jongsma’s paper.1 One particularly important insight concerns the relationship between epistemology and ethics in medical artificial intelligence. In clinical environments, the task of AI systems is to provide risk estimates or diagnostic decisions, which then need to be weighed by physicians. Hence, while the implementation of AI systems might give rise to ethical issues—for example, overtreatment, defensive medicine or paternalism2—the issue that lies at the heart is an epistemic problem: how can physicians (...) know whether to trust decisions made by AI systems? In this manner, various studies examining the interaction of AI systems and physicians have shown that without being able to evaluate their trustworthiness, especially novice physicians become over-reliant on algorithmic support—and ultimately are led astray by incorrect decisions.3–5 This leads to a second insight from the paper, namely that even if some AI system happens to be opaque, it is still not built on the moon. To assess its trustworthiness, AI developers or physicians have different sorts of higher order evidence at hand. Most importantly, …. (shrink)

This paper challenges Thi Nguyen's argument, in Games: Agency as Art, a central part of the value of game-play comes from the aesthetic experiences it allows, especially of our own agency, so playing a game is importantly like engaging with art. It challenges three arguments Nguyen makes in support of this view and argues, to the contrary, that the principal value in game-play rests in the achievments it allows.

In this response to Neil Manson’s latest intervention in our debate about the best consent model for biobank research we show, contra Manson that the ‘expiry problem’ that affects broad consent models because of changes over time in methods, purposes, types of data used and governance structures is a real and significant problem. We further show that our preferred implementation of meta consent as a national consent platform solves this problem and is not subject to the cost and burden objections (...) that Manson raises. (shrink)

As one of America’s "public intellectuals," John Dewey was engaged in a lifelong struggle to understand the human mind and the nature of human inquiry. According to Thomas C. Dalton, the successful pursuit of this mission demanded that Dewey become more than just a philosopher; it compelled him to become thoroughly familiar with the theories and methods of physics, psychology, and neurosciences, as well as become engaged in educational and social reform. Tapping archival sources and Dewey’s extensive correspondence, Dalton (...) reveals that Dewey had close personal and intellectual ties to scientists and scholars who helped form the mature expression of his thought. Dewey’s relationships with F. M. Alexander, Henri Matisse, Niels Bohr, Myrtle McGraw, and Lawrence K. Frank, among others, show how Dewey dispersed pragmatism throughout American thought and culture. (shrink)

Over the past decades, we have witnessed calls for greater transdisciplinary engagement between scientific and societal actors to develop more robust answers to complex societal challenges. Although there seems to be agreement that these approaches might nurture innovations of a new kind, we know little regarding the research practices, their potential, and the limitations. To fill this gap, this article investigates a funding scheme in the area of transdisciplinary sustainability research. It offers a detailed analysis of the imaginaries and expectations (...) on which the funding scheme rests and how researchers actually practice transdisciplinarity within the respective projects. Identifying three ideal typical models of science–society relations at work, attention is paid to how, where, and when societal and scientific arenas get entangled. This article discusses the tensions between classical academic values and efforts to open research to society, the prevailing power structures that make societal participation challenging, the importance of place and technopolitical cultures, and how temporal project structures impede more radical openings to new ways of knowledge production. We finally emphasize that transdisciplinary knowledge production can only become a serious option for addressing societal challenges if broader changes are made to the knowledge regimes in place. (shrink)

This new translation of Thomas Aquinas’s most important study of Aristotle casts bright light on the thinking of both philosophers. Using a new text of Aquinas’s original Latin commentary, Robert Pasnau provides a precise translation that will enable students to undertake close philosophical readings. He includes an introduction and notes to set context and clarify difficult points as well as a translation of the medieval Latin version of Aristotle’s _De anima _ so that readers can refer to the text (...) Aquinas had at hand. In his _De anima commentary_, Aquinas offers the first and most original of his studies of Aristotle. His influential, cogent reading of Aristotle’s notoriously difficult text not only contributes to our understanding of the Greek philosopher but also expresses in full detail Aquinas’s own views on central philosophical topics. Writing at the height of his intellectual powers, Aquinas considers in full detail the nature of the soul, the mind-body problem, the role of the intellect, the character of sensation, and many other related issues. (shrink)

