本書已再版多次，越來越受到世人的關注，大概人們對這個宇宙確實有很多疑問，他們對當今世界的宗教、哲學和科學理論對自然的解釋越來越不滿意，他們期待著一個更重大的發現和突破，而本書正好在這個時候出現，回答了 現行宗教、哲學和科學無法回答的問題，給出了可能的答案。 遵循宇宙法則，全球宗教（“.”）將被統一，人們再不會為這些宗教戰爭所痛苦，世界將變得和平和美好。 遵循宇宙法則，全部社會哲學理論（“o”）將被統一，統治階級將更關心民眾疾苦，虛心接受人民的監督，社會再不會有腐敗和貪官，國家將變的更進步和富強。 遵循宇宙法則，全部自然科學理論（“1”）將被統一，科學家將花更多精力在創造和對宇宙的探索上，而不是專為統治階級研製殺人武器來危害社會。 相信將來，會有越來越多的人們接受這部書、喜歡它、支持它，並不斷完善它。人們也會從這部書中，不斷感受到它的力量，發現社會的弊病，改革它、摒棄它，這樣我們的社會就會前進，知識就會進步，更不會有戰爭。到那時 ，我們地球人就會自豪地對全宇宙智人說，我們也理解了宇宙法則，現在就加入你們的行列。.

With more countries implementing Open Notes, the practice of providing patients with unhindered access to their clinical visit notes, research on this practice is finally increasing. Many studies report positive findings, especially around self-reported outcomes, such as feeling more in control of one’s care, increased medication adherence and a strengthened patient–doctor relationship. 1 However, comparatively less research has been done on the potential ramifications that may also arise from Open Notes. Blease’s recent article underscores this and demonstrates why Open Notes (...) must also be considered in terms of nocebo effects, negative side effects that arise from negative expectations. 2 The article presents a compelling and well-thought-out argument for how nocebo effects may vary across different populations by linking patient–clinician communication inequalities with and by presenting preliminary evidence of nocebo effects. Blease’s argument does not detract from Open Notes, but rather takes a balanced approach by imploring us... (shrink)

Despite recurring efforts, a gap exists across a variety of contexts between the protection of patients' safety in theory and in practice. This timely Research Handbook highlights these critical issues and suggests both legal and policy changes are necessary to better protect patients' safety. Multidisciplinary in nature, this Research Handbook features contributions from eminent academics, policy makers and medical practitioners from the Global North and South, discussing the essential facets concerning patient safety and the law. It highlights how the role (...) of legislation and case law has the potential to influence, both positively and negatively, medical practice and the quality of care. Chapters explore patient safety and the global health agenda; physiotherapy; 'non-therapeutic' clinical research with children; patient safety awareness in healthcare education; and the increasing use of robotics and artificial intelligence in healthcare. Outlining a wide range of international perspectives on patient safety and the law, this Research Handbook will appeal to academics and researchers specialising in health and medical law, human rights and healthcare regulation. It will also serve as a valuable resource for legal and medical practitioners alike, as well as clinicians and professionals working in healthcare governance. (shrink)

This book continues and revises the ideas of justice as fairness that John Rawls presented in _A Theory of Justice_ but changes its philosophical interpretation in a fundamental way. That previous work assumed what Rawls calls a "well-ordered society," one that is stable and relatively homogenous in its basic moral beliefs and in which there is broad agreement about what constitutes the good life. Yet in modern democratic society a plurality of incompatible and irreconcilable doctrines -- religious, philosophical, and (...) moral -- coexist within the framework of democratic institutions. Recognizing this as a permanent condition of democracy, Rawls asks how a stable and just society of free and equal citizens can live in concord when divided by reasonable but incompatible doctrines? This edition includes the essay "The Idea of Public Reason Revisited," which outlines Rawls' plans to revise _Political Liberalism,_ which were cut short by his death. "An extraordinary well-reasoned commentary on _A Theory of Justice_...a decisive turn towards political philosophy." -- _Times Literary Supplement_. (shrink)

