The last year has seen major advances in the study of Alzheimer's disease (AD).† Four mutations involving amino acid substitutions in axons 16 and 17 of the amyloid precursor protein (APP) gene, have been identified which co‐segregate with the disease in some families multiply affected by early onset Alzheimer's disease. These mutations are strongly suggestive of a causative role for the amyloid preursor protein in Alzheimer's disease. Despite their rarity, these mutations are important because they represent the first known cause (...) of Alzheimer's disease. Processing of APP must be central to the pathogenesis of the disease although the precise effects of these amino acid substitutions are not understood. Work is now being undertaken to characterise the processing pathways of APP and to identify other causes of AD. The development of models of AD using the APP mutations offers the possibility of identifying drug targets and developing more effective treatments than are presently available. (shrink)

I argue that understanding why p involves a kind of intellectual know how and differsfrom both knowledge that p and knowledge why p (as they are standardly understood).I argue that understanding, in this sense, is valuable.

Recently, the theory theory has led to much interesting research. However, this is the first book to look at the theory in extensive detail and to systematically contrast it with other theories.

This paper argues that, by construing emotion as epistemologically subversive, the Western tradition has tended to obscure the vital role of emotion in the construction of knowledge. The paper begins with an account of emotion that stresses its active, voluntary, and socially constructed aspects, and indicates how emotion is involved in evaluation and observation. It then moves on to show how the myth of dispassionate investigation has functioned historically to undermine the epistemic authority of women as well as other social (...) groups associated culturally with emotion. Finally, the paper sketches some ways in which the emotions of underclass groups, especially women, may contribute to the development of a critical social theory. (shrink)

Understanding causal structure is a central task of human cognition. Causal learning underpins the development of our concepts and categories, our intuitive theories, and our capacities for planning, imagination and inference. During the last few years, there has been an interdisciplinary revolution in our understanding of learning and reasoning: Researchers in philosophy, psychology, and computation have discovered new mechanisms for learning the causal structure of the world. This new work provides a rigorous, formal basis for theory theories of concepts and (...) cognitive development, and moreover, the causal learning mechanisms it has uncovered go dramatically beyond the traditional mechanisms of both nativist theories, such as modularity theories, and empiricist ones, such as association or connectionism. (shrink)

abstract: Religion for many of Canada's earliest Chinese community was not about faith or belief in God, the Buddha, or the Goddess of Compassion (Guanyin). While the majority of Chinese migrants did not convert to Christianity or Buddhism before 1947, a very large number of them joined and became converted to Chinese nationalism (Zhongguo guomindang, aka KMT). This paper reflects on the findings of sixteen years of ethnographic and archival research to understand how sixty-two years of institutionalized racism in Canada, (...) along with bioregionalism and the built environment, determined Chinese migrant religious identities and behaviors in Canada up to 1947. Different Canadian provinces not only had different race-based laws that restricted individual rights and freedoms, they also had varying bioregional characteristics that influenced experiences and interactions with the built environments of churches, temples, and clubhouses. Chinese migrants adapted to legislation that limited their personal rights and freedoms by being efficacious or ling by professing Christian identities in public settings. They might have made offerings to Buddhist deities and frequented Buddhist temples in their home village before migration. But in Canada, being Buddhist was associated with being Japanese, and it was efficacious to be a practicing Buddhist in private. For Canada's Chinese migrants, it was conversion to Chinese nationalism and the veneration of Sun Yat-sen that was the epitome of ling. Being a devoted member met important practical as well as spiritual needs. (shrink)

I argue that explanation should be thought of as the phenomenological mark of the operation of a particular kind of cognitive system, the theory-formation system. The theory-formation system operates most clearly in children and scientists but is also part of our everyday cognition. The system is devoted to uncovering the underlying causal structure of the world. Since this process often involves active intervention in the world, in the case of systematic experiment in scientists, and play in children, the cognitive system (...) is accompanied by a theory drive, a motivational system that impels us to interpret new evidence in terms of existing theories and change our theories in the light of new evidence. What we usually think of as explanation is the phenomenological state that accompanies the satisfaction of this drive. However, the relation between the phenomenology and the cognitive system is contingent, as in similar cases of sexual and visual phenomenology. Distinctive explanatory phenomenology may also help us to identify when the theory-formation system is operating. (shrink)

