New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)
Christian Godin | : Le Tout de Lavelle n’est ni celui, panthéistique, de l’univers, ni celui, épistémique, des holismes et des théories du système. Il s’agira donc dans cet article de dégager une présence et un sens diffus, pour tâcher de déterminer la fonction que Lavelle fait jouer à l’idée de Tout dans l’économie générale de sa pensée. | : It is neither the whole of the universe (pantheistic), nor the whole of the holisms and theories of system (epistemic), (...) that concerns Lavelle. This article will seek to bring out a presence and a diffuse sense of the whole, with a view to determining the function which Lavelle makes the idea of the whole play in the general economy of his thought. (shrink)
The history of innovation as a category is dominated by economists and by the contribution of J. A. Schumpeter. This paper documents the contribution of a neglected but influential author, the American sociologist William F. Ogburn. Over a period of more than 30 years, Ogburn developed pioneering ideas on three dimensions of technological innovation: origins, diffusion, and effects. He also developed the first conceptual framework for innovation studies—based on the concept of cultural lags—which led to studying and forecasting the impacts (...) of technological innovation on society. All in all, Ogburn has been as important to the sociology of technology as Robert K. Merton has been to the sociology of science and Schumpeter to the economics of technological innovation. (shrink)
J. Schumpeter is a key figure, even a seminal one, on technological innovation. Most economists who study technological innovation refer to Schumpeter and his pioneering role in introducing innovation into economic studies. However, despite having brought forth the concept of innovation in economic theory, Schumpeter provided few if any analyses of the process of innovation itself. This paper suggests that the origin of systematic studies on technological innovation owes its existence to the economist W. Rupert Maclaurin from MIT. In the (...) 1940s and 1950s, Maclaurin developed Schumpeter’s ideas, analyzing technological innovation as a process composed of several stages or steps, and proposed a theory of technological innovation, later called the linear model of innovation. The paper also argues that Maclaurin constructed one of the first taxonomies for measuring technological innovation. (shrink)
In this article, we apply a special case of holographic representations to letter position coding. We translate different well-known schemes into this format, which uses distributed representations and supports constituent structure. We show that in addition to these brain-like characteristics, performances on a standard benchmark of behavioral effects are improved in the holographic format relative to the standard localist one. This notably occurs because of emerging properties in holographic codes, like transposition and edge effects, for which we give formal demonstrations. (...) Finally, we outline the limits of the approach as well as its possible future extensions. (shrink)
Euthanasia remains controversial in Canada and an issue of debate among physicians. Most studies have explored the opinion of health professionals regarding its legalization, but have not investigated their intentions when faced with performing euthanasia. These studies are also considered atheoretical. The purposes of the present study were to fill this gap in the literature by identifying the psychosocial determinants of physicians’ intention to practice euthanasia in palliative care and verifying whether respecting the patient’s autonomy is important for physicians.
Innovation has become a very popular concept over the twentieth century. However, few have stopped to study the origins of the category and to critically examine the studies produced on innovation. This paper conducts such an analysis on one type of innovation, namely technological innovation. The study of technological innovation is over one hundred years old. From the early 1900s onward, anthropologists, sociologists, historians, and economists began theorizing about technological innovation, each from his own respective disciplinary framework. However, in the (...) last forty years an economic and “dominant” understanding of technological innovation has developed: technological innovation defined as commercialized invention. This paper documents the origins of this representation and the tradition of research to which it gave rise: “innovation studies.” More specifically, it analyzes what distinguishes this tradition from that concerned with technological change as the use of inventions in industrial production, and looks at why such a tradition originated in Europe. (shrink)
Official science and technology statistics arefifty years old. Among industrial countries,the forerunners were the United States, Canadaand Great Britain. This paper traces thedevelopment and the construction of S&Tstatistics in these three countries, and theirsubsequent standardization, mainly by theOECD, in the 1960s. It shows how military andscience policy needs drove the construction ofstatistics, until economic considerations cameto dominate their development. It alsodiscusses how statistics interacted withpolitics by way of studies that documentedgaps between OECD Member countries and betweenthe OECD and the USSR.
La contre-utopie 1 est le double inversé de l’utopie. Elle délivre l’image d’une société de cauchemar là où l’utopie faisait le tableau d’une société de rêve. Les utopies décrivaient des communautés ordonnées et prospères. Elles donnaient à penser que la conjonction de l’abondance2 et de la tranquillité est possible, que les hommes pourraient enfin parvenir..
Fernand Braudel distinguait trois rythmes historiques. Le premier, le plus lent, est lié aux inerties de la géographie et du langage. Le deuxième, plus rapide, est celui des grands faits, à l’échelle des décennies. Le troisième, très agité, est celui des événements. Une revue d’idées comme Cités n’a pas pour vocation de suivre des événements..
For centuries, _innovation_ was a political and contested concept and linguistic weapon used against one's enemy. To support their case, opponents of innovation made use of arguments from ethos and pathos to give power and sustenance to their criticisms and to challenge the innovators. However, since the nineteenth century the arguments have changed completely. _Innovation_ gradually got rehabilitated. This article looks at one type of rehabilitation: the semantic rehabilitation. People started to reread history and to redescribe what _innovation_ is. What (...) was bad innovation became good innovation because of long-lasting and beneficial effects, so it was believed. (shrink)