In the 24 years since the founding of BioEssays, the level of translational research, as well as the expectations for its success, have burgeoned. Based on our analysis of current and projected US efforts to establish effective centers of translational research, our own institutional experience and discussions with academic research center leaders and institutional research executives, we have arrived at several critical conclusions about how best to foster disease‐based research on the institutional, national and international level, what summary statistics may (...) best serve as a measurement of successful practice, roughly how much more money will be required to fund the ongoing venture in the US and how to organize and promote this vision. BioEssays 30:1025–1029, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

The zetetic turn in epistemology raises three questions about epistemic and zetetic norms. First, there is the relationship question: what is the relationship between epistemic and zetetic norms? Are some epistemic norms zetetic norms, or are epistemic and zetetic norms distinct? Second, there is the tension question: are traditional epistemic norms in tension with plausible zetetic norms? Third, there is the reaction question: how should theorists react to a tension between epistemic and zetetic norms? Drawing on an analogy to practical (...) philosophy, I develop a focal point view to resolve these motivating questions. On the focal point view, traditional epistemic norms and zetetic norms answer different types of normative questions. There is nevertheless a familiar type of evaluative tension between traditional epistemic norms and zetetic norms, but this tension is an unavoidable feature of the normative landscape and not a sign that traditional epistemic norms need revision. But if traditional epistemic norms are not zetetic norms, then in what sense is zetetic epistemology a project for epistemologists? I conclude by articulating a sense in which some nontraditional epistemic norms are zetetic norms, and in which zetetic epistemology is an important part of the study of theoretical rationality. (shrink)

I attempt to get as clear as possible on the chain of reasoning by which irreversible macrodynamics is derivable from time-reversible microphysics, and in particular to clarify just what kinds of assumptions about the initial state of the universe, and about the nature of the microdynamics, are needed in these derivations. I conclude that while a “Past Hypothesis” about the early Universe does seem necessary to carry out such derivations, that Hypothesis is not correctly understood as a constraint on the (...) early Universe’s entropy. (shrink)

Our aim in this entry is to articulate the state of the art in the moral psychology of personal identity. We begin by discussing the major philosophical theories of personal identity, including their shortcomings. We then turn to recent psychological work on personal identity and the self, investigations that often illuminate our person-related normative concerns. We conclude by discussing the implications of this psychological work for some contemporary philosophical theories and suggesting fruitful areas for future work on personal identity.

Recently T. M. Scanlon and others have advanced an ostensibly comprehensive theory of moral responsibility—a theory of both being responsible and being held responsible—that best accounts for our moral practices. I argue that both aspects of the Scanlonian theory fail this test. A truly comprehensive theory must incorporate and explain three distinct conceptions of responsibility—attributability, answerability, and accountability—and the Scanlonian view conflates the first two and ignores the importance of the third. To illustrate what a truly comprehensive theory might look (...) like, I investigate what it would say about the difficult case of the psychopath. (shrink)

Hylomorphists hold that substances are, in some sense, composites of matter and form. The form of a substance is typically taken to play a fundamental role in determining the unity or identity of the whole. Staunch hylomorphists think that this role is of a kind that precludes the ontological reduction of form to the physical and thus take their position to be inconsistent with physicalism. Forms, according to staunch hylomorphism, play a fundamental role in grounding their bearers’ proper parts and (...) that, it seems, rules out the physical grounding of form itself. I shall develop a physicalist version of hylomorphism that treats form as geometric structure and which, I shall argue, entails many of the central theses endorsed by staunch hylomorphists. Based on Shoemaker’s notion of conditional powers, I shall argue that the geometric structures of complex wholes are the conditions on at least some of the conditional powers of their bearers’ proper parts, transforming those powers into powers simpliciter. Thus, forms play a fundamental role in the dynamical evolution of the physical world, but without bestowing causal powers themselves and hence without violating the causal closure of the physical domain. If a substance’s proper parts are taken to be individuated by their powers simpliciter, then they derive their identities from their places in the substantial whole, which thus determines the identities of its proper parts without changing their intrinsic natures. (shrink)

