This article examines two questions about scientists’ search for knowledge. First, which search strategies generate discoveries effectively? Second, is it advantageous to diversify search strategies? We argue pace Weisberg and Muldoon, “Epistemic Landscapes and the Division of Cognitive Labor”, that, on the first question, a search strategy that deliberately seeks novel research approaches need not be optimal. On the second question, we argue they have not shown epistemic reasons exist for the division of cognitive labor, identifying the errors that led (...) to their conclusions. Furthermore, we generalize the epistemic landscape model, showing that one should be skeptical about the benefits of social learning in epistemically complex environments. (shrink)

This book collects essays from the 2006 and 2007 International Philosophy Colloquia Evian, centred around a central problem in the philosophy of mind: the relationship between the human faculty of sensory experience and the faculty of conceptual reflection, that is self-consciousness. Containing articles by philosophers of eight nationalities, in three languages (English, French, German), and of "analytical" as well as "continental" provenance, it beautifully represents the spirit of the colloquia. Authors include Joshua Andresen (AU Beirut), Valérie Aucouturier (Kent U / (...) U Paris I), Karin de Boer (KU Leuven), Santiago Echeverri (U Genève), Roberto Farneti (LU Bolzano), Tim Henning (JLU Giessen), Felix Koch (Columbia U), Christophe Laudou (Madrid), David Lauer (FU Berlin), Jason Leddington (Bucknell U), Nicolas Monseu (UC Louvain), Soraya Nour (HU Berlin), Hans Bernhard Schmid (U Wien), Henning Tegtmeyer (U Leipzig). (shrink)

Ontological nihilism is the radical-sounding thesis that there is nothing at all. This chapter first discusses how the most plausible forms of this thesis aim to be slightly less radical than they sound and what they will have to do in order to succeed in their less radical ambitions. In particular, they will have to paraphrase sentences of best science into ontologically innocent counterparts. The chapter then points out the defects in two less plausible strategies, before going on to argue (...) that strategies that look more promising, including one based on Quine's predicate-functor language, face the same defects. (shrink)

Wisdom, long a topic of interest to moral philosophers, is increasingly the focus of social science research. Philosophers have historically been concerned to develop a rationally defensible account of the nature of wisdom and its role in the moral life, often inspired in various ways by virtue theoretical accounts of practical wisdom (phronesis). Wisdom scientists seek to, among other things, define wisdom and its components so that we can measure them. Are the measures used by wisdom scientists actually measuring what (...) philosophers have in mind when they discuss practical wisdom? I argue that they are not. Contemporary measures of wisdom and its components may pick out some necessary prerequisites of practical wisdom, but they do not measure a philosophically plausible practical wisdom or its components. After explaining the argument and defending it against objections, I consider its implications. Should wisdom scientists ignore the philosophical conception of practical wisdom in favor of other conceptions, revise their methods to try to measure it, or continue the interdisciplinary study of practical wisdom without expecting to measure it? I make a preliminary argument for the third option. (shrink)

Pediatric intervention principles help clinicians and health-care institutions determine appropriate responses when parents’ medical decisions place children at risk. Several intervention principles have been proposed and defended in the pediatric ethics literature. These principles may appear to provide conflicting guidance, but much of that conflict is superficial. First, seemingly different pediatric intervention principles sometimes converge on the same guidance. Second, these principles often aim to solve different problems in pediatrics or to operate in different background conditions. The potential for convergence (...) between intervention principles—or at least an absence of conflict between them—matters for both the theory and practice of pediatric ethics. This article builds on the recent work of a diverse group of pediatric ethicists tasked with identifying consensus guidelines for pediatric decision-making. (shrink)

Fragmentary utterances such as short answers and subsentential XPs without linguistic antecedents are proposed to have fully sentential syntactic structures, subject to ellipsis. Ellipsis in these cases is preceded by A-movement of the fragment to a clause-peripheral position; the combination of movement and ellipsis accounts for a wide range of connectivity and anti-connectivity effects in these structures. Fragment answers furthermore shed light on the nature of islands, and contrast with sluicing in triggering island effects; this is shown to follow from (...) an articulated syntax and the PF theory of islands. Fragments without linguistic antecedents are argued to be compatible with an ellipsis analysis, and do not support direct interpretation approaches to these phenomena. (shrink)

