Results for 'Debomoy K. Lahiri'

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  1. Elephants and people in India : historical patterns of capture and management.Dhriti K. Lahiri Choudhury - 2008 - In Christen M. Wemmer & Catherine A. Christen (eds.), Elephants and ethics: toward a morality of coexistence. Baltimore, Md.: Johns Hopkins University Press. pp. 149.
     
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  2.  14
    Finding the insphere of a convex polyhedron: an analytical approach.K. K. Sahu & A. K. Lahiri - 2004 - Philosophical Magazine 84 (12):1185-1196.
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  3. 51. Whither Non-Conventional Energy.S. K. Goswami & P. K. Lahiry - 1992 - In B. C. Chattopadhyay (ed.), Science and technology for rural development. New Delhi: S. Chand & Co.. pp. 399.
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  4.  22
    Lessons from a BACE1 inhibitor trial: off-site but not off base.D. K. Lahiri, B. Maloney, J. M. Long & N. H. Greig - 2014 - Alzheimers Dement 10:S411-9.
    Alzheimer's disease is characterized by formation of neuritic plaque primarily composed of a small filamentous protein called amyloid-beta peptide . The rate-limiting step in the production of Abeta is the processing of Abeta precursor protein by beta-site APP-cleaving enzyme . Hence, BACE1 activity plausibly plays a rate-limiting role in the generation of potentially toxic Abeta within brain and the development of AD, thereby making it an interesting drug target. A phase II trial of the promising LY2886721 inhibitor of BACE1 was (...)
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  5.  19
    PuF, an antimetastatic and developmental signaling protein, interacts with the Alzheimer's amyloid-beta precursor protein via a tissue-specific proximal regulatory element.D. K. Lahiri, B. Maloney, J. T. Rogers & Y. W. Ge - 2013 - Bmc Genomics 14:68.
    BACKGROUND: Alzheimer's disease is intimately tied to amyloid-beta peptide. Extraneuronal brain plaques consisting primarily of Abeta aggregates are a hallmark of AD. Intraneuronal Abeta subunits are strongly implicated in disease progression. Protein sequence mutations of the Abeta precursor protein account for a small proportion of AD cases, suggesting that regulation of the associated gene may play a more important role in AD etiology. The APP promoter possesses a novel 30 nucleotide sequence, or "proximal regulatory element" , at -76/-47, from the (...)
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    Taking down the unindicted co-conspirators of amyloid beta-peptide-mediated neuronal death: shared gene regulation of BACE1 and APP genes interacting with CREB, Fe65 and YY1 transcription factors. [REVIEW]D. K. Lahiri, Y. W. Ge, J. T. Rogers, K. Sambamurti, N. H. Greig & B. Maloney - 2006 - Curr Alzheimer Res 3:475-83.
    Major hallmarks of Alzheimer's disease include brain deposition of the amyloid-beta peptide , which is proteolytically cleaved from a large Abeta precursor protein by beta and gamma- secretases. A transmembrane aspartyl protease, beta-APP cleaving enzyme , has been recognized as the beta-secretase. We review the structure and function of the BACE1 protein, and of 4129 bp of the 5'-flanking region sequence of the BACE1 gene and its interaction with various transcription factors involved in cell signaling. The promoter region and 5'-untranslated (...)
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  7.  16
    Autism, Alzheimer disease, and fragile X: APP, FMRP, and mGluR5 are molecular links.D. K. Sokol, B. Maloney, J. M. Long, B. Ray & D. K. Lahiri - 2011 - Neurology 76:1344-52.
    The present review highlights an association between autism, Alzheimer disease , and fragile X syndrome . We propose a conceptual framework involving the amyloid-beta peptide , Abeta precursor protein , and fragile X mental retardation protein based on experimental evidence. The anabolic effect of the secreted alpha form of the amyloid-beta precursor protein may contribute to the state of brain overgrowth implicated in autism and FXS. Our previous report demonstrated that higher plasma sAPPalpha levels associate with more severe symptoms of (...)
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  8.  21
    Co-localization and distribution of cerebral APP and SP1 and its relationship to amyloidogenesis.B. Brock, R. Basha, K. DiPalma, A. Anderson, G. J. Harry, D. C. Rice, B. Maloney, D. K. Lahiri & N. H. Zawia - 2008 - J Alzheimers Dis 13:71-80.
    Alzheimer's disease is characterized by amyloid-beta peptide -loaded plaques in the brain. Abeta is a cleavage fragment of amyloid-beta protein precursor and over production of APP may lead to amyloidogenesis. The regulatory region of the APP gene contains consensus sites recognized by the transcription factor, specificity protein 1 , which has been shown to be required for the regulation of APP and Abeta. To understand the role of SP1 in APP biogenesis, herein we have characterized the relative distribution and localization (...)
