We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

As a result of the world-wide COVID-19 epidemic, an internal tension in the goals of medicine has come to the forefront of public debate. Medical professionals are continuously faced with a tug of...

Many servicemen and women began suffering from a variety of symptoms and illnesses soon after the 1991 Gulf War. Some veterans believe that their illnesses are related to toxic exposures during their service, though scientific research has been largely unable to demonstrate any link. Disputes over the definition, etiology, and treatment of Gulf War-related illnesses continue. The authors examine the roles of science, policy, and veteran activism in developing an understanding of GWRIs. They argue that the government’s stress-based explanation of (...) GWRIs and its insistence on a scientific link between service in the gulf and veteran illnesses forced veterans to shift from pleas for care, treatment, and compensation on moral grounds to engagement in the scientific process and debates over the interpretation of scientific findings. The authors compare the experiences of veterans to those of breast cancer activists to explain the stages of illness contestation in general. (shrink)

In this paper we examine a puzzle recently posed by Aaron Preston for the traditional realist assay of property (quality) instances. Consider Socrates (a red round spot) and red1—Socrates’ redness. For the traditional realist, both of these entities are concrete particulars. Further, both involve redness being `tied to’ the same bare individuator. But then it appears that red1 is duplicated in its ‘thicker’ particular (Socrates), so that it can’t be predicated of Socrates without redundancy. According to Preston, this suggests that (...) a concrete particular and its property instances aren’t genuinely related. We argue that Preston’s proffered solution here—to treat property instances as “mental constructs”—is fraught with difficulty. We then go on to show how, by fine-tuning the nature of bare particulars, treating them as abstract modes of things rather than concrete particulars, the traditional realist can neatly evade Preston’s puzzle. (shrink)

Philosophical Pragmatism and International Relations bridges the gap between philosophical pragmatism and international relations, two disciplinary perspectives that together shed light on how to advance the study and conduct of foreign affairs. Authors in this collection discuss a broad range of issues, from policy relevance to peacekeeping operations, with an eye to understanding how this distinctly American philosophy, pragmatism, can improve both international relations research and foreign policy practice.

A core challenge for contemporary bioethics is how to address the tension between respecting an individual’s autonomy and promoting their wellbeing when these ideals seem to come into conflict (Not...

Important features of the self-concept can be located outside of the individual and inside close or related others. The authors use this insight to reinterpret data previously said to support the empathy-altruism model of helping, which asserts that empathic concern for another results in selflessness and true altruism. That is, they argue that the conditions that lead to empathic concern also lead to a greater sense of self-other overlap, raising the possibility that helping under these conditions is not selfless but (...) is also directed toward the self. In 3 studies, the impact of empathic concern on willingness to help was eliminated when oneness--a measure of perceived self-other overlap--was considered. Path analyses revealed further that empathic concern increased helping only through its relation to perceived oneness, thereby throwing the empathy-altruism model into question. The authors suggest that empathic concern affects helping primarily as an emotional signal of oneness. (shrink)

Deciphering the neural basis of subjective experience remains one of the great challenges in the natural sciences. The structural complexity and the limitations around invasive experimental manipulations of the human brain have impeded progress towards this goal. While animals cannot directly report first-person subjective experiences, their ability to exhibit flexible behaviours such as motivational trade-offs are generally considered evidence of sentience. The worm _Caenorhabditis elegans_ affords the unique opportunity to describe the circuitry underlying subjective experience at a single cell level (...) as its whole neural connectome is known and moreover, these animals exhibit motivational trade-offs. We started with the premise that these worms were sentient and then sought to understand the neurons that were both necessary and sufficient for a motivational trade-off involving the rewarding experience of food and the negative experience of an aversive odour. A simple hierarchical network consisting of two chemosensory neurons and three interneurons was found to produce an output to motoneurons that enabled worms to respond in a contextually appropriate manner to an aversive odour according to the worm's hunger state. Given that this circuitry is like that found in the human spinal cord, retina, and primary visual cortex, three regions which are neither necessary nor sufficient for subjective experience, we conclude that motivational trade-offs are not a criterion for subjective experience in worms. Furthermore, once the neural substrate for a behaviour is described, we question the explanatory role of subjective experience in behaviour. (shrink)

