We argue that the pictorial nature of certain constructions in signs and in gestures explains surprising properties of their syntax. In several sign languages, the standard word order (e.g. SVO) gets turned into SOV (with preverbal arguments) when the predicate is a classifier, a distinguished construction with highly iconic properties (e.g. Pavlič, 2016). In silent gestures, participants also prefer an SOV order in extensional constructions, irrespective of the word order of the language they speak (Goldin-Meadow et al., 2008). But in (...) silent gestures and in Brazilian Sign Language (Libras), intensional constructions can override these SOV preferences, yielding SVO instead (Schouwstra & de Swart, 2014; Napoli et al., 2017). This distinction was argued to be due to iconicity: arguments are expressed before the verb if they correspond to entities that are present before the action, otherwise they follow the verb. While agreeing with this intuition, we propose that the extensional/intensional distinction is neither empirically nor theoretically appropriate. In new data from American Sign Language, we replicate the distinction among extensional classifier predicates: for _x ate up the ball_, the ball is typically seen before the eating and a preposed object is preferred; but for _x spit out the ball_, the ball is typically seen after the spitting and a postposed object is preferred, although both _eat up_ and _spit out_ are used extensionally. We extend this finding to data involving pro-speech (= speech-replacing) gestures embedded in French sentences. We argue for a Visibility Generalization according to which arguments appear before the verb if their denotations are typically visible before the action, and we develop a new formal account within a pictorial semantics for visual animations (inspired by Greenberg and Abusch). It derives the observed word order preferences, it explains how the semantics of classifier predicates combines iconic and conventional properties, and it makes a more general point: sign language semantics combines logical semantics with pictorial semantics. (shrink)

Antimicrobial resistance (AMR) poses an increasing threat to patient care and population health and there is a growing need for novel therapies to tackle AMR. Bacteriophage (phage) therapy is a re-emerging antimicrobial strategy with the potential to transform how bacterial infections are treated in patients and populations. Currently, in the UK, phages can be used as unlicensed medicinal products on a ‘named-patient’ basis. We make an ethical case for why it is crucially important for the UK to invest in Good (...) Manufacturing Practice (GMP) for both ongoing unlicensed and future licensed phage therapy. Access to phages produced to GMP (GMP phages) will ensure effective patient care and better outcomes as well as health systems benefits. The UK also has the potential to become a global leader in the timely and cost-efficient manufacturing and supply of a therapy that meets internationally recognised standards. (shrink)

Anti-racist education within the Academy holds the potential to truly reflect the cultural hybridity of our diverse, multi-cultural society through the canons of knowledge that educators celebrate, proffer and embody. The centrality of Whiteness as an instrument of power and privilege ensures that particular types of knowledge continue to remain omitted from our curriculums. The monopoly and proliferation of dominant White European canons does comprise much of our existing curriculum; consequently, this does impact on aspects of engagement, inclusivity and belonging (...) particularly for Black, Asian and Minority Ethnic (BAME) learners. This paper explores the impact of a dominant Eurocentric curriculum and the Decolonising the Curriculum agenda within higher education and its influence upon navigating factors such as BAME attainment, engagement and belonging within the Academy. This paper draws on a Critical Race Theory (CRT) theoretical framework to centralize the marginalized voices of fifteen BAME students and three academics of colour regarding this phenomena. Aspects examined consider the impact of a narrow and restrictive curriculum on BAME students and staff and how the omission of diverse histories and multi-cultural knowledge canons facilitates marginalization and discriminatory cultures. (shrink)

This paper critically examines the biology of species identity and the morality of crossing species boundaries in the context of emerging research that involves combining human and nonhuman animals at the genetic or cellular level. We begin with the notion of species identity, particularly focusing on the ostensible fixity of species boundaries, and we explore the general biological and philosophical problem of defining species. Against this backdrop, we survey and criticize earlier attempts to forbid crossing species boundaries in the creation (...) of novel beings. We do not attempt to establish the immorality of crossing species boundaries, but we conclude with some thoughts about such crossings, alluding to the notion of moral confusion regarding social and ethical obligations to novel interspecies beings. (shrink)

There are a plethora of issues within higher education which continually reinforce aspects of inequality and discrimination. These particular issues are aligned to institutionally racist struc...