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  9.  74
    NF-B mediates amyloid beta peptide-stimulated activity of the human apolipoprotein E gene promoter in human astroglial cells.Y. Du, X. Chen, X. Wei, K. R. Bales, D. T. Berg, S. M. Paul, M. R. Farlow, B. Maloney, Y. W. Ge & D. K. Lahiri - 2005 - Brain Res Mol Brain Res 136:177-88.
    The apolipoprotein E gene plays an important role in the pathogenesis of Alzheimer's disease , and amyloid plaque comprised mostly of the amyloid-beta peptide ) is one of the major hallmarks of AD. However, the relationship between these two important molecules is poorly understood. We examined how A treatment affects APOE expression in cultured cells and tested the role of the transcription factor NF-B in APOE gene regulation. To delineate NF-B's role, we have characterized a 1098 nucleotide segment containing the (...)
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  10.  56
    Lifespan profiles of Alzheimer's disease-associated genes and products in monkeys and mice.R. Dosunmu, J. Wu, L. Adwan, B. Maloney, M. R. Basha, C. A. McPherson, G. J. Harry, D. C. Rice, N. H. Zawia & D. K. Lahiri - 2009 - J Alzheimers Dis 18:211-30.
    Alzheimer's disease is characterized by plaques of amyloid-beta peptide, cleaved from amyloid-beta protein precursor . Our hypothesis is that lifespan profiles of AD-associated mRNA and protein levels in monkeys would differ from mice and that differential lifespan expression profiles would be useful to understand human AD pathogenesis. We compared profiles of AbetaPP mRNA, AbetaPP protein, and Abeta levels in rodents and primates. We also tracked a transcriptional regulator of the AbetaPP gene, specificity protein 1 , and the beta amyloid precursor (...)
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  11.  56
    Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing.Y. Wen, W. H. Yu, B. Maloney, J. Bailey, J. Ma, I. Marie, T. Maurin, L. Wang, H. Figueroa, M. Herman, P. Krishnamurthy, L. Liu, E. Planel, L. F. Lau, D. K. Lahiri & K. Duff - 2008 - Neuron 57:680-90.
    Cyclin-dependent kinase 5 has been implicated in Alzheimer's disease pathogenesis. Here, we demonstrate that overexpression of p25, an activator of cdk5, led to increased levels of BACE1 mRNA and protein in vitro and in vivo. A p25/cdk5 responsive region containing multiple sites for signal transducer and activator of transcription was identified in the BACE1 promoter. STAT3 interacts with the BACE1 promoter, and p25-overexpressing mice had elevated levels of pSTAT3 and BACE1, whereas cdk5-deficient mice had reduced levels. Furthermore, mice with a (...)
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  12.  35
    Early-emerging cognitive vulnerability to depression and the serotonin transporter promoter region polymorphism.E. P. Hayden, L. R. Dougherty, B. Maloney, T. M. Olino, H. Sheikh, C. E. Durbin, J. I. Nurnberger Jr, D. K. Lahiri & D. N. Klein - 2008 - J Affect Disord 107:227-30.
    BACKGROUND: Serotonin transporter promoter genotype appears to increase risk for depression in the context of stressful life events. However, the effects of this genotype on measures of stress sensitivity are poorly understood. Therefore, this study examined whether 5-HTTLPR genotype was associated with negative information processing biases in early childhood. METHOD: Thirty-nine unselected seven-year-old children completed a negative mood induction procedure and a Self-Referent Encoding Task designed to measure positive and negative schematic processing. Children were also genotyped for the 5-HTTLPR gene. (...)
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  13.  37
    Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA-protein interactions.B. Maloney, Y. W. Ge, R. C. Petersen, J. Hardy, J. T. Rogers, J. Perez-Tur & D. K. Lahiri - 2010 - Am J Med Genet B Neuropsychiatr Genet 153:185-201.
    Variations in levels of apolipoprotein E have been tied to the risk and progression of Alzheimer's disease . Our group has previously compared and contrasted the promoters of the mouse and human ApoE gene promoter sequences and found notable similarities and significant differences that suggest the importance of the APOE promoter's role in the human disease. We examine here three specific single-nucleotide polymorphisms within the human APOE promoter region, specifically at -491 , -427 , and at -219 upstream from the (...)
