New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

So-called 'dynamic' semantic theories such as Kamp's discourse representation theory and Heim's file change semantics account for such phenomena as cross-sentential anaphora, donkey anaphora, and the novelty condition on indefinites, but compare unfavorably with Montague semantics in some important respects (clarity and simplicity of mathematical foundations, compositionality, handling of quantification and coordination). Preliminary efforts have been made by Muskens and by de Groote to revise and extend Montague semantics to cover dynamic phenomena. We present a new higher-order theory of discourse (...) semantics which improves on their accounts by incorporating a more articulated notion of context inspired by ideas due to David Lewis and to Craige Roberts. On our account, a context consists of a common ground of mutually accepted propositions together with a set of discourse referents preordered by relative salience. Employing a richer notion of contexts enables us to extend our coverage beyond pronominal anaphora to a wider range of presuppositional phenomena, such as the factivity of certain sentential-complement verbs, resolution of anaphora associated with arbitrarily complex definite descriptions, presupposition 'holes' such as negation, and the independence condition on the antecedents of conditionals. Formally, our theory is expressed within a higher-order logic with natural number type, separation-style subtyping, and dependent coproducts parameterized by the natural numbers. The system of semantic types builds on proposals due to Thomason and to Pollard in which the type of propositions (static meanings of sentential utterances) is taken as basic and worlds are constructed from propositions (rather than the other way around as in standard Montague semantics). (shrink)

From time to time we explain what people do by referring to their habits. We explain somebody’s putting the kettle on in the morning as done through “force of habit”. We explain somebody’s missing a turning by saying that she carried straight on “out of habit”. And we explain somebody’s biting her nails as a manifestation of “a bad habit”. These are all examples of what will be referred to here as habit explanations. Roughly speaking, they explain by referring to (...) a pattern of a particular kind of behaviour which is regularly performed in characteristic circumstances, and has become automatic for that agent due to this repetition. (shrink)

The past 15 years have witnessed an increasing interest in the comparative study of language and music as cognitive systems. This book presents an interdisciplinary study of language and music, exploring the following core areas - structural comparisons, evolution, learning and processing, and neuroscience.

Experimental research by social and cognitive psychologists has established that cooperative groups solve a wide range of problems better than individuals. Cooperative problem solving groups of scientific researchers, auditors, financial analysts, air crash investigators, and forensic art experts are increasingly important in our complex and interdependent society. This comprehensive textbook--the first of its kind in decades--presents important theories and experimental research about group problem solving. The book focuses on tasks that have demonstrably correct solutions within mathematical, logical, scientific, or verbal (...) systems, including algebra problems, analogies, vocabulary, and logical reasoning problems.The book explores basic concepts in group problem solving, social combination models, group memory, group ability and world knowledge tasks, rule induction problems, letters-to-numbers problems, evidence for positive group-to-individual transfer, and social choice theory. The conclusion proposes ten generalizations that are supported by the theory and research on group problem solving. Group Problem Solving is an essential resource for decision-making research in social and cognitive psychology, but also extremely relevant to multidisciplinary and multicultural problem-solving teams in organizational behavior, business administration, management, and behavioral economics. (shrink)

Virtuous actions seem to be both habitual and rational. But if we combine an intuitive understanding of habituality with the currently predominant paradigm of rational action, these two features of virtuous actions are hard to reconcile. Intuitively, acting habitually is acting as one has before in similar contexts, and automatically, that is, without thinking about it. Meanwhile, contemporary philosophers tend to assume the truth of what I call the reasons theory of rational action, which states that all rational actions are (...) actions for reasons. Whilst interpretations of this phrase are disputed, I argue that neither of the two leading views – which I call reasons internalism and reasons externalism – makes room for habitual actions to count as actions for reasons; by the reasons theory, they cannot be rational either. I suggest one way of effecting the reconciliation which, whilst it allows us to keep the reasons theory, requires us to conceive of reasons as even more radically external than current externalists believe them to be. (shrink)