In arguing against the likelihood of consciousness in non-human animals, Descartes advances a slippery slope argument that if thought were attributed to any one animal, it would have to be attributed to all, which is absurd. This paper examines the foundations of Thomas Willis’ comparative neuroanatomy against the background of Descartes’ slippery slope argument against animal consciousness. Inspired by Gassendi’s ideas about the corporeal soul, Thomas Willis distinguished between neural circuitry responsible for reflex behaviour and that responsible for cognitively or (...) consciously mediated behaviour. This afforded Willis a non-arbitrary basis for distinguishing between animals with thought and consciousness and those without, a methodology which retains currency for neuroscience today. (shrink)

This paper argues that there exists a collective epistemic state of ‘Broad Medical Uncertainty’ regarding the effectiveness of many medical interventions. We outline the features of BMU, and describe some of the main contributing factors. These include flaws in medical research methodologies, bias in publication practices, financial and other conflicts of interest, and features of how evidence is translated into practice. These result in a significant degree of uncertainty regarding the effectiveness of many medical treatments and unduly optimistic beliefs about (...) the benefit/harm profiles of such treatments. We argue for an ethical presumption in favour of openness regarding BMU as part of a ‘Corrective Response’. We then consider some objections to this position, including concerns that public honesty about flaws in medical research could undermine trust in healthcare institutions. We suggest that, as it stands, the Anti-Corrective Response is unconvincing. (shrink)

Broadening access to both computational and educational resources is crit- ical to diffusing machine learning (ML) innovation. However, today, most ML resources and experts are siloed in a few countries and organizations. In this article, we describe our pedagogical approach to increasing access to applied ML through a massive open online course (MOOC) on Tiny Machine Learning (TinyML). We suggest that TinyML, applied ML on resource-constrained embedded devices, is an attractive means to widen access because TinyML leverages low-cost and globally (...) accessible hardware and encourages the development of complete, self-contained applications, from data collection to deployment. To this end, a collaboration between academia and industry produced a four part MOOC that provides application-oriented instruction on how to develop solutions using TinyML. The series is openly available on the edX MOOC platform, has no prerequisites beyond basic programming, and is designed for global learners from a variety of backgrounds. It introduces real-world applications, ML algorithms, data-set engineering, and the ethi- cal considerations of these technologies through hands-on programming and deployment of TinyML applications in both the cloud and on their own microcontrollers. To facili- tate continued learning, community building, and collaboration beyond the courses, we launched a standalone website, a forum, a chat, and an optional course-project com- petition. We also open-sourced the course materials, hoping they will inspire the next generation of ML practitioners and educators and further broaden access to cutting-edge ML technologies. (shrink)

Absence of evidence arguments are indispensable to comparative neurobiology. The absence in a given species of a homologous neural architecture strongly correlated with a type of conscious experience in humans should be able to be taken as a prima facie reason for concluding that the species in question does not have the capacity for that conscious experience. Absence of evidence reasoning is, however, widely disparaged for being both logically illicit and unscientific. This paper argues that these concerns are unwarranted. There (...) is no logical barrier to formulating cogent absence of evidence arguments; indeed, accepting such arguments is part of what it is to be committed to falsifiability as a critical aspect of the scientific method. Absence of evidence arguments can always be blocked, however, by assuming that psychological properties are ‘multiply realizable’. While we take multiple realizability to be highly likely at some level of analysis, we argue that it is question-begging to assume that it exists at every level of analysis, and thus it should not automatically be thought to undermine absence of evidence reasoning in the animal consciousness debate. Using the example of pain and focusing on homologies at the level of information processing tasks, we show how, in the science of consciousness, an absence of evidence might well serve as evidence of absence. (shrink)

1 Evidence-based policy requires researchers to provide the answers to ecological questions that are of interest to policy makers. To find out what those questions are in the UK, representatives from 28 organizations involved in policy, together with scientists from 10 academic institutions, were asked to generate a list of questions from their organizations. 2 During a 2-day workshop the initial list of 1003 questions generated from consulting at least 654 policy makers and academics was used as a basis for (...) generating a short list of 100 questions of significant policy relevance. Short-listing was decided on the basis of the preferences of the representatives from the policy-led organizations. 3 The areas covered included most major issues of environmental concern in the UK, including agriculture, marine fisheries, climate change, ecosystem function and land management. 4 The most striking outcome was the preference for general questions rather than narrow ones. The reason is that policy is driven by broad issues rather than specific ones. In contrast, scientists are frequently best equipped to answer specific questions. This means that it may be necessary to extract the underpinning specific question before researchers can proceed. 5 Synthesis and applications. Greater communication between policy makers and scientists is required in order to ensure that applied ecologists are dealing with issues in a way that can feed into policy. It is particularly important that applied ecologists emphasize the generic value of their work wherever possible. (shrink)