Thomas Murray's graceful and humane book illuminates one of the most morally complex areas of everyday life: the relationship between parents and children. What do children mean to their parents, and how far do parental obligations go? What, from the beginning of life to its end, is the worth of a child? Ethicist Murray leaves the rarefied air of abstract moral philosophy in order to reflect on the moral perplexities of ordinary life and ordinary people. Observing that abstract moral (...) terms such as altruism and selfishness can be buried in the everyday doings of families, he maintains that ethical theory needs a richer description than it now has of the moral life of parents and children. How far should adults go in their quest for children? What options are available to women who do not want to bear a child now? Should couples be allowed to reject a child because of genetic disability or "wrong" gender? How can we weigh the competing claims of the genetic and the rearing parents to a particular child? _The Worth of a Child_ couples impressive learning with a conversational style. Only by getting down to cases, Murray insists, can we reach moral conclusions that are unsentimental, farsighted, and just. In an era of intense public and private acrimony about the place and meaning of "family values," his practical wisdom about extraordinary difficult moral issues offers compelling reading for both experienced and prospective parents, as well as for ethicists, social and behavioral scientists, and legal theorists. (shrink)

Many states recognize a legal right to bodily integrity, understood as a right against significant, nonconsensual interference with one’s body. Recently, some have called for the recognition of an analogous legal right to mental integrity: a right against significant, nonconsensual interference with one’s mind. In this chapter, we describe and distinguish three different rationales for recognizing such a right. The first appeals to case-based intuitions to establish a distinctive duty not to interfere with others’ minds; the second holds that, if (...) we accept a legal right to bodily integrity, then we must, on pain of philosophical inconsistency, accept a case for an analogous right over the mind; and the third holds that recent technological developments create a need for a legal right to mental integrity. (shrink)

Rhetoric is widely regarded by both its detractors and advocates as a kind of antithesis to reason. In this book Thomas B. Farrell restores rhetoric as an art of practical reason and enlightened civic participation, grounding it in its classical tradition—particularly in the rhetoric of Aristotle. And, because prevailing modernist world views bear principal responsibility for the disparagement of rhetorical tradition, Farrell also offers a critique of the dominant currents of modern humanist thought. Farrell argues that rhetoric is not (...) antithetical to reason but is a manner of posing and answering questions that is distinct from the approaches of analytic and dialectical reason. He develops this position in a number of ways: through a series of bold reinterpretations of Aristotle's _Rhetoric_; through a detailed appraisal of traditional rhetorical concepts as seen in modern texts from the Army-McCarthy hearings to Edward Kennedy's memorial for his brother, Mario Cuomo's address on abortion, Betty Friedan's _Feminine Mystique_, and Vaclav Havel's inaugural address; and through a fresh appraisal of theories on the character of language and discourse found in contemporary philosophy, literary criticism, anthropology, deconstructionism, Marxism, and especially in Habermas's critical theory of communicative action. (shrink)

The fourteenth-century thinker Thomas Bradwardine is well known in both the history of science and the history of theology. The first of the Merton Calculators (mathematical physicists) and passionate defender of the Augustinian doctrine of salvation through grace alone, he was briefly archbishop of Canterbury before succumbing to the Black Death in 1349. This new edition of his Insolubilia, made from all thirteen known manuscripts, shows that he was also a logician of the first rank. The edition is accompanied (...) by a full English translation. In the treatise, Bradwardine considers and rejects the theories of his contemporaries about the logical puzzles known as 'insolubles,' and sets out his own solution at length and in detail. In a substantial introduction, Stephen Read describes Bradwardine's analysis, compares it with other more recent theories, and places it in its historical context. The text is accompanied by three appendices, the first of which is an extra chapter found in two manuscripts (and partly in a third) that appears to contain further thoughts by Bradwardine himself. The second contains an extract from Ralph Strode's Insolubilia, composed in the 1360s, repeating and enlarging on Bradwardine's text; and the third consists of an anonymous text that applies Bradwardine's solution to a succession of different insolubles"--P. [4] of cover. (shrink)

Thomas Wheatland examines the influence of the Frankfurt School, or Horkheimer Circle, and how they influenced American social thought and postwar German sociology.

'Altruism' was coined by the French sociologist Auguste Comte in the early 1850s as a theoretical term in his 'cerebral theory' and as the central ideal of his atheistic 'Religion of Humanity'. In The Invention of Altruism, Thomas Dixon traces this new language of 'altruism' as it spread through British culture between the 1850s and the 1900s, and in doing so provides a new portrait of Victorian moral thought. Drawing attention to the importance of Comtean positivism in setting the (...) agenda for debates about science and religion, this volume challenges received ideas about both Charles Darwin and Herbert Spencer as moral philosophers. Darwin saw sympathy and love, not only selfishness and competition, throughout the natural world. Spencer was the instigator of an Anti-Aggression League and an advocate of greater altruism in Britain's dealings with the 'lower races'. It also sheds light on the rise of popular socialism in the 1880s, on the creation of the idealist 'altruist' in novels of the 1890s, and on the individualistic philosophies of Friedrich Nietzsche, Oscar Wilde, and G. E. Moore - authors considered by some to be representative of fin de siècle 'egomania.' This wide-ranging study in the history of ideas is highly relevant to contemporary debates about altruism, evolution, religion, and ethics. (shrink)