At least since Augustine, philosophers have constructed developmental just-so stories about the origins of certain concepts. In these just-so stories, philosophers tell us how children must develop these concepts. However, philosophers have by and large neglected the empirical data about how children actually do develop their ideas about the world. At best they have used information about children in an anecdotal and unsystematic, though often illuminating, way.

This paper argues that there are powerful similarities between cognitive development in children and scientific theory change. These similarities are best explained by postulating an underlying abstract set of rules and representations that underwrite both types of cognitive abilities. In fact, science may be successful largely because it exploits powerful and flexible cognitive devices that were designed by evolution to facilitate learning in young children. Both science and cognitive development involve abstract, coherent systems of entities and rules, theories. In both (...) cases, theories provide predictions, explanations, and interpretations. In both, theories change in characteristic ways in response to counterevidence. These ideas are illustrated by an account of children's developing understanding of the mind. (shrink)

The Beloved Self is about the holy grail of moral philosophy, an argument against egoism that proves that we all have reasons to be moral. Part One introduces three different versions of egoism. Part Two looks at attempts to prove that egoism is false, and shows that even the more modest arguments that do not try to answer the egoist in her own terms seem to fail. But in part Three, Hills defends morality and develops a new problem for egoism, (...) an epistemological problem. She shows that it is not epistemically rational to believe the most plausible versions of egoism. The first part of the book will be most relevant to those interested in moral theory, as it contains detailed discussions of recent interpretations of virtue ethics and especially of Kant's moral theory. The second and third part of the book turn to epistemology, particularly moral epistemology, and include an account of the relationship between knowledge and action, a new theory of moral understanding, and a discussion of the epistemically rational response to various kinds of disagreement. Hills also defends a new account of virtue and of morally worthy action. (shrink)

This chapter examines several ways in which philosophical attention to intuition can contribute to empirical scientific psychology. The authors then discuss one prevalent misuse of intuition. An unspoken assumption of much argumentation in the philosophy of mind has been that to articulate our folk psychological intuitions, our ordinary concepts of belief, truth, meaning, and so forth, is itself sufficient to give a theoretical account of what belief, truth, meaning, and so forth, actually are. It is believed that this assumption rests (...) on an inadequate understanding of the nature of intuition and its appropriate applications, and that it results in errors. Three notable examples of this sort of misuse of intuition in philosophy are briefly discussed. Finally, the authors provide developmental evidence for the mutability and fallibility of everyday intuitions about the mind, evidence that undermines arguments, that depend on taking such intuitions as a final authority for substantive claims about what the mind is like. (shrink)

The essays in this interdisciplinary collection share the conviction that modern western paradigms of knowledge and reality are gender-biased.

Previous research suggests that children can infer causal relations from patterns of events. However, what appear to be cases of causal inference may simply reduce to children recognizing relevant associations among events, and responding based on those associations. To examine this claim, in Experiments 1 and 2, children were introduced to a “blicket detector”, a machine that lit up and played music when certain objects were placed upon it. Children observed patterns of contingency between objects and the machine’s activation that (...) required them to use indirect evidence to make causal inferences. Critically, associative models either made no predictions, or made incorrect predictions about these inferences. In general, children were able to make these inferences, but some developmental differences between 3- and 4- year-olds were found. We suggest that children’s causal inferences are not based on recognizing associations, but rather that children develop a mechanism for Bayesian structure learning. Experiment 3 explicitly tests a prediction of this account. Children were asked to make an inference about ambiguous data based on the base-rate of certain events occurring. Fouryear-olds, but not 3-year-olds were able to make this inference. (shrink)

This chapter contains section titled: The Theory Theory The Theory Theory vs. Other Empiricist Alternatives Innate Theories and Starting‐state Nativism Phenomenological and Social Objections Universality, Uniformity, and Learning Theory Formation and Language.