Bounded rationality gets a bad rap in epistemology. It is argued that theories of bounded rationality are overly context‐sensitive; conventionalist; or dependent on ordinary language (Carr, 2022; Pasnau, 2013). In this paper, I have three aims. The first is to set out and motivate an approach to bounded rationality in epistemology inspired by traditional theories of bounded rationality in cognitive science. My second aim is to show how this approach can answer recent challenges raised for theories of bounded rationality. My (...) third aim is to clarify the role of rational ideals in bounded rationality. (shrink)

Since the announcement and establishment of the Oversight Board (OB) by the technology company Meta as an independent institution reviewing Facebook and Instagram’s content moderation decisions, the OB has been subjected to scholarly scrutiny ranging from praise to criticism. However, there is currently no overarching framework for understanding the OB’s various strengths and weaknesses. Consequently, this article analyses, organises, and supplements academic literature, news articles, and Meta and OB documents to understand the OB’s strengths and weaknesses and how it can (...) be improved. Significant strengths include its ability to enhance the transparency of content moderation decisions and processes, to effect reform indirectly through policy recommendations, and its assertiveness in interpreting its jurisdiction and overruling Meta. Significant weaknesses include its limited jurisdiction, limited impact, Meta’s control over the OB’s precedent, and its lack of diversity. The analysis of a recent OB case in Ethiopia shows these strengths and weaknesses in practice. The OB’s relationship with Meta and governments will lead to challenges and opportunities shaping its future development. Reforms to the OB should improve the OB’s control over its precedent, apply OB precedent to currently disputed cases, and clarify the standards for invoking OB precedent. Finally, these reforms provide the foundation for an additional improvement to address the OB’s institutional weaknesses, by involving users in determining whether the OB’s precedent should be applied to decide current content moderation disputes. (shrink)

This chapter contains sections titled: The Indictment Background Institutions for Distributive Justice A Non‐Capitalist Property‐Owning Democracy Economic Democracy ED Versus POD POD Modified References.

This is the best overview of Foucault's work to date. A principal architect of poststructuralism, Michel Foucault reshaped the varied disciplines of history, philosophy, literary theory, and social science. David Shumway has provided, for the nonspecialist, a systematic analysis of the works of Foucault that is both thorough and accessible. Shumway connects Foucault's various conceptual and linguistic techniques to the basic critical strategies and purpose of his philosophy.

Longtermists have recently argued that it is overwhelmingly important to do what we can to mitigate existential risks to humanity. I consider three mistakes that are often made in calculating the value of existential risk mitigation. I show how correcting these mistakes pushes the value of existential risk mitigation substantially below leading estimates, potentially low enough to threaten the normative case for existential risk mitigation. I use this discussion to draw four positive lessons for the study of existential risk. -/- (...) . (shrink)

Libertarian self-ownership views have traditionally maintained that we enjoy very powerful deontological protections against any infringement upon our property. This stringency yields very counter-intuitive results when we consider trivial infringements such as very mildly toxic pollution or trivial risks such having planes fly overhead. Maintaining that other people's rights against all infringements are very powerful threatens to undermine our liberty, as Nozick saw. In this paper I consider the most sophisticated attempts to rectify this problem within a libertarian self-ownership framework. (...) I argue that all of these responses are significantly flawed. (shrink)

As neurotechnologies continue to develop and diffuse, this fast-paced field must be guided by robust governance frameworks in order to promote responsible innovation. The article by Bublitz (2024)...

I point out a radical indeterminism in potential-based formulations of Newtonian gravity once we drop the condition that the potential vanishes at infinity. This indeterminism, which is well known in theoretical cosmology but has received little attention in foundational discussions, can be removed only by specifying boundary conditions at all instants of time, which undermines the theory's claim to be fully cosmological, i.e., to apply to the Universe as a whole. A recent alternative formulation of Newtonian gravity due to Saunders (...) pp.22-48) provides a conceptually satisfactory cosmology but fails to reproduce the Newtonian limit of general relativity in homogenous but anisotropic universes. I conclude that Newtonian gravity lacks a fully satisfactory cosmological formulation. (shrink)

