Hastings Center Report, Volume 52, Issue 5, Page 32-42, September–October 2022.

Confirmation in evolutionary biology depends on what biologists take to be the genuine rivals. Investigating what constrains the scope of biological possibility provides part of the story: explaining how possible helps determine what counts as a genuine rival and thus informs confirmation. To clarify the criteria for genuine rivalry I distinguish between global and local constraints on biological possibility, and offer an account of how-possibly explanation. To sharpen the connection between confirmation and explaining how possible I discuss the view that (...) formal inquiry can provide a kind of confirmation-theoretic support for evolutionary models, and offer an example of how-possibly explanation interacting with testing practice. (shrink)

There is an urgent need for novel protection strategies to sustainably secure crop production under changing climates. Studying microbial effectors, defined as microbe‐derived proteins that alter signalling inside plant cells, has advanced our understanding of plant immunity and microbial plant colonisation strategies. Our understanding of effectors in the establishment and beneficial outcome of plant symbioses is less well known. Combining functional and comparative interaction assays uncovered specific symbiont effector targets in highly interconnected plant signalling networks and revealed the potential of (...) effectors in beneficially modulating plant traits. The diverse functionality of symbiont effectors differs from the paradigmatic immuno‐suppressive function of pathogen effectors. These effectors provide solutions for improving crop resilience against climate stress by their evolution‐driven specification in host protein targeting and modulation. Symbiont effectors represent stringent tools not only to identify genetic targets for crop breeding, but to serve as applicable agents in crop management strategies under changing environments. (shrink)

Linear logic, introduced by Girard, is a refinement of classical logic with a natural, intrinsic accounting of resources. This accounting is made possible by removing the ‘structural’ rules of contraction and weakening, adding a modal operator and adding finer versions of the propositional connectives. Linear logic has fundamental logical interest and applications to computer science, particularly to Petri nets, concurrency, storage allocation, garbage collection and the control structure of logic programs. In addition, there is a direct correspondence between polynomial-time computation (...) and proof normalization in a bounded form of linear logic. In this paper we show that unlike most other propositional logics, full propositional linear logic is undecidable. Further, we prove that without the modal storage operator, which indicates unboundedness of resources, the decision problem becomes PSPACE-complete. We also establish membership in NP for the multiplicative fragment, NP-completeness for the multiplicative fragment extended with unrestricted weakening, and undecidability for fragments of noncommutative propositional linear logic. (shrink)

This paper examines the impact of a shift in focus from political praxis to trauma work in the context of a failed democratisation movement. It investigates the various phenomena which emerge when intellectuals, under the traumatic impact of violence and atrocities, place trauma narration at the core of their interventions. Drawing on document analysis, participant observation and semi-structured interviews with twenty nine exiled Syrian intellectuals in Paris and Berlin who had participated in the revolutionary movement of 2011, the paper suggests (...) that an inversion of the normative power structures pertaining to how intellectuals relate to their publics occurs when they adopt, under conditions of extreme violence and trauma, what we call a radically embedded positionality vis-à-vis ‘the people’. This results in the dismantling of previous figurations of the ‘militant intellectual’ along with praxis-focused notions of the ‘responsibility of intellectuals’, ultimately undermining their ideational influence upon domestic publics and weakening their political impact and critical role within a revolutionary movement. (shrink)

We discuss the scientific task of historical reconstruction and the problem of epistemic access. We argue that strong epistemic support for historical claims consists in the consilience of multiple independent lines of evidence, and analyze the impact hypothesis for the End-Cretaceous mass extinction to illustrate the accrual of epistemic support. Although there are elements of the impact hypothesis that enjoy strong epistemic support, the general conditions for this are strict, and help to clarify the difficulties associated with reconstructing the deep (...) past. (shrink)

D. Alan Shewmon has advanced a well-documented challenge to the widely accepted total brain death criterion for death of the human being. We show that Shewmon's argument against this criterion is unsound, though he does refute the standard argument for that criterion. We advance a distinct argument for the total brain death criterion and answer likely objections. Since human beings are rational animals – sentient organisms of a specific type – the loss of the radical capacity for sentience involves a (...) substantial change, the passing away of the human organism. In human beings total brain death involves the complete loss of the radical capacity for sentience, and so in human beings total brain death is death. (shrink)