Testimony is an important source of our knowledge about the world. But to some, there seems something odd, perhaps even wrong, about trusting testimony about specifically moral matters. In this paper, I discuss several different explanations of what might be wrong with trusting moral testimony. These include the possibility that there is no moral knowledge; that moral knowledge cannot be transmitted by moral testimony; that there are reasons not to trust moral testimony either because you should try to gain and (...) use “moral understanding” to make your moral judgements instead or because doing so is damaging to your moral character in various ways. Finally, I discuss some “debunking explanations” according to which it is right and rational to trust moral testimony from a trustworthy source. © 2013 The Author. Philosophy Compass © 2013 Blackwell Publishing Ltd. (shrink)

This paper argues that there are powerful similarities between cognitive development in children and scientific theory change. These similarities are best explained by postulating an underlying abstract set of rules and representations that underwrite both types of cognitive abilities. In fact, science may be successful largely because it exploits powerful and flexible cognitive devices that were designed by evolution to facilitate learning in young children. Both science and cognitive development involve abstract, coherent systems of entities and rules, theories. In both (...) cases, theories provide predictions, explanations, and interpretations. In both, theories change in characteristic ways in response to counterevidence. These ideas are illustrated by an account of children's developing understanding of the mind. (shrink)

Five studies investigated (a) children’s ability to use the dependent and independent probabilities of events to make causal inferences and (b) the interaction between such inferences and domain-specific knowledge. In Experiment 1, preschoolers used patterns of dependence and independence to make accurate causal inferences in the domains of biology and psychology. Experiment 2 replicated the results in the domain of biology with a more complex pattern of conditional dependencies. In Experiment 3, children used evidence about patterns of dependence and independence (...) to craft novel interventions across domains. In Experiments 4 and 5, children’s sensitivity to patterns of dependence was pitted against their domain-specific knowledge. Children used conditional probabilities to make accurate causal inferences even when asked to violate domain boundaries. (shrink)

Judith Butler's contribution to feminist political thought is usually approached in terms of her concept of performativity, according to which gender exists only insofar as it is ritualistically and repetitively performed, creating permanent possibilities for performing gender in new and transgressive ways. In this paper, I argue that Butler's politics of performativity is more fundamentally grounded in the concept of genealogy, which she adapts from Foucault and, ultimately, Nietzsche. Butler understands women to have a genealogy: to be located within a (...) history of overlapping practices and reinterpretations of femininity. This genealogical understanding of femininity allows Butler to propose a coalitional feminist politics, which requires no unity among women but only loosely overlapping connections. For Butler, feminist coalitions should aim to subvert, not consolidate, entrenched norms concerning femininity. Butler has been criticized, however, for failing to explain either how subversive agency is possible or why the subversion of gender norms is desirable. Reviewing these criticisms, I argue that Butler offers a convincing explanation of the possibility of subversive agency, but that the normative dimension of her political thought remains relatively underdeveloped. I explore how the normative aspect of Butler's thought could be strengthened by recasting her notion of genealogy along more thoroughly Nietzschean and materialist lines, in terms of an idea of active and multiple bodily forces. (shrink)

Successfully navigating the norms of a society is a complex task that involves recognizing diverse kinds of rules as well as the relative weight attached to them. In the United States, different kinds of rules—federal statutes and regulations, scientific norms, and professional ideals—guide the work of researchers. Penalties for violating these different kinds of rules and norms can range from the displeasure of peers to criminal sanctions. We proposed that it would be more difficult for researchers working in the U.S. (...) who were born in other nations to distinguish the seriousness of violating rules across diverse domains. We administered a new measure, the evaluating rules in science task, to National Institutes of Health-funded investigators. The ERST assessed perceptions of the seriousness of violating research regulations, norms, and ideals, and allowed us to calculate the degree to which researchers distinguished between the seriousness of each rule category. The ERST also assessed researchers’ predictions of the seriousness that research integrity officers would assign to the rules. We compared researchers’ predictions to the seriousness ratings of 112 RIOs working at U.S. research-intensive universities. U.S.-born researchers were significantly better at distinguishing between the seriousness of violating federal research regulations and violating ideals of science, and they were more accurate in their predictions of the views of RIOs. Acculturation to the U.S. moderated the effects of nationality on accuracy. We discuss the implications of these findings in terms of future research and education. (shrink)