Moses Mendelssohn (1729-1786) was the premier Jewish thinker of his day and one of the best-known figures of the German Enlightenment, earning the sobriquet 'the Socrates of Berlin'. He was thoroughly involved in the central issue of Enlightenment religious thinking: the inevitable conflict between reason and revelation in an age contending with individual rights and religious toleration. He did not aspire to a comprehensive philosophy of Judaism, since he thought human reason was limited, but he did see Judaism as compatible (...) with toleration and rights. David Sorkin offers a close study of Mendelssohn's complete writings, treating the German, and the often-neglected Hebrew writings, as a single corpus and arguing that Mendelssohn's two spheres of endeavour were entirely consistent. (shrink)

Interpretation -- Introduction -- Interpreting Plato -- The political culture of Plato's early dialogues -- Dialogue -- Character and history -- The mouthpiece principle -- Forms of evidence -- Desire -- Socrates and eros -- The subjectivist conception of desire -- Instrumental and terminal desire -- Rational and irrational desires -- Desire in the critique of Akrasia -- Interpreting Lysis -- The deficiency conception of desire -- Inauthentic friendship -- Platonic desire -- Antiphilosophical desires -- Knowledge -- Excellence as wisdom (...) -- The epistemic unity of excellence -- Dunamis and technê -- Goodness and form -- The epistemological priority of definitional knowledge -- Ordinary ethical knowledge -- Method -- The Socratic fallacy -- Socrates' pursuit of definitions -- Hupothesis -- Two postulates -- The geometrical illustration -- Geometrical analysis -- The method of reasoning from a postulate -- Elenchus and hupothesis -- Knowledge and aitia -- F-conditions -- Cognitive security -- Aporia -- Forms of aporia -- Dramatic aporia -- The example of Charmides -- Charmides as autobiography -- The politics of Sôphrosunê -- Critias' Philotimia -- Self-knowledge and the knowledge of knowledge -- Knowledge of knowledge and knowledge of the good -- Philosophy and the polis. (shrink)

Recent contributions in moral philosophy have raised questions concerning the prevalent assumption that moral judgments are typologically discrete, and thereby distinct from ordinary and/or other types of judgments. This paper adds to this discourse, surveying how attempts at defining what makes moral judgments distinct have serious shortcomings, and it is argued that any typological definition is likely to fail due to certain questionable assumptions about the nature of judgment itself. The paper concludes by raising questions for future investigations into the (...) nature of moral judgment. (shrink)

Epistemology has taken a zetetic turn from the study of belief towards the study of inquiry. Several decades ago, theories of bounded rationality took a procedural turn from attitudes towards the processes of inquiry that produce them. What is the relationship between the zetetic and procedural turns? In this paper, I argue that we should treat the zetetic turn in epistemology as part of a broader procedural turn in the study of bounded rationality. I use this claim to motivate and (...) clarify the zetetic turn in epistemology, as well as to reveal the need for a second zetetic turn within practical philosophy. (shrink)

What kind of hypocrite should voters choose as their next leader? The question seems utterly cynical. But, as David Runciman suggests, it is actually much more cynical to pretend that politics can ever be completely sincere. Political Hypocrisy is a timely, and timeless, book on the problems of sincerity and truth in politics, and how we can deal with them without slipping into hypocrisy ourselves. Runciman draws on the work of some of the great truth-tellers in modern political thought--Hobbes, (...) Mandeville, Jefferson, Bentham, Sidgwick, and Orwell--and applies his ideas to different kinds of hypocritical politicians from Oliver Cromwell to Hillary Clinton. He argues that we should accept hypocrisy as a fact of politics--the most dangerous form of political hypocrisy is to claim to have a politics without hypocrisy. Featuring a new foreword that takes the story up to Donald Trump, this book examines why, instead of vainly searching for authentic politicians, we should try to distinguish between harmless and harmful hypocrisies and worry only about the most damaging varieties. (shrink)