Many real-world agents recognise that they impose harms by choosing to emit carbon, e.g., by flying. Yet many do so anyway, and then attempt to make things right by offsetting those harms. Such offsetters typically believe that, by offsetting, they change the deontic status of their behaviour, making an otherwise impermissible action permissible. Do they succeed in practice? Some philosophers have argued that they do, since their offsets appear to reverse the adverse effects of their emissions. But we show that (...) they do not. In practice, standard carbon offsetting does not reverse the harms of the original action, nor does it even benefit the same group as was harmed. Standard moral theories hence deny that such offsetting succeeds. Indeed, we show that any moral theory that allows offsetting in this setting faces a dilemma between allowing any wrong to be offset, no matter how grievous, and recognising an implausibly sharp discontinuity between offsettable actions and non-offsettable actions. The most plausible response is to accept that carbon offsetting fails to right our climate wrongs. (shrink)

Mill predicted that "[t]he Liberty is likely to survive longer than anything else that I have written...because the conjunction of [Harriet Taylor’s] mind with mine has rendered it a kind of philosophic text-book of a single truth, which the changes progressively taking place in modern society tend to bring out in ever greater relief." Indeed, On Liberty is one of the most influential books ever written, and remains a foundational document for the understanding of vital political, philosophical and social issues. (...) In addition to its many useful appendices, this new edition includes a chronology, bibliography, and a substantial introduction which outlines Mill’s life and works, and sets this central work of 1859 in the context of both his own intellectual development and of the play of ideas and political forces in Victorian society. (shrink)

The most important voices concerning the changes now occurring in Central and Eastem Europe are those that come from within, for those voices are informed not only by indifferent data and objective reports, but by personal hopes, fears, desires and needs. Without careful consideration of what such voices say, judgment can only be sterile. Furthermore, policy decisions made without the benefit of the intemal perspective are likely to be flawed, and ineffectual. Policies won’t work if they do not take into (...) account the point of view of those who are supposed to be affected by them. There nevertheless remains an important role for outsiders to play in the discussion of the impact of political change on the future of philosophical thought, especially if the outside perspective can serve as a test of the internal view. (shrink)

Science (episteme) -- Division of the sciences according to aims and objects -- Demonstration (apodeixis) -- The axioms of the sciences -- Being or substance (ousia) -- Being before aristotle -- Being in the categories -- The science of being: first philosophy -- Being in metaphysics zeta -- Nature (physis) -- Principles of change -- The four causes or explanations (aitiai) -- Defense of teleology -- Soul (psyche) -- Soul as substance, form and actuality -- What the student of soul (...) investigates -- Perception -- Thought -- Success (eudaimonia) -- The practical science of ethics -- The chief and final good for human beings -- Virtues of character -- Virtues of intellect. (shrink)

Deploring this prospect, he theorized elite-dominated forms of society in which democratic change could be reined in."--BOOK JACKET.

Intriguing, and occasionally unsettling, In Defense of Sin is a refreshingly frank exploration of some real facts of life. Portmann gathers an on-target collection of great writers on transgressions large and small. Read about defenses for promiscuity, greed, deceit, gossip, lust, breaking the golden rule, and more--and use this unusual guide to decide for yourself if sin has a place in our contemporary, and virtually unshockable, society. Provocative and illuminating, this book may change how you think about sin, morality, and (...) what's right. Contributors include Aaron Ben-Ze'ev, Anthony Ellis, Jane English, Ludwig Feuerbach, Sigmund Freud, Bernard Mandeville, Jerome Neu, Friedrich Nietzsche, David Novitz, Joyce Carol Oates, David A.J. Richards, Seneca, Jonathan Swift, Richard Wasserstrom, and Oscar Wilde. (shrink)

A great philosopher will change the way you think about your life. For most of human history, religion provided a clear explanation of life and death. But in the late 19th and early 20th centuries new ideas -- from psychiatry to evolution to Communist -- seemed to suggest that our fate was now in our own hands. We would ourselves become God. This is the theme of a remarkable new book by one of the world's greatest lving philosophers. It is (...) a brilliant and frightening look at the problems and opportunities of a world coming to grips with humankind's now solitary, unaided place in the universe. Gray takes two major examples: the belief that the science-backed Communism of the new USSR could reshape the planet, and the belief among a group of Edwardian intellectuals -- popularized through mediums and automatic writing -- that there was a non-religious form of life after death. Gray presents an extraordinary cast of philosophers, journalists, politicians, charlatans and mass murderers, all of whom felt driven by a specifically scientific and modern world view. He raises a host of fascinating questions about what it means to be human. The implications of Gray's book will haunt its readers for the rest of their lives. (shrink)

