Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

This book is a collection of secondary essays on America's most important philosophic thinkers—statesmen, judges, writers, educators, and activists—from the colonial period to the present. Each essay is a comprehensive introduction to the thought of a noted American on the fundamental meaning of the American regime.

Neural substrates of fatigue in traumatic brain injury are not well understood despite the considerable burden of fatigue on return to productivity. Fatigue is associated with diminishing performance under conditions of high cognitive demand, sense of effort, or need for motivation, all of which are associated with cognitive control brain network integrity. We hypothesize that the pathophysiology of TBI results in damage to diffuse cognitive control networks, disrupting coordination of moment-to-moment monitoring, prediction, and regulation of behavior. We investigate the cingulo-opercular (...) and frontoparietal networks, which are engaged to sustain attention for task and maintain performance. A total of 61 individuals with mild TBI and 42 orthopedic control subjects participated in functional MRI during performance of a constant effort task requiring altering the amount of effort utilized to manually squeeze a pneumostatic bulb across six 30-s trials. Network-based statistics assessed within-network organization and fluctuation with task manipulations by group. Results demonstrate small group differences in network organization, but considerable group differences in the evolution of task-related modulation of connectivity. The mild TBI group demonstrated elevated CO connectivity throughout the task with little variation in effort level or time on task, while CO connectivity diminished over time in controls. Several interregional CO connections were predictive of fatigue in the TBI group. In contrast, FP connectivity fluctuated with task manipulations and predicted fatigue in the controls, but connectivity fluctuations were delayed in the mild traumatic brain injury group and did not relate to fatigue. Thus, the mTBI group’s hyper-connectivity of the CO irrespective of task demands, along with hypo-connectivity and delayed peak connectivity of the FP, may allow for attainment of task goals, but also contributes to fatigue. Findings are discussed in relation to performance monitoring of prediction error that relies on internal cues from sensorimotor feedback during task performance. Delay or inability to detect and respond to prediction errors in TBI, particularly evident in bilateral insula-temporal CO connectivity, corresponds to day-to-day fatigue and fatigue during task performance. (shrink)

Recognizing the growing interdependence of the European Union and the importance of codes of conduct in companies’ operations, this research examines the effect of a country’s culture on the implementation of a code of conduct in a European context. We examine whether the perceptions of an activity’s ethicality relates to elements found in company codes of conduct vary by country or according to Hofstede’s (1980, Culture’s Consequences (Sage Publications, Beverly Hills, CA)) cultural constructs of: Uncertainty Avoidance, Masculinity/Femininity, Individualism, and Power (...) Distance. The 294 individuals, who participated in our study, were from 8 Western European countries. Their responses to our 13 scenarios indicate that differences in the perceptions of ethicality associate primarily with the participants’ country as opposed to their employer (i.e., accounting firm), employment level, or gender. The evidence also indicates that these country differences associate with Hofstede constructs of Individualism and Masculinity. (shrink)

‘Generally speaking, the errors in religion are dangerous; those in philosophy only ridiculous.’—Hume, Treatise , I, iv, 7. Several years have elapsed since Professor Malcolm's astonishing revival of St Anselm's ontological argument . The first shock-wave of criticism has likewise passed, having been absorbed by now into the bound volumes of the periodical literature. This note is not intended to add much weight to the common conclusion of that impressive body of criticism, for, though interesting and important logical issues remain (...) to be discussed in connection with the ontological argument, there can be little doubt that it fails as a demonstration of God's existence. Nevertheless, there is one move made by Malcolm in his determined defence of Anselm which may have had unfortunate repercussions far beyond the reaches of philosophical theology. Perhaps a discussion of this one step in the argument will help to dispel some erroneous impressions. (shrink)

The knockdown argument, the logically impregnable position are rarities in philosophy. Indeed, there are some who might argue that no philosophical argument or position is immune from damaging criticism: what seems utterly convincing to one generation of philosophers is 1iable to be held up as a classic blunder by the next. Nevertheless, Hume's presentation of the problem of evil and his allied criticisms of a Christian-type theism have seemed conclusive to an impressive array of nineteenth- and twentieth-century philosophers, and both (...) his efforts, consequently, might be regarded as likely exceptions to the principle of philosophical fallibility. But now, in a fairly recent article, Professor Nelson Pike has seen fit to challenge even these supposedly reliable cornerstones of our philosophical heritage. More recently still, Pike has included this article, unchanged, in an anthology which he has edited, and he has backed it up with an introductory note which reaffirms his challenge to Hume on evil. (shrink)

