Descartes understood the subject matter of physics (or natural philosophy) to encompass the whole of nature, including living things. It therefore comprised not only nonvital phenomena, including those we would now denominate as physical, chemical, minerological, magnetic, and atmospheric; it also extended to the world of plants and animals, including the human animal (with the exception of those aspects of the human mind that Descartes assigned to solely to thinking substance: pure intellect and will). Descartes wrote extensively on physiology (...) and on the physiology and psychology of the senses. This chapter examines the notions of *physiology* and *psychology* in medical and natural philosophical works of Descartes' day; follows his efforts to bring physiology into his mechanistic idiom; considers the relation between physiology of the animal machine and psychological functions that yield functionally appropriate behavior; goes into his physiology and psychology of vision; and elaborates the tension in Descartes' works between his metaphysically supported micro-corpuscularism and his discussion of the animal machine as an organic unity comprising various functionally and teleologically characterized systems. The chapter draws on Descartes' works in both metaphysics and natural philosophy, including his Treatise on Man (originally published as L'Homme, 1664). (shrink)

One of the immediate eukaryotic cellular responses to DNA breakage is the covalent post‐translational modification of nuclear proteins with poly(ADP‐ribose) from NAD+ as precursor, mostly catalysed by poly(ADP‐ribose) polymerase‐1 (PARP‐1). Recently several other polypeptides have been shown to catalyse poly(ADP‐ribose) formation. Poly(ADP‐ribosyl)ation is involved in a variety of physiological and pathophysiological phenomena. Physiological functions include its participation in DNA‐base excision repair, DNA‐damage signalling, regulation of genomic stability, and regulation of transcription and proteasomal function, supporting the previously observed (...) correlation of cellular poly(ADP‐ribosyl)ation capacity with mammalian life. The pathophysiology effects are mediated through PARP‐1 overactivity, which can cause cell suicide by NAD+ depletion. It is apparent that the latter effect underlies the pathogenesis of a wide range of disease states including type‐1 diabetes, ischaemic infarcts in various organs, and septic or haemorrhagic shock. Therefore pharmacological modulation of poly(ADP‐ribosyl)ation may prove to be an exciting option for various highly prevalent, disabling and even lethal diseases. BioEssays 23:795–806, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Chakras are a basic concept of yoga but typically are ignored by scientific research on yoga, probably because descriptions of chakras can appear like a fanciful mythology. Chakras are commonly considered to be centers of concentrated metaphysical energy. Although clear physiological effects exist for yoga practices, no explanation of how chakras influence physiological function has been broadly accepted either in the scientific community or among yoga scholars. This problem is exacerbated by the fact that yoga is based on (...) subjective experience, and practitioners often shun objective descriptions. This essay builds on earlier work hypothesizing that intercellular gap junction connections provide a physiological mechanism underlying subtle energy systems described in yoga as well as other disciplines such as acupuncture. Three physical aspects of chakras are distinguished that are integrated through gap junction mechanisms and are proposed to have arisen during embryological development. Furthermore, electrical conductance associated with a high concentration of gap junctions could generate phenomena that, when subjectively experienced, have the radiant qualities attributed to chakras. This theory provides a scientific rationale for previously unexplained details of chakra theory and offers a new orientation to conceptualizing and studying such subjective phenomena. (shrink)