It is unclear whether the regulatory distinction between non-identifiable and identifiable information—information used to determine informed consent practices for the use of clinically derived samples for genetic research—is meaningful to patients. The objective of this study was to examine patients' attitudes and preferences regarding use of anonymous and identifiable clinical samples for genetic research. Telephone interviews were conducted with 1,193 patients recruited from general medicine, thoracic surgery, or medical oncology clinics at five United States academic medical centers. Wanting to know (...) about research being done was important to 72% of patients when samples would be anonymous and to 81% of patients when samples would be identifiable. Only 17% wanted to know about the identifiable scenario but not the anonymous scenario. Curiosity-based reasons were the most common among patients who wanted to know about anonymous samples. Of patients wanting to know about either scenario, approximately 57% would require researchers to seek permission, whereas 43% would be satisfied with notification only. Patients were more likely to support permission in the anonymous scenario if they had more education, were Black, less religious, in better health, more private, and less trusting of researchers. The sample, although not representative of the general population, does represent patients at academic medical centers whose clinical samples may be used for genetic research. Few patients expressed preferences consistent with the regulatory distinction between non-identifiable and identifiable information. Data from this study should cause policy-makers to question whether this distinction is useful in relation to research with previously collected clinically derived samples. (shrink)

There are challenges to the dominant research paradigm in breast cancer science. In the United States, science and social activism create paradigmatic shifts. Using interviews, ethnographic observations, and an extensive review of the literature, we create a three-dimensional model to situate changes in scientific controversy concerning environmental causes of breast cancer. We identify three paradigm challenges posed by activists and some scientists: to move debates about causation upstream to address causes; to shift emphasis from individual to modifiable societal-level factors beyond (...) an individual’s control; and to allow direct lay involvement in research, which may raise new questions and change how questions are approached, the methods used, and the standards of proof. We use our model to examine controversies about doing scientific research, interpreting scientific results, and acting on science. Ultimately, we aim to understand what impedes construction of new methodologies and knowledge about environmental factors in human disease. (shrink)

It is often taken to be intuitively obvious that if one is in a given conscious state, then one knows that one is in that state. This alleged obvious truth lies at the heart of two very different philosophical doctrines fithe Cartesian doctrine that one has incorrigible knowledge about one?s own conscious states (which still has its defenders today), and the view that one can explain all conscious states in terms of higher-order awareness of mental states. The present paper begins (...) with a description of the real-life case of Simon Browne, a man who believed he had no conscious states whatsoever, although all external evidence overwhelmingly suggests that he had. This case as well as other cases of what can be called ?being in denial? figives reason to reject both the alleged intuitively obvious truth and the two philosophical doctrines which attempt to exploit it. Having abandoned these doctrines, it remains to give an account of Browne?s condition, which picks out both why it is possible and why it is so unusual. This is done by arguing that Browne?s belief is contrary to evidence which he absolutely ought to accept, and that this is necessarily, not just contingently, unusual. In addition, it is shown how Browne?s philosophical beliefs about the mind?body relation contributed to his odd belief. (shrink)