Abstract Of the many ways in which identity is constructed and performed online, few are as strongly ‘anchored’ to existing offline relationships as in online social networks like Facebook and Myspace. These networks utilise profiles that extend our practical, psychological and even corporeal identity in ways that give them considerable phenomenal presence in the lives of spatially distant people. This raises interesting questions about the persistence of identity when these online profiles survive the deaths of the users behind them, via (...) the practice of ‘memorialising’ social network profile pages. I situate these practices within a phenomenology of grief that accounts for the ways in which the dead can persist as moral patients, and show how online survival in this case illuminates an important difference between persons and selves within contemporary philosophy of personal identity. Ultimately, the online persistence of the dead helps bring into view a deep ontological contradiction implicit in our dealings with death: the dead both live on as objects of duty and yet completely cease to exist. Content Type Journal Article Category Special Issue Pages 1-17 DOI 10.1007/s13347-011-0050-7 Authors Patrick Stokes, Philosophy Group, School of Humanities, University of Hertfordshire de Havilland Campus, Hatfield, Hertfordshire AL10 9AB, UK Journal Philosophy & Technology Online ISSN 2210-5441 Print ISSN 2210-5433. (shrink)

Most definitions of radical emergentism characterize it epistemologically. This leads to misunderstandings and makes it hard to assess the doctrine's metaphysical worth. This paper puts forward purely metaphysical characterizations of emergentism and property emergence. It explores the nature of the necessitation relation between base and emergent and argues that emergentism entails a Humean account of causation and related relations. Then it presents arguments against emergentism, both as a wider metaphysic and as an account of consciousness. These maintain that emergentism makes (...) implausible claims about how the world works. The paper also stresses the doctrine's contemporary relevance: most current property dualists endorse views effectively identical to classical emergentism less its historical commitment to novel emergent forces. (shrink)

This introduction provides background information on the emerging field of nanotechnology and its ethical dimensions. After defining nanotechnology and briefly discussing its status as a discipline, about which there exists a meta-controversy, this introduction turns to a discussion of the status of nanoethics and lays out particular issues of concern in the field, both current and emerging.

Does science successfully uncover the deep structure of the natural world? Or are the depths forever beyond our epistemic grasp? Since the decline of logical positivism and logical empiricism, scientific realism has become the consensus view: of course our scientific theories apprehend the deep structure of the world. What else could explain the remarkable success of science? This is the explanationist defense of scientific realism, the “ultimate argument.” Kyle Stanford starts here and, using the history of theorizing about biological inheritance (...) as his case study, constructs a convincing argument against the realist consensus in his thought provoking book, Exceeding Our Grasp.1 Here I will review the core of Stanford’s new argument for instrumentalism (§ 1) and discuss his considered view of theoretical science (§ 2). (shrink)

Cognitive Science, Literature, and the Arts is the first student-friendly introduction to the uses of cognitive science in the study of literature, written specifically for the non-scientist. Patrick Colm Hogan guides the reader through all of the major theories of cognitive science, focusing on those areas that are most important to fostering a new understanding of the production and reception of literature. This accessible volume provides a strong foundation of the basic principles of cognitive science, and allows us to (...) begin to understand how the brain works and makes us feel as we read. (shrink)

A new solution to the liar paradox is developed using the insight that it is illegitimate to even suppose (let alone assert) that a liar sentence has a truth-status (true or not) on the grounds that supposing this sentence to be true/not-true essentially defeats the telos of supposition in a readily identifiable way. On that basis, the paradox is blocked by restricting the Rule of Assumptions in Gentzen-style presentations of the sequent-calculus. The lesson of the liar is that not all (...) assumptions are for free. One merit of this proposal is that it is free from the revenge problem. (shrink)

The military is a major driver of technological, world-changing innovations which, like the Internet, often have unpredictable dual uses and widespread civilian impact (?blowback?). Ethical and policy concerns arising from such technologies, therefore, are not limited to military affairs, but can have great implications for society at large as well. This paper will focus on two technology areas making headlines at present: human enhancement technologies and robotics, representing both biological and technological upgrades to the military. The concerns we will raise (...) are about (1) the unintended effects that these technologies could have on society and (2) the possibly self-defeating nature of these military programs in making war itself more, rather than less likely to occur. Given that society also can influence military programs (e.g., through civil protests) it is important for the military to attend to such concerns. (shrink)

The determination of individual moral status is a central factor in the ethical evaluation of controversial practices such as elective abortion, human embryo-destructive research, and the care of the severely disabled and those in persistent vegetative states. A review of recent work on Kant reveals the need for a careful examination of the content of Kant ’s biological and psychological theories and their relation to his views about moral status. Such an examination, in conjunction with Kant ’s practical-metaphysical analysis of (...) the origins of freedom, reveals Kant ’s principled basis for his contention that all human beings possess moral status. (shrink)

ABSTRACT In this article, I reply to criticisms of Dean Stretton of the pro‐life argument from substantial identity. When the criterion for the right to life proposed by most proponents of the pro‐life position is rightly understood – being a person, a distinct substance of a rational nature – this position does not lead to the difficulties Stretton claims it does.