The concept of a G‐quartet, a unique structural arrangement intrinsic to guanine‐rich DNA, was first introduced by Gellert and colleagues1 over 40 years ago. For decades, it has been uncertain whether the G‐quartet and the structure that it gives rise to, the G‐quadruplex, are purely in vitro phenomena. Nevertheless, the presence of signature G‐rich motifs in the eukaryotic genome, and the plethora of proteins that bind to, modify or resolve this nucleic acid structure in vitro have provided circumstantial evidence (...) for its physiological relevance. More recently, direct visualisation of G‐quadruplex DNA at native telomeres was achieved, bolstering the evidence for its existence in the cell. Furthermore, G‐quadruplex folded telomeric DNA has been found to perturb telomere function and to impede the action of telomerase, an enzyme overexpressed in >85% of human cancers, hence opening up a novel avenue for cancer therapy in the form of G‐quadruplex stabilising agents. BioEssays 29: 155–165, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Ideas 63.3 (2002) 465-481 [Access article in PDF] The Physiology of Political Economy: Vitalism and Adam Smith's Wealth of Nations Catherine Packham The Scottish Enlightenment has been described as uniting a concern with the origins and foundations of knowledge with a preoccupation with the useful application of knowledge in schemes of practical improvement. 1 Adam Smith's Inquiry into the Nature and Causes of the (...) Wealth of Nations, which combines a theoretical account of political economy with specific proposals on politico-economic matters, might seem to exemplify such a characterization. For some commentators at the time of its publication, however, Smith's lack of practical experience in the field of trade disqualified any claims he might make to authoritative knowledge. Sir John Pringle, for instance, military surgeon and friend of Smith's, thought that a man "who had never been in trade could not be expected to write well on the subject"; and while Dr. Johnson repudiated this, suggesting that all that was necessary was "extensive views," Pringle's opinion was not unusual. 2 Such objections, interrogating the very basis of Smith's expertise, reiterate, in the context of his work, the same kinds of questions regarding knowledge's provenance which preoccupied his age, and which were indeed addressed by Smith himself. Smith's own account of the formation of philosophical knowledge rests not on the authority of experience but on the role of the imagination; he understood systematic knowledge as an imaginative "machine" or work of fancy created to please and soothe a mind disturbed by phenomena which are observed but unexplained. 3 Smith's account of philosophical [End Page 465] knowledge, in which he would include his own Wealth of Nations, suggests that his own expertise should be judged not on the extent of his personal experience of the matters discussed but on the explanatory power and pleasurable nature of the system which he outlines. With its emphasis on the work of the philosophical imagination, his account also suggests that some of the sources for that system might be somewhat unexpected, a suggestion which this paper will pursue.Such questions concerning the genesis and formation of the new discourse of political economy instituted by Wealth of Nations have recurred in our own time, informing some of the more illuminating of recent work on Smith. Rejecting a tradition which assesses the significance of Wealth of Nations in terms of its anticipation of modern economic analysis, revisionist historians of political and economic thought have, since the late 1970s, offered more contextualist accounts of the work, tracing the relations between Smith's moral and economic philosophy and the contemporary discourses of natural jurisprudence and civic humanism. Other commentators have borrowed from literary scholarship to examine the textual and discursive conventions through which Smith's writings construct and sustain their meanings. 4 Such work has given a new emphasis to the textual and discursive nature of Smith's work as a means to understand its derivation, sources, and influences; it has replaced an older perception of Smith as inspired prophet-founder of the new political economy with an effort to interpret his work in the context of other, adjacent and contemporary forms of inquiry. Collectively, such work highlights the varied and disparate discourses which informed Smith's thinking on economic and other matters and seeks to understand how the complex and diverse forms of interaction with and assimilation of aspects of these philosophical and other discourses may have contributed to the formation of Smith's work—and hence, must also figure in our own attempts to read it.This paper, by exploring a strand of physiological language and imagery which runs through Wealth of Nations and considering it in the context of new developments in Scottish physiological research in the middle decades of the eighteenth century, also seeks to understand Smith's work by examining its relations with contemporary philosophical discourse. Where other recent accounts of Wealth of Nations have reassessed its relationship with moral, political and legal discourses, it will... (shrink)

Bruno Petermann in his The Gestalt Theory and the Problem of Configuration and S. H. MacColl in her A Comparative Study of the Systems of Lewin and Koffka with special reference to Memory Phenomena have shown that the gestalt concept is fundamentally valid but that as a tool of psychological explanation it has been developed with unrecognized inconsistencies and without a successful correlation with physiological facts. And John J. Ryan in his “Volition” has shown that psychology must provide (...) a place for ethical responsibility. The purpose of the present paper is to show that the gestalt concept when conceived in accord with the fundamentals of experimental psychology and of theoretical mathematics and physics: avoids unrecognized inconsistencies; opens the gates to an increasingly refined mensurational correlation between physiological facts and psychological experience; and provides a place within a comprehensive psychology for freedom and purpose, integrated with conditioning, which result in understanding and cooperation in the achievement of ideal purposes. (shrink)

In this paper, we will explore the relation between molecular structure and functions displayed by biochemical molecules in complex physiological processes by using tools from the philosophy of science and the philosophy of scientific practice. We will argue that biochemical functions are weakly emergent from molecular structure by using an account of weak. In order to explore this thesis, we will consider the role of vitamin B12 in contributing to the process of erythropoiesis. The structure of the paper is (...) the following: First, we will consider biochemical functions and why they cannot be easily reduced to their chemical realisers. We will suggest weak emergence as an alternative while also accounting for the relevance of the context, in our case, systemic and organisational. The paper will conclude by considering (1) how the usage of tools from the philosophy of science, such as weak emergence, can aid our understanding of the relations between the components of complex phenomena, such as erythropoiesis, and (2) how the philosophy of scientific practice sheds light on the explanatory role of processes that are dynamically stabilised and the different levels of organisation implied. (shrink)