To explain why, in scientific problem solving, a diagram can be “worth ten thousand words,” Jill Larkin and Herbert Simon (1987) relied on a computer model: two representations can be “informationally” equivalent but differ “computationally,” just as the same data can be encoded in a computer in multiple ways, more or less suited to different kinds of processing. The roots of this proposal lay in cognitive psychology, more precisely in the “imagery debate” of the 1970s on whether there are image-like (...) mental representations. Simon (1972, 1978) hoped to solve this debate by thoroughly reducing the differences between forms of mental representations (e.g., between images and sentences) to differences in computational efficiency; to carry out this reduction, he borrowed from computer science the concepts of data type and of data structure. I argue that, in the end, his account amounted to nothing more than characterizing representations by the fast operations on them. This analysis then allows me to assess what Simon’s approach actually achieves when transported from psychology to the study of scientific representations, as in Larkin and Simon (1987): it allows comparing, not representations in and of themselves, but rather the computational roles they play in particular problem-solving processes—that is, representations together with a particular way of using them. (shrink)

Personal Identity and Ethics provides a lively overview of the relationship between the metaphysics of personal identity and ethics. How does personal identity affect our ethical judgments? It is a commonplace to hold that moral responsibility for past actions requires that the responsible agent is in some relevant respect identical to the agent who performed the action. Is this true? On the other hand, can ethics constrain our account of personal identity? Do the practical requirements of moral theory commit us (...) to holding that persons do remain identical over time? Or is it the case that personal identity is not, in fact, relevant to ethics? -/- Shoemaker provides the first comprehensive examination of these issues for the undergraduate audience. Topics include personal identity and prudential rationality; personal identity's significance for moral responsibility and ethical theory; and the practical consequences of accounts of personal identity for issues such as abortion, stem cell research, cloning, advance directives, populations ethics, multiple personality disorder, and the definition of death. (shrink)

Even among scholars who emphasize Nietzsche’s naturalism (“the naturalists”), what it actually involves is disputed. This article identifies the foundations of Nietzsche’s naturalism and then elaborates on these foundations through a critical analysis of the works of those naturalists who also identify them. Nietzsche is a methodological naturalist, who, epistemically, is a reliabilist, and while he acknowledges the innate limitations of our cognitive inheritance, which is reflected in his perspectivism, he sees no reason to conclude that we cannot grasp the (...) natural world truly. As to the primary issue in scientific explanation, causation, Nietzsche adopts a regularity theory as early as The Gay Science, and, on the basis of this theory, rejects determinism. One consequence of this analysis is that Nietzsche’s naturalism is not as restrictive as the naturalists tend to portray it, and this opens up new possibilities for interpreting many of his other commitments. (shrink)

The article discusses retributive justice and punitive restraint in response to the worst types of crime. I take the Breivik Case as a starting point. Anders Behring Breivik was sentenced to 21 years of preventive detention for killing 69 people, mainly youths, at Utøya and 8 people in Oslo on July 22nd, 2011. Retributivist theories as well as commonly held retributive intuitions suggest that much harsher punishment is required for such crimes. According to some retributivist theories, most notably on the (...) influential theories of Kant and Hegel, the death penalty is warranted for murderers like Breivik. This suggests that the rationale for punitive restraint in a case like the Breivik Case can only be found in forward- looking, consequentialist theories of punishment, or by adding to retributivist theories a side-constraint in the form of a principle of parsimony. However, I argue that if we look closer at the function of punishment in the retributivist theories of Kant and Hegel, they too imply a rationale for punitive restraint, even for such horrific crimes as here discussed. Against Kant and Hegel’s own views on the death penalty, I argue that their broader “freedom theories” of retributive justice do not imply the justice of the death penalty or life imprisonment. In the last part of the article, I explore differences in the concepts of freedom entailed by Kant and Hegel’s theories, and I relate these to some of the background factors relevant to the Breivik Case. (shrink)

In this chapter I consider the narrow and wider benefits of permitting assisted dying in the specific context of organ donation and transplantation. In addition to the commonly used arguments, there are two other neglected reasons for permitting assisted suicide and/or euthanasia: assisted dying enables those who do not wish to remain alive to prolong the lives of those who do, and also allows many more people to fulfill their wish to donate organs after death. In the first part of (...) this chapter I explore the possibility of allowing those who die with assistance to donate their organs and the potential benefits of doing so in countries where some form of assisted dying is legal; in the second part I consider the added force that organ donation considerations bring to the argument in favour of legalizing assisted dying in countries where such practices remain forbidden. (shrink)