Amodel for inventing newsignals is introduced in the context of sender–receiver games with reinforcement learning. If the invention parameter is set to zero, it reduces to basic Roth–Erev learning applied to acts rather than strategies, as in Argiento et al. (Stoch. Process. Appl. 119:373–390, 2009). If every act is uniformly reinforced in every state it reduces to the Chinese Restaurant Process—also known as the Hoppe–Pólya urn—applied to each act. The dynamics can move players from one signaling game to another during (...) the learning process. Invention helps agents avoid pooling and partial pooling equilibria. (shrink)

In their article, Nielsen Busch and Mjaaland defend the moral permissibility of cDCD, suggesting that much of the controversy around this donation practice has been the result of a misinterpretatio...

If, relative to a context, what a sentence says is necessarily true, then what it says must be so. If, relative to a context, what a sentence says is possible, then what it says could be true. Following natural philosophical usage, it would thus seem clear that in assessing an occurrence of a sentence for possibility or necessity, one is assessing what is said by that occurrence. In this paper, I argue that natural philosophical usage misleads here. In assessing an (...) occurrence of a sentence for possibility or necessity, one is not assessing the modal status of the proposition expressed by that occurrence of the sentence. (shrink)

An important disagreement in contemporary debates about free will hinges on whether an agent must have alternative possibilities to be morally responsible. Many assume that notions of alternative possibilities are ubiquitous and reflected in everyday intuitions about moral responsibility: if one lacks alternatives, then one cannot be morally responsible. We explore this issue empirically. In two studies, we find evidence that folk judgments about moral responsibility call into question two popular principles that require some form of alternative possibilities for moral (...) responsibility. Survey participants given scenarios involving agents that fail to satisfy these principles nonetheless found these agents to be morally responsible, blameworthy, deserving of blame, and at fault for morally bad actions and consequences. We defend our interpretation of this evidence against objections and explore some implications of these findings for the free will debate. (shrink)

In this paper, I defend what may seem a surprising view: that John Stuart Mill’s famous harm principle would, if taken to be what justifies government action, disallow the existence of corporations. My claim is not that harmful activities of currently existing corporations warrants their losing corporate status according to the harm principle. The claim, rather, is that taken strictly, the harm principle and the legal possibility of incorporation are mutually exclusive. This view may be surprising—and I do not at (...) all mean to attribute it to Mill—but if I am right, it should be obvious. It should also encourage us to think more about the nature of the markets within which business occurs. (shrink)

A provocative case for the inherently political nature of language In The Politics of Language, David Beaver and Jason Stanley present a radical new approach to the theory of meaning, offering an account of communication in which political and social identity, affect, and shared practices play as important a role as information. This new view of language, they argue, has dramatic consequences for free speech, democracy, and a range of other areas in which speech plays a central role. Drawing (...) on a wealth of disciplines, The Politics of Language argues that the function of speech—whether in dialogue, larger group interactions, or mass communication—is to attune people to something, be it a shared reality, emotion, or identity. Reconceptualizing the central ideas of pragmatics and semantics, Beaver and Stanley apply their account to a range of phenomena that defy standard frameworks in linguistics and philosophy of language—from dog whistles and covert persuasion to echo chambers and genocidal speech. The authors use their framework to show that speech is inevitably political because all communication is imbued with the resonances of particular ideologies and their normative perspectives on reality. At a time when democracy is under attack, authoritarianism is on the rise, and diversity and equality are being demanded, The Politics of Language offers a powerful new vision of the language of politics, ideology, and protest. (shrink)

The term ‘artificial intelligence’ has arguably come to function in political discourse as, what Laclau called, an ‘empty signifier’. This article traces the shifting political discourse on AI within three key institutions of global governance–OHCHR, WHO, and UNESCO–and, in so doing, highlights the role of ‘crisis’ moments in justifying a series of pivotal re-articulations. Most important has been the attachment of AI to the narrative around digital automation in human healthcare. Greatly enabled by the societal context of the pandemic, all (...) three institutions have moved from being critical of the unequal power relations in the economy of AI to, today, reframing themselves primarily as facilitators tasked with helping to ensure the application of AI technologies. The analysis identifies a shift in which human health and healthcare is framed as in a ‘crisis’ to which AI technology is presented as the remedy. The article argues the need to trace these discursive shifts as a means by which to understand, monitor, and where necessary also hold to account these changes in the governance of AI in society. (shrink)