In this essay, I want to explore one of the most ironic episodes in the history of propaganda, the attempt by various federal agencies to moderate American WWII anti-Japanese propaganda films. My texts will be four films, two produced by the military, and two by Hollywood: December 7th (1943), directed by Gregg Toland and revised by John Ford; Air Force (1943), directed Howard Hawks; Know Your Enemy: Japan (1945), directed by Frank Capra; and Betrayal for the East (1945), directed by (...) William Berke. As all of these films are readily available on YouTube, I will be brief in my description of them. Instead, I will focus on how they served to intensify racial hatred of Japanese in general and Japanese-Americans in particular, and how the federal government tried to control that propaganda—but was limited by its own policies regarding Japanese-Americans. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Hume's Knave and the Interests of JusticeJason Baldwin, doctoral student in philosophyHume's account of the artificial virtues of justice and promise-keeping developed in Book III, Part ii of the Treatise is among the most provocative elements of his ethics. His goal there is to tell a naturalistic story of the origin and moral standing of these virtues, a story that makes no appeal to any irreducibly moral motives or (...) properties but instead grounds even our most basic and apparently binding obligations in the same thoroughly human passions and sentiments with which Hume explains all our actions. Several modern critics, including David Gauthier and Stephen Darwall, have claimed that Hume's story of the artificial virtues is inconsistent with his account of natural human motivations, and have further claimed that Hume himself became aware of this problem in the second Enquiry, where he discussed it in the famous "sensible knave" passage in the last paragraphs of the "Conclusion." They therefore claim that Hume abandoned in the Enquiry what is usually taken to be his official Treatise account of justice and promise-keeping, and may also have intended a different account in the Treatise itself.This paper argues that the sensible knave passage neither signals nor requires any significant change in Hume's official Treatise story of the artificial virtues. Part 1 summarizes this official account, Part 2 explains the challenge Gauthier and Darwall believe the sensible knave poses to this account, and Part 3 defends the standard Humean account from this challenge. Whatever other problems Hume's account of justice and promise-keeping may have, the free rider problem, as developed by Gauthier and Darwall through the character of the sensible knave, is not among them.1. The Interest Account of Artificial Virtues1.1 Hume's Predecessor TraditionsHume makes few explicit references to the English-speaking predecessors whose work informs his thinking about the artificial virtues, and I shall follow his example. [End Page 277] But without pretending to survey that rich and varied history, we may usefully think of Hume's approach to justice and its allied virtues as an attempt to preserve the strengths of two opposed predecessor traditions.1 The first tradition, represented most prominently by Hobbes but also by Mandeville, explains the origin of virtues generally, including Humean artificial virtues, in purely naturalistic terms, without any appeal to divinely ordained ends or observer-independent moral facts. Hume shares this humanistic aspiration, but he disavows the cynical skepticism and crude egoism which are usually taken to accompany it. He wants to tell a story about justice which will allow us to admire its genuine moral worth even as we acknowledge its human pedigree.The second tradition, a reaction to the first, is the moral sense school represented by Shaftesbury, Butler, and especially Hutcheson. This tradition insists, against the cynical egoists, on a moral reality to which our sentiments or consciences give us immediate access, an access secured by God's design. Also characteristic of the moral sense theorists is the claim that human nature contains benevolent motives which are the objects of the moral sense's approval and which are just as basic to our constitution as are selfish motives. Hume avails himself of both moral sense strands, albeit in attenuated form. He agrees that justice and injustice are known by the sentiments, and he also believes that benevolent first-order motives are a part of human nature. But Hume rejects the moral sense tradition's Christian teleology, and he is also less optimistic about the potential of benevolence to explain such complex moral behaviors as are involved in our institutions of justice and promise-keeping.Hume's standard Treatise story of the origin of justice and promise-keeping, which we may call the "interest account," has two stages. In the first stage, Hume explains how the practices which constitute justice and promise-keeping arise through the working of our natural interests; in this stage Hume might be seen as working in the broadly naturalistic-egoist tradition. In the second stage, Hume explains how these practices and the motives which underlie them become the objects of moral evaluation, i.e., why... (shrink)

This special issue has emerged out of the continuing concern for discriminatory tensions situated within the context of race, education, and social mobility. The institutionally racist structures w...