Nearly all success is due to some mix of ability and luck. But some successes we attribute to the agent’s ability, whereas others we attribute to luck. To better understand the criteria distinguishing credit from luck, we conducted a series of four studies on knowledge attributions. Knowledge is an achievement that involves reaching the truth. But many factors affecting the truth are beyond our control and reaching the truth is often partly due to luck. Which sorts of luck are compatible (...) with knowledge? We find that knowledge attributions are highly sensitive to lucky events that change the explanation for why a belief is true. By contrast, knowledge attributions are surprisingly insensitive to lucky events that threaten but ultimately fail to change the explanation for why a belief is true. These results shed light on our concept of knowledge, help explain apparent inconsistencies in prior work on knowledge attributions, and constitute progress toward a general understanding of the relation between success and luck. (shrink)

Niccolo Machiavelli (1469-1527) is the most famous and controversial figure in the history of political thought and one of the iconic names of the Renaissance. The Cambridge Companion to Machiavelli brings together sixteen original essays by leading experts, covering his life, his career in Florentine government, his reaction to the dramatic changes that affected Florence and Italy in his lifetime, and the most prominent themes of his thought, including the founding, evolution, and corruption of republics and principalities, class conflict, liberty, (...) arms, religion, ethics, rhetoric, gender, and the Renaissance dialogue with antiquity. In his own time Machiavelli was recognized as an original thinker who provocatively challenged conventional wisdom."--Provided by publisher. (shrink)

I will develop a new problem for almost all realist theories of colour. The problem involves fluctuations in our colour experiences that are due to visual noise rather than changes in the objects we are looking at.

This chapter discusses how we should think about experiences that threaten to radically transform our understanding of the world. While it can be rational to treat the “doxastically transformative” potential of an experience as a reason to choose against it, such a decision must be based in something more than the fact that this experience would alter one’s current beliefs. It only in light of knowledge of how things are that a person can choose rationally against transformative processes that would (...) destroy this knowledge. (shrink)

Various schools of philosophy have tried to claim Henri Bergson as one of their own. In France he has been regarded primarily as an early phenomenologist. In the United States and Britain he is still regarded as a vitalist philosopher. This introductory study looks at Bergson’s use of philosophical form and aims to dispel the view that Bergson ever stuck to one type of philosophy at all, be it vitalism or phenomenology. The claim of any one form of thought to (...) the title of “first philosophy” is challenged by the idea of a Bergsonian _metaphilosophy,_ which states that, in a universe with no static foundations, there can never be first philosophies. In other words, if everything is changing, then this must be no less true of philosophy. _Bergson and Philosophy_ is an important and lucid reassessment of an influential philosopher that sets his work in philosophical contexts. (shrink)

Aquinas, Ockham, and Burdan all claim that a person can be numerically identical over time, despite changes in size, shape, and color. How can we reconcile this with the Indiscernibility of Identicals, the principle that numerical identity implies indiscernibility across time? Almost all contemporary metaphysicians regard the Indiscernibility of Identicals as axiomatic. But I will argue that Aquinas, Ockham, and Burdan would reject it, perhaps in favor of a principle restricted to indiscernibility at a time.

Many philosophers claim that interesting forms of epistemic evaluation are insensitive to truth in a very specific way. Suppose that two possible agents believe the same proposition based on the same evidence. Either both are justified or neither is; either both have good evidence for holding the belief or neither does. This does not change if, on this particular occasion, it turns out that only one of the two agents has a true belief. Epitomizing this line of thought are thought (...) experiments about radically deceived “brains in vats.” It is widely and uncritically assumed that such a brain is equally justified as its normally embodied human “twin.” This “parity” intuition is the heart of truth-insensitive theories of core epistemological properties such as justification and rationality. Rejecting the parity intuition is considered radical and revisionist. In this paper, I show that exactly the opposite is true. The parity intuition is idiosyncratic and widely rejected. A brain in a vat is not justified and has worse evidence than its normally embodied counterpart. On nearly every ordinary way of evaluating beliefs, a false belief is significantly inferior to a true belief. Of all the evaluations studied here, only blamelessness is truth-insensitive. (shrink)