In the philosophy of perception, olfaction is the perennial problem child, presenting a range of difficulties to those seeking to define its proper referents, and its phenomenological content. Here, we argue that many of these difficulties can be resolved by recognizing the object-like representation of odors in the brain, and by postulating that the basic objects of olfaction are best defined by their biological value to the organism, rather than physico-chemical dimensions of stimuli. Building on this organism-centered account, we speculate (...) that the phenomenological space of olfaction is organized into a number of coarse affective dimensions that apply categorically. This organization may be especially useful for coupling sensation to decision-making and instrumental action in a sensory modality where the stimulus space is especially complex and high-dimensional. (shrink)

ABSTRACTIn this paper, I explain why I disagree with David Pilgrim’s claim that critical realists should deny any ‘natal male’ claim to womanhood. Specifically, Pilgrim and I have different definitions of the transitive and intransitive dimensions of reality. In my version – which I believe is in the spirit of the Bhaskarian version – the transitive dimension embraces everything that is currently being affected by human praxis. This allows for an intersectional view of gender in which it is perfectly possible (...) for the same human, in different contexts, to be an ontological woman, an ontological trans woman ; and an ontological person with a prostate gland, some might say a man. In the same way, it is perfectly possible for a room to contain 17 people for the purposes of setting out tea cups, but 18 people for the purposes of providing lecture hand-outs. For the purposes of everyday life, and even, I argue, for the fight against sexism, trans women have the same claim to being women as cis women. (shrink)

I formulate and defend a version of the many universes (or multiverse) reply to the atheistic argument from evil. Specifically, I argue that (i) if we know that any argument from evil (be it a logical or evidential argument) is sound, then we know that God would be (or at least probably would be) unjustified in actualizing our universe. I then argue that (ii) there might be a multiverse and (iii) if so, then we do not know that God would (...) be (or at least probably would be) unjustified in actualizing our universe. It follows that we cannot know that the atheistic argument from evil is sound, in which case we cannot be certain that the argument succeeds, and so it is rational to refuse to reject theism because of such arguments. (shrink)

Politics, Philosophy & Economics, Volume 21, Issue 4, Page 415-436, November 2022. Recent debates over ideal theory have reinvigorated interest in the question of anarchy. Would a perfectly just society need—or even permit—a state? Ideal anarchists such as Jason Brennan, G.A. Cohen, Christopher Freiman, and Jacob Levy argue that strict compliance with justice obviates the need for a state. Ideal statists such as David Estlund, Gregory Kavka, and John Rawls think that coercive political institutions serve indispensable functions even in (...) ideal conditions. This paper defends ideal anarchism. Our argument begins by describing a camping trip inspired by Cohen that illustrates why an anarchist form of cooperation is more intrinsically desirable than the statist alternative. After detailing Rawls's ideal theory and Estlund's “nonconcessive” moral theory, we argue—contrary to Rawls, Estlund, and Kavka—that large-scale societies without moral imperfection do not need a state. (shrink)

Emergence is much discussed by both philosophers and scientists. But, as noted by Mitchell (2012), there is a significant gulf; philosophers and scientists talk past each other. We contend that this is because philosophers and scientists typically mean different things by emergence, leading us to distinguish being emergence and pattern emergence. While related to distinctions offered by others between, for example, strong/weak emergence or epistemic/ontological emergence (Clayton, 2004, pp. 9–11), we argue that the being vs. pattern distinction better captures what (...) the two groups are addressing. In identifying pattern emergence as the central concern of scientists, however, we do not mean that pattern emergence is of no interest to philosophers. Rather, we argue that philosophers should attend to, and even contribute to, discussions of pattern emergence. But it is important that this discussion be distinguished, not conflated, with discussions of being emergence. In the following section we explicate the notion of being emergence and show how it has been the focus of many philosophical discussions, historical and contemporary. In section 3 we turn to pattern emergence, briefly presenting a few of the ways it figures in the discussions of scientists (and philosophers of science who contribute to these discussions in science). Finally, in sections 4 and 5, we consider the relevance of pattern emergence to several central topics in philosophy of biology: the emergence of complexity, of control, and of goal-directedness in biological systems. (shrink)

