Tells the story of Thomas Paine's creation of the revolutionary pamphlet COMMON SENSE in graphic novel format.

Nanomedicine is yielding new and improved treatments and diagnostics for a range of diseases and disorders. Nanomedicine applications incorporate materials and components with nanoscale dimensions where novel physiochemical properties emerge as a result of size-dependent phenomena and high surface-to-mass ratio. Nanotherapeutics and in vivo nanodiagnostics are a subset of nanomedicine products that enter the human body. These include drugs, biological products, implantable medical devices, and combination products that are designed to function in the body in ways unachievable at larger scales. (...) Nanotherapeutics andin vivonanodiagnostics incorporate materials that are engineered at the nanoscale to express novel properties that are medicinally useful. These nanomedicine applications can also contain nanomaterials that are biologically active, producing interactions that depend on biological triggers. Examples include nanoscale formulations of insoluble drugs to improve bioavailability and pharmacokinetics, drugs encapsulated in hollow nanoparticles with the ability to target and cross cellular and tissue membranes and to release their payload at a specific time or location, imaging agents that demonstrate novel optical properties to aid in locating micrometastases, and antimicrobial and drug-eluting components or coatings of implantable medical devices such as stents. (shrink)

This festschrift collects a number of insightful essays by a group of accomplished Christian scholars, all of who have either worked with or studied under Hendrik Hart during his 35-year tenure as Senior Member in Systematic Philosophy at the Institute for Christian Studies, Toronto, Canada.

Jeffrey King, Scott Soames, and others have recently challenged the familiar identification of a Russellian proposition, such as the proposition that Brutus stabbed Caesar, with an ordered sequence constructed out of objects, properties, and relations. There is, as they point out, a surplus of candidate sequences available that are each equally serviceable. If so, any choice among these candidates will be arbitrary. In this paper, I show that, unless a controversial assumption is made regarding the nature of nonsymmetrical relations, (...) none of the proffered candidate sequences are in fact adequate to the play the role. Moreover, as I argue, the most promising alternative theory of relations—one that avoids the problematic assumption and, in addition, fits most naturally into the sequentialist’s framework—fails to meet a basic requirement: it cannot distinguish between the proposition that Brutus stabbed Caesar and the proposition that Caesar stabbed Brutus. The upshot is that the conspicuously structured entities that are widely assumed to be up to the task of “playing the proposition role” shed no light on the very structure they are invoked to represent. (shrink)

What is it to "value" something, in the semi-technical sense of the term that Gary Watson establishes? I argue that valuing something consists in caring about it. Caring involves not only emotional dispositions of the sort that Agnieszka Jaworska has elaborated, but also a distinctive cognitive disposition – namely, a (defeasible) disposition to believe the object cared about to be a source of agent-relative reasons for action and for emotion. Understood in this way, an agent's carings have a stronger (...) claim to "speak for" her as her values than do other attitudes that have been proposed for this role. In particular, an agent's carings establish more robust psychological continuities and cross-temporal connections than do self-governing policies of the sort that Michael Bratman has described; and they forge diachronic coherence not just in her deliberation and action, as self-governing policies do, but also in her cognitive and emotional life. An agent's carings thus help to constitute her identity as a temporally persisting subject . Self-governing policies are at best ersatz -values, which an agent may choose to adopt when she finds that her proper values – her cares – leave her course underdetermined. (shrink)

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

This essay is focused upon the question raised by the economic historian Andrei Znamenski: was National Socialism really socialist? I lay out his answer—that indeed it was—and explore it. I introduce the notion of neo-socialism as a way to characterize the Nazi regime, and fascist regimes more generally. I explore the key role played in the development of this ideology a number of thinkers called by Jeffrey Herf “reactionary modernists”: Ferdinand Tonnies; Werner Sombart; Hans Freyer; Martin Heidegger; Ernst Junger; (...) Carl Schmitt; and (to a lesser degree) Oswald Spengler. I conclude the essay by explaining the role of the uniquely virulent Nazi anti-Semitism—as well as the changes of the breakout of the war in 1939—played in the decision to exterminate the Jews. (shrink)