Literature provides us with otherwise unavailable insights into the ways emotions are produced, experienced and enacted in human social life. It is particularly valuable because it deepens our comprehension of the mutual relations between emotional response and ethical judgment. These are the central claims of Hogan's study, which carefully examines a range of highly esteemed literary works in the context of current neurobiological, psychological, sociological and other empirical research. In this work, he explains the value of literary study for a (...) cognitive science of emotion and outlines the emotional organization of the human mind. He explores the emotions of romantic love, grief, mirth, guilt, shame, jealousy, attachment, compassion and pity - in each case drawing on one work by Shakespeare and one or more works by writers from different historical periods or different cultural backgrounds, such as the eleventh-century Chinese poet Li Ch'ing-Chao and the contemporary Nigerian playwright Wole Soyinka. (shrink)

An embedding of the implicational propositional intuitionistic logic into the nonmodal fragment of intuitionistic linear logic is given. The embedding preserves cut-free proofs in a proof system that is a variant of IIL. The embedding is efficient and provides an alternative proof of the PSPACE-hardness of IMALL. It exploits several proof-theoretic properties of intuitionistic implication that analyze the use of resources in IIL proofs.

This book explores how the creations of great authors result from the same operations as our everyday counterfactual and hypothetical imaginations, which cognitive scientists refer to as 'simulations'. Drawing on detailed literary analyses as well as recent research in neuroscience and related fields, Patrick Colm Hogan develops a rigorous theory of the principles governing simulation that goes beyond any existing framework. He examines the functions and mechanisms of narrative imagination, with particular attention to the role of theory of mind, (...) and relates this analysis to narrative universals. In the course of this theoretical discussion, Hogan explores works by Austen, Faulkner, Shakespeare, Racine, Brecht, Kafka and Calvino. He pays particular attention to the principles and parameters defining an author's narrative idiolect, examining the cognitive and emotional continuities that span an individual author's body of work. (shrink)

The media, perhaps more than any other slice of culture, influence what we think and talk about, what we take to be important, what we worry about. And this was especially true when news of Dolly hit the airwaves and newstands. Most Americans received training in the ethics of cloning before they knew what cloning was. Media coverage fixed the content and outline of the public moral debate, both revealing and creating the dominant public worries about cloning humans. The primary (...) characterization of cloning as an ethical issue centers around three connected concerns: the loss of human uniqueness and individuality, the pathological motivations of a cloner, and the fear of out‐of‐control scientists. (shrink)

Patrick Riley traces the forgotten roots of Rousseau's concept to seventeenth-century questions about the justice of God. If He wills that all men be saved, does He have a general will that produces universal salvation? And, if He does not, why does He will particularly" that some men be damned? The theological origin of the "general will" was important to Rousseau himself. He uses the language of divinity bequeathed to him by Pascal, Malebranche, Fenelon, and others to dignify, to (...) elevate, and to "save" politics. Originally published in 1986. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905. (shrink)

Cet article présente, contre le physicalisme, un argument métaphysique fondé sur la distinction entre les propriétés intrinsèques et extrinsèques. Il soutient que le physique, comme le physicalisme doit le comprendre, comprend uniquement des propriétés extrinsèques, tandis que la conscience implique au moins certaines propriétés intrinsèques. Il conclut que la conscience a des propriétés non-physiques et que le physicalisme est faux. L’article défend ensuite ses prémisses contre la pensée physicaliste actuelle. Autant que possible, il offre des arguments métaphysiques portant sur les (...) propriétés physiques et conscientes plutôt que des arguments épistémologiques portant sur nos concepts physiques et phénoménaux. (shrink)

Recent decades have witnessed an explosion in neuroscientific and related research treating aesthetic response. This book integrates this research with insights from philosophical aesthetics to propose new answers to longstanding questions about beauty and sublimity. Hogan begins by distinguishing what we respond to as beautiful from what we count socially as beautiful. He goes on to examine the former in terms of information processing and emotional involvement. In the course of the book, Hogan examines such issues as how universal principles (...) of aesthetic response may be reconciled with individual idiosyncrasy, how it is possible to argue rationally over aesthetic response, and what role personal beauty and sublimity might play in the definition of art. To treat these issues, the book considers works by Woolf, Wharton, Shakespeare, Arthur Miller, Beethoven, Matisse, and Kiran Rao, among others. (shrink)