"The Federalist" is commonly read as an exemplar of political realism. However, alongside Publius' arguments against the enthusiastic imagination --its tendency to inflame the passions, betray the intellect, and subvert political authority--are formative appeals to the imagination 's role in reconstituting the public authority shaken during the postrevolutionary years. This essay explores three central aspects of Publius' restorative appeal to the imagination : the appeal to the public veneration required for sustaining political authority across time; the strategies for shifting citizen (...) loyalty from the state and local level to that of a newly energized federal government; and the rhetorical elicitation of the public's imagination in aestheticized portrayals of Providential nationality. These aspects of Publius' argument make up the core of "The Federalist's aesthetics of rule. In each instance, Publius invokes the imagination as a heteronomic support to navigate familiar dilemmas of democratic self-authorization. (shrink)

The term ‘ellipsis’ can be used to refer to a variety of phenomena: syntactic, semantic, and pragmatic. In this article, I discuss the recent comprehensive survey by Stainton 2006 of these kinds of ellipsis with respect to the analysis of nonsententials and try to show that despite his trenchant criticisms and insightful proposal, some of the criticisms can be evaded and the insights incorporated into a semantic ellipsis analysis, making a ‘divide-and-conquer’ strategy to the properties of nonsententials feasible after all. (...) -/- Editor's comment: To find the contribution, please go to item 16 of the URL, which contains the full text. Professor Merchant has permitted this. (shrink)

Many Catholics have expressed hesitancy or resistance to being vaccinated for COVID-19, with magisterial authorities and influential Catholic organizations advocating divergent views regarding the moral liceity of the vaccines, the justification of vaccination mandates, and whether such mandates should include religious exemptions. We address each of these disputed points and argue that vaccination for COVID-19 falls within the definition of being an ordinary—and thereby morally obligatory—treatment. To that end, we offer a brief overview of the Catholic moral tradition regarding the (...) development of the distinction between ordinary and extraordinary treatment, show how the Church morally evaluates vaccination as a good act, and underline the importance of positive witnessing in supporting vaccination. (shrink)

One of the most startling, and hence theoretically challenging, properties of wh-movement in Sluicing is that it can move wh-phrases out of islands, an important observation which goes back to Ross (1969). Equally challenging is the fact that similar wh-movement out of VP Ellipsis sites remains for the most part illicit. Briefly put, it seems that for a wide range of cases, deletion of an IP containing an island voids the effect of that island for wh-movement, while deletion of a (...) VP containing an island does not. This chapter investigates one aspect of this puzzling dichotomy with respect to island repair, and attempts to show that an interesting and partly novel range of data follow if island deviancies come about due to illicit traces of intermediate movement, working in tandem with a constraint on ellipsis operative in structures that host wh-movement. I will argue that a wide range of islands are indeed active at PF, but not in the way that this claim has usually been understood thus far. Instead of the island node itself being responsible for the degradation in acceptability, I will show that the data support the idea that it is the traces of wh-movement outside the island itself which trigger a PF-crash. I begin with some relevant Background on Sluicing, given in section 6.1, before taking up the Sluicing data in section 6.2 and the VP Ellipsis facts in section 6.3. (shrink)

In Liberalism without Perfection, Jonathan Quong develops what is perhaps the most comprehensive defense of the consensus model of public reason – a model which incorporates both a public-reasons-only requirement and an accessibility requirement framed in terms of shared evaluative standards. While the consensus model arguably predominates amongst public reason liberals, it is criticized by convergence theorists who reject both the public-reasons-only requirement and the accessibility requirement. In this paper, I argue that while we have good reason to reject Quong’s (...) call for a public-reasons-only requirement, all public reason liberals should endorse at least some shared evaluative standards and, hence, an accessibility requirement. (shrink)

We share Minkoff et al.’s (2024) concern regarding the potential disavowal of pregnant patients’ right to refuse medical interventions, without or against their explicit consent, aimed at preservin...