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  14. Alzheimer's disease -like pathology in aged monkeys after infantile exposure to environmental metal lead : evidence for a developmental origin and environmental link for AD.J. Wu, M. R. Basha, B. Brock, D. P. Cox, F. Cardozo-Pelaez, C. A. McPherson, J. Harry, D. C. Rice, B. Maloney, D. Chen, D. K. Lahiri & N. H. Zawia - 2008 - J Neurosci 28:3-9.
    The sporadic nature of Alzheimer's disease argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead during brain development predetermined the expression and regulation of the amyloid precursor protein and its amyloidogenic beta-amyloid product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 ] as well as their transcriptional regulator were elevated in aged (...)
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  15.  58
    Functional activity of the novel Alzheimer's amyloid beta-peptide interacting domain in the APP and BACE1 promoter sequences and implications in activating apoptotic genes and in amyloidogenesis.J. A. Bailey, B. Maloney, Y. W. Ge & D. K. Lahiri - 2011 - Gene 488:13-22.
    Amyloid-beta peptide plaque in the brain is the primary diagnostic criterion of Alzheimer's disease . The physiological role of Abeta are poorly understood. We have previously determined an Abeta interacting domain in the promoters of AD-associated genes . This AbetaID interacts in a DNA sequence-specific manner with Abeta. We now demonstrate novel Abeta activity as a possible transcription factor. Herein, we detected Abeta-chromatin interaction in cell culture by ChIP assay. We observed that human neuroblastoma cells treated with FITC conjugated Abeta1-40 (...)
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  16.  23
    Temperamental fearfulness in childhood and the serotonin transporter promoter region polymorphism: a multimethod association study.E. P. Hayden, L. R. Dougherty, B. Maloney, C. Emily Durbin, T. M. Olino, J. I. Nurnberger Jr, D. K. Lahiri & D. N. Klein - 2007 - Psychiatr Genet 17:135-42.
    OBJECTIVES: Early-emerging, temperamental differences in fear-related traits may be a heritable vulnerability factor for anxiety disorders. Previous research indicates that the serotonin transporter promoter region polymorphism is a candidate gene for such traits. METHODS: Associations between 5-HTTLPR genotype and indices of fearful child temperament, derived from maternal report and standardized laboratory observations, were examined in a community sample of 95 preschool-aged children. RESULTS: Children with one or more long alleles of the 5-HTTLPR gene were rated as significantly more nervous during (...)
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  17. New work for a theory of universals.David K. Lewis - 1983 - Australasian Journal of Philosophy 61 (4):343-377.
  18. Conjectures and Refutations.K. Popper - 1963 - Les Etudes Philosophiques 21 (3):431-434.
     
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  19. What experience teaches.David K. Lewis - 1990 - In William G. Lycan (ed.), Mind and cognition: a reader. Cambridge, Mass., USA: Blackwell. pp. 29--57.
  20. Body and Mind.Karlyn K. Campbell - 1970 - Notre Dame, Ind.: Doubleday.
     
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  21. The Unconscious Reconsidered.K. S. Bowers & D. Meichenbaum (eds.) - 1982 - Wiley.
  22. I do not exist.Peter K. Unger - 1979 - In Graham Macdonald (ed.), Perception and Identity. Cornell University Press.
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  23. Criteria for consciousness in humans and other mammals.Anil K. Seth, Bernard J. Baars & David B. Edelman - 2005 - Consciousness and Cognition 14 (1):119-39.
    The standard behavioral index for human consciousness is the ability to report events with accuracy. While this method is routinely used for scientific and medical applications in humans, it is not easy to generalize to other species. Brain evidence may lend itself more easily to comparative testing. Human consciousness involves widespread, relatively fast low-amplitude interactions in the thalamocortical core of the brain, driven by current tasks and conditions. These features have also been found in other mammals, which suggests that consciousness (...)
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  24. Should a materialist believe in qualia?David K. Lewis - 1995 - Australasian Journal of Philosophy 73 (1):140-44.
  25. Identity and Indiscernibility.K. Hawley - 2009 - Mind 118 (469):101-119.
    Putative counterexamples to the Principle of Identity of Indiscernibles (PII) are notoriously inconclusive. I establish ground rules for debate in this area, offer a new response to such counterexamples for friends of the PII, but then argue that no response is entirely satisfactory. Finally, I undermine some positive arguments for PII.
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  26. Postscript to "mad pain and Martian pain".David K. Lewis - 1983 - Philosophical Papers 12:122-133.
  27.  71
    Ateizm için Bir Argüman.Graham Oppy & Musa Yanık - 2024 - Öncül Analitik Felsefe Dergisi. Translated by Musa Yanık.