In Gottfried Wilhelm Leibniz's time, micro-mechanism seemed to dominate, though not exclusively, the more innovative trend in physiology, and microscopic anatomy determined the representation of living beings. The basic postulate was that human understanding could rely on microscopic observation and account for microstructures by framing mechanical models: along that trend, hope was to attain the real causes of physiological phenomena. In his natural philosophy, Leibniz grants living beings a prominent place. His metaphysics contains arguments and notions that build (...) on physiological concepts to express the condition of finite substances and the relationship between substances in the phenomenal world. For Leibniz, at least in the later stages of his career, the account of living individuals and of their properties would provide access to a well-founded representation of corporeal substances in general. This article looks at Leibniz's views on physiology and organic bodies, focusing on his conception of living beings as "machines of nature" and his theory of monads. (shrink)

SynopsisThe response to physics and chemistry which characterized mid-nineteenth century physiology took two major directions. One, found most prominently among the German physiologists, developed explanatory models which had as their fundamental assumption the ultimate reducibility of all biological phenomena to the laws of physics and chemistry. The other, characteristic of the French school of physiology, recognized that physics and chemistry provided potent analytical tools for the exploration of physiological activities, but assumed in the construction of explanatory models that (...) the organism involved special levels of organization and that there must, in consequence, be special biological laws.The roots of this argument about concept formation in physiology are explored in the works of Theodor Schwann, Johannes Müller, François Magendie and Claude Bernard among others. (shrink)

The paper seeks to refute the idea that physiology can explain at best an organism’s behaviour, outward and inner, but not the conscious experiences that accompany that behaviour. To do so, the paper clarifies the idea by confrontation with an actual example of psychophysical explanation of perceptual experience. This reveals that the idea relies on a prejudice about physiological practice. Then the paper explores some peculiar ways in which this prejudice may survive its refutation. This is to bring out (...) that such explanations of experience as are actually offered by contemporary psychophysics explain nothing less than what they purport to explain; and that these achievements are not, in some peculiar way, more remarkable than equally clever physical explanations of other phenomena. (shrink)

It is proposed that subconscious retro-predictions in conjunction with brain state update cycles are instrumental in the physiological generation of conscious sensations and perceptions, and in all abstract thought. In this paper the hypothesis is supported by conducting a detailed a re-evaluation of the self-referential statements in Set Theory and Formal Logic known as antinomies. This study concludes that the recursive behavior exhibited by abstract enigmas such as "Russell’s Paradox" is analogous to the oscillations typical of bistable perceptual (...) class='Hi'>phenomena. (shrink)

Beginning in the mid-1930s the comparative physiologists Laurence Irving and Per Fredrik Scholander pioneered the study of diving mammals, particularly harbor seals. Although resting on earlier work dating back to the late nineteenth century, their research was distinctive in several ways. In contrast to medically oriented physiology, the approaches of Irving and Scholander were strongly influenced by natural history, zoology, ecology, and evolutionary biology. Diving mammals, they argued, shared the cardiopulmonary physiology of terrestrial mammals, but evolution had modified these basic (...) adaptive processes in extreme ways. In particular, seals’ remarkable ability to hold breath, lower metabolism, produce energy anaerobically, and resist asphyxiation, provided a sharp contrast with terrestrial mammals, including humans. This diving physiology was an extreme elaboration of a general regulatory mechanism that allowed seals and other diving mammals to remain active underwater for extended periods. The decrease in heart rate referred to as bradycardia or the “diving reflex” was highly developed in diving mammals, but also found in less developed form in many other organisms faced by asphyxia. It therefore served as a kind of “master switch” for lowering metabolism in diving, hibernation, parturition, drowning, and other physiological responses involving lack of oxygen. Studying bradycardia unified a wide diversity of physiological phenomena, while also providing a context for contrasting the physiological responses of various species, including humans. Conducted in the laboratory and the field, this research served as a bridge between a comparative physiological ecology focused on non-human species and a human-centered general physiology. (shrink)

The discovery of participation of astrocytes as active elements in glutamatergic tripartite synapses (composed by functional units of two neurons and one astrocyte) has led to the construction of models of cognitive functioning in the human brain, focusing on associative learning, sensory integration, conscious processing and memory formation/retrieval. We have modelled human cognitive functions by means of an ensemble of functional units (tripartite synapses) connected by gap junctions that link distributed astrocytes, allowing the formation of intra- and intercellular calcium waves (...) that putatively mediate large-scale cognitive information processing. The model contains a diagram of molecular mechanisms present in tripartite synapses and contributes to explain the physiological bases of cognitive functions. It can be potentially expanded to explain emotional functions and psychiatric phenomena. (shrink)

Generalized Quantum Theory seeks to explain and predict quantum-like phenomena in areas usually outside the scope of quantum physics, such as biology and psychology. It draws on fundamental theories and uses the algebraic formalism of quantum theory that is used in the study of observable physical matter such as photons, electrons, etc. In contrast to quantum theory proper, GQT is a very generalized form that does not allow for the full application of formalism. For instance neither a commutator, such (...) as Planck’s constant, nor any additive operations are defined, which precludes the usage of a