Ethics consultation in institutions of the healthcare system has been given a standard form based on three pillars: education, the development of guidelines and concrete ethics consultation in case conferences. The spread of ethics committees, which perform these tasks on an organizational level, is a remarkable historic achievement. At the same time it cannot be denied that modern ethics consultation neglects relevant aspects of care ethics approaches. In our essay we present an “ethics of care” approach as well as an (...) empirical pilot project—“Ethics from the bottom up”—which organizes ethics consultation based on this focus. Findings and philosophy of the project will be discussed as far as relevant for ethics consultation in the healthcare system. (shrink)

A modal logic is developed to deal with finite ordered binary trees a they are used in linguistics. A modal language is introduced with operators for the ‘mother of’, ‘first daughter of’ and ‘second daughter of’ relations together with their transitive reflexive closures. The relevant class of tree models is defined and three linguistic applications of this language are discussed: context free grammars, command relations, and trees decorated with feature structures. An axiomatic proof system is given for which completeness is (...) shown with respect to the class of finite ordered binary trees. A number of decidability results follow. (shrink)

This is a survey of the concept of continuity. Efforts to explicate continuity have produced a plurality of philosophical conceptions of continuity that have provably distinct expressions within contemporary mathematics. I claim that there is a divide between the conceptions that treat the whole continuum as prior to its parts, and those conceptions that treat the parts of the continuum as prior to the whole. Along this divide, a tension emerges between those conceptions that favor philosophical idealizations of continuity and (...) those that are more readily available for mathematico-scientific use. (shrink)

. How does the doctrine of double effect apply to business decisions to sell products which may be harmful to consumers? Lawrence Masek believes that some authors have misapplied the doctrine to this type of decision and, as a consequence, have committed themselves to placing unwarranted constraints on businesses. Seeking to correct this mistake, Masek presents his account of how the doctrine applies here, an account which is rather permissive but which, he claims, nevertheless preserves the virtues of the doctrine. (...) It will be seen, though, that his attempt to loosen these putatively unnecessary constraints by appealing to consumer autonomy and an intuition about the morality of producing harmful products leaves the doctrine of double effect irrelevant to this type of decision. His argument that the doctrine is less restrictive in this context than others suppose leads ultimately to the conclusion that the doctrine does not constrain this kind of business decision at all. (shrink)

Griinbaum's own article sets forth his views on the ontology of the curvature of empty space, especially in the geometrodynamics of Clifford and Wheeler. ...

A hyperintensional semantics for natural language is proposed which is agnostic about the question of whether propositions are sets of worlds or worlds are sets of propositions. Montague’s theory of intensional senses is replaced by a weaker theory, written in standard classical higher-order logic, of fine-grained senses which are in a many-to-one correspondence with intensions; Montague’s theory can then be recovered from the proposed theory by identifying the type of propositions with the type of sets of worlds and adding an (...) axiom to the effect that each world is the set of propositions which are true there. Senses are compositionally assigned to linguistic expressions by a categorial grammar with only two rule schemas, based on the implicative fragment of intuitionistic linear propositional logic, and a fully explicit grammar fragment is provided that illustrates the compositional assignment of sense to a variety of constructions, including dummy-subject constructions, infinitive complements, predicative adjectives and nominals, raising to subject, ‘tough-movement’, and quantifier scope ambiguities. Notably, the grammar and the derivations that it licenses never make reference to either worlds or to the extensions of senses. (shrink)

In their editors’ introduction, Rebuschat and Monaghan provide the background to the special issue. They outline the rationale for bringing together, in a single volume, leading researchers from two distinct, yet related research strands, implicit learning and statistical learning. The editors then introduce the new contributions solicited for this special issue and provide their perspective on the agenda setting that results from combining these two approaches.