In the Bayesian framework, a language learner should seek a grammar that explains observed data well and is also a priori probable. This paper proposes such a measure of prior probability. Indeed it develops a full statistical framework for lexicalized syntax. The learner's job is to discover the system of probabilistic transformations (often called lexical redundancy rules) that underlies the patterns of regular and irregular syntactic constructions listed in the lexicon. Specifically, the learner discovers what transformations apply in the language, (...) how often they apply, and in what contexts. It considers simpler systems of transformations to be more probable a priori. Experiments show that the learned transformations are more effective than previous statistical models at predicting the probabilities of lexical entries, especially those for which the learner had no direct evidence. (shrink)

Elided VPs and their antecedent VPs can mismatch in voice, with passive VPs being elided under apparent identity with active antecedent VPs, and vice versa. Such voice mismatches are not allowed in any other kind of ellipsis, such as sluicing and other clausal ellipses. These latter facts indicate that the identity relation in ellipsis is sensitive to syntactic form, not merely to semantic form. The VP-ellipsis facts fall into place if the head that determines voice is external to the phrase (...) being elided, here argued to be v P; such an account can only be framed in approaches that allow for the separation of syntactic features from the heads on which they are morphologically realized. Alternatives to this syntactic, articulated view of ellipsis and voice either undergenerate or overgenerate. (shrink)

False “Aha!” moments can be elicited experimentally using the False Insight Anagram Task (FIAT), which combines semantic priming and visual similarity manipulations to lead participants into having “Aha!” moments for incorrect anagram solutions. In a preregistered experiment (N = 255), we tested whether warning participants and explaining to them exactly how they were being deceived, would reduce their susceptibility to false insights. We found that simple warnings did not reduce the incidence of false insights. On the other hand, participants who (...) were given a detailed explanation of the methods used to deceive them experienced a small reduction in false insights compared to participants given no warning at all. Our findings suggest that the FIAT elicits a robust false insight effect that is hard to overcome, demonstrating the persuasive nature of false insights when the conditions are ripe for them. (shrink)

Understanding the individual-level factors associated with sustainable behaviour in the workplace is important to advance corporate ethics and sustainability efforts. In two studies, we simultaneously assess the role of core values and personality traits in relation to a broad set of sustainability actions, both beneficial and harmful. Results from a student sample and then a national sample confirm that values and personality are distinct constructs that incrementally and differentially predict economic, social, and environmental outcomes. We successfully replicate previous findings pertaining (...) to values and find that, controlling for values, the personality dimension of Honesty–Humility is the strongest negative predictor of harmful actions. Our analyses highlight the unique characteristics of values and personality and their distinct implications for ethical and sustainable management practice. By assessing values and personality together, we also contribute to more general efforts within psychology to develop an integrative view of the person. (shrink)

This article considers the emergence of world environmental history as a rapidly growing but undertheorized research field. Taking as its central problematic the gap between the fertile theorizations of environmentally-oriented social scientists and the empirically rich studies of world environmental historians, the article argues for a synthesis of theory and history in the study of longue dureesocio-ecological change. This argument proceeds in three steps. First, I offer an ecological reading of Immanuel Wallerstein's The Modern World-System. Wallerstein's handling of the ecological (...) dimensions of the transition from feudalism to capitalism is suggestive of a new approach to world environmental history. Second, I contend that Wallerstein's theoretical insights may be effectively complemented by drawing on Marxist notions of value and above all the concept of “metabolic rift,” which emphasize the importance of productive processes and regional divisions of labor within the modern world-system. Finally, I develop these theoretical discussions in a short environmental history of the two great “commodity frontiers” of early capitalism – the sugar plantation and the silver mining complex. (shrink)