It is often taken to be intuitively obvious that if one is in a given conscious state, then one knows that one is in that state. This alleged obvious truth lies at the heart of two very different philosophical doctrines fithe Cartesian doctrine that one has incorrigible knowledge about one?s own conscious states, and the view that one can explain all conscious states in terms of higher-order awareness of mental states. The present paper begins with a description of the real-life (...) case of Simon Browne, a man who believed he had no conscious states whatsoever, although all external evidence overwhelmingly suggests that he had. This case as well as other cases of what can be called?being in denial? figives reason to reject both the alleged intuitively obvious truth and the two philosophical doctrines which attempt to exploit it. Having abandoned these doctrines, it remains to give an account of Browne?s condition, which picks out both why it is possible and why it is so unusual. This is done by arguing that Browne?s belief is contrary to evidence which he absolutely ought to accept, and that this is necessarily, not just contingently, unusual. In addition, it is shown how Browne?s philosophical beliefs about the mind?body relation contributed to his odd belief. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Buddhist-Christian Studies 23 (2003) 170-174 [Access article in PDF] A Buddhist History of the West: Studies In Lack. By David R. Loy. Albany: State University of New York Press, 2002. 244 pp. The religious and philosophical situation of our time seems polarized between resurgent fundamentalisms and a cosmopolitan awareness bridging heretofore separated traditions. Even a few decades ago the notion of a dialogue between East and West was a (...) novelty in which demarcated traditions and cultures (say the Buddhist East and the Christian West) experimented with attempts to find a common language to speakacross the boundaries between their respective identities. In such a context,"Western Buddhists" were those pilgrims of the counterculture who "went East" in search of some civilizational and spiritual other; the West, abjected to the realm of soulless scientism or outdated religious authoritarianism, was left behind. The situation is different at the beginning of the twenty-first Christian century. The dialectical complexities, both inwardly in the soul or mind of seekers, and outwardly in the strange twists of contemporary history, emerge to forbid any simple assessments of what can be left behind or indeed what the use can be of what seekers have found in the "non-West." People of Western background begin to realize and consciously address the [End Page 170] karmic-historical presuppositions of their search, which continue to constitute a kind of historical unconscious to the formulation of any possible "Western Buddhisms." Meanwhile, while fundamentalists of many backgrounds posit "clashes of civilizations" that assume an absoluteness of traditional distinctions, cosmopolitans realize that, for all the particularity of their respective starting points, the global situation is inextricably a shared one. In such a context, what canWestern Buddhist intellectuals, cognizant of their own starting points but having learned some things along the Way that are perhaps of universal relevance, speak to our common condition?The "Buddhist History of the West" that David Loy provides is less a historical narrative of the events constitutive of the societies descending from Greco-Roman civilization through European epochs and American empire into the age of globalization than a form of psychoanalytic anamnesis of those societies' cultural constructions of reality. Loy's psychoanalytic interpretive frame is composed of Buddhist insight into the human mind's deep-seated grasping for solidity and certainty in the face of a reality fundamentally characterized by impermanence and ungroundedness (the "Lack" of the subtitle, our simultaneous awareness of death, impermanence, andontological emptiness and the ego's wish for eternal selfhood in an endless but impossibly fulfilling world). Loy's Buddhism is combined with the existential psychology of Ernest Becker and the revisionist Freudianism of Norman O. Brown called on as Western resources for the spiritual therapeutics "the West" seems to need as it enters the third Christian millennium both triumphant and in despair of any meaning to accompany its economic and pop-cultural hegemony.Seven anamnestic chapters take us through twenty-five hundred years of Western cultural constructions, from the Greek and Roman philosophical inquiries into Freedom, a kind of origin-tale of Humanism seen as a "religious" (religion for Loy being the way humans attempt to answer the problem of Lack as if to ground our groundlessness) vision of meaning as the development of human capacities for rational thought, through the intertwining of classical and Christian constructions in medieval and Renaissance periods, through the Protestant Reformation into the political and ideological space of modernity, culminating in a vision of the globalizing West as purveying a "Religion of the Market," an ironically meaningless (centered on the symbolic code for Value—Money—as a displacement of Value itself) system of meaning. This last, our contemporary situation, would perhaps be simply a problem of aesthetic tastelessness (American pop culture performing the dissolution of all surviving traditional sacred orders following the description of capitalism by Marx as causing "all that is sacred" to "melt into air") were it not for the massive social injustice and environmental devastation it structurally produces. Loy's therapeutic vision, following the Buddhist deconstruction of the demarcated "self" and Becker and Brown's cultural-historical or collective... (shrink)