I argue that the debate concerning the nature of first-person moral judgment, namely, whether such moral judgments are inherently motivating or whether moral judgments can be made in the absence of motivation, may be founded on a faulty assumption: that moral judgments form a distinct kind that must have some shared, essential features in regards to motivation to act. I argue that there is little reason to suppose that first-person moral judgments form a homogenous class in this respect by considering (...) an ordinary case: student readers of Peter Singer’s “Famine, Affluence, and Morality”. Neither internalists nor externalists can provide a satisfying account as to why our students fail to act in this particular case, but are motivated to act by their moral judgments in most cases. I argue that the inability to provide a satisfying account is rooted in this shared assumption about the nature of moral judgments. Once we consider rejecting the notion that first-person moral decision- making forms a distinct kind in the way it is typically assumed, the internalist/externalist debate may be rendered moot. (shrink)

Part of the appeal of the biological approach to personal identity is that it does not have to countenance spatially coincident entities. But if the termination thesis is correct and the organism ceases to exist at death, then it appears that the corpse is a dead body that earlier was a living body and distinct from but spatially coincident with the organism. If the organism is identified with the body, then the unwelcome spatial coincidence could perhaps be avoided. It is (...) argued that such an identification would be a mistake. A living organism has a different part/whole relationship and persistence conditions than the alleged body. A case will be made that the concept ‘human body’ is a conceptual mess, vague in an unprincipled manner, and that an eliminativist stance towards dead bodies is the appropriate response. CiteULike Connotea Del.icio.us What's this? (shrink)

In virtue of what are later and an earlier group members of one and the numerically same tradition? Gallie was one of the few philosophers to have engaged with issues surrounding this question. My article is not a faithful exegesis of Gallie but develops a terminology in which to discuss issues surrounding the numerical identity of a tradition over time, based on some of his insights.

Ethical consumerism -- Caveat emptor -- The consumer as causal agent -- The consumer as complicit participant -- Toward a practical consumer ethic.

I develop an account of how mathematized theories in physics represent physical systems, in response to the frequent claim that any such account must presuppose a non-mathematized, and usually linguistic, description of the system represented. The account I develop contains a circularity, in that representation is a mathematical relation between the models of a theory and the system as represented by some other model --- but I argue that this circularity is not vicious, in any case refers in linguistic accounts (...) of meaning and representation, and is simply a consequence of the fact that we have no unmediated, representation-independent access to the world. (shrink)

The simulation hypothesis has recently excited renewed interest, especially in the physics and philosophy communities. However, the hypothesis specifically concerns {computers} that simulate physical universes, which means that to properly investigate it we need to couple computer science theory with physics. Here I do this by exploiting the physical Church-Turing thesis. This allows me to introduce a preliminary investigation of some of the computer science theoretic aspects of the simulation hypothesis. In particular, building on Kleene's second recursion theorem, I prove (...) that it is mathematically possible for us to be in a simulation that is being run on a computer \textit{by us}. In such a case, there would be two identical instances of us; the question of which of those is ``really us'' is meaningless. I also show how Rice's theorem provides some interesting impossibility results concerning simulation and self-simulation; briefly describe the philosophical implications of fully homomorphic encryption for (self-)simulation; briefly investigate the graphical structure of universes simulating universes simulating universes, among other issues. I end by describing some of the possible avenues for future research that this preliminary investigation reveals. (shrink)

I criticise the view that the relativity and equivalence principles are consequences of the small-scale structure of the metric in general relativity, by arguing that these principles also apply to systems with non-trivial self-gravitation and hence non-trivial spacetime curvature (such as black holes). I provide an alternative account, incorporating aspects of the criticised view, which allows both principles to apply to systems with self-gravity.