In these papers Duclow views the thought of Eriugena, Eckhart and Cusanus through the lens of contemporary philosophical hermeneutics. He highlights the interplay of creativity, symbolic expression and language, interpretation and silence as they comment on the mind's work in naming God. This work itself becomes mystical theology when negation opens into a silent awareness of God's presence, from which the Word once again 'speaks' within the mind. Comparative studies with Gregory of Nyssa, Pseudo-Dionysius, Anselm and Hadewijch suggest the book's (...) wider implications for medieval philosophy and theology. (shrink)

Retractions have traditionally been reserved for correcting the scientific record and discouraging research misconduct. Nonetheless, the potential for actual societal harm resulting from accurately reported published scientific findings, so-called information hazards, has been the subject of several recent article retractions. As these instances increase, the extent of support for such decisions among the scientific community and lay public remains unclear. Undergraduates (Study 1) and federally funded researchers (Study 2) reported their support for retraction decisions described as due to misconduct, honest (...) errors, or potential information hazards. Participants supported retraction on the former two grounds more than the latter. Despite limited support, women remained more receptive to retractions based on information hazards. Activist tendencies additionally predicted undergraduate men’s receptivity. Receptivity toward retraction due to information hazards was unrelated to scientists’ engagement in activism, suggesting that formal scientific training affords researchers an ability to separate personal and professional values in scientific discourse. Findings could inform the development of educational materials that may aid less experienced scientists and the lay public in understanding retraction ethics. (shrink)

This paper investigates the status of the purported explanatory gap between pain phenomena and natural science, when the “gap” is thought to exist due to the special properties of experience designated by “ qualia ” or “the pain quale” in the case of pain experiences. The paper questions the existence of such a property in the case of pain by: looking at the history of the conception of pain; raising questions from empirical research and theory in the psychology of pain; (...) considering evidence from the neurophysiological systems of pain; investigating the possible biological role or roles of pain; and considering methodological questions of the comparable status of the results of the sciences of pain in contrast to certain intuitions underpinning “the explanatory gap” in the case of pain. Skepticism concerning the crucial underlying intuitions seems justified by these considerations. (shrink)

SIMPLE SEEING I met Virgil Aldrich for the first time in the fall of 1969 when I arrived in Chapel Hill to attend a philosophy conference. My book, Seeing and Knowing,1 had just appeared a few months earlier.

The problem of the Cartesian Circle has been with us ever since the publication of the Meditations. This is quite remarkable, since the error of circularity which Descartes is accused of having committed is not a subtle one but is, if there is such an error, a gigantic blunder which is not difficult to discover, which was pointed out to Descartes shortly after the Meditations appeared, and which completely undermines Descartes’ primary project, the establishment of sure and certain knowledge. It (...) is incredible that Descartes, a slow and careful thinker with considerable philosophical talent, could have made such an obvious and egregious error. It is much more plausible that there really is no circularity in Descartes’ argument, and that the charges of circularity grow out of a misunderstanding of Descartes’ intention or of the way in which his argument progresses.The incredible, of course, is possible, and I am not proposing that the question of the circle be resolved merely by dismissing it, nor am I suggesting that the text be ignored in order to force consistency onto Descartes’ thought. (shrink)

Engaging Eriugena, Eckhart and Cusanus contains two new essays and nine others published between 2005 and 2019. The essays explore Eriugena, Eckhart and Cusanus as bold thinkers deeply engaged with their times and culture. John Scottus Eriugena, Meister Eckhart and Nicholas of Cusa are key figures in the medieval Christian Neoplatonic tradition. This book focuses on their engagement with practical, experiential issues and controversies. Eriugena revises Genesis' Adam and Eve narrative and makes sexual difference and overcoming it central to his (...) Periphyseon. Eckhart's Annunciation sermons urge his hearers to give birth to God's son within their lives, and he develops a distinctive approach to pain and suffering. His radical preaching on the Eucharist and mystical union was judged heretical, but was later taken up by Nicholas of Cusa. Coins and banking became key symbols in Cusanus' exploration of humanity as created in God's image, and he used mechanical clocks in reflecting on time and eternity. 'Engagement' also describes these thinkers' reception of their predecessors and how later readers appropriated their works. Eriugena struggled with the legacy of Augustine and the Greek Fathers. Eckhart's theology of suffering provoked varied responses from his students Henry Suso and Johannes Tauler, and the twentieth-century therapist Ursula Fleming. Cusanus provides the volume's lynchpin as two articles analyse his reading of Eriugena and Eckhart, and a third discusses how he deftly countered Johannes Wenck's accusations of heresy. The book will be of interest to students of Medieval Philosophy, Theology, Spirituality and their place within Cultural History. (shrink)

The current study sought to determine research scientists’ sensitivity to various justifications for engaging in behaviors typically considered to be questionable research practices by asking them to evaluate the appropriateness and ethical defensibility of each. Utilizing a within-subjects design, 107 National Institutes of Health principal investigators responded to an invitation to complete an online survey in which they read a series of research behaviors determined, in prior research, to either be ambiguous or unambiguous in their ethical defensibility. Additionally, each behavior (...) was paired with either an ostensibly sound or unsound reason for the behavior. Consistent with hypotheses, the results indicated that scientists perceived QRPs as more appropriate and defensible when paired with a justifiable motive relative to when paired with a clearly unethical motive, particularly for QRPs that are more ambiguous in their ethicality. In fact, ambiguous QRPs were perceived as categorically defensible when given a justifiable motive. This suggests scientists are sensitive to contextual factors related to QRPs’ appropriateness, which could inform how institutions develop appropriate training modules for research integrity. (shrink)

Donald F. Koch supplies the only extant complete transcription of the annual three-course sequence on ethics Dewey gave at the University of Chicago from 1894 to 1904. Koch argues that these lectures offer the best systematic, overall introduction to Dewey’s approach to moral philosophy and are the only account showing the unity of his views in nearly all phases of ethical inquiry. These lectures are the only work by Dewey to set forth a complete theory of moral language. They (...) offer a clear illustration of the central methodological questions in the development of a pragmatic instrumentalist ethic and the actual working out of the instrumentalist approach as distinct from simply presenting it as a conclusion. (shrink)

There is a traditional view of pain as a conscious phenomenon which satisfies the following two principles at least: Pain is essentially a belief- or cognition-independent sensation, given for consciousness in an immediate way, and pain′s unitary physical base is responsible for both its phenomenal or felt qualities and it′s functional, causal features. These are "The Raw Feels Principle" and "The Unity of Pain Principle" . Each is shown to be implausible. Evidence comes from recent pain research in a number (...) of dimensions. A further argument against The Unity of Pain Principle is constructed by analogy with facts about blindsight. The consequences of rejecting P or Q are examined in light of the traditional epistemological role of pain as exemplar of sensations thought to be foundational for knowledge, the prospects of a modularity theory of the pain system, recent accounts of pain among contemporary philosophers, a naturalist and realist conception of pain, and views about the status of Folk Psychology. (shrink)

In Stephanie Beardman's discussion of the empirical results of Kahneman and Tversky and Kahneman, et al. on pain preference and rational utility decision she argues that an interpretation of these results does not require that false memory for pain episodes yields irrational preferences for future pain events. I concur with her conclusion and suggest that there are reasons from within the pain sciences for agreeing with Beardman's reinterpretation of the Kahneman, et al. data. I cite some of these theoretical and (...) empirical reasons. I engage in some speculation as to why preferences for pain experiences, which harbor the Peak and Ending profile, make biological sense. Given the results from the pain sciences and the clinical practices based in them, I conclude that the medical ethical issue Kahneman raises and Beardman tries to solve is not a pressing moral demand on medical practitioners. (shrink)

Henry Sedgewick's The Methods of Ethics challenges comparison, as no other work in moral philosophy, with Aristotle's Ethics in the depth of its understanding of practical rationality, and in its architectural coherence it rivals the work of Kant. In this historical, rather than critical study, Professor Schneewind shows how Sidgewick's arguments and conclusions represent rational developments of the work of Sidgewick's predecessors, and brings out the nature and structure of the reasoning underlying his position.

In _Lectures on Ethics, 1900–1901_,_ _Donald F. Koch supplies the only extant complete transcription of the annual three-course sequence on ethics John Dewey gave at the University of Chicago. In his introduction Koch argues that these lectures offer the best systematic, overall introduction to Dewey’s approach to moral philosophy and are the only account showing the unity of his views in nearly all phases of ethical inquiry. These lectures are the only work by Dewey to set forth a complete theory (...) of moral language. They offer a clear illustration of the central methodological questions in the development of a pragmatic instrumentalist ethic and the actual working out of the instrumentalist approach as distinct from simply presenting it as a conclusion. (shrink)

The fact that a number of printed editions of Greek physicians appeared during the sixteenth century is clear evidence that publishing houses of the time believed that a substantial interest in such texts existed. What is most surprising is that, until the last decade of the fifteenth century, a prevailing shortage of Greek medical manuscripts had not at all troubled the scholarly and medical communities. This essay shows how minor a niche Galen and other Greek medical writers occupied in the (...) West for a long period of time, until some significant occurrences brought them to the forefront in the 1490s. (shrink)

The shape, function, and dynamic of the field of bioethics is in constant flux, and nowhere is this more apparent than at gatherings of those immersed in th discipline. This section presents coverage and commentary on conferences and settings where voices out-side the mainstream of biomedical ethics can be heard.