[opening paragraph]: Imagine you are a scientist from Mars observing Gary Kasparov playing a tournament with a chess computer. Would you have any reason to postulate consciousness in one player, but not the other? What is consciousness? How does the body produce it, and what is it for? Most people do not realize that there is a problem here because our conscious experience is the thing we know best. We are all familiar with the colours, smells and scenes around (...) us, the pains and itches we feel and the thoughts that are in our heads. Our world consists of conscious experiences. By `conscious experience' I mean anything that you have an awareness of, absolutely anything. I do not mean anything recondite like your capacity to reflect upon your own experiences, something which one might suppose that only we as human beings have and animals do not. I mean the absolute basics, like feeling pain. (shrink)

The idea of a new aestheticism is now explicit in both philosophical aesthetics and cultural theory with the publication of Gary Iseminger's The Aesthetic Function of Art and an anthology of essays edited by John Joughin and Simon Malpas critiquing the anti-aestheticism of literary theory. Both are significant in marking a wider trend reacting to, broadly speaking, intellectualised and historicised accounts of art, refocusing on the idea of appreciation itself, and working away from the emphasis on ideology and disregard (...) for the particularity of works in, especially, literary theory. This broader context also includes renewed debates running within philosophical aesthetics about non-perceptual aesthetic properties and the aesthetic experience of conceptual artworks, and about beauty in art, considerations that have engaged two philosophers normally identified by their commitment to art theoretical and historical (and by extension, non-aesthetic) accounts of artistic making and viewing, namely Noël Carroll and Arthur Danto. So Carroll acknowledges that what's at stake is an aesthetic theory of art that is potentially 'back in business', while Danto's 'surprising' theoretic re-engagement with the concept of beauty has been noted by Diarmuid Costello. (shrink)

The Bhagavad-Gita, as a multivalent text, has been a source of inspiration for all areas of Indian thought. This paper identifies elements in the Bhagavad-Gita which may have influenced the formation of Nyaya philosophy in the centuries after it was written. Part one of the paper reviews Nyaya epistemology as a whole, focusing on aspects that play an important role in the Bhagavad-Gita: perception (pratyaksa), inference (anumana), ‘syllogism’, verbal utterance (sabda) and the practical orientation of knowledge. The second part shows (...) how those aspects appear in the text of the Bhagavad-Gita. In praticular, Krishna relies on a number of techniques in convincing Arjuna of his obligation as a ksatria which would later be formalized in Nyaya philosophy as pramana or methods of knowing. As a whole, the Bhagavad-Gita also emphasizes the Nyaya view that knowledge is only useful insofar as it helps the knower achieve a particular goal. This paper does not, and has no pretention to prove the existence of a direct line of influence connection the Bhagavad-Gita and Nyaya philosophy; readers will instead gain an appreciation of the shared cultural context which gave rise to both of these forms of Indian thought. Abstrak Bhagavad-Gita, sebagai teks yang multitafsir, telah menjadi sumber inspirasi bagi segala pemikiran India. Makalah ini mengidentifikasikan unsur-unsur dalam Bhagavad-Gita yang mungkin memengaruhi pembentukan filsafat Nyaya selama beberapa abad setelah Bhagavad-Gita ditulis. Bagian pertama makalah meringkas epistemologi Nyaya secara keseluruhan dengan berfokus pada aspek-aspek yang memainkan peran penting dalam Bhagavad-Gita: persepsi (pratyaksa), penyimpulan (anumana), ‘silogisme’, saksi verbal (sabda), dan orientasi praktis pengetahuan. Bagian kedua memperlihatkan bagaimana aspek-aspek tersebut muncul dalam teks Bhagavad-Gita. Secara khusus, Krishna mengandalkan berbagai teknik dalam meyakinkan Arjuna akan kewajibannya sebagai ksatria yang kemudian diformalkan dalam filsafat Nyaya sebagai pramana atau sarana pengetahuan. Secara keseluruhan, Bhagavad-Gita juga menekankan pandangan Nyaya bahwa pengetahuan hanya berguna sejauh dapat membantu si penahu mencapai tujuan tertentu. Makalah ini tidak dapat membuktikan adanya garis pengaruh langsung yang menghubungkan Bhagavad-Gita dengan filsafat Nyaya; namun, kita tetap dapat mengapresiasi suatu ‘kemiripan keluarga’ di antara keduanya yang menunjukkan kekayaan konteks kebudayaan yang menghasilkan kedua buah pemikiran peradaban India ini. (shrink)

This paper delineates the normative and empirical approaches to business ethics based upon five categories: 1) academic horne; 2) language; 3) underlying assumptions; 4) theory purpose and scope; 5) theory grounds and evaluation criteria. The goal of the discussion is to increase understanding of the distinctive contributions of each approach and to encourage further dialogue about the potential for integration of the field.