In most children’s hospitals, there are very few ethics consultations, even though there are many ethically complex cases. We hypothesize that the reason for this may be that hospitals develop different mechanisms to address ethical issues and that many of these mechanisms are closer in spirit to the goals of the pioneers of clinical ethics than is the mechanism of a formal ethics consultation. To show how this is true, we first review the history of collaboration between philosophers and physicians (...) about clinical dilemmas. Then, as a case-study, we describe the different venues that have developed at one children’s hospital to address ethical issues. At our hospital, there are nine different venues in which ethical issues are regularly and explicitly addressed. They are ethics committee meetings, Nursing Ethics Forum, ethics Brown Bag workshops, PICU ethics rounds, Grand Rounds, NICU Comprehensive Care Rounds, Palliative Care Team case conferences, multidisciplinary consults in Fetal Health Center, and ethics consultations. In our hospital, ethics consults account for only a tiny percentage of ethics discussions. We suspect that most hospitals have multiple and varied venues for ethics discussions. We hope this case study will stimulate research in other hospitals analyzing the various ways in which ethicists and ethics committees can build an ethical environment in hospitals. Such research might suggest that ethicists need to develop a different set of “core competencies” than the ones that are needed to do ethics consultations. Instead, they should focus on their skills in creating multiple “moral spaces” in which regular and ongoing discussion of ethical issues would take place. A successful ethicist would empower everyone in the hospital to speak up about the values that they believe are central to respectful, collaborative practice and patient care. Such a role is closer to what the first hospital philosophers set out to do than in the role of the typical hospital ethics consultant today. (shrink)

Philosophers have typically shown high confidence in their evaluations of Utilitarianism, whether as an endorsement or a disparagement. Rarely, however, has much effort been spent on investigating...

“The Routledge [series] is designed to introduce students to classic works of philosophy. Brian Leiter’s Nietzsche on Morality does that, and much more. The book offers a complete commentary of On the Genealogy of Morality, but it also articulates a comprehensive and original interpretation of Nietzsche’s critique of morality. The product is an exceptionally clear and cohesive account of philosophical views known neither for their clarity nor their cohesiveness…. “The distinction, and the chief merit, of Leiter’s account is its (...) emphasis on the naturalism of Nietzsche’s approach to morality. Leiter may not quite be the first to portray Nietzsche as a naturalist, but his characterization of Nietzschean naturalism in connection with morality is the most systematic and compelling to date…. “In general, the book offers one of the most comprehensive and compelling interpretations of Nietzsche’s critique of morality…. With its distinctive emphasis on naturalistic themes, it forms a very significant contribution to the study of Nietzsche and is poised to become a work of reference in the field. Indeed, even the criticisms I have raised about this interpretation owe much to the exceptional clarity and cogency with which it is articulated.” --Bernard Reginster (Brown University), writing in Notre Dame Philosophical Review, January 2, 2003 (http://ndpr.icaap.org/content/archives/2003/1/reginster-leiter.html). (shrink)

Already in 1835 Lobachevski entertained the possibility of multiple geometries of the same type playing a role. This idea of rival geometries has reappeared from time to time but had yet to become a key idea in space-time philosophy prior to Brown's _Physical Relativity_. Such ideas are emphasized towards the end of Brown's book, which I suggest as the interpretive key. A crucial difference between Brown's constructivist approach to space-time theory and orthodox "space-time realism" pertains to modal scope. Constructivism takes (...) a broad modal scope in applying to all local classical field theories---modal cosmopolitanism, one might say, including theories with multiple geometries. By contrast the orthodox view is modally provincial in assuming that there exists a _unique_ geometry, as the familiar theories have. These theories serve as the "canon" for the orthodox view. Their historical roles also suggest a Whiggish story of inevitable progress. Physics literature after c. 1920 is relevant to orthodoxy primarily as commentary on the canon, which closed in the 1910s. The orthodox view explains the spatio-temporal behavior of matter in terms of the manifestation of the real geometry of space-time, an explanation works fairly well within the canon. The orthodox view, Whiggish history, and the canon have a symbiotic relationship. If one happens to philosophize about a theory outside the canon, space-time realism sheds little light on the spatio-temporal behavior of matter. Worse, it gives the _wrong_ answer when applied to an example arguably _within_ the canon, a sector of Special Relativity, namely, _massive_ scalar gravity with universal coupling. Which is the true geometry---the flat metric from the Poincare' symmetry group, the conformally flat metric exhibited by material rods and clocks, or both---or is the question faulty? How does space-time realism explain the fact that all matter fields see the same curved geometry, when so many ways to mix and match exist? Constructivist attention to dynamical details is vindicated; geometrical shortcuts can disappoint. The more exhaustive exploration of relativistic field theories in particle physics, especially massive theories, is a largely untapped resource for space-time philosophy. (shrink)