This essay was prompted by the question of how Hathayoga, literally 'the Yoga of force', acquired its name. Many Indian and Western scholars have understood the 'force' of Haṭhayoga to refer to the effort required to practice it. Inherent in this understanding is the assumption that Haṭhayoga techniques such as _praṇayama_ are strenuous and may even cause pain. Others eschew the notion of force altogether and favor the so-called 'esoteric' definition of Haṭhayoga and moon in the body). This essay examines (...) these interpretations in light of definitions of _haṭhayoga_ and the adverbial uses of _haṭha_ in Sanskrit Yoga texts that predate the fifteenth-century _Hathapradipika_. (shrink)

Michael Bergmann claims that all versions of epistemic internalism face an irresolvable dilemma. We show that there are many plausible versions of internalism that falsify this claim. First, we demonstrate that there are versions of ‘‘weak awareness internalism’’ that, contra Bergmann, do not succumb to the ‘‘Subject’s Perspective Objection’’ horn of the dilemma. Second, we show that there are versions of ‘‘strong awareness internalism’’ that do not fall prey to the dilemma’s ‘‘vicious regress’’ horn. We note along the way that (...) these versions of internalism do not, in avoiding one horn of the dilemma, succumb to the dilemma’s other horn. The upshot is that internalists have many available strategies for avoiding dilemmatic defeat. (shrink)

There have been several recent defenses of biocentric individualism, the position that all living beings have at least some moral standing, simply insofar as they are alive. I develop a virtue-based version of biocentric individualism, focusing on a virtue of reverence for life. In so doing, I attempt to show that such a virtuebased approach allows us to avoid common objections to biocentric individualism, based on its supposed impracticability (or, on the other hand, its emptiness).

An agent S wants to A and knows that if she A-s she will also bring about B. S does not care at all about B. S then A-s, also bringing about B. Did she intentionally bring B about? Joshua Knobe (2003b) has recently argued that, according to the folk concept of intentional action, the answer depends on B's moral significance. In particular, if B is reprehensible, people are more likely to say that S intentionally brought it about. Knobe defends (...) this position with empirical facts about how ordinary people use the adjective 'intentionally.' Knobe's results are consistent with the thesis that the concept of intentional action is fundamentally evaluative. There is an alternative hypothesis, however, which can account for Knobe's data and which keeps the concept of intentional action within the purview of action theory. The current author suggests that the following conditions are jointly sufficient for a side effect E, produced by S's action A, being intentional: (i) S knows that E will (or is likely to) occur as a result of A-ing, (ii) bringing about E counts against A-ing (from the S's perspective), and (iii) S does not try to keep E from occurring. Known immoral side effects will always, from the folk's perspective, satisfy condition (ii) of this hypothesis. (shrink)

BackgroundNo standard method exists to assess how many consults a healthcare ethics consultation (HCEC) service should perform. To address this, we developed a method to estimate the volume of HCEC services based on a mixed-methods approach that included a systematic review and survey data on the volume of consult services requested.MethodsOur investigation included a systematic review of studies that reported the volume of HCEC services that were requested from 2000 to 2017, institutional surveys, and statistical analyses that estimated the volume (...) of HCEC services that were adjusted to the size of the hospitals in the survey and to population acuity.ResultsWe contacted the authors of 19 studies that met our inclusion criteria; 17 authors responded to the institutional survey and five provided annualized data points. We found that standard methods of reporting the volume of HCEC services led to inaccuracies in estimating the growth of HCEC services over time. To rectify this, we proposed two means to estimate volume based on either the service goals of HCEC services or hospital size and acuity.DiscussionThe statistical limitations of our study highlight the need to standardize the sharing and reporting of data in clinical ethics. Future work should further standardize methods of HCEC quality assessment using measures similar to those we describe. (shrink)

This article reports results of a survey about employment and compensation models for clinical ethics consultants working in the United States and discusses the relevance of these results for the professionalization of clinical ethics. This project uses self-reported data from healthcare ethics consultants to estimate compensation across different employment models. The average full-time annualized salary of respondents with a clinical doctorate is $188,310.08 (SD=$88,556.67), $146,134.85 (SD=$55,485.63) for those with a non-clinical doctorate, and $113,625.00 (SD=$35,872.96) for those with a masters as (...) their highest degree. Pay differences across degree level and type were statistically significant (F = 3.43; p. (shrink)

Some feminists and animal advocates defend what I call the Linked Oppressions Thesis, according to which the oppression of women and the oppression of animals are linked causally, materially, normatively, and/or conceptually. Alasdair Cochrane offers objections to several versions of the Linked Oppressions Thesis and concludes that the Thesis should be rejected in all its forms. In this paper I defend the Thesis against Cochrane's objections as well as objections leveled by Beth Dixon, and argue that the failure of these (...) objections illuminates the idea of linked oppressions as well as misunderstandings of the Linked Oppressions Thesis, and may provide guidance to philosophers theorizing animal rights from a feminist perspective. (shrink)