ABSTRACTDavid Pilgrim is, in his words, ‘not at all hostile’ to transgender people. Nevertheless, in my opinion, his position allows him to provide a veneer of philosophical acceptability to transphobic arguments: such as that, if a person can choose their gender, they should be able to choose their age. In stripping away the veneer, I demonstrate that Bhaskar's version of the transitive and intransitive dimensions resolves the supposed conundrum. I also take issue with the idea that sex is biological and (...) gender is a social construct, i.e. that there is a duality between object and subject. I argue that this duality does more harm than good in the fight for equality since it gives philosophical resources to those who would bully LGBTIQ, allowing them to blame their victims. I use my understanding of gender to arrive at a compassionate resolution of the restroom debate, in which everyone's wellbeing is considered. I also warn that the debate may have been commandeered by men to achieve a transphobic agenda and that all women are likely to pay a high price because of it. Furthermore, an unexpected result of my analysis is that Judith Butler's position is, in significant ways and contrary to the opinion of some critical realists, similar to the Bhaskarian critical realist position. (shrink)

This squib investigates a paradox that arises from the interaction of two well-studied domains of grammar: antecedent-contained deletion and the licensing of negative polarity items. The conflict arises from a simple set of facts that have been overlooked in the literature, given in (1).

Research on firm initial public offering (IPO) performance has primarily utilized an economics of information perspective, which assumes that publicly available information is incorporated into a stock’s price when it is issued. However, the valuation process associated with IPOs remains manifest with considerable uncertainty for the prospective investor. This study argues that corporate political activity undertaken prior to the firm’s IPO acts as a signal to investors, reducing the uncertainty the market places on the value of the firm’s equity. Utilizing (...) a sample of 180 IPOs, we show that the more a firm invests in corporate political activity prior to its IPO, the better its IPO performance. These findings provide evidence that corporate political activity acts as a nonmarket signal, influencing investor behavior by reducing the information asymmetries between investors and the target firm. (shrink)

The “participatory turn” cutting across technical approaches for appraising environment, risk, science, and technology has been accompanied by intense debates over the desired nature, extent, and quality of public engagement in science. Burgeoning work evaluating the effectiveness of such processes and the social study of science in society more generally is notable, however, for lacking systematic understanding of the very actors shaping these new forms science-society interaction. This paper addresses this lacuna by drawing on United Kingdom based in-depth empirical research (...) that made space for participatory appraisal experts to reflect on effective practice and novel questions of competence, expertise, and citizen-specialist relations within analytic-deliberative processes. Emerging practitioner principles warn that existing participatory models have not sufficiently considered constructivist perspectives on knowledge, analysis, and deliberation. Effective participatory appraisal under uncertainty needs to guard against the “technocracy of participation” by opening up to diversity, difference, antagonism, and uncertainties/indeterminacies. (shrink)

This paper challenges the widely held assumption that paintings and other works of graphic art have a communicable rhythmic structure. I defend the view that although the experience of viewing a picture takes place in time, and thus is successive, it cannot be temporally structured in a sufficiently determinate manner to sustain the kind of attentional focus required for the communication of even simple rhythmic patterns. With reference to examples of both abstract and figurative painting, I argue that the graphic (...) arts—unlike music and poetry—are non-sequential and that this has important consequences for how a work of graphic art is perceived. In the concluding sections of the paper, I consider some recent empirical research that offers an alternative way of approaching these issues. (shrink)

Given the significance of Nicholas of Cusa’s ecclesiastical career, it is no surprise that a good deal of academic attention on Nicholas has focused on his role in the history of the church. Nevertheless, it would also be fair to say that a good deal of the attention that is focused on the life and thought of Nicholas of Cusa is the legacy of prior generations of scholars who saw in his theoretical work an opportunity to define the most salient (...) features of transformations in the habits of thinking leading from the Middle Ages into the epoch of modernity. Thus, although contemporary scholars have not been able to achieve any clear consensus on the question of whether Nicholas belongs to the Middle Ages or to modernity, the field of Cusanus studies has become much more attentive to the possibility that the uniqueness and significance of Nicholas’s vision is a function of his ability to synthesize and redeploy a variety of strands in the Catholic intellectual tradition—strands that are as apt to involve practical matters of canon law and church reform as they are to hinge on a unique and richly developed mystical theology. Given the flourishing of the attention devoted to Nicholas in the late 20th and early 21st centuries, the choices about which texts to include in this article were difficult ones. The rationale for this article’s predominant focus on scholarship of the late 20th and early 21st centuries is that, insofar as the recent studies listed here enter into the debates that have been shaped by their predecessors, the sources mentioned here will point readers to the prior work in the field not acknowledged here. (shrink)