This exploratory study investigates the ways in which secondary U.S. history teachers who attended two iterations of a teacher professional development workshop, focusing on the history of school desegregation in Virginia, planned to teach the history of school desegregation through historical inquiry. Conceptualizing the history of school desegregation as difficult history, the authors conducted the content analysis of 23 written lesson plans generated by workshop participants. The historiography of school desegregation, and research on four dimensions of historical inquiry such as (...) Change and Continuity, Causation, Multiple Perspectives and Historical Sources, guided the data analysis. The findings suggest that teachers in this study were most likely to design their inquiry around Causation, framing the history of school desegregation within the classical timeline of the Civil Rights Movement, which begins with the Brown v. Board of Education decision (1954) and ends with the Civil Rights Act of 1968. What was often absent in these inquiries was Massive Resistance, the backlash against the Brown v. Board of Education decision, collective and political actions of African American communities to implement the Brown decision, and varying perspectives within African American communities as well as Whites who opposed the Brown decision. Implications for theory and practice are discussed. (shrink)

One of Ireland's foremost literary and cultural historians, Terence Brown's command of the intellectual and cultural currents running through the Irish literary canon is second to none, and he has been enormously influential in shaping the field of Irish studies. These essays reflect the key themes of Brown's distinguished career, most crucially his critical engagement with the post-colonial model of Irish cultural and literary history currently dominant in Irish Studies. With essays on major figures such as Yeats, MacNeice, Joyce and (...) Beckett, as well as contemporary authors including Seamus Heaney, Derek Mahon, Michael Longley, Paul Muldoon and Brian Friel, this volume is a major contribution to scholarship, directing scholars and students to new approaches to twentieth-century Irish cultural and literary history. (shrink)

The modern literature on responding to global poverty is over fifty years old and has attracted the attention of some of the most prominent analytical political theorists of the age, including Brian Barry, Charles Beitz, Simon Caney, Thomas Pogge, John Rawls, and Peter Singer. Yet in spite of this extraordinary concentration of brainpower, the problem of global poverty has quite clearly not been solved or, indeed, adequately defined. We are therefore entitled to ask two questions of any new contribution (...) to this literature: first, what does it have to offer that past work does not; and second, what reason is there to think that, this time, it will truly make a difference. These questions will be posed below, but before undertaking this task it may be useful to offer an overview of the field, with particular attention to why the problem of global poverty seems so intractable. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Eternal Life and Human Happiness in Heaven: Philosophical Problems, Thomistic Solutions by Christopher M. BrownElizabeth C. Shaw and Staff*BROWN, Christopher M. Eternal Life and Human Happiness in Heaven: Philosophical Problems, Thomistic Solutions. Washington, D.C.: The Catholic University of America Press, 2021. xiii + 487 pp. Cloth, $75.00The contents of the book are straightforwardly announced by the title. Christopher Brown entertains four apparent problems about eternal life in heaven (...) considered by contemporary philosophers and theologians and offers solutions to them from the thought of St. Thomas Aquinas. The book consists of seventeen chapters together with an introduction and conclusion and is divided into four parts. In the first part Brown lays out the problems and the solutions to them proposed by contemporary philosophers and theologians. In the second part he explains St. Thomas's distinction between essential and accidental reward in heaven and goes on to treat of the former—which consists in the beatific vision, that is, our beholding of God—and its proper accidents—which are delight, joy, and charity. In the third part he then deals with the accidental reward, which has to do with the perfected condition of our glorified bodies, society with other persons, and so on. Finally, in the fourth part Brown, drawing on his expositions of St. Thomas's doctrine in the two previous parts, details Thomistic solutions to the four problems discussed in the first part and argues that these solutions are superior to those proposed by the contemporary philosophers and theologians he has engaged.So, what are the four problems that Brown addresses? Let's present them as questions. (1) Is heaven just a private communion between a human person and God, or is it a perfect community centered on God that also involves angels, other human persons, and other creatures? (2) Is heaven just a spiritual affair, or are our resurrected bodies a part of it? (3) Is heaven a static or dynamic reality? (4) Is heaven boring?The answers are as follows. Ad primum: Heaven is a perfect community centered on God that also involves angels, other human persons, and other creatures. Ad secundum: Heaven is a spiritual and physical affair that includes our souls and our resurrected bodies. Ad tertium: Heaven is a dynamic reality. Ad quartum: Heaven is not boring!I cannot cover here all of the specifics of the way Brown shows how St. Thomas arrives at these answers. People who know St. Thomas well, even if they have not reflected much on these problems before, probably will [End Page 135] not have great difficulty thinking through how he might get to the first and second answers, at least in general terms. But the third and fourth, I think, call for further comment. My comments will necessarily be brief.If I understand Brown correctly, he wants to say (and contends that St. Thomas holds) that heaven is dynamic insofar as in heaven we are in act. But we can be in act in two senses: We can be in act in an unchanging way or in a changing way. In heaven my capacities to know God and to love him are both fully perfected, that is, they are fully actualized and undergo no change. But in heaven we will enjoy our resurrected bodies as well, and our bodies will also be active and interacting with other bodies. This activity will entail change. So, either way we will be active in heaven and, therefore, heaven will be something dynamic.What, then, about the problem of boredom? Because we will be perfectly happy in heaven, argues Brown (interpreting St. Thomas), heaven won't be boring. But the matter doesn't end there. Brown points out that Brian Ribeiro, developing an idea of Bernard Williams, objects that a person who is perfectly happy in the way that we are supposed to be in heaven, cannot be personally identical with any person in this life because the conditions of the beatified person and the nonbeatified person are just too radically different for there to be continuity between the two. Brown replies that St. Thomas convincingly shows that God can, by grace, prepare persons in this... (shrink)