Made-Up Minds addresses fundamental questions of learning and concept invention by means of an innovative computer program that is based on the cognitive ...

I argue for an alternative to Quine’s conception of observation sentences, one that better satisfies the roles Quine envisages for them, and that otherwise respects Quinean constraints. After reviewing a certain predicament Quine got into in balancing the needs of the intersubjectivity of observation sentences with his notion of the stimulus meaning of an observation sentence, I push for replacing the latter with what I call the ‘stimulus field’ of an observation sentence, a notion that remains ‘proximate’ but is shared (...) between different language users. Throughout, I emphasize the epistemological role of observation sentences. (shrink)

(2013). Two aspects of propositional unity. Canadian Journal of Philosophy: Vol. 43, Essays on the Nature of Propositions, pp. 518-533.

In _Foucault Beyond Foucault_ Jeffrey Nealon argues that critics have too hastily abandoned Foucault's mid-career reflections on power, and offers a revisionist reading of the philosopher's middle and later works. Retracing power's "intensification" in Foucault, Nealon argues that forms of political power remain central to Foucault's concerns. He allows us to reread Foucault's own conceptual itinerary and, more importantly, to think about how we might respond to the mutations of power that have taken place since the philosopher's death in (...) 1984. In this, the book stages an overdue encounter between Foucault and post-Marxist economic history. (shrink)

Details the intellectual development of George Herbert Mead as a thinker of great originality and as a practitioner of social reform.

It is often claimed (1) that levels of nature are related by supervenience, and (2) that processes occurring at particular levels of nature should be studied using dynamical systems theory. However, there has been little consideration of how these claims are related. To address the issue, I show how supervenience relations give rise to ‘supervenience functions’, and use these functions to show how dynamical systems at different levels are related to one another. I then use this analysis to describe a (...) graded approach to non-reductive physicalism, and to critically assess Davidson’s arguments for psychological anomaly. I also show how this approach can inform empirical research in cognitive science. (shrink)

In this book Gary Gutting offers a powerful account of the nature of human reason in modern times. The fundamental question addressed by the book is what authority human reason can still claim once it is acknowledged that our fundamental metaphysical and religious pictures of the world no longer command allegiance. If ethics and science remain sources of authority what is the basis of that authority? Gutting develops answers to these questions through critical analysis of the work of three (...) dominant philosophical voices in our time: Richard Rorty, Alasdair MacIntyre, and Charles Taylor. His own position is defined as 'pragmatic liberalism'. (shrink)

This article explores disciplinary approaches to educational studies over the past fifty years, in particular those developed by exponents of the 'foundation disciplines' of history, philosophy, psychology and sociology. It investigates the establishment of the disciplines during the first half of the period, and their consolidation, survival, and adaptation since the 1970s in a rapidly changing educational and political context. The nature of the contribution of the disciplines, both separately and together, to the study of education is assessed. The article (...) also considers the role of the disciplines in stimulating a pluralist and eclectic approach to the study of education, as opposed to the notion of a unitary and autonomous field of knowledge represented as 'educational research'. (shrink)

If there was a new wonder drug on the market that got kids to behave better, improve their grades, feel happier, and avoid risky behaviors, many parents around the world would be willing to empty their bank accounts to acquire it. Amazingly, such a product actually does exist. It’s not regulated by the FDA, it has no ill side-effects, and it’s absolutely free and avail­able to anyone at any time. This miracle cure is gratitude. Over the past decade, science has (...) shown that gratitude is one of the most valuable and important emotions we possess, and it is a virtue that anyone can cultivate. In fact, researchers have developed many different methods people can use to foster an attitude of gratitude, and the science shows that many of them really work. In _Making Grateful Kids, _two of the leading authorities on gratitude among young people, Jeffrey J. Froh and Giacomo Bono, introduce their latest and most compelling research, announce groundbreaking findings, and share real-life stories from adults and youth to show parents, teachers, mentors, and kids themselves how to achieve greater life satisfaction through gratitude. Most importantly perhaps, they expand on this groundbreaking research to offer practical and effec­tive common-sense plans that can be used in day-to-day interactions between kids and adults to enhance success and wellbeing. Their unique, scientifically-based approach for producing grateful youth works whether these kids are very young ele­mentary school students or troubled teenagers. Not only does the purposeful practice of gratitude increase their happiness, but the research indicates that grateful kids also report more self-discipline, fulfilling relationships, and engagement with their schools and communities when compared to their less grateful counterparts. After reading _Making Grateful Kids_, parents, teachers, and anyone who works with youth will be able to connect more mean­ingfully with kids so that all parties can focus on the things that matter most and, in turn, create a more cooperative and thriving society. (shrink)