The relationship between gender and ethics has been extensively researched. However, previous studies have assumed that the gender–ethics association is constant; hence, scholars have seldom investigated factors potentially affecting the gender–ethics association. Thus, using managers as the research target, this study examined the relationship between gender and ethics and analyzed the moderating effect of cultural values on the gender–ethics association. The results showed that, compared with female managers, their male counterparts are more willing to justify business-related unethical behaviors such as (...) bribery and tax evasion, and that the gender difference in ethics becomes more pronounced under the cultural dimensions of collectivism, humane orientation, performance orientation, and gender egalitarianism. This study used data obtained through surveying 2,754 managers in 27 nations. (shrink)

Appeals to ordinary thought and talk are frequent in philosophy, perhaps nowhere more than in contemporary epistemology. When an epistemological theory implies serious error in “commonsense” or “folk” epistemology, it is counted as a cost of the view. Similarly, when an epistemological theory respects or vindicates deep patterns in commonsense epistemology, it is viewed as a benefit of the view. Philosophers typically rely on introspection and anecdotal social observation to support their characterizations of commonsense epistemology. But recent experimental research shows (...) that philosophers employing these methods often seriously mischaracterize commonsense. Based on these findings, I propose a fundamental change to standard practice in the field. Whether the fundamental goal of epistemology is descriptive or prescriptive, experimentation is an integral part of the project. (shrink)

This book continues and revises the ideas of justice as fairness that John Rawls presented in _A Theory of Justice_ but changes its philosophical interpretation in a fundamental way. That previous work assumed what Rawls calls a "well-ordered society," one that is stable and relatively homogenous in its basic moral beliefs and in which there is broad agreement about what constitutes the good life. Yet in modern democratic society a plurality of incompatible and irreconcilable doctrines--religious, philosophical, and moral--coexist within (...) the framework of democratic institutions. Recognizing this as a permanent condition of democracy, Rawls asks how a stable and just society of free and equal citizens can live in concord when divided by reasonable but incompatible doctrines? This edition includes the essay "The Idea of Public Reason Revisited," which outlines Rawls ' plans to revise _Political Liberalism,_ which were cut short by his death. "An extraordinary well-reasoned commentary on _A Theory of Justice_...a decisive turn towards political philosophy." --_Times Literary Supplement_. (shrink)

This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1752 edition. Excerpt:... to which the original Exclusion had been owing, the Points of two short and slender Hairs appear'd protruding themselves from its oval Surface. The thicker butoblong Bodies, from whose Extremities these grew, next forc'd themselves out, and it was evident to a-'n accustom'd Eye, that they were (...) the Antennze of a two wing'd Fly; next presented themselves the anterior Surfaces of two chequeffd Orbs, which were plainly the complex Eyes of anlnsect' of the same Species, separated by a plain Portion of a Forehead; and soon after the whole Head. This was no sooner all in View, than it swell'd to a Diameter equal to twice the Measure of that of the Breast. lt might have appear'd from the first, that the Head was growing under the Eye of the Observer, from the Extremity of the Thorax, but tho' a more rational Enquiry could not but produce for its Answer, that it was only now thrust forth out of the Cavity of the Breast in which it had before been lodg'd; it yet appear'd singular after this sudden Change in Size to conceive how a Thing should have been till that Moment lodg'd in a Cavityz not equal to half its own Diameter. P a The The Head was now entire and in its Place, and the Legs were firm, and supported the Body well, but the Wings did not yet appear. On examining the Place where they were to be expacted, I discover'd two irregular Protuberances of a wrinkled Surface, and considerably large, and under them the two oblong Pedicies which we see supporting the Balls under the Wings of all the two wing'd Flies. It was evident from this, that the Protuberances at the two Sides of the Base of the Thorax were the very Wings in their folded State, and this was soon prov'd by their expanding. The Wings in all this Race of Creatures are the last Part... (shrink)

This stuff is everywhere -- The damage that it does -- On weasel words -- Building your own bullshitometer -- Noble monkeys: where we all came from -- The wonderful power of woo -- Bugs, bodies: mysteries of medicine -- Implacable foes of reason: the antivaxers -- No hoax: the truth about climate change -- That isn't exactly how it went: faking history -- Coprolite claims: faking archaeology -- All the news that's fit to fake.