Brian Gladman est un ancien directeur des communications électroniques stratégiques du ministère de la Défense britannique et de l'Otan; Ian Brown, est un cryptographe anglais, membre de l'ONG Privacy International. En l'an 2000, ils rendaient public un texte expliquant comment contourner, en toute légalité, les diverses mesures de « cybersurveillance » adoptées par les législateurs. Ces techniques s'avéreraient en effet « techniquement ineptes et inefficaces à l'encontre des criminels » et risqueraient, a contrario, de « saper le droit à (...) la vie privée et à la sécurité des citoyens et du marché ». Leur démarche est d'autant plus salutaire que les gouvernements se contentent généralement, au mieux, d'expliquer que toute action informatique laisse des traces, et que l'on est de toute façon surveillé , au pire, de passer des lois sécuritaires renforçant cette cybersurveillance, contribuant d'autant à créer un climat de peur, loin du climat de confiance nécessaire à toute démocratie.Brian Gladman is a former Director for strategic electronic communications for the British Ministry of Defence and NATO; Ian Brown is a British cryptographer and a member of the NGO Privacy International In 2000, they published a paper detailing various countermeasures that can be used, perfectly legally, to evade the technical systems that governments adopt in order to monitor what users are doing on the Internet. These systems are criticised as not only "technically inept and ineffective against criminals" but also liable to "undermine the privacy, safety and security of law-abiding citizens and businesses". Their work is all the more valuable as governments either, at best, merely explain that any IT activity leaves traces and that people are monitored in any case or, at worst, pass laws on "security" that reinforce cybersurveillance systems, thus helping to create a climate of fear that can only undermine the trust on which a democratic society relies. (shrink)

Brian Skyrms offers a fascinating demonstration of how fundamental signals are to our world. He uses various scientific tools to investigate how meaning and communication develop. Signals operate in networks of senders and receivers at all levels of life, transmitting and processing information. That is how humans and animals think and interact.

Brian Skyrms, author of the successful Evolution of the Social Contract has written a sequel. The book is a study of ideas of cooperation and collective action. The point of departure is a prototypical story found in Rousseau's A Discourse on Inequality. Rousseau contrasts the pay-off of hunting hare where the risk of non-cooperation is small but the reward is equally small, against the pay-off of hunting the stag where maximum cooperation is required but where the reward is so (...) much greater. Thus, rational agents are pulled in one direction by considerations of risk and in another by considerations of mutual benefit. Written with Skyrms's characteristic clarity and verve, this intriguing book will be eagerly sought out by students and professionals in philosophy, political science, economics, sociology and evolutionary biology. (shrink)