One contested moral commitment shared by the American Medical Association and American Nurses Association has to do with the place of conscience in the practice of medicine. These organizations, each in their own way, urge their respective members to engage in careful moral discernment regarding their professional life, and they assert the existence of an obligation on the part of others to respect the conscientious objections of healthcare professionals and to accommodate objecting individuals. Yet despite the value that these organizations (...) place on conscience and objector rights, these organizations do not offer elaborate philosophical defenses of their positions. This shortcoming is exposed by the light of contemporary philosophical challenges to conscience-friendly policies. What such challenges demand is a philosophical defense of these organizations’ moral commitments and corresponding policy recommendations. The point of this article is to indicate how the Catholic philosophical tradition’s account of the nature and importance of conscience can philosophically underwrite these organizations’ conscience-related principles and practices. It can be seen, then, that the Catholic tradition is far from inimical to the contemporary practice of medicine and that, on the contrary, this tradition offers philosophically serious grounds on which to rest some of the most morally significant values and guidelines endorsed by these contemporary health-professional organizations and their members. (shrink)

This essay addresses a stream of thought manifested in some forms of social justice activism – namely, that members of marginalized groups have privileged insight into the nature of social reality which others cannot understand, much less critique. This position, which I call “epistemic isolationism,” seems to rest on the claim that the knowledge that is embedded in lived experience is incommunicable. The essay proceeds in three parts: first, there is a brief overview of standpoint epistemology, including a recent version (...) which seems to support epistemic isolationism. Second, there is an explication of the concept of “lived experience” as developed by Wilhelm Dilthey. Third, there is an argument against the claim that lived experience is incommunicable, drawing from the work of Dilthey, Hans-Georg Gadamer, and Paul Ricoeur. The payoff of the argument is that sharing lived experience through expressions like literature and narrative inspires mutual recognition and respect which can, in turn, support a robust form of solidarity and serve as a foundation for more effective social justice advocacy. (shrink)

This book offers a comprehensive overview of the arguments relating to the extent and manner to which social influences enable epistemic agents.

ABSTRACT In this article, I reply to criticisms of Dean Stretton of the pro‐life argument from substantial identity. When the criterion for the right to life proposed by most proponents of the pro‐life position is rightly understood – being a person, a distinct substance of a rational nature – this position does not lead to the difficulties Stretton claims it does.

I argue for the possibility of hypergunk: that is, it is possible that there exists an x such that every part of x has a proper part and, for any set S of parts of x, there is a set S′ of parts of...

We are creatures of habit. Familiar ways of doing things in familiar contexts become automatic for us. That is to say, when we acquire a habit we can act without thinking about it at all. Habits free our minds to think about other things. Without this capacity for habitual action our daily lives would be impossible. Our minds would be crowded with innumerable mundane considerations and decisions. Habitual actions are not always mundane. Aristotle famously said that acting morally is a (...) matter of exercising the right habits.2 For him, a lack of conscious thought is no bar on an action’s moral status. Habits are involved in our most prized activities. Of course our natural capacity for acquiring habits is sometimes a nuisance, and we acquire bad habits all too easily. But we nevertheless could not do without a vast array of habits which are not like this, and we can’t help but exercise them in our daily lives. It does not seem too strong to say that we spend much more of our time acting habitually than we do acting in the light of conscious thought. We are also rational creatures. It is because of our rationality that we naturally think that most human actions are different in kind from the behaviour of other animals. This difference is manifest in the fact that we hold rational creatures personally responsible for what they do, in ways that would make no sense for nonrational creatures. Our rationality, then, appears to give our actions a unique quality. (shrink)

Sellars, Brandom, and McDowell (whom Maher aptly calls the “Pittsburgh School”) have tremendous influence on the current shape of the analytic tradition. Despite their differing views on philosophy of language, the philosophy of mind, philosophy of action, and epistemology, their shared application of ‘normative functionalism’ highlights important similarities in their approaches to the aforementioned disciplines. Normative functionalism interprets the ability to form judgments, possess concepts, rationally defend or be critical of judgments, and consequently act as an agent, as largely guided (...) by one’s responsiveness to norms. In this article, I argue for two related claims. First, I argue that the Pittsburgh School’s normative functionalism has germinated from the seed of Sellars’ ‘psychological nominalism’ and cannot be separated from it. Second, no philosophical question or approach can be free of competing claims as to the manner in which human beings think, communicate, act, and know. As a result, normative functionalism (insofar as it is a natural extension of psychological nominalism) is relevant to many philosophical disciplines, because it opposes nearly all the traditional views concerning how the human intellect comes into being and functionally operates. (shrink)