In this chapter, we analyze intellectual patience as a character trait. We look at the contexts that call for patience and at what patience demands in those contexts. Together these constitute our account of patience, though the focus is on patience in the life of the mind. We also consider how patience and perseverance differ, which offers a better understanding of the former and sheds light on how character traits can cooperate. We then consider how to become virtuously patient. We (...) conclude reflecting on some remarks made by the poet Rilke. (shrink)

In Late Works of Mou Zongsan , this influential Chinese philosopher speaks on the future of Chinese culture, the achievements of Confucianism, the place of Buddhism and Daoism in Chinese philosophy, and the possibility of partnership between Chinese and Western thought.

The term ellipsis has been applied to a wide range of phenomena across the centuries, from any situation in which words appear to be missing (in St. Isidore’s definition), to a much narrower range of particular constructions. Ellipsis continues to be of central interest to theorists of language exactly because it represents a situation where the usual form/meaning mappings, the algorithms, structures, rules, and constraints that in nonelliptical sentences allow us to map sounds and gestures onto their corresponding meanings, break (...) down. In fact, in ellipsis, the usual mappings seems to be entirely absent. In ellipsis, there is meaning without form. VP-ellipsis and sluicing are two of the best investigated instances of ellipsis and generally show remarkable similarities in their licensing requirements, both usually necessitating some equivalent antecedent which is subject to some kind of parallelism. It is no exaggeration to say that debates over the nature of this parallelism have formed the core of most of the generative work on ellipsis over the last forty years. Almost all conceivable positions on the parallelism question have been explored and advanced, and these debates are important exactly because they are often used to argue for the necessity of one or another kind of linguistic representation. Most of the debate is located in the arena of semantics and abstract syntactic structures—it is clear that surface syntactic or phonological parallelism is not at stake—and as such, elliptical structures often play an important role in fundamental ontological debates in linguistics. The logic is clear: if the parallelism or identity conditions found in ellipsis resolution require reference to certain kinds of objects, then our theories of linguistic competence must countenance objects of that kind. In generative linguistics, research has focused on two sets of constructions. Central examples of the first set, drawn from English, include sluicing as in (1), verb phrase ellipsis (VP-ellipsis) as in (2), and NP-ellipsis (or N -ellipsis) 2 as in (3).. (shrink)

Epistasis plays an important role in the genetic architecture of common human diseases and can be viewed from two perspectives, biological and statistical, each derived from and leading to different assumptions and research strategies. Biological epistasis is the result of physical interactions among biomolecules within gene regulatory networks and biochemical pathways in an individual such that the effect of a gene on a phenotype is dependent on one or more other genes. In contrast, statistical epistasis is defined as deviation from (...) additivity in a mathematical model summarizing the relationship between multilocus genotypes and phenotypic variation in a population. The goal of this essay is to review definitions and examples of biological and statistical epistasis and to explore the relationship between the two. Specifically, we present and discuss the following two questions in the context of human health and disease. First, when does statistical evidence of epistasis in human populations imply underlying biomolecular interactions in the etiology of disease? Second, when do biomolecular interactions produce patterns of statistical epistasis in human populations?Answers to these two reciprocal questions will provide an important framework for using genetic information to improve our ability to diagnose, prevent and treat common human diseases. We propose that systems biology will provide the necessary information for addressing these questions and that model systems such as bacteria, yeast and digital organisms will be a useful place to start. BioEssays 27:637–646, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

As we reread Mary Shelley's Frankenstein at two hundred years, it is evident that Victor Frankenstein is both a mad scientist (fevered, obsessive) and a bad scientist (secretive, hubristic, irresponsible). He's also not a very nice person. He's a narcissist, a liar, and a bad “parent.” But he is not genuinely evil. And yet when we reimagine him as evil—as an evil scientist and as an evil person—we can learn some important lessons about science and technology, our contemporary society, and (...) ourselves. (shrink)