Almost every country today contains adherents of different religions and different secular conceptions of the good life. Is there any alternative to a power struggle among them, leading most probably to either civil war or repression? The argument of this book is that justice as impartiality offers a solution. According to the theory of justice as impartiality, principles of justice are those principles that provide a reasonable basis for the unforced assent of those subject to them. The object of this (...) book is to set the theory out, explain its rationale, and respond to a variety of criticism that have been made of it. As the second volume of his work-in-progress, A Treatise on Social Justice, this work lies at the heart of a thriving academic debate which the author has played a key role in shaping. (shrink)

Intuitively, Gettier cases are instances of justified true beliefs that are not cases of knowledge. Should we therefore conclude that knowledge is not justified true belief? Only if we have reason to trust intuition here. But intuitions are unreliable in a wide range of cases. And it can be argued that the Gettier intuitions have a greater resemblance to unreliable intuitions than to reliable intuitions. Whats distinctive about the faulty intuitions, I argue, is that respecting them would mean abandoning a (...) simple, systematic and largely successful theory in favour of a complicated, disjunctive and idiosyncratic theory. So maybe respecting the Gettier intuitions was the wrong reaction, we should instead have been explaining why we are all so easily misled by these kinds of cases. (shrink)

Brian Skyrms constructs a theory of "dynamic deliberation" and uses it to investigate rational decision-making in cases of strategic interaction. This illuminating book will be of great interest to all those in many disciplines who use decision theory and game theory to study human behavior and thought. Skyrms begins by discussing the Bayesian theory of individual rational decision and the classical theory of games, which at first glance seem antithetical in the criteria used for determining action. In his effort (...) to show how methods for dealing with information feedback can be productively combined, the author skillfully leads us through the mazes of equilibrium selection, the Nash equilibria for normal and extensive forms, structural stability, causal decision theory, dynamic probability, the revision of beliefs, and, finally, good habits for decision. The author provides many clarifying illustrations and a handy appendix called "Deliberational Dynamics on Your Personal Computer." His powerful model has important implications for understanding the rational origins of convention and the social contract, the logic of nuclear deterrence, the theory of good habits, and the varied strategies of political and economic behavior. (shrink)

Dogmatism is sometimes thought to be incompatible with Bayesian models of rational learning. I show that the best model for updating imprecise credences is compatible with dogmatism.

Kaplan (1989a) insists that natural languages do not contain displacing devices that operate on character—such displacing devices are called monsters. This thesis has recently faced various empirical challenges (e.g., Schlenker 2003; Anand and Nevins 2004). In this note, the thesis is challenged on grounds of a more theoretical nature. It is argued that the standard compositional semantics of variable binding employs monstrous operations. As a dramatic first example, Kaplan’s formal language, the Logic of Demonstratives, is shown to contain monsters. For (...) similar reasons, the orthodox lambda-calculus-based semantics for variable binding is argued to be monstrous. This technical point promises to provide some far-reaching implications for our understanding of semantic theory and content. The theoretical upshot of the discussion is at least threefold: (i) the Kaplanian thesis that “directly referential” terms are not shiftable/bindable is unmotivated, (ii) since monsters operate on something distinct from the assertoric content of their operands, we must distinguish ingredient sense from assertoric content (cf. Dummett 1973; Evans 1979; Stanley 1997), and (iii) since the case of variable binding provides a paradigm of semantic shift that differs from the other types, it is plausible to think that indexicals—which are standardly treated by means of the assignment function—might undergo the same kind of shift. (shrink)

Conciliatory theories of disagreement face a revenge problem; they cannot be coherently believed by one who thinks they have peers who are not conciliationists. I argue that this is a deep problem for conciliationism.

Many writers have held that in his later work, David Lewis adopted a theory of predicate meaning such that the meaning of a predicate is the most natural property that is (mostly) consistent with the way the predicate is used. That orthodox interpretation is shared by both supporters and critics of Lewis's theory of meaning, but it has recently been strongly criticised by Wolfgang Schwarz. In this paper, I accept many of Schwarze's criticisms of the orthodox interpretation, and add some (...) more. But I also argue that the orthodox interpretation has a grain of truth in it, and seeing that helps us appreciate the strength of Lewis's late theory of meaning. (shrink)