One familiar criticism of utilitarianism is that it is too demanding. It requires us to promote the happiness of others, even at the expense of our own projects, our integrity, or the welfare of our friends and family. Recently Ashford has defended utilitarianism, arguing that it provides compelling reasons for demanding duties to help the needy, and that other moral theories, notably contractualism, are committed to comparably stringent duties. In response, I argue that utilitarianism is even more demanding than is (...) commonly realized: both act- and rule-utilitarianism are committed to extremely stringent duties to wild animals. In this regard, utilitarianism is more demanding (and more counter-intuitive) than contractualism. (shrink)

Abstract: A current debate in semantics and pragmatics is whether all contextual effects on truth-conditional content can be traced to logical form, or 'unarticulated constituents' can be supplied by the pragmatic process of free enrichment. In this paper, I defend the latter position. The main objection to this view is that free enrichment appears to overgenerate, not predicting where context cannot affect truth conditions, so that a systematic account is unlikely (Stanley, 2002a). I first examine the semantic alternative proposed by (...) Stanley and others, which assumes extensive hidden structure acting as a linguistic trigger for pragmatic processes, so that all truth-conditional effects of context turn out to be instances of saturation. I show that there are cases of optional pragmatic contributions to the proposition expressed that cannot plausibly be accounted for in this way, and that advocates of this approach will therefore also have to appeal to free enrichment. The final section starts to address the question of how free enrichment is constrained: I argue that it involves only local development or adjustment of parts of logical form, any global developments being excluded by the requirement for the proposition expressed to provide an inferential warrant for the intended implications of the utterance. (shrink)

Philosophers and Buddhist scholars have noted the affinities between David Hume's empiricism and the Buddhist philosophical tradition. I show that it was possible for Hume to have had contact with Buddhist philosophical views. The link to Buddhism comes through the Jesuit scholars at the Royal College of La Fleche. Charles Francois Dolu was a Jesuit missionary who lived at the Royal College from 1723-1740, overlapping with Hume's stay. He had extensive knowledge both of other religions and cultures and of scientific (...) ideas. Dolu had had first-hand experience with Theravada Buddhism as part of the second French embassy to Siam in 1687-1688. In 1727, Dolu also had talked with Ippolito Desideri, a Jesuit missionary who visited Tibet and made an extensive study of Tibetan Buddhism from 1716-1721. It is at least possible that Hume heard about Buddhist ideas through Dolu. (shrink)

Ricœur lectured and wrote for over twenty years on negation (‘Do I understand something better if I know what it is not, and what is not-ness?') and never published his extensive writings on this subject. Ricœur concluded that there are multiple forms of negation; it can, for example, be the other person (Plato), the not knowable nature of our world (Kant), the included opposite (Hegel), apophatic spirituality (Plotinus on not being able to know God) and existential nothingness (Sartre). Ricœur, working (...) on Kant, Hegel and Sartre, decided that all these forms of negation are incompatible and also fatally flawed because they fail to resolve false binaries of negative: positive. Alison Scott-Baumann demonstrates how Ricœur subsequently incorporated negation into his linguistic turn, using dialectics, metaphor, narrative, parable and translation in order to show how negation is in us, not outside us: language both creates and clarifies false binaries. He bestows upon negation a strong and central role in the human condition, and its inevitability is reflected in his writings, if we look carefully. Ricœur and the Negation of Happiness draws on Ricœur's published works, previously unavailable archival material and many other sources. Alison Scott-Baumann argues that thinking positively is necessary but not sufficient for aspiring to happiness - what is also required is affirmation of negative impulses: we know we are split by contradictions and still try to overcome them. She also demonstrates the urgency of analysing current socio-cultural debates about wellbeing, education and equality, which rest insecurely upon our loose use of the negative as a category mistake. (shrink)

This paper focuses on how Soldiers make hard choices between competing options. To understand the psychological processes behind these types of decisions, we present qualitative data collected from...

