In this paper I propose a new account of living natural products in Kant’s physical geography. I argue that Kant adopts Buffon’s twofold conception of natural history, which consists of a general theory of nature as a physical nexus of causes and a particular account of living natural products in the setting of the earth. Yet in contrast to Buffon, who placed the two parts of natural history on equal epistemic footing, Kant’s physical geography can be understood as a second, (...) pragmatic level of inquiry that stands under the formal conditions of nature outlined in Universal Natural History. On the higher, formal level, natural history provides a physical account of time and space as an expanding causal sequence. On the lower, pragmatic level, physical geography provides a causal account of particular natural products as developing within a specific place. I argue that this two-tiered account not only clarifies the relation between metaphysics and experience in Kant’s pre-critical philosophy, it also sheds light on the continuity between the method of physical geography and the systematisation of nature presented in the critical philosophy. (shrink)

This paper walks through four different approaches to Hegel's notion of Consciousness in the Phenomenology of Spirit. Through taking four different approaches our aim is to explore the multifaceted nature of the phenomenological movement of consciousness. The first part provides an overview of the three chapters of the section on Consciousness, namely Sense-Certainty, Perception and Force and the Understanding, attempting to unearth the implicit logic that undergirds Consciousness’ experience. The second part focuses specifically on the shape of Sense-Certainty, providing an (...) analysis of the movement from Sense-Certainty to Perception from a neuroscientific view. Thirdly, we consider an inferentialist reading of the chapters on Consciousness which has been made popular by Robert Brandom. We think that while this view elucidates the connection that Hegel draws between meaning and use, it fails to account for the vital place of immediacy in each of the shapes. Finally, the fourth part suggests that Hegel’s notion of Consciousness improves the reading of tragedy he develops in chapters 5 and 7 of the Phenomenology. While many critics have noted that Hegel fails to do justice to tragic experience, Consciousness contains an epistemology that develops analogously to the heroes of ancient tragedy. Each approach in this paper comes at Hegel’s description of the journey of Consciousness from a different angle, and together they paint a multi-layered picture of a highly important part of Hegel’s corpus. (shrink)

NOT BOLDNESS, but circumspection, and again circumspection, and always circumspection." That is the motto A. O. Lovejoy, in his presidential address to the Eastern Division of the American Philosophical Association, recommended to his fellow philosophers. Observing that the course of American philosophy from the turn of the century to the first World War had undergone a revolution against the alleged certitudes of idealism and witnessed the rise of discordant realisms and pragmatisms, Lovejoy wondered whether philosophy must lose itself in incessant (...) disagreement and fail forever to arrive at universally intelligible and definitely cogent results. He ascribed the failures of philosophers to their confusion of the distinct activities of edification and of inquiry; and he undertook to formulate the conditions for progress in philosophical inquiry. Above all, he urged that philosophers pledge themselves to dispassionate, disinterested inquiry. Philosophers, he contended, must develop the habit of "logical observation." They must deliberately and systematically attempt to enumerate exhaustively all the elements that bear upon a philosophical problem. Philosophy, he held, is intrinsically a cooperative enterprise, since it requires more than one mind to advance toward the truth. Yet, he readily added, philosophical cooperation consists primarily in disagreement, for he quoted Harrington's aphorism with approval: "Truth is a spark to which objections are like bellows." Nevertheless, he seldom wavered from his conviction that truth would win unanimous assent. Philosophers, he advised, should adopt a common and an unambiguous terminology and should formulate a common set of rules for the purposes of philosophical discussions. They should treat individual problems in isolation and deal with general issues in piecemeal fashion. And finally, they should prepare an undogmatic, nonpartisan, comprehensive catalogue of philosophical considerations, organized according to the problems or theses to which they are pertinent. Thus the cooperative pursuit of objective truths would be facilitated, and progress in philosophical inquiry, based upon circumspection, would be attained. (shrink)

In Big Gods, Norenzayan (2013) presents the most comprehensive treatment yet of the Big Gods question. The book is a commendable attempt to synthesize the rapidly growing body of survey and experimental research on prosocial effects of religious primes together with cross-cultural data on the distribution of Big Gods. There are, however, a number of problems with the current cross-cultural evidence that weaken support for a causal link between big societies and certain types of Big Gods. Here we attempt to (...) clarify these problems and, in so doing, correct any potential misinterpretation of the cross-cultural findings, provide new insight into the processes generating the patterns observed, and flag directions for future research. (shrink)

Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that (...) has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility. (shrink)

Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...) On Interpretation and boethius'S textbook on topical inference. They comprise a freestanding Dialectica (“Logic”; probably c.1116), a set of commentaries (known as the Logica [Ingredientibus], c. 1119) and a later (c. 1125) commentary on the Isagoge (Logica Nostrorum Petititoni Sociorum or Glossulae). In a work Abelard called his Theologia, issued in three main versions (between 1120 and c.1134), he attempted a logical analysis of trinitarian relations and explored the philosophical problems surrounding God's claims to omnipotence and omniscience. The Collationes (“Debates,” also known as “Dialogue between a Christian, a Philosopher and a Jew”; probably c.1130) present a rational investigation into the nature of the highest good, in which the Christian and the Philosopher (who seems to be modeled on a philosopher of pagan antiquity) are remarkably in agreement. The unfinished Scito teipsum (“Know thyself,” also known as the “Ethics”; c.1138) analyses moral action. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Ideas 63.4 (2002) 697-716 [Access article in PDF] "La Mère Humanité":Femininity in the Romantic Socialism of Pierre Leroux and the Abbé A.-L. Constant Naomi J. Andrews Humanity, my mother, since you have led me, by so many paths, to conceive this design, support me, inspire me, affirm me. —Pierre Leroux, "Invocation to my Muse." 1It was during the July Monarchy in France, in the (...) era immediately preceding the Revolution of 1848, that the ideology we call socialism became more than an abstraction held by isolated intellectuals and conspirators. 2 A series of individuals, loose-knit associations, and more formal écoles were active during the 1830s and 1840s, developing a varied agenda of social reform, economic cooperation, or association, mystical Christianity, and women's liberation. Roughly lumped under the pejorative rubric of utopian socialism, and perhaps more accurately called romantic socialism, this movement was ultimately unsuccessful in achieving its diverse goals, but contributed significantly to the political discourse of the nineteenth and twentieth centuries. 3Socialism at this stage of its development overlapped in many ways with republicanism, both being, to quote one historian of the latter, "an amalgam of responses to the Enlightenment, the 1789 Revoluation and above all economic [End Page 697] change." 4 Many early socialists were also republicans, and socialist ideas influenced the ideology articulated by republicans such as Alexandre Ledru-Rollin and Auguste Blanqui. Louis Blanc, perhaps the best-known socialist of the decade surrounding the 1848 revolution, was and is known as a Jacobin socialist. 5From a certain perspective republicanism and socialism shared common origins and assumptions during the July Monarchy. Most socialists had come out of the political milieu of republicanism, whether through the carbonarist movement, opposition political clubs such as Droits de l'Homme and Les Amis du Peuple, or through the influential journalism trade of the Bourbon Restoration and early July Monarchy. Pierre Leroux, for one, had been a co-founder of the widely read journal le Globe, a bastion of liberalism, which he later turned over to the Saint-Simonians upon his conversion to their "church." 6 Although diverse in many ways, the left of this era did share certain core tenets, chief among them opposition to the Orleanist monarchy and, to varying degrees the belief in more democratic rule of the French nation.To say this, however, might erroneously imply a unity that was certainly not a feature of socialism during this period. In fact socialism, despite its near mystical devotion to ideas of unity, was anything but singular during its pre-Marxian phase. The spectrum of socialist thinkers and groups ranged widely. Standing closest to the republicans in their beliefs about politics and the revolutionary tradition were Jacobin socialists, most usually associated with Louis Blanc. Blanc and others articulated a social philosophy that sought "to unite two distinct ideologies: Jacobin democracy and co-operative socialism." 7 Thus Jacobin socialism combined republican political priorities and commitment to national political processes in general and to a centralized state in particular with attention to economic change, to reforming the distribution process along more equitable lines and to putting the situation of working people at the center of political change. In this goal Jacobin socialism reflected, as did other strains of socialism, the economic instability of the era and the emergence of an organized working class movement which followed the aborted revolution of 1830. 8At the other end of the spectrum one might put the Saint-Simonians and the Fourierist École Sociétaire. 9 Vehemently anti-republican, these groups shared [End Page 698] very little with the Jacobin socialists, other than a certain concern with the emerging working class, one of the few consistent features of early socialism. Unlike Jacobin socialists, these groups focused their theories of community at a very low level, having a strongly utopian component to their thinking. As a result, they tended to see national politics as irrelevant to the situation of ordinary people and even as a... (shrink)

This article reports a comparative test of the central-union theory vis-à-vis several other game-theoretic solution concepts in 3-person sidepayment games. Based on a laboratory experiment, this comparison utilizes nine games in characteristic function form. The solution concepts under test include the equal excess model, the Myerson–Shapley solution, the kernel, and two variants of the central-union theory. With regard to the player's payoffs, results show that the CU-1, CU-2, kernel, and equal excess theories have essentially equal predictive accuracy and that all (...) of these are more accurate than Myerson–Shapley. When the solution concepts are extended and coalition structure probability predictions are incorporated in the test, one version of the central-union theory is overall more accurate than the other solutions. (shrink)

Andrew Cooper presents the first systematic study of Kant's account of natural history. Cooper contends that Kant made a decisive contribution to one of the most explosive and understudied revolutions in the history of science: the addition of time to the frame in which explanations are required, sought, and justified in natural science. Through addressing a wide range of Kant's works, Cooper challenges the claim that Kant's theory of science denies a developmental conception of nature and argues instead that (...) it establishes a method by which natural historians can genuinely dispute historical claims and potentially come to consensus. This method, Cooper argues, can be used to expose serious flaws in Kant's own historical reasoning, including the formation and defence of his racist views. The book will be valuable to philosophers seeking to discern both the power and limitations of Kant's theory of science, and to historians of science working on the fractured landscape of eighteenth-century Newtonianism. (shrink)

Heidegger's later thought is a thinking of things, so argues Andrew J. Mitchell in The Fourfold. Heidegger understands these things in terms of what he names "the fourfold"--a convergence of relationships bringing together the earth, the sky, divinities, and mortals--and Mitchell's book is the first detailed exegesis of this neglected aspect of Heidegger's later thought. As such it provides entré to the full landscape of Heidegger's postwar thinking, offering striking new interpretations of the atomic bomb, technology, plants, animals, weather, (...) time, language, the holy, mortality, dwelling, and more. What results is a conception of things as ecstatic, relational, singular, and, most provocatively, as intrinsically tied to their own technological commodification. A major new work that resonates beyond the confines of Heidegger scholarship, The Fourfold proposes nothing less than a new phenomenological thinking of relationality and mediation for understanding the things around us. (shrink)

Empirical evidence shows that people have multiple time-biases. One is near-bias; another is future-bias. Philosophical theorising about these biases often proceeds on two assumptions. First, that the two biases are _independent_: that they are explained by different factors (the independence assumption). Second, that there is a normative asymmetry between the two biases: one is rationally impermissible (near-bias) and the other rationally permissible (future-bias). The former assumption at least partly feeds into the latter: if the two biases were not explained by (...) different factors, then it would be less plausible that their normative statuses differ. This paper investigates the independence assumption and finds it unwarranted. In light of this, we argue, there is reason to question the normative asymmetry assumption. (shrink)

In this paper I will introduce a new compatibilist account of free action: indirect conscious control compatibilism, or just indirect compatibilism for short. On this account, actions are free either when they are caused by compatibilist‐friendly conscious psychological processes, or else by sub‐personal level processes influenced in particular ways by compatibilist‐friendly conscious psychological processes. This view is motivated by a problem faced by a certain family of compatibilist views, which I call conscious control views. These views hold that we act (...) freely when we act in a way that is caused by certain conscious psychological processes. One problem for such views is that current neuroscience suggests that most of our actions are not caused by such processes. Instead, many of the actions we typically suppose are free are caused by sub‐personal level processes and hence would count as not free according to contemporary conscious control views. I argue, contra these views, that many actions caused by these sub‐personal level processes are indirectly free. Further, most of the actions we ordinarily judge to be free are free in this indirect manner. (shrink)

This book brings together an international group of scholars to discuss the ramifications of Heidegger's Black Notebooks for philosophy and the humanities. In contrast to both those who seek to exonerate Heidegger and those who simply condemn him, they urge careful reading and rereading of his work to turn Heideggerian thought against itself.

Some postcolonial theorists argue that the idea of a single system of belief known as "Hinduism" is a creation of nineteenth-century British imperialists. Andrew J. Nicholson introduces another perspective: although a unified Hindu identity is not as ancient as some Hindus claim, it has its roots in innovations within South Asian philosophy from the fourteenth to seventeenth centuries. During this time, thinkers treated the philosophies of Vedanta, Samkhya, and Yoga, along with the worshippers of Visnu, Siva, and Sakti, as (...) belonging to a single system of belief and practice. Instead of seeing such groups as separate and contradictory, they re-envisioned them as separate rivers leading to the ocean of Brahman, the ultimate reality. Drawing on the writings of philosophers from late medieval and early modern traditions, including Vijnanabhiksu, Madhava, and Madhusudana Sarasvati, Nicholson shows how influential thinkers portrayed Vedanta philosophy as the ultimate unifier of diverse belief systems. This project paved the way for the work of later Hindu reformers, such as Vivekananda, Radhakrishnan, and Gandhi, whose teachings promoted the notion that all world religions belong to a single spiritual unity. In his study, Nicholson also critiques the way in which Eurocentric concepts—like monism and dualism, idealism and realism, theism and atheism, and orthodoxy and heterodoxy—have come to dominate modern discourses on Indian philosophy. (shrink)

In this paper I extend the case for a necessitation account of particular laws in Kant's philosophy of science by examining the relation between reason's hypothetical use in the Appendix to the Transcendental Dialectic and the legitimate hypotheses identified in the Doctrine of Method. Building on normative accounts of reason's ideas, I argue that reason's hypothetical use does not describe the connections between objects and their grounds, which lie beyond the reach of the understanding, but merely prescribes the relations between (...) appearances and their conditions, for which the understanding must seek. A legitimate hypothesis, I suggest, is a proposition we hold to be true that fills in one or several of those relations. The problematic character of hypotheses requires that we evaluate our reasons for holding them to be true. While natural modality is grounded in the nature of things, which cannot be fully known, our reasons for assent can and must be grounded on features of objects that are epistemically available to us. (shrink)

There are two kinds of time-bias: near-bias and future-bias. While philosophers typically hold that near-bias is rationally impermissible, many hold that future-bias is rationally permissible. Call this normative hybridism. According to arbitrariness objections, certain patterns of preference are rationally impermissible because they are arbitrary. While arbitrariness objections have been levelled against both near-bias and future-bias, the kind of arbitrariness in question has been different. In this paper we investigate whether there are forms of arbitrariness that are common to both kinds (...) of preferences, and hence whether there are versions of the arbitrariness objection that are objections both to near-bias and future-bias. If there are, then this might go some way towards undermining normative hybridism and to defending a thorough-going time-neutralism. (shrink)

In this paper I extend the case for a necessitation account of particular laws in Kant's philosophy of science by examining the relation between reason's hypothetical use in the Appendix to the Transcendental Dialectic and the legitimate hypotheses identified in the Doctrine of Method. Building on normative accounts of reason's ideas, I argue that reason's hypothetical use does not describe the connections between objects and their grounds, which lie beyond the reach of the understanding, but merely prescribes the relations between (...) appearances and their conditions, for which the understanding must seek. A legitimate hypothesis, I suggest, is a proposition we hold to be true that fills in one or several of those relations. The problematic character of hypotheses requires that we evaluate our reasons for holding them to be true. While natural modality is grounded in the nature of things, which cannot be fully known, our reasons for assent can and must be grounded on features of objects that are epistemically available to us. (shrink)

ObjectiveTo present the ethical issues, moral arguments, and reasons found in the ethical literature on organoid models.DesignIn this systematic review of reasons in ethical literature, we selected sources based on predefined criteria: The publication mentions moral reasons or arguments directly relating to the creation and/or use of organoid models in biomedical research; These moral reasons and arguments are significantly addressed, not as mere passing mentions, or comprise a large portion of the body of work; The publication is peer-reviewed and published (...) in an academic article, book, national-level report, working paper, or Ph.D. thesis; The publications collected are in English.AnalysisEach article was read in-depth for identifiable moral reasons, arguments, and concerns. These were then inductively classified and synthesized to create broader categories of reasons, and eventually an overarching conceptual scheme was created.ResultsA total of twenty-three sources were included and analyzed out of an initial 266 collected sources. Five themes of ethical issues and arguments were found: Animal Experimentation; Clinical Applications and Experiments; Commercialization and Consent; Organoid Ontology and Moral Status; and Research Ethics and Research Integrity. These themes are then further broken down into sub-themes and topics. Given the extensive nature of the topics found, we will focus on describing the topics that comprised of more in-depth reasons and arguments rather than few, passing mentions or concerns.ConclusionsThe ethics of organoids requires further deliberation in multiple areas, as much of the discussions are not presented as in-depth arguments. Such sentiments are also echoed throughout the organoid ethics literature. (shrink)

European Journal of Philosophy, EarlyView.

While many aspects of cognition have been shown to be shared between humans and non-human animals, there remains controversy regarding whether the capacity to mentally time travel is a uniquely human one. In this paper, we argue that there are four ways of representing when some event happened: four kinds of temporal representation. Distinguishing these four kinds of temporal representation has five benefits. First, it puts us in a position to determine the particular benefits these distinct temporal representations afford an (...) organism. Second, it provides the conceptual resources to foster a discussion about which of these representations is necessary for an organism to count as having the capacity to mentally time travel. Third, it enables us to distinguish stricter from more liberal views of mental time travel that differ regarding which kind(s) of temporal representation is taken to be necessary for mental time travel. Fourth, it allows us to determine the benefits of taking a stricter or more liberal view of mental time travel. Finally, it ensures that disagreement about whether some species can mentally time travel is not merely the product of unrecognised disagreement about which temporal representation is necessary for mental time travel. We argue for a more liberal view, on the grounds that it allows us to view mental time travel as an evolutionarily continuous phenomenon, and to recognise that differences in the ways that organisms mentally time travel might reflect different temporal representations, or combinations thereof, that they employ. Our ultimate aim, however, is to create the conceptual framework for further discussion regarding what sorts of temporal representations are required for mental time travel. (shrink)

In his article, “What should ChatGPT mean for bioethics?” I. Glenn Cohen explores the bioethical implications of Open AI’s chatbot ChatGPT and the use of similar Large Language Models (LLMs) (Cohen...

Empirical evidence suggests that a majority of people believe that time robustly passes, and that many also report that it seems to them, in experience, as though time robustly passes. Non-dynamists deny that time robustly passes, and many contemporary non-dynamists—deflationists—even deny that it seems to us as though time robustly passes. Non-dynamists, then, face the dual challenge of explaining why people have such beliefs and make such reports about their experiences. Several philosophers have suggested the stable-self explanation, according to which (...) what partly explains one or both of the explananda is that people believe themselves to have a stable persisting self which is imagined either as moving through time, or as being stationary, with time moving around it. This paper empirically investigates this explanation. We found, however, no evidential support for the stable-self explanation, leaving the non-dynamist but also, we will argue, the dynamist, with an extant explanatory challenge. (shrink)

Empirical evidence suggests that a majority of people believe that time robustly passes and that many also report that it seems to them, in experience, as though time robustly passes. Non-dynamists deny that time robustly passes, and many contemporary non-dynamists—deflationists—even deny that it seems to us as though time robustly passes. Non-dynamists, then, face the dual challenge of explaining why people have such beliefs and make such reports about their experiences. Several philosophers have suggested the stable-self explanation, according to which (...) what partly explains one or both of the explananda is that people believe themselves to have a stable persisting self that is imagined either as moving through time or as being stationary with time moving around it. This paper empirically investigates this explanation. We found, however, no evidential support for the stable-self explanation, leaving the non-dynamist but also, we will argue, the dynamist with an extant explanatory challenge. (shrink)

Ethical deliberations are unfolding for potentially controversial organoid‐entities such as brain organoids and embryoids. Much of the ethical deliberation centers on the questionable moral status of such organoid‐entities. However, while such work is important and appropriate, ethical deliberations may become too exclusively rooted in moral status and potentially overshadow other relevant moral dilemmas. The ethical discussion on organoid models can benefit from insights brought forth by both Judith Jarvis Thomson and Don Marquis in how they attempted to advance the abortion (...) debate. To discuss other abortion ethical issues more fully, both Thomson and Marquis assumed differing moral status positions of the conceptus and followed lines of reasoning based on these moral status assumptions. We suggest a similar approach with controversial organoid‐entities like brain organoids and embryoids. To avoid overshadowing or overlooking other relevant ethical issues, ethicists ought to first assume an organoid‐entity moral status position (such as a high moral status or no moral status) and explore any possible arguments that may result from such a position. While we ought not to copy the content of Thomson and Marquis' arguments exactly for organoid‐entities, it is worthwhile to translate their arguments' overarching structures. This paper explores the relevant insights of Thomson and Marquis, how they can be translated into the organoid ethics debate, and what possible lines of inquiry may be worth exploring based on particular moral status assumptions. (shrink)

Proponents of manipulation arguments against compatibilism hold that manipulation scope (how many agents are manipulated) and manipulation type (whether the manipulator intends that an agent perform a particular action) do not impact judgments about free will and moral responsibility. Many opponents of manipulation arguments agree that manipulation scope has no impact but hold that manipulation type does. Recent work by Latham and Tierney (2022, 2023) found that people's judgments were sensitive to manipulation scope: people judged that an agent was less (...) free and responsible when a manipulation was existential (impacting at least one but not all agents) than when the manipulation was universal (impacting every agent). This study examines people's judgements about existential and universal manipulation cases that involve both intentional and non‐intentional outcomes. We found that manipulation scope also affects people's free will and responsibility judgments in manipulation cases involving both intentional and non‐intentional outcomes. Interestingly, we also found that manipulation type influences the effect that manipulation scope has on people's free will judgments but not their moral responsibility judgments, which indicates that people's free will and responsibility judgments can come apart. This puts pressure on the prevalent assumption that judgments about free will and moral responsibility are conceptually bound together. (shrink)

Cerebral organoid models in-of-themselves are considered as an alternative to research animal models. But their developmental and biological limitations currently inhibit the probability that organoids can fully replace animal models. Furthermore, these organoid limitations have, somewhat ironically, brought researchers back to the animal model via xenotransplantation, thus creating hybrids and chimeras. In addition to attempting to study and overcome cerebral organoid limitations, transplanting cerebral organoids into animal models brings an opportunity to observe behavioral changes in the animal itself. Traditional animal (...) ethics frameworks, such as the well-known three Rs (reduce, refine, and replace), have previously addressed chimeras and xenotransplantation of tissue. But these frameworks have yet to completely assess the neural-chimeric possibilities. And while the three Rs framework was a historical landmark in animal ethics, there are identifiable gaps in the framework that require attention. The authors propose to utilize an expanded three Rs framework initially developed by David DeGrazia and Tom L. Beauchamp, known as the Six Principles (6Ps). This framework aims to expand upon the three Rs, fill in the gaps, and be a practical means for assessing animal ethical issues like that of neural-chimeras and cerebral organoid xenotransplantation. The scope of this 6Ps application will focus on two separate but recent studies, which were published in 2019 and 2020. First, they consider a study wherein cerebral organoids were grown from donors with Down syndrome and from neurotypical donors. After these organoids were grown and studied, they were then surgically implanted into mouse models to observe the physiological effects and any behavioral change in the chimera. Second, they consider a separate study wherein neurotypical human embryonic stem cell-derived cerebral organoids were grown and transplanted into mouse and macaque models. The aim was to observe if such a transplantation method would contribute to therapies for brain injury or stroke. The authors place both studies under the lens of the 6Ps framework, assess the relevant contexts of each case, and provide relevant normative conclusions. In this way, they demonstrate how the 6Ps could be applied in future cases of neural-chimeras and cerebral organoid xenotransplantation. (shrink)

Most studies deny that Kritik der Urteilskraft played a significant role in the early reception of Kant’s philosophy in England. In this paper, I examine the notebooks, letters and lectures of several members of British medical and scientific institutions to tell a different story. Drawing from the writings of Thomas Beddoes, Samuel Taylor Coleridge, Joseph Henry Green and William Whewell, I identify a line of reception in which Kant’s critique of judgement’s power of reflection was used to establish the consilience (...) of the mind’s anticipation of systematic order and the organization of natural bodies. Each discovered in Kant’s Kritik der Urteilskraft a shared principle for judgements of taste and scientific inquiry, made available through the mind’s affective response to the appearance of contingent order in nature. Their writings, I contend, evince a more sophisticated reception of Kant’s philosophy in England than has hitherto been recognized. (shrink)

The literature on metaphysical explanation contains three widely accepted assumptions. First, that the notion of metaphysical explanation with which philosophers are interested is a notion with which the folk are familiar: it is at least continuous with the folk notion. Second, that metaphysical explanations are true propositions of a certain form that are true, (or false), simpliciter. Third, that it is at least the case that mostly, if x metaphysically explains y, then y does not metaphysically explain x. On the (...) basis of empirical investigations that we pursued, we argue that at least two of these assumptions are false . (shrink)

It has widely been assumed, by philosophers, that most people unambiguously have a phenomenology as of time passing, and that this is a datum that philosophical theories must accommodate. Moreover, it has been assumed that the greater the extent to which people have said phenomenology, the more likely they are to endorse a dynamical theory of time. This paper is the first to empirically test these assumptions. Surprisingly, our results do not support either assumption. One experiment instead found the reverse (...) correlation: people were more likely to report having passage phenomenology if they endorsed a non-dynamical theory of time. Given that people do not have an unambiguous phenomenology as of time passing, we conclude that this is suggestive evidence in favor of veridical non-dynamism—the view that our phenomenology is veridical, and that it does not unambiguously represent that time passes. Instead, our phenomenology veridically has some quite different content. (shrink)

Recent research (Latham, Miller and Norton, forthcoming) reveals that a majority of people represent actual time as dynamical. But do they, as suggested by McTaggart and Gödel, represent time as essentially dynamical? This paper distinguishes three interrelated questions. We ask (a) whether the folk representation of time is sensitive or insensitive: i.e., does what satisfies the folk representation of time in counterfactual worlds depend on what satisfies it actually—sensitive—or does is not depend on what satisfies it actually—insensitive, and (b) do (...) those who represent actual time as dynamical, represent time in all possible worlds as dynamical—what we call insensitive dynamism—or do they represent time in all possible worlds as dynamical only conditional on the actual world in fact being dynamical—what we call sensitive dynamism and (c) do dynamists and non-dynamists deploy two different representations of time, or deploy the same representation, but disagree about what actually satisfies that representation? We found no evidence that the folk representation of time is sensitive, or that the folk representation of time is essentially dynamical in either sense, though we did find evidence of a shared representation, on which dynamical features are sufficient, but not necessary, for time. (shrink)

Over the past few decades, philosophers of biology have debated the need for a revised evolutionary synthesis that could integrate the causal dynamics of singular organisms into mainstream biological theory. In this chapter I examine two synthesizing arguments (extension and accretion) by turning to a historical source that has recently caught the attention of philosophers on both sides of the debate: Immanuel Kant’s Critique of the Power of Judgment. I argue that accretionists and extenders both pick out one of two (...) key components in Kant’s account of teleological judgment, which, according to Kant, must be held together. By emphasizing one part of Kant’s account of teleological judgment at the expense of the other, both sides overlook the practical nature of his critique. Kant does not simply identify the conditions that render it necessary to judge some products of nature teleologically, I suggest, but also demonstrates the need for second-order analysis to define various domains of inquiry that arise in response to the explanatory demands of nature. The shared turn to Kant indicates that synthesizing arguments can be evaluated against their capacity to accommodate ongoing negotiation between the plurality of research aims in practice. I conclude that a deflationary version of the extension argument is best suited to the task. (shrink)

In this bold new study, Andrew J. Mason seeks both to shed light on the key issue of flux in Plato s work, and to show that there is also in Plato a notion of "flow" that needs to be distinguished from flux. Mason brings out the importance of this hitherto neglected distinction, and proposes on its basis a new way of understanding the development of Plato s thought. The opposition between the being of Forms and the becoming or (...) flux of sensibles has been fundamental to the understanding of Plato from Aristotle to the present day. One key concern of this volume is to clarify which kinds or levels of flux Plato accepts in sensibles. In addition, Mason argues that this traditional approach is unsatisfactory, as it leaves out the important notion of flow. Unlike flux, flow is a kind of motion that does not entail intrinsic change. It is also not restricted to the sensible, but covers motions of soul as well, including the circular motion of "nous" that is crucial in Plato s later thought, particularly his cosmology. In short, flow is not incompatible with being, and in this study Plato s development is presented, largely, as his arrival at this view, in correction of his earlier conflation of flux and flow in establishing the dichotomy between being and becoming. Mason s study offers fresh insights into many dialogues and difficult passages in Plato s oeuvre, and situates Plato s conception and usage of flow and flux in relation to earlier usage in the Greek poetic tradition and the Presocratic thinkers, particularly Heraclitus. The first study of its kind, "Flow and Flux" uncovers dimensions of Plato s thinking that may reshape the way his philosophy is understood.". (shrink)

Philosophers have proposed many accounts of biological function. A coarse-grained distinction can be made between backward-looking views, which emphasise historical contributions to fitness, and forward-looking views, which emphasise the current contribution to fitness or role of a biological component within some larger system. These two views are often framed as being incompatible and conflicting with one another. The emerging field of synthetic biology, which involves applying engineering principles to the design and construction of biological systems, complicates things further by adding (...) intentional design as a source of function. In the current study we explored how biology experts and novices think about function in the context of single-celled, multi-celled, and synthetic organisms. We also explored the extent to which each group were function pluralists, and if they were function pluralists, which accounts of function tended to be endorsed together. The results showed a surprising degree of similarity between experts and novices in most contexts, although certain differences were apparent. Most surprisingly, we found evidence not only of function pluralism in both groups, but pluralism between backward-looking and forward-looking accounts. We discuss these findings in the context of the philosophical debate on function and consider the practical implications for public acceptance of synthetic biology. First, we argue that philosophers of biology should re-examine the purported incompatibility between accounts of function. Second, we argue that due to the introduction of an intentional aetiology in synthetic biology, there may be an inherent conflict between the views of experts and novices when thinking about synthetic biology. (shrink)

We investigated, experimentally, the contention that the folk view, or naïve theory, of time, amongst the population we investigated is dynamical. We found that amongst that population, ~ 70% have an extant theory of time that is more similar to a dynamical than a non-dynamical theory, and ~ 70% of those who deploy a naïve theory of time deploy a naïve theory that is more similar to a dynamical than a non-dynamical theory. Interestingly, while we found stable results across our (...) two experiments regarding the percentage of participants that have a dynamical or non-dynamical extant theory of time, we did not find such stability regarding which particular dynamical or non-dynamical theory of time they take to be most similar to our world. This suggests that there might be two extant theories in the population—a broadly dynamical one and a broadly non-dynamical one—but that those theories are sufficiently incomplete that participants do not stably choose the same dynamical theory as being most similar to our world. This suggests that while appeals to the ordinary view of time may do some work in the context of adjudicating disputes between dynamists and non-dynamists, they likely cannot do any such work adjudicating disputes between particular brands of dynamism. (shrink)

In this paper I return to Hegel's dispute with Kant over the conceptual ordering of external and internal purposiveness to distinguish between two conceptions of teleology at play in the contemporary function debate. I begin by outlining the three main views in the debate (the etiological, causal role and organizational views). I argue that only the organizational view can maintain the capacity of function ascriptions both to explain the presence of a trait and to identify its contribution to a current (...) system, for it is the only view that considers teleology as a natural cause. To establish how teleology can be considered as a natural cause, advocates of the organizational view return to Kant's analysis of internal purposiveness. However, while Kant identifies the requirements that an object must meet to satisfy the demands of teleological judgment, I suggest that he denies that we can know whether they are truly met. I argue that Hegel's philosophy of nature is better equipped to determine how internal purposiveness can be considered as a natural cause, for it grounds organization in a form of purposiveness that is more fundamental than a designer's intention. (shrink)

Idiopathic generalized epilepsy is a common type of epilepsy and despite an increase in the number of available anti-seizure medications, approximately 20–30% of people with IGE continue to experience seizures despite adequate medication trials. Unlike focal epilepsy, resective surgery is not a viable treatment option for IGE; however, neuromodulation may be an effective surgical treatment for people with IGE. Thalamic stimulation through deep brain stimulation and responsive neurostimulation have been explored for the treatment of generalized and focal epilepsies. Although the (...) data regarding DBS and RNS in IGE is limited to case reports and case series, the results of the published studies have been promising. The current manuscript will review the published literature of DBS and RNS within the centromedian nucleus of the thalamus for the treatment of IGE, as well as highlight an illustrative case. (shrink)