A key political-strategic question facing those aiming to foster environmental action is, When and how do environmental concerns resonate widely with citizens? This question invites reflection upon the rhetoric of “sacrifice,” especially as often deployed within wealthy consumer societies. This rhetoric has become a political sticking point that often entangles environmental discourse in a false dichotomy between sacrifice and self-interest and thereby constrains the political imaginary. By challenging this dichotomy we can draw attention to the ubiquity of notions of sacrifice (...) in everyday life, thereby defusing its ability to shut down ambitious proposals for action. We might use this insight to reorient talk about sacrifice in a manner that expands our imaginary and opens up broader possibilities for democratic change. (shrink)

In this engaging and provocative study, John Peter Kenney examines the emergence of monotheism within Greco-Roman philosophical theology by tracing the changing character of ancient realism from Plato through Plotinus. Besides acknowledging the philosophical and theological significance of such ancient thinkers as Plutarch, Numenius, Alcinous, and Atticus, he demonstrates the central importance of Plotinus in clarifying the relation of the intelligible world to divinity. Kenney focuses especially on Plotinus's novel concept of deity, arguing that it constitutes a type of (...) mystical monotheism based upon an ultimate and inclusive divine One beyond description or discursive knowledge. Presenting difficult material with grace and clarity, Kenney takes a wide-ranging view of the development of ancient Platonic theology from a philosophical perspective and synthesizes familiar elements in a new way. His is a revisionist thesis with significant implications for the study of Greco-Roman, Jewish, and Christian thought in this period and for the history of Western religious thought in general. (shrink)

Traditionally, two clinical models have been dominant in psychoanalysis: the classical paradigm, which views the analyst as an objective mirror, and the participant-observation paradigm, which views the analyst as an intersubjective participant-observer. According to John Fiscalini, an evolutionary shift in psychoanalytic consciousness has been taking place, giving rise to coparticipant inquiry, a third paradigm that represents a dramatic shift in analytic clinical theory and that has profound clinical implications. Coparticipant inquiry integrates the individualistic focus of the classical tradition and (...) the social focus of the participant-observer perspective. It is marked by a radical emphasis on analysts' and patients' analytic equality, emotional reciprocity, psychic symmetry, and relational mutuality. Unlike the previous two paradigms, coparticipant inquiry suggests that we are all inherently communal beings and, yet, are simultaneously innately self-fulfilling, unique individuals. The book looks closely at the therapeutic dialectics of the personal and interpersonal selves and discusses narcissism -- the perversion of the self -- within its clinical role as the neurosis that contextualizes all other neuroses. Thus the goal of this book is to define coparticipant inquiry; articulate its major principles; analyze its implications for a theory of the self and the treatment of narcissism; and discuss the therapeutic potential of the coparticipant field and the coparticipant nature of transference, resistance, therapeutic action, and analytic vitality. Fiscalini explores "analytic space," which marks the psychic limit of coparticipant activity; the "living through process," which, he suggests, subtends all analytic change; and "openness to singularity," which is essential to analytic vitality. _Coparticipant Psychoanalysis_ brings crucial insights to clinical theory and practice and is an invaluable resource for psychoanalysts and therapists, as well as students and practitioners of psychology, psychiatry, and social work. (shrink)

This volume is the first of three which will contain all of Locke's extant writings on philosophy which relate to An Essay Concerning Human Understanding, other than those contained in volumes of the Clarendon Edition of John Locke such as the Correspondence. The book contains the two earliest known drafts of the Essay, both written in 1671, and provides for the first time an accurate version of Locke's text together with a record of virtually all his changes, in notes (...) at the foot of each page. (shrink)

The non-identity problem arises when an intervention or behavior changes the identity of those affected. Delaying pregnancy is an example of such a behavior. The problem is whether and in what ways such changes in identity affect moral considerations. While a great deal has been written about the non-identity problem, relatively little has been written about the implications for physicians and how they should understand their duties. We argue that the non-identity problem can make a crucial moral difference in some (...) circumstances, and that it has some interesting implications for when it is or is not right for a physician to refuse to accede to a patient's request. If a physician is asked to provide an intervention (identity preserving) that makes a person worse off, then such harm provides a good reason for the physician to refuse to provide the intervention. However, in cases where different (identity-altering) interventions result in different people having a better or worse life, physicians should normally respect patient choice. (shrink)