The relationship between Goethe and Salomon Maimon has only been touched on once in the literature, and further clarification of the link between them remains a desideratum. Below I propose that the way to grasp their seeing eye to eye is through Spinoza, and specifically Spinoza's notion of scientia intuitiva. Initially I provide some context in order to illustrate what makes Maimon's role here rather unique. Then I sketch the relationship Maimon and Goethe had both to Spinoza and each other (...) while emphasizing what is at stake. I conclude with various new findings. (shrink)

Our decision-making is often subject to framing effects: alternative but equally informative descriptions of the same options elicit different choices. When a decision-maker is vulnerable to framing, she may consent under one description of the act, which suggests that she has waived her right, yet be disposed to dissent under an equally informative description of the act, which suggests that she has not waived her right. I argue that in such a case the decision-maker’s consent is simply irrelevant to the (...) permissibility of proceeding. I then consider two alternative views. According to the first, people susceptible to framing are able to give valid consent so long as they are sufficiently informed. This suggestion, I argue, maintains an overly narrow focus on mere quantity of information to the exclusion of other choice-affecting factors. A second response, which appeals to hypothetical consent, is likewise of little use in resolving the moral problem posed by framing effects. I conclude that if susceptibility to framing undermines the validity of consent, we may have good reason to reconsider whether consent has the rights-waiving function commonly attributed to it. (shrink)

Abstract Theories of personal well-being are typically developed so that they render verdicts on (a) how well-off a person is at a moment, (b) how well-off a person is over an interval of time, and (c) how good a whole life is for the person who lives it. Conative theories of welfare posit welfare-atoms that consist, e.g., in episodes of desire-satisfaction, aim-achievement, or values-realisation. Most extant conative theories are additive: they compute well-being over time - up to and including the (...) value of a whole life - by adding up the values of these welfare atoms. Here, it is shown that such atomistic, additive conative theories do not always generate plausible verdicts on (b) and (c) above. They imply that lives featuring incoherent plans and rapidly changing projects go surprisingly well for those who lived them. Holistic theories of well-being are often thought to provide a solution to problems like these. However, one of the best-known versions of welfare holism within the conative family, Rawls? rational life-preferentism, is based on the problematic assumption that there is one ideal life plan for each person. This paper presents a new form of paradigm-resemblance based conative holism that does not make this assumption and that explains the limits of additivity. (shrink)

Most anti-paternalists claim that informed and competent self-regarding choices are protected by autonomy, while ill-informed or impaired self-regarding choices are not. Joel Feinberg, among many others, argues that we can in this way distinguish impermissible “hard” paternalism from permissible “soft” paternalism. I argue that this view confronts two related problems in its treatment of ill-informed decision-makers. First, it faces a dilemma when applied to decision-makers who are responsible for their ignorance: it either permits too much, or else too little, intervention (...) to satisfy its proponents. Second, the most promising rationales in favor of the view ignore the distinction between an agent’s voluntarily bringing about some state of affairs, on the one hand, and an agent’s voluntarily assuming a risk, on the other. I conclude that a decision-maker’s ignorance is irrelevant to the permissibility of intervention on her behalf. If it is permissible to intervene in a given ill-informed choice, it would be permissible to intervene in an otherwise similar but informed choice, at least provided that intervention would produce similar benefits in both cases. This shows that we should sometimes accept straightforwardly paternalistic rationales. (shrink)

The new field of sustainability science that has arisen over the past three decades, largely oriented toward cities, under closer examination may prove to be wholly inadequate to deal with the issues it was initially designed to address. Built largely upon modernist value assumptions, its entire range of outlooks has failed to account for the character virtues needed to realize sustainable approaches for the future, which are better found working within different religious traditions’ theologies and ethical outlooks. In light of (...) this, the present article takes up a replicable agenda for analyzing how these particular character virtues—with special focus on parsimony and futuremindedness—work with regard to visions of sustainability that promise to bring about a more just transition in cities. (shrink)

We argue that A. Damasio’s (1994) Somatic Marker hypothesis can explain why humans don’t generally suffer from the frame problem, arguably the greatest obstacle facing the Computational Theory of Mind. This involves showing how humans with damaged emotional centers are best understood as actually suffering from the frame problem. We are then able to show that, paradoxically, these results provide evidence for the Computational Theory of Mind, and in addition call into question the very distinction between easy and hard problems (...) in the contemporary philosophy of mind. (shrink)