Central to any form of Deflationism concerning truth (hereafter ‘DT’) is the claim that truth has no substantial theoretical role to play. For this reason, DT faces the following immediate challenge: if truth can play no substantial theoretical role then how can we model various prevalent kinds of indeterminacy—such as the indeterminacy exhibited by vague predicates, future contingents, liar sentences, truth-teller sentences, incomplete stipulations, cases of presupposition failure, and such-like? It is too hasty to assume that these phenomena are all (...) to be modelled via some epistemic conception of indeterminacy whereby indeterminacy is just some special species of ignorance which arises because of our limited powers of discrimination. Some non-epistemic model is called for—at least for certain species of indeterminacy. On what is perhaps the most enduring and popular non-epistemic model, indeterminacy gives rise to truth-value gaps. But is DT compatible with the possibility of truth-value gaps? Compatibilism says Yes; Incompatibilism says No. The broad goal of this paper is to defend a form of Incompatibilism. If DT is to make sense of various kinds of indeterminacy then truth-value gaps cannot be invoked to do so. The particular goals of this paper are: (i) To set forth a new form of Compatibilism which can address an argument against truth-value gaps given by Williamson (1994, pp. 187-192). (ii) To offer a new argument against truth-value gaps using principles entailed by DT, thereby undermining Compatibilism. (shrink)

ABSTRACTThe Chief Ethics and Compliance Officer is an essential and important function in organizations. The CECO position is, however, a relatively new position and, as such, is not yet institutionalized as a separate function within those organizations. This article addresses what the author believes are the reasons the CECO should be independent from the General Counsel and that the position should report to the highest levels within that organization, including the Board of Directors. The questions addressed will have a lasting (...) impact on the strength and lasting viability of the CECO in organizations in future years. The author outlines seven conditions that, if met, will enhance and fortify the CECO position for the future. (shrink)

Evolutionary biology, indeed any science that attempts to reconstruct prehistory, faces practical limitations on available data. These limitations create the problem of contrast failure: specific observations may fail to discriminate between rival evolutionary hypotheses. Assessing the risk of contrast failure provides a way to evaluate testing protocols in evolutionary science. Here I will argue that part of the methodological critique in the Spandrels paper involves diagnosing contrast failure problems. I then distinguish the problem of contrast failure from the more familiar (...) philosophical problem of underdetermination, and demonstrate how contrast failure arises in scientific practice with an investigation into Lewontin and White’s estimation of an adaptive landscape. (shrink)

There is a longstanding argument that purports to show that divine foreknowledge is inconsistent with human freedom to do otherwise. Proponents of this argument, however, have for some time been met with the following reply: the argument posits what would have to be a mysterious non-causal constraint on freedom. In this paper, I argue that this objection is misguided – not because after all there can indeed be non-causal constraints on freedom (as in Pike, Fischer, and Hunt), but because the (...) success of the incompatibilist's argument does not require the real possibility of non-causal constraints on freedom. I contend that the incompatibilist's argument is best seen as showing that, given divine foreknowledge, something makes one unfree – and that this something is most plausibly identified, not with the foreknowledge itself, but with the causally deterministic factors that would have to be in place in order for there to be infallible foreknowledge in the first place. (shrink)

We present a generalization of Segerberg's onion semantics for belief revision, in which the linearity of the spheres need not occur. The resulting logic is called broccoli logic. We provide a minimal relational logic, with a bi-modal neighborhood semantics. We then show that broccoli logic is a well-known conditional logic, the Burgess-Veltman minimal conditional logic.

This paper explores the role of ethics in design. Traditionally, ethical questions have been seen as marginal issues in the design of technology. Part of the reason for this stems from the widely held notion of technology being “out of control.” This notion is a barrier to what I call “ethical design” because it implies that ethics has no role to play in the development of technology. This view, however, is challenged by recent work in the field of Science and (...) Technology Studies (STS). Looking into the dynamics of technological change, STS scholars argue that human choices are present at every stage of a technology’s development and, furthermore, that human values are reflected in the very design of artifacts. This alternative view suggests that ethics can and should be included in the design process. Drawing on examples from the privacy arena. I point to some of the potential advantages of addressing ethical concerns early on in the design of a technology. I conclude with some general strategies for bringing ethics back into design. (shrink)