Using research into learning from sequences of examples, we generate predictions about what cultural products become widely distributed in the social marketplace of ideas. We investigate what we term the Repetition‐Break plot structure: the use of repetition among obviously similar items to establish a pattern, and then a final contrasting item that breaks with the pattern to generate surprise. Two corpus studies show that this structure arises in about a third of folktales and story jokes. An experiment shows that jokes (...) with this structure are more interesting than those without the initial repetition. Thus, we document evidence for how a cognitive factor influences the cultural products that are selected in the marketplace of ideas. (shrink)

A new understanding of Kant’s theory of a priori knowledge and his natural philosophy emerges from Jeffrey Edwards’s mature and penetrating study. In the Third Analogy of Experience, Kant argues for the existence of a dynamical plenum in space. This argument against empty space demonstrates that the dynamical plenum furnishes an a priori necessary condition for our experience and knowledge of an objective world. Such an a priori existence proof, however, transgresses the limits Kant otherwise places on transcendental arguments (...) in the _Critique of Pure Reason_ because it establishes a _material_ transcendental condition of possible experience. This finding motivates Edwards to examine the broader context of Kant’s views about matter, substance, causal influence, and physical aether in connection with the developmental history of his theory of transcendental idealism. Against the backdrop of early modern metaphysics and contemporaneous physical theory, Edwards explicates the origins of the Third Analogy in Kant’s early work on the metaphysics of nature. The argument against empty space presented in the Third Analogy reveals a central aspect of Kant’s transcendental theory of experience that Edwards explains lucidly. By clarifying the epistemological standpoint at issue in the Third Analogy, he shows that the fundamental revisions to which Kant subjects his theory of knowledge in the _Opus postumum_ not only originate in his precritical metaphysics of nature but are developments of an argument central to the _Critique of Pure Reason_ itself. Edwards’s work is important to scholars working in the history of philosophy and the history and philosophy of science, as well as to Kant specialists. (shrink)

A defining characteristic of Alzheimer’s disease is difficulty in retrieving semantic memories, or memories encoding facts and knowledge. While it has been suggested that this impairment is caused by a degradation of the semantic store, the precise ways in which the semantic store is degraded are not well understood. Using a longitudinal corpus of semantic fluency data, we derive semantic network representations of patients with Alzheimer’s disease and of healthy controls. We contrast our network-based approach with analyzing fluency data with (...) the standard method of counting the total number of items and perseverations in fluency data. We find that the networks of Alzheimer’s patients are more connected and that those connections are more randomly distributed than the connections in networks of healthy individuals. These results suggest that the semantic memory impairment of Alzheimer’s patients can be modeled through the inclusion of spurious associations between unrelated concepts in the semantic store. We also find that information from our network analysis of fluency data improves prediction of patient diagnosis compared to traditional measures of the semantic fluency task. (shrink)

Scientific research is subject to a number of regulations which impose incidental (time, place), rather than substantive (type of research), restrictions on scientific research and the knowledge created through such research. In recent years, however, the premise that scientific research and knowledge should be free from substantive regulation has increasingly been called into question. Some have suggested that the law should be used as a tool to substantively restrict research which is dual-use in nature or which raises moral objections. There (...) are, however, some problems with using law to restrict or prohibit certain types of scientific research, including (i) the inherent imprecision of law for regulating complex and rapidly evolving scientific research; (ii) the difficulties of enforcing legal restrictions on an activity that is international in scope; (iii) the limited predictability of the consequences of restricting specific branches of scientific research; (iv) inertia in the legislative process; and (v) the susceptibility of legislators and regulators to inappropriate factors and influence. Rather than using law to restrict scientific research, it may be more appropriate and effective to use a combination of non-traditional legal tools including norms, codes of conduct, restrictions on publication, and scientist-developed voluntary standards to regulate problematic scientific research. (shrink)

Laying foundations -- Rejecting aggression -- Safeguarding cooperation -- Enforcing law -- Rectifying injury -- Liberating society -- Situating liberation.