We agree with Emily Walsh (2020) that the current preferences of patients with dementia should sometimes supersede those patients’ advance directives. We also agree that consensus clinical ethics guidance does a poor job of explaining the moral value of such patients’ preferences. Furthermore, Walsh correctly notes that clinicians are often averse to treating patients with dementia over their objections, and that this aversion reflects clinical wisdom that can inform revisions to clinical ethics guidance. But Walsh’s account of the moral value (...) of the preferences of patients with dementia suffers from three major problems: (1) it does not engage the actual practices of clinical ethics; (2) it provides an inadequate account of why these patients’ preferences matter; and (3) it offers a poor explanation of clinicians’ intuitions in these cases. Her arguments engage a philosophical debate that is largely irrelevant to clinical practice and she therefore leaves pressing real-world clinical ethics questions unaddressed. After underscoring some of Walsh’s main points, we will discuss each of these shortcomings. (shrink)

Résumé: Les analogies peuvent être des outils précieux d’argumentation lors-qu’elles sont bonnes, mais quand elles sont mauvaises, elles faussent inévitablement la question qu’elles sont censées élucider. Tel est le cas de la comparaison entre la sécession et le divorce, qu’il s’agisse du divorce sous conditions ou du divorce sans égard à la faute. L’objectif de cet article est de montrer que la sécession se distingue empirique ment d’un divorce par trois différences significatives: entre personnes et peuple, entre mariage et union (...) politique, et entre divorce et sécession. Cela révèle que les deux versions de l’analogie du divorce sont inadéquates. Même si, cependant, ces écarts pou vaient être comblés et que l’analogie du divorce sous condition puisse être sauvée, je conteste le caractère approprié de l’autre version en montrant qu’aborder la sécession comme un divorce civil entraînerait des implications normatives contre-intuitives qui enlèveraient tout attrait à l’analogie du divorce sans égard à la faute, ou qui amèneraient ceux qui l’emploient à promouvoir des modifications irréalistes aux institutions légales internationales. (shrink)

Most deontologists claim that it is more objectionable to do harm than it is to allow harm of comparable magnitude. I argue that this view faces a largely neglected puzzle regarding the moral relevance of an agent's past behavior. Consider an agent who chooses to save five people rather than one, where the one person's life is in jeopardy because of something the agent did earlier. How are the agent's obligations affected by the fact that his now letting the one (...) die would retroactively make it the case that he has killed? I argue that the most promising deontological responses to this question are difficult to defend. Further, it is unclear how the deontologist can resolve a further set of cases, in which commonsense intuition indicates that an agent is required to terminate a threat she initiated more recently in preference to a threat she initiated less recently. (shrink)

Schelling argued that early modern science had discarded the ancient teaching of matter – the world soul (die Weltseele or anima mundi, the unity of soul and body, eternity and time, absolute possibility and existence) – «into the common grave they dug for nature and have brought about the death of all science». In order to put science on a more philosophical tract, Schelling retrieved the work of Giordano Bruno as part of his «handful» of thinkers who in a contemporary (...) context appear on the border between an ancient but still vital sense of philosophy and the emerging scientific study of nature. (shrink)

Some physicians refuse to perform life-sustaining interventions, such as tracheostomy, on patients who are very likely to remain permanently unconscious. To explain their refusal, these clinicians often invoke the language of “futility”, but this can be inaccurate and can mask problematic forms of clinical power. This paper explores whether such refusals should instead be framed as conscientious objections. We contend that the refusal to provide interventions for patients very likely to remain permanently unconscious meets widely recognized ethical standards for the (...) exercise of conscience. We conclude that conscientious objection to tracheostomy and other life-sustaining interventions on such patients can be ethical because it does not necessarily constitute a form of invidious discrimination. Furthermore, when a physician frames their refusal as conscientious objection, it makes transparent the value-laden nature of their objection and can better facilitate patient access to the requested treatment. (shrink)

That’s great, it starts with an earthquake… are the famous opening tenets to REM’s anthemic stream of political consciousness, ‘It’s the end of the world as we know it’ and within this treatise, th...