    Bu [makalede], nihai olarak kesin bir sonucu olduğunu iddia etmemekle birlikte, ateizm için geliştirebileceğim en iyi argümanı öne sürmeye çalışacağım ve ortaya koyacağım şeyin, Tanrı’nın varlığına dair yürütülen tartışmaların herhangi bir kısmındaki, en iyi argüman olduğunu iddia edeceğim.
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    Social roles and utilities in reasoning with deontic conditionals.K. I. Manktelow & D. E. Over - 1991 - Cognition 39 (2):85-105.
  29.  31
    Framing sentences.K. Bock - 1990 - Cognition 35 (1):1-39.
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  30. Self-deception, motivation, and the desire to believe.Dana K. Nelkin - 2002 - Pacific Philosophical Quarterly 83 (4):384-406.
    In this paper, I take up the question of whether the phenomenon of self-deception requires a radical sort of partitioning of the mind, and argue that it does not. Most of those who argue in favor of partitioning accept a model of self-deception according to which the self-deceived person desires to and intentionally sets out to form a certain belief that she knows to be false. Such a model is similar to that of deception of other persons, and for this (...)
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  31.  7
    Tanzanya’da Leibzig Misyoner Cemiyeti Misyonerliği, Karşılaşılan Zorluklar ve Kullanılan Yöntemler.Şeyma Han & Şahin Kızılabdullah - 2024 - Dini Araştırmalar 66:129-163.
    “Tanzanya’da Leibzig Misyoner Cemiyeti Misyonerliği, Karşılaşılan Zorluklar ve Kullanılan Yöntemler” isimli makale “Tanzanya’da Misyonerlik Faaliyetler Lutheran Kilise Örneği” isimli yüksek lisans tezine dayanmaktadır. Makale, Lutheran misyonerliğinin Tanzanya’da faaliyetlerine nasıl başladıkları, ilerleme yöntemleri ve karşılaşılan güçlükleri anlama noktasında önem arz etmektedir. Makalede ana konuya odaklanmadan önce, Tanzanya hakkında genel bir bilgilendirme yapılmış, ardından Leibzig Misyon Cemiyeti’nin (LMS) faaliyetlerine nasıl başladığı, kronolojik bir şekilde açmış olduğu istasyonlar, bu istasyonlarda karşılaşmış olduğu zorluklar ve kullanılan yöntemler hakkında bilgi verilmiştir. Ayrıca, Tanzanya’da Lutheran misyoner cemiyetlerinin, (...)
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  32.  40
    Emotion in Action: A Predictive Processing Perspective and Theoretical Synthesis.K. Richard Ridderinkhof - 2017 - Emotion Review 9 (4):319-325.
    Starting from a decidedly Frijdian perspective on emotion in action, we adopt neurocognitive theories of action control to analyze the mechanisms through which emotional action arises. Appraisal of events vis-à-vis concerns gives rise to a determinate motive to establish a specific state of the world; the pragmatic idea of the action’s effects incurs the valuation of action options and a change in action readiness in the form of incipient ideomotor capture of the selected action. Forward modeling of the sensory consequences (...)
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  33.  30
    The differential response in animals to stimuli varying within a single dimension.K. W. Spence - 1937 - Psychological Review 44 (5):430-444.
  34.  19
    A Theory of Freedom: From the Psychology to the Politics of Agency.K. Kristjansson - 2002 - Mind 111 (444):902-905.
  35.  80
    Scientific authorship in the age of collaborative research.K. Brad Wray - 2006 - Studies in History and Philosophy of Science Part A 37 (3):505-514.
    I examine two challenges that collaborative research raises for science. First, collaborative research threatens the motivation of scientists. As a result, I argue, collaborative research may have adverse effects on what sorts of things scientists can effectively investigate. Second, collaborative research makes it more difficult to hold scientists accountable. I argue that the authors of multi-authored articles are aptly described as plural subjects, corporate bodies that are more than the sum of the individuals involved. Though journal editors do not currently (...)
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  36.  36
    Absolute logics and L∞ω.K. Jon Barwise - 1972 - Annals of Mathematical Logic 4 (3):309-340.
  37.  2
    Trust in automation: Designing for appropriate reliance.J. D. Lee & K. A. See - 2004 - Human Factors 46.
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  38. Above All Things Human: Bestimmung in Salomo Friedlaender’s Kant for Children.Krista K. Thomason - 2024 - In Salomo Friedlaender (ed.), Kant for Children. De Gruyter. pp. 121-140. Translated by Bruce Krajewski.