This work argues for the need to close the gap between the fields of the philosophy of religion and religious studies. Thomas A. Lewis takes up what, in recent years, has often been seen as a fundamental reason for excluding religious ethics and philosophy of religion from religious studies: their explicit normativity. Against this presupposition, Lewis argues that normativity is pervasive--not unique to ethics and philosophy of religion--and therefore not a reason to exclude them from religious studies. He bridges (...) more philosophical and historical subfields by arguing for the importance of history to the philosophy of religion. He considers the future of religious ethics, explaining that the field as whole should learn from the methodological developments associated with recent work in comparative religious ethics and 'comparative religious ethics' should no longer be conceived as a distinct subfield. The concluding chapter engages broader, post-9/11 arguments about the importance of studying religion, arguing that prominent contemporary notions of 'religious literacy' actually hinder our ability to grasp the significance of religion and impact in the world today. (shrink)

In diesem Buch verbindet Thomas Khurana eine innovative Neubeschreibung des zentralen Konzepts der Psychoanalyse mit wesentlichen Elementen neuerer Theorien des Sozialen. In drei originellen Studien zu Freud, Lacan und Luhmann wird die These vorgestellt, dass sich der Begriff des Unbewussten nur dann in seiner erschließenden Kraft entfalten kann, wenn das Unbewusste nicht mehr substantialistisch verstanden wird.

This paper offers a novel account of how complaints of unfairness arise in risky distributive cases. According to a recently proposed view in distributive ethics, the Competing Claims View, an individual has a claim to a benefit when her well-being is at stake, and the strength of this claim is determined by the expected gain to the individual’s well-being, along with how worse off the individual is compared to others. If an individual is at a lower level of well-being than (...) another, their claim to a given benefit is stronger. On this view, the strength of individuals’ claims are a function of their comparative well-being levels. In this paper, I instead argue that competing claims obtain only when a particular relationship obtains between the fates of individuals: that one individual’s gain is at the expense of another. This is a particular complaint that obtains when the fates of individuals are tied together in such a way that inequality that is to the detriment of the person who is worse off is guaranteed to obtain. I demonstrate that this complaint arises only when individuals are exposed to a particular type of risk that allows some to gain only if others lose. As such, I propose that complaints of unfairness occur less frequently than we might think if we take the Competing Claims View to be true. A purely comparative view is unable to account for this unique complaint of unfairness. I argue that this complaint is not only independently plausible, but can serve as a foundation for a more general account of competing claims complaints. (shrink)

This work investigates how ancient philosophers understood productive knowledge or technê and used it to explain ethics, rhetoric, politics and cosmology. In eleven chapters leading scholars set out the ancient debates about technê from the Presocratic and Hippocratic writers, through Plato and Aristotle and the Hellenistic age, ending in the Neoplatonism of Plotinus and Proclus. Amongst the many themes that come into focus are: the model status of ancient medicine in defining the political art, the similarities between the Platonic and (...) Aristotelian conceptions of technê, the use of technê as a paradigm for virtue and practical rationality, technê´s determining role in Platonic conceptions of cosmology, technê´s relationship to experience and theoretical knowledge, virtue as an 'art of living', the adaptability of the criteria of technê to suit different skills, including philosophy itself, the use in productive knowledge of models, deliberation, conjecture and imagination. (shrink)

The most common objection to the Fine-Tuning Argument for the Multiverse is that the argument commits the Inverse Gambler’s Fallacy. Simon Friederich has recently composed an interesting version of this fine-tuning argument that avoids this fallacy and better-matches important scientific instances of anthropic reasoning. My thesis in this paper is that this new argument, while it may avoid the fallacy, contains a disputable premise concerning the prior probabilities of the hypotheses at issue. I consider various ways to modify the argument (...) to avoid this problem, but I argue that plausible replacements render other lines unjustified. I also briefly compare ‘indexical’ fine-tuning arguments such as Friederich’s, according to which our universe permits life, to ‘existential’ fine-tuning arguments, according to which some universe or other permits life. I conclude that while Friederich is correct that the new fine-tuning argument avoids the Inverse Gambler’s Fallacy, the argument nevertheless depends on an unjustified premise, and this is further reason for proponents of fine-tuning arguments for the multiverse to employ existential arguments rather than indexical arguments. (shrink)