This is the first of two companion articles drawn from a larger project, provisionally entitled Undisciplining Moral Epistemology. The overall goal is to understand how moral claims may be rationally justified in a world characterized by cultural diversity and social inequality. To show why a new approach to moral justification is needed, it is argued that several currently influential philosophical accounts of moral justification lend themselves to rationalizing the moral claims of those with more social power. The present article explains (...) how discourse ethics is flawed just in this way. The article begins by identifying several conditions of adequacy for assessing reasoning practices designed to achieve moral justification and shows that, when used in contexts of cultural diversity and social inequality, discourse ethics fails these conditions. It goes on to argue that the failure of discourse ethics is rooted in its reliance on a broader conception of moral epistemology that is invidiously idealized. It concludes by pointing to the need to rethink both the mission and the method of moral epistemology. (shrink)

Word count (excluding abstract and references): 2,498 words. Address for correspondence: T. Kushnir, Psychology Department, University of California, 3210 Tolman Hall #1650, Berkeley, CA 94720-1650. Phone: 510-205-9847. Fax: 510-642- 5293. E-mail: [email protected].

We outline a cognitive and computational account of causal learning in children. We propose that children employ specialized cognitive systems that allow them to recover an accurate “causal map” of the world: an abstract, coherent representation of the causal relations among events. This kind of knowledge can be perspicuously represented by the formalism of directed graphical causal models, or “Bayes nets”. Human causal learning and inference may involve computations similar to those for learnig causal Bayes nets and for predicting with (...) them. Preliminary experimental results suggest that 2- to 4-year-old children spontaneously construct new causal maps and that their learning is consistent with the Bayes-Net formalism. (shrink)

Faultless disagreements are disagreements between two people, neither of whom has made a mistake or is at fault. It has been argued that there are faultless moral disagreements, that they cannot be accommodated by moral realism, and that in order to account for them, a form of relativism must be accepted. I argue that moral realism can accommodate faultless moral disagreement, provided that the phenomena is understood epistemically, and I give a brief defence of the relevant moral epistemology.

Why should we be interested in Kant's ethical theory? One reason is that we find his views about our moral responsibilities appealing. Anyone who thinks that we should treat other people with respect, that we should not use them as a mere means in ways to which they could not possibly consent, will be attracted by a Kantian style of ethical theory. But according to recent supporters of Kant, the most distinctive and important feature of his ethical theory is not (...) his claims about the particular ethical duties that we owe to each other, but his views about the nature of value. They argue that Kant has an account of the relationship between practical reason and value, known as "Kantian constructivism" that is far superior to the traditional "value realist" theory, and that it is because of this that we should accept his theory.1 It is now standard for both supporters and critics to claim that Kant's moral theory stands or falls with Kantian constructivism.2 But this is a mistake. In this paper, I sketch a rival Kantian theory of value, which I call Kantian value realism. I argue that there is textual evidence that Kant himself accepted value realism rather than constructivism. Whilst my aim in this paper is to set out the theory clearly rather than to defend it, I will try to show that Kantian value realism is preferable to Kantian constructivism and that it is worthy of further study. (shrink)

The difficulty of distinguishing between the intended and the merely foreseen consequences of actions seems to many to be the most serious problem for the doctrine of double effect. It has led some to reject the doctrine altogether, and has left some of its defenders recasting it in entirely different terms. I argue that these responses are unnecessary. Using Bratman’s conception of intention, I distinguish the intended consequences of an action from the merely foreseen in a way that can be (...) used to support the doctrine of double effect. (shrink)