Friedrich Nietzsche has emerged as one of the most important and influential modern philosophers. For several decades, the book series Monographien und Texte zur Nietzsche-Forschung (MTNF) has set the agenda in a rapidly growing and changing field of Nietzsche scholarship. The scope of the series is interdisciplinary and international in orientation reflects the entire spectrum of research on Nietzsche, from philosophy to literary studies and political theory. The series publishes monographs and edited volumes that undergo a strict peer-review process. The (...) book series is led by an international team of editors, whose work represents the full range of current Nietzsche scholarship. (shrink)

Where would humanity be now without fire, vaccinations, farming--or wine? A great idea is one that has changed the path of human civilisation. But which is the greatest of them all? John Farndon, author of the bestselling Do You Think You're Clever?, has set out to find the answer. A distinguished panel of experts agreed on a list of 50 ideas, and each chapter of The World's Greatest Idea sees Farndon explore the argument for a different one. The candidates (...) are intriguingly varied: Electricity grids enable us to power our cities, but then sewers allowed those cities to grow. Without the wheel, modern civilisation would be pretty much impossible, but take away Logic and we'd lose the essential structures for rational thought... But then what would be the point of all of this without the idea of romance? The World's Greatest Idea is an enthralling voyage of discovery through the most powerful intellectual, social, scientific and creative brainwaves humans have ever had. They are ranked in the book determined by a public vote on www.theworldsgreatestidea.com But will you agree with the verdict? (shrink)

John Mackie's stimulating book is a complete and clear treatise on moral theory. His writings on normative ethics-the moral principles he recommends-offer a fresh approach on a much neglected subject, and the work as a whole is undoubtedly a major contribution to modern philosophy.The author deals first with the status of ethics, arguing that there are not objective values, that morality cannot be discovered but must be made. He examines next the content of ethics, seeing morality as a functional (...) device, basically the same at all times but changing significantly in response to changes in the human condition. He sketches a practical moral system, criticizing but also borrowing from both utilitarian and absolutist views. Thirdly, the frontiers of ethics, areas of contact with psychology, metaphysics, theology, law and politcs, are explored.Throughout, his aim is to discuss a wide range of questions that are both philosophical and practical, working within a distinctive version of subjectivism-an "error" theory of the apparent objectivity of values. John Mackie has drawn on the contributions of such classic thinkers as Plato, Aristotle, Hobbes, Hume, Kant and Sidgwick, and on more recent discussions, to produce a thought-provoking account that will inspire both the general reader and the student of philosophy. (shrink)

Scientists and 'anti-scientists' alike need a more realistic image of science. The traditional mode of research, academic science, is not just a 'method': it is a distinctive culture, whose members win esteem and employment by making public their findings. Fierce competition for credibility is strictly regulated by established practices such as peer review. Highly specialized international communities of independent experts form spontaneously and generate the type of knowledge we call 'scientific' - systematic, theoretical, empirically-tested, quantitative, and so on. Ziman shows (...) that these familiar 'philosophical' features of scientific knowledge are inseparable from the ordinary cognitive capabilities and peculiar social relationships of its producers. This wide-angled close-up of the natural and human sciences recognizes their unique value, whilst revealing the limits of their rationality, reliability, and universal applicability. It also shows how, for better or worse, the new 'post-academic' research culture of teamwork, accountability, etc. is changing these supposedly eternal philosophical characteristics. (shrink)

How induction was understood took a substantial turn during the Renaissance. At the beginning, induction was understood as it had been throughout the medieval period, as a kind of propositional inference that is stronger the more it approximates deduction. During the Renaissance, an older understanding, one prevalent in antiquity, was rediscovered and adopted. By this understanding, induction identifies defining characteristics using a process of comparing and contrasting. Important participants in the change were Jean Buridan, humanists such as Lorenzo Valla and (...) Rudolph Agricola, Paduan Aristotelians such as Agostino Nifo, Jacopo Zabarella, and members of the medical faculty, writers on philosophy of mind such as the Englishman John Case, writers of reasoning handbooks, and Francis Bacon. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