How Wittgenstein's theories have been bent, transformed, and expanded in the world outside philosophy. The expression of his eyes remained the same, a cold, piercing sadness. Yet his final words were "Tell them I had a happy life." This poetic book examines the way Ludwig Wittgenstein has influenced artists of the word beyond his own field, thereby touching the subject of how philosophy can be relevant at large. By studying the ways Wittgenstein's theories have been bent, transformed, and expanded, (...) class='Hi'>David Rothenberg shows that responses to the reading of philosophy can take many deep, reflective, and different forms. Aphoristically constructed in the style of E. M. Cioran or Edmond Jabès, carefully illustrated with paintings and drawings by Doug Hall, Leif Haglund, and Debra Pughe, The Possibility of Reddish Green situates Wittgenstein in the age of the sound bite and the artistic fragment, promoting the aesthetic of detachment and yet seeking to find a route through the sea of disconnected, jumbled ideas and changes that mark our time. (shrink)

Introduction -- The commercialisation of science and the construction of the knowledge-based bio-economy -- The KBBE reality--the case of agriculture -- Intellectual property rights and the global commodification of knowledge -- Privatizing Chinese science : national development vs. neoliberal financialization -- Critical realism and the importance of ontological attention -- Critical realism and beyond in economics -- The realist transcendental argument.

Discussion of Alexander Bogdanov as a Marxist revisionist has largely centred on his philosophy of being and cognition and on Plekhanov’s and Lenin’s accusation that Bogdanov was an idealist renegade from Marxism. However, the real issue of revisionism at the time was not materialism but determinism: the question of whether socialism would appear by the working of the objective laws of nature or the subjective will of human beings. Bogdanov did indeed revise Marxism, but he did so in order to (...) defend it as a natural science. He conceived of society as a form of life subject to biological laws of nature: the need to assimilate energy from the environment and the need to adapt to the environment in the struggle to survive. He reinterpreted the key elements of scientific socialism – the idea that existence determines consciousness and the labour theory of value – in terms of this worldview. (shrink)

The assumption, that speech is merely the appearance of an external reality to which it refers, is here reversed, in order to shift attention to speech as a ...

This volume collects thirteen of David Schmidtz's essays on the question of what it takes to live a good life, given that we live in a social and natural world. Part One defends a non-maximizing conception of rational choice, explains how even ultimate goals can be rationally chosen, defends the rationality of concern and regard for others (even to the point of being willing to die for a cause), and explains why decision theory is necessarily incomplete as a tool (...) for addressing such issues. Part Two uses the tools of analytic philosophy to explain what we can do to be deserving, what is wrong with the idea that we ought to do as much good as we can, why mutual aid is good, but why the welfare state does not work as a way of institutionalizing mutual aid, and why transferring wealth from those who need it less to those who need it more can be a bad idea even from a utilitarian perspective. Most ambitiously, Part Two offers an overarching, pluralistic moral theory that defines the nature and limits of our obligations to each other and to our individual selves. Part Three discusses the history and economic logic of alternative property institutions, both private and communal, and explains why economic logic is an indispensable tool in the field of environmental conflict resolution. In the final essay, Schmidtz brings the volume full circle by considering the nature and limits of our obligations to nonhuman species, and how the status of nonhuman species ought to enter into our deliberations about what sort of life is worth living. (shrink)

Moore's paradox is a paradox in which certain kinds of belief or assertion, such as a belief that ?it is raining and I do not believe that it is raining?, are irrational despite involving no obvious contradiction in what is believed. But is there a parallel paradox involving other kinds of attitude, in particular desire? I argue that certain kinds of desire would be irrational to have for similar, distinctive reasons that having Moorean beliefs would be irrational to have. Hence, (...) I argue that such desires, a desire that ?one have a particular desire that was frustrated? or a desire that ?some state of affairs obtain about which one was indifferent?, are a parallel Moorean paradox of desire. I further argue that this analogous paradox has implications for practical reasoning, in particular by presenting a problem for instrumentalism about the objects of desire. (shrink)

I. Prelude -- About this Book -- II. School Mathematics and Its Consequences -- The Foundations of Mathematical Thinking -- Compression, Connection and Blending of Mathematical Ideas -- Set-befores, Met-befores and Long-term Learning -- Mathematics and the Emotions -- The Three Worlds of Mathematics -- Journeys through Embodiment and Symbolism -- Problem-Solving and Proof -- III. Interlude -- The Historical Evolution of Mathematics -- IV. University Mathematics and Beyond -- The Transition to Formal Knowledge -- Blending Knowledge Structures in the (...) Calculus -- Expert Thinking and Structure Theorems -- Contemplating the Infinitely Large and the Infinitely Small -- Expanding the Frontiers through Mathematical Research -- Reflections -- Appendix: Where the Ideas Came From. (shrink)