Many arguments have been advanced in favor of employee participation in firm decision-making. Two of the most influential are the "interest protection argument" and the "autonomy argument." I argue that the case for granting participation rights to some other stakeholders, such as suppliers and community members, is at least as strong, according to the reasons given in these arguments, as the case for granting them to certain employees. I then consider how proponents of these arguments might modify their arguments, or (...) views, in response to this conclusion. (shrink)

Thomas Hobbes and John Locke sit together in the canon of political thought but are rarely treated in common historical accounts. This book narrates their intertwined careers during the Restoration period, when the two men found themselves in close proximity and entangled in many of the same political conflicts. Bringing new source material to bear, In the Shadow of Leviathan establishes the influence of Hobbesian thought over Locke, particularly in relation to the preeminent question of religious toleration. Excavating Hobbes's now (...) forgotten case for a prudent, politique toleration gifted by sovereign power, Jeffrey R. Collins argues that modern, liberal thinking about toleration was transformed by Locke's gradual emancipation from this Hobbesian mode of thought. This book investigates those landmark events - the civil war, Restoration, the popish plot, the Revolution of 1688 - which eventually forced Locke to confront the limits of politique toleration, and to devise an account of religious freedom as an inalienable right. (shrink)

As is reasonably well-appreciated, Quine struggled with his definition of the all-important notion of an observation sentence; especially in order to make them bear out his commitment to language’s being a ‘social art’. In an earlier article (_Mind_ 131(523):805–825, 2022), I proposed a certain repair, which here I will explain, justify and articulate further. But it also infects the definition of observation categoricals, and furthermore makes it a secondary matter, a seeming afterthought, that evidence, science and knowledge generally are shared—are (...) joint, social and collaborative products. Without forsaking Quine’s strict naturalism, I try to make the necessary adjustments to Quine’s scheme. (shrink)

Richard Wollheim was hardly alone in supposing that his account of pictorial depiction implies that a trompe-l’œil is not a depiction. I recommend removing this apparent implication by inserting a Kant-style version of aspect-perception into his account. I characterize the result as Neo-Wollheimian and retain the centrality of Wollheim’s notion of twofoldedness in the theory of depiction, but I demote it to a contingent feature of depictions and I criticize his employment of it for determining the category of both the (...) trompe-l’œil and depictions in general. (shrink)

I make a Quinean case that Quine’s ontological relativity marked a wrong turn in his philosophy, that his fundamental commitments point toward the classical view of ontology that was worked out in most detail in hisWord and Object. This removes the impetus toward structuralism in his later philosophy.

This article examines some of the interactions between law, science, and society taking place during a trial. By focusing on a restricted set of scientific and nonscientific actors engaged in negotiating the meaning, relevance, and reliability of scientific evidence, the article illustrates how the categories—law, science, and society—are inextricably interrelated in the legal negotiations and outcome. The introduction of scientific evidence into adversarial legal settings produces strategies, opinions, and claims that are not shaped solely by scientists, lawyers, or legal processes. (...) The situated law-science negotiations provide a site where social order and scientific knowledges are mutually constituted. The outcome of specific law-science interactions will be open to a range of readings and constraints that are not reducible to some putatively correct scientific understanding nor adequately described as the distortion of scientific evidence by the legal system. (shrink)

Interactive theories of lexical retrieval in language production assume that activation cascades from earlier to later processing levels, and feeds back in the reverse direction. This commentary invites Pickering & Garrod (P&G) to consider whether cascading and feedback can be seen as a form of forwarding modeling within a hierarchical production system.

A survey of diverse aspects of the reception, attitudes toward, and activities of foreigners in the major cuneiform cultures of the third through first millennia B.C.E. While outsiders could play important roles in their new environments, they were generally soon assimilated into their host societies without effecting significant changes in them. Only toward the close of this period did the arrival of large groups of invaders convinced of the superiority of their own cultures, such as Persians and Greco-Macedonians, radically alter (...) the age-old civilizations of Mesopotamia, Syria, and Anatolia. (shrink)