The aim of the article is to intervene in debates about the digital and, in particular, framings that imagine the digital in terms of epochal shifts or as redefining life. Instead, drawing on recent developments in digital methods, we explore the lively, productive and performative qualities of the digital by attending to the specificities of digital devices and how they interact, and sometimes compete, with older devices and their capacity to mobilize and materialize social and other relations. In doing so, (...) our aim is to explore the implications of digital devices and data for reassembling social science methods or what we call the social science apparatuses that assemble digital devices and data to ‘know’ the social and other relations. Building on recent work at CRESC on the social life of methods, we recommend a genealogical approach that is alive to the ways in which digital devices are simultaneously shaped by social worlds, and can in turn become agents that shape those worlds. This calls for attending to the specificities of digital devices themselves, how they are varied and composed of diverse socio-technical arrangements, and are enrolled in the creation of new knowledge spaces, institutions and actors. Rather than exploring what large-scale changes can be revealed and understood through the digital, we argue for explorations of how digital devices themselves are materially implicated in the production and performance of contemporary sociality. To that end we offer the following nine propositions about the implications of digital data and devices and argue that these demand rethinking the theoretical assumptions of social science methods: transactional actors; heterogeneity; visualization; continuous time; whole populations; granularity; expertise; mobile and mobilizing; and non-coherence. (shrink)

According to the hypotheses of distributed and extended cognition, remembering does not always occur entirely inside the brain but is often distributed across heterogeneous systems combining neural, bodily, social, and technological resources. These ideas have been intensely debated in philosophy, but the philosophical debate has often remained at some distance from relevant empirical research, while empirical memory research, in particular, has been somewhat slow to incorporate distributed/extended ideas. This situation, however, appears to be changing, as we witness an increasing level (...) of interaction between the philosophy and the empirical research. In this editorial, we provide a high-level historical overview of the development of the debates around the hypotheses of distributed and extended cognition, as well as relevant theory and empirical research on memory, considering both the role of memory in theoretical debates around distributed/extended ideas and strands of memory research that resonate with those ideas; we emphasize recent trends towards increased interaction, including new empirical paradigms for investigating distributed memory systems. We then provide an overview of the special issue itself, drawing out a number of general implications from the contributions, and conclude by sketching promising directions for future research on distributed memory. (shrink)

This study provides a comprehensive reinterpretation of the meaning of Locke's political thought. John Dunn restores Locke's ideas to their exact context, and so stresses the historical question of what Locke in the Two Treatises of Government was intending to claim. By adopting this approach, he reveals the predominantly theological character of all Locke's thinking about politics and provides a convincing analysis of the development of Locke's thought. In a polemical concluding section, John Dunn argues that liberal and (...) Marxist interpretations of Locke's politics have failed to grasp his meaning. Locke emerges as not merely a contributor to the development of English constitutional thought, or as a reflector of socio-economic change in seventeenth-century England, but as essentially a Calvinist natural theologian. (shrink)

Traditionally, two clinical models have been dominant in psychoanalysis: the classical paradigm, which views the analyst as an objective mirror, and the participant-observation paradigm, which views the analyst as an intersubjective participant-observer. According to John Fiscalini, an evolutionary shift in psychoanalytic consciousness has been taking place, giving rise to coparticipant inquiry, a third paradigm that represents a dramatic shift in analytic clinical theory and that has profound clinical implications. Coparticipant inquiry integrates the individualistic focus of the classical tradition and (...) the social focus of the participant-observer perspective. It is marked by a radical emphasis on analysts' and patients' analytic equality, emotional reciprocity, psychic symmetry, and relational mutuality. Unlike the previous two paradigms, coparticipant inquiry suggests that we are all inherently communal beings and, yet, are simultaneously innately self-fulfilling, unique individuals. The book looks closely at the therapeutic dialectics of the personal and interpersonal selves and discusses narcissism -- the perversion of the self -- within its clinical role as the neurosis that contextualizes all other neuroses. Thus the goal of this book is to define coparticipant inquiry; articulate its major principles; analyze its implications for a theory of the self and the treatment of narcissism; and discuss the therapeutic potential of the coparticipant field and the coparticipant nature of transference, resistance, therapeutic action, and analytic vitality. Fiscalini explores "analytic space," which marks the psychic limit of coparticipant activity; the "living through process," which, he suggests, subtends all analytic change; and "openness to singularity," which is essential to analytic vitality. _Coparticipant Psychoanalysis_ brings crucial insights to clinical theory and practice and is an invaluable resource for psychoanalysts and therapists, as well as students and practitioners of psychology, psychiatry, and social work. (shrink)