According to the causal theory of parenthood, people incur parental obligations by causing children to exist. Proponents of the causal theory often argue that gamete donors have special obligations to their genetic offspring. In response, many defenders of current gamete donation practices would reject the causal theory. In particular, they may invoke the ‘too many parents problem’: many people who causally contribute to the existence of children – for instance, fertility doctors – do not thereby incur parental obligations. This article (...) argues that the conclusions commonly drawn by causal theorists, and by their critics, are premature. Causal theorists have a promising response to the too many parents problem. This response, however, defuses the moral concern that many causal theorists have raised about gamete donation. A similar point, it is argued, applies to Rivka Weinberg’s ‘Hazmat Theory’. -/- . (shrink)

By most accounts Deleuze's engagement with Marx begins with the two volumes of Capitalism and Schizophrenia he co-authored with Félix Guattari. However, Deleuze's Difference and Repetition alludes to a connection between Deleuze's critique of common sense and Marx's theory of fetishism, suggesting a connection between the critique of the image of thought and the critique of capital. By tracing this connection from its emergence in the early texts on noology, or the image of thought, to the development in the critique (...) of state thought in A Thousand Plateaus, it can be argued that what initially appears as an entirely infra-philosophical problem, concerned with the presuppositions of philosophy, is not only a political problem as well, but ultimately bears on the very nature of the conjunction between thought and politics, making possible a re-examination of what is meant by revolutionary thought. It is a transition from noology to noopolitics. In the end it can be argued that revolutionary thought is no longer an eschatology, attempting to discern the signs of the future revolution in the present, but a thought oriented towards everything that exceeds the fetish of society, towards the virtual relations and micropolitical transformations that constitute society but exceed its representation. (shrink)

Contemporary theories of universals have two things in common: first, they are unable to account for necessary connections between universals that form a structure. Second, they leave teleology out of their accounts of instantiation. These facts are not unrelated; the reason why contemporary theories have such trouble is they neglect the ancient idea that universals are ends at which nature aims. If we want a working theory of universals, however, we must return to this idea. Despite its unpopularity among realists, (...) teleology is not a disposable eccentricity, and its dismissal is not an improvement on ancient views. (shrink)

Here I explore the aesthetic implications of this new paradigm, the central implication being that scientific cognitivism, when combined with the new paradigm in ecology, may require updating the qualities associated with positive aesthetics. After reviewing Allen Carlson's defense of both scientific cognitivism and the positive aesthetics thesis, I show how the significantly different conceptual framework that the new paradigm in ecology provides will require equally significant adjustments to how we aesthetically appreciate nature. I make two suggestions. First, the new (...) paradigm in ecology suggests that aesthetic appreciation should focus on natural processes, which will require a more theoretical approach to aesthetic appreciation. Second, because the new paradigm appeals to aesthetic qualities such as imbalance, disorder, and disharmony to make the natural world intelligible, these qualities are consistent with an updated positive aesthetics thesis and should therefore replace the qualities associated with the old paradigm. Collectively, these two suggestions imply that the beauty of nature is dynamic and chaotic rather than stable and orderly. (shrink)

In this paper I clarify a major affinity between Nietzsche and Spinoza that has been neglected in the literature—but that Nietzsche was aware of—namely a tendency to what I call etiology. Etiologies provide second- order explanations of some opponents’ first-order views, but not in order to decide first-order matters. The example I take up here is Nietzsche’s and Spinoza’s rejections of free will—and especially their etiologies concerning how we wrongly come to think that we may boast of such a capacity. (...) In working through the former (i.e., their rejections of free will) in order to make my central metaphilosophical point regarding the latter (i.e., their accounts of why we generally affirm that we have free will), I shed important new light on Nietzsche’s relation to Spinoza. I also further our understanding of what role such second-order accounts play within each of their larger projects on their own terms. (shrink)

I begin by examining how genetics drivesschizophrenia research, and raise both familiar andrelatively novel criticisms of the evidence putativelysupporting the genetic basis of schizophrenia. Inparticular, I call attention to a set of concernsabout the effects of placentation on concordance ratesof schizophrenia in monozygotic twins, which furtherweakens the case for schizophrenia''s so-called stronggenetic component. I then underscore two criticalpoints. First, I emphasize the importance of takingseriously considerations about the complexity of bothontogenesis and the development of hereditarydiseases. The recognition of developmentalconstraints and (...) supports is crucial, for attention todevelopment exposes the naivete of too many models ofgene action in the aetiology of disease. Secondly, Iattend to those schizophreniologists who ignoremethodological criticisms and thus presume a geneticbasis for schizophrenia, and then seek the schizophrenic genotype lacking an adequatephenotype. In response I attempt to demonstrate thenecessity of a sustained effort at characterizing thephenotype of schizophrenia as an enabling conditionfor the whole enterprise of psychiatric genetics – andfor psychiatry itself. Without the organism-levelphenotype, research at the level of genes will remainunproductive – assuming of course that research at thegenetic level is appropriate at all. (shrink)