The Pareto argument for inequality holds that any change from a position of equality to one of inequality is justified so long as everyone benefits from the change. G.A. Cohen criticizes this argument (which he attributes to Rawls) on the ground that changes can normally be found which preserve both equality and Pareto‐efficiency. However, this does not resolve the basic conflict between the two desiderata. Strong egalitarians hold that Pareto changes are not for the better if they increase inequality too (...) greatly. Thus if the Pareto argument holds, then strong egalitarianism is unsustainable. I argue that egalitarians need not be troubled by the Pareto argument for inequality. The Pareto criterion would not be widely accepted unless it takes account of moral harms; but if it does take account of moral harms then there is no reason to doubt that egalitarian concerns can be incorporated into the Pareto argument. (shrink)

International lawyers have often been interested in the link between their discipline and the foundational issues of jurisprudential method, but little that is systematic has been written on this subject. In this book, an attempt is made to fill this gap by focusing on issues of concept-formation in legal science in general with a view to their application to the specific concerns of international law. In responding to these issues, the author argues that public international law seeks to establish and (...) institutionalise a system of authoritative judgment whereby the conditions by which a community of states can co-exist and co-operate are ensured. A state, in turn, must be understood as ultimately deriving legitimacy from the pursuit of the human dignity of the community it governs, as well as the dignity of those human beings and states affected by its actions in international relations. This argument is in line with a long and now resurgent Kantian tradition in legal and political philosophy. The book shows how this approach is reflected in accepted paradigm cases of international law, such as the United Nations Charter. It then explains how this approach can provide insights into the theoretical foundations of these accepted paradigms, including our understanding of the sources of international law, international legal personality and the design of global institutions. (shrink)

In this essay, I argue for an account of property possession as strict, numerical identity. According to this account, for an entity to possess a property is for that entity to be numerically identical to that property.

Despite the recent increase of interest in the work of Merleau-Ponty there is still a persistent tendency to overlook the uniqueness of the philosophical position he advances in Phenomenology of Perception. In this article I present a reading of Merleau-Ponty’s account of the phenomenological reduction that explains how it is original. I do this by contrasting his presentation of the reduction with that of the early Husserl, highlighting how his emphasis on the phenomenology of the ‘perceived world’ leads him to (...) reject Husserl’s conception of phenomenology as a ‘philosophical science,’ and the Kantian language in which the this account is framed. I go on to critically discuss the interpretations of the reduction advanced by Stephen Priest and Joel Smith as examples of readings that fail to fully grasp Merleau-Ponty’s account of the ‘natural attitude’ as resting on the inherent objectivizing structure that is built into perception itself. The way that these authors misinterpret Merleau-Ponty helps to make maximally clear the profound philosophical significance that he places on the phenomenology of the ‘perceived world’. (shrink)

Patrick D Walsh; Education: one concept in many uses, Journal of Philosophy of Education, Volume 19, Issue 2, 30 May 2006, Pages 167–180, https://doi.org/10.111.

Max Weber described the modern world as disenchanted. By contrast, some contemporary writers have said that postmodernism and other developments are re‐enchanting the world. I put Weber and these writers alongside each other, and then undercut the discussion by considering a third possibility raised by some recent writers on theological aesthetics: that the world is still enchanted in certain ways. But this third point of view depends on a wide reading of the concept of “sacrament”, and one very different from (...) Weber's understanding. (shrink)

One of the main characteristics of today’s democratic societies is their pluralism. As a result, liberal political philosophers often claim that the state should remain neutral with respect to different conceptions of the good. Legal and social policies should be acceptable to everyone regard- less of their culture, their religion or their comprehensive moral views. One might think that this commitment to neutrality should be especially pronounced in urban centres, with their culturally diverse populations. However, there are a large number (...) of laws and policies adopted at the municipal level that contradict the liberal principle of neutrality. In this paper, I want to suggest that these perfectionist laws and policies are legitimate at the urban level. Specifically, I will argue that the principle of neutrality applies only indirectly to social institutions within the broader framework of the nation-state. This is clear in the case of voluntary associations, but to a certain extent this rationale applies also to cities. In a liberal regime, private associations are allowed to hold and defend perfectionist views, focused on a particular conception of the good life. One problem is to determine the limits of this perfectionism at the urban level, since cities, unlike private associations, are public institutions. My aim here is therefore to give a liberal justification to a limited form of perfectionism of municipal laws and policies. (shrink)

This essay defends the following two claims: (1) liraitation-of-size reasoning yields enough sets to meet the needs of most mathematicians; (2) set formation and mereological fusion share enough logical features to justify placing both in the genus composition (even when the components of a set are taken to be its members rather than its subsets).

Preface -- Identity and the subjunctive -- Representing the seducer -- Interrupting philosophy: -- The complaint about knowledge -- Transcendence and negativity -- The moodiness of the subjunctive -- The accusation of ethics -- Working through love -- The subjunctive hopes all things -- Freedom -- Suffering, faith, and forgiveness -- Concluding with the unscientific.

The publication of two new books by Professor D.Z. Phillips provides a suitable opportunity to consider some recent attempts to apply Wittgenstein's philosophy to religious issues. I shall concentrate mainly on Phillips' work, with particular reference to his treatment of the question of religious truth, but I shall also discuss some other writers and topics.

Allen s has proposed a new approach to possible worlds, designed explicitly to overcome Cantorian difficulties for possible worlds construed as maximal consistent set of propositions. I emphasize some of the distinctive features of Hazenworlds, some of their weaknesses, and some further Cantorian problems for worlds against which they seem powerless.

The essays that make up my dissertation share a methodological approach that aims to explore the philosophical implications of linguists' accounts of ordinary language use. In particular, all of them focus on epistemic natural language and the implications that linguists' accounts of such language has for epistemology. The first essay focuses on the debate about the norms that govern assertion and shows the ways in which research on natural language evidentiality has direct bearing. This essay uses existing cross-linguistic data about (...) assertions in Quechua and Cheyenne to argue that assertions and the norms that govern them are more complex than allowed for in extant views. What makes Quechua and Cheyenne important is that they allow speakers to assert sentences the content of which they do not believe, or even believe to be false, as long as the sentence contains the right evidential marker. This is a problem for the current theories as they all take belief in the proposition being expressed as a minimal requirement for a speaker to felicitously assert. Given the data, I argue that we should see evidential markers as modifying the norm that is in place governing felicity of the current content. I go on to present three implementations of a context-sensitive norm and argue that only the ones that are evidence-based or completely contextual can properly capture the entire set of linguistic data. In the second essay I argue that epistemic uses of 'should' can be modelling using the standard Kratzerian modal canon. In Kratzer's system, modals induce quantification over some partially ordered, restricted class of worlds. The relevant partially ordered, restricted class of worlds is generally fixed by two ingredients: a modal base and an ordering source. Modelling epistemic uses of 'should' requires us to rethink and expand what has traditionally been thought of as making up an epistemic modal base. Traditionally it has been thought that epistemic modal bases just include information about probabilities but this thought needs to be updated in order to bring epistemic 'should' into the fold. I argue that there are good theoretical reasons for having as uniform a semantics as possible then show that the context-sensitive semantic model that I develop meets all empirical demands. I end the essay by arguing that this updated way of thinking about epistemic modals bases has implications for epistemology. The final essay outlines the broad type of methodological approach mentioned above that guides the research throughout the dissertation. In it, I argue that the results of linguistics' theorizing about semantics, especially within the epistemic domain, ought to be seen as an accurate guide to reality. Looking to the way that language evolves over time and what it takes for information to become encoded into language is what drives this result. Buttressing the evolutionary explanation with results from the Condorcet Jury Theorem gives us more reason to believe that language is an accurate, albeit defeasible, guide to reality. If these results hold, they not only have broad implications for how we ought to be conducting our epistemological theorizing but our philosophical theorizing in general. (shrink)