    Kant’s commitment to universalism has been called into question since increasing attention has been paid to his work on race in the last 20 years. This worry can easily be applied to Kant’s work on education: when Kant describes education as allowing humanity to fulfill its Bestimmung (vocation), scholars might reasonably conclude that such a claim only applies certain racial groups. Yet Salomo Friedlaender claims that if Kant’s moral theory is taught to children, “Every person is valued according to her (...)
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  39.  70
    Executive functions in insight versus non-insight problem solving: An individual differences approach.K. J. Gilhooly & E. Fioratou - 2009 - Thinking and Reasoning 15 (4):355-376.
  40.  27
    Telling, Hearing, and Believing: A Critical Analysis of Narrative Bioethics.K. M. Saulnier - 2020 - Journal of Bioethical Inquiry 17 (2):297-308.
    Narrative ethics taps into an inherent human need to tell our own stories centred on our own moral values and to have those stories heard and acknowledged. However, not everyone’s words are afforded equal power. The use of narrative ethics in bioethical decision-making is problematized by a disparity in whose stories are told, whose stories are heard, and whose stories are believed. Here, I conduct an analysis of narrative ethics through a critical theory lens to show how entrenched patterns of (...)
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  41.  78
    Hypnosis modulates activity in brain structures involved in the regulation of consciousness.Pierre Rainville, Rrrobert K. Hofbauer, M. Catherine Bushnell, Gary H. Duncan & Donald D. Price - 2002 - Journal of Cognitive Neuroscience 14 (6):887-901.
  42.  24
    The sense of freedom.Dana K. Nelkin - 2004 - In Freedom and Determinism. Cambridge MA: Bradford Book/MIT Press. pp. 105.
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  43.  70
    Time and Experience.Peter K. McInerney - 1991 - Philadelphia: Temple University Press.
    Introduction Ordinary experience seems both to take place in time and to concern things that happen in time. This seemingly simple fact is the starting ...
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  44.  26
    The L/K-capture ratio of argon 37.P. W. Dougan, K. W. D. Ledingham & R. W. P. Drever - 1962 - Philosophical Magazine 7 (75):475-482.
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  45. Reality monitoring: An experimental phenomenological approach.M. K. NJohnson - 1988 - Journal of Experimental Psychology 117:390-94.
  46. Colours.K. Campbell - 1969 - In Robert Brown & Calvin Dwight Rollins (eds.), Contemporary philosophy in Australia. New York,: Humanities P..
     
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  47. Logical Constants.K. Warmbrõd - 1999 - Mind 108 (431):503 - 538.
    There is as yet no settled consensus as to what makes a term a logical constant or even as to which terms should be recognized as having this status. This essay sets out and defends a rationale for identifying logical constants. I argue for a two-tiered approach to logical theory. First, a secure, core logical theory recognizes only a minimal set of constants needed for deductively systematizing scientific theories. Second, there are extended logical theories whose objectives are to systematize various (...)
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  48.  34
    'Ambivalence' at the end of life: How to understand patients' wishes ethically.K. Ohnsorge, H. R. G. Keller, G. A. Widdershoven & C. Rehmann-Sutter - 2012 - Nursing Ethics 19 (5):629-641.
    Health-care professionals in end-of-life care are frequently confronted with patients who seem to be ‘ambivalent’ about treatment decisions, especially if they express a wish to die. This article investigates this phenomenon by analysing two case stories based on narrative interviews with two patients and their caregivers. First, we argue that a respectful approach to patients requires acknowledging that coexistence of opposing wishes can be part of authentic, multi-layered experiences and moral understandings at the end of life. Second, caregivers need to (...)
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  49. Simple 'might's, indicative possibilities and the open future.K. DeRose - 1998 - Philosophical Quarterly 48 (190):67-82.
    are ambiguous. In the mouth of someone who cannot remember whether it was Michael, or rather someone else, who was top scorer, can express the epistemic possibility that Michael led the league in scoring. But from someone who knows that Michael did not even play last season, but is wondering what would have happened if he had, means something quite different. Now where it has this quite different meaning, may still turn out to be the expression of some epistemic possibility. (...)
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  50. Are there extrinsic desires?David K. Chan - 2004 - Noûs 38 (2):326-50.
    An extrinsic desire is defined as a desire for something, not for its own sake, but for its supposed propensity to secure something else that one desires. I argue that the notion of ‘extrinsic desire’ is theoretically redundant. I begin by defining desire as a propositional attitude with a desirability characterization. The roles of desire and intention in practical reasoning are distinguished. I show that extrinsic desire does not have its own motivational role. I also show that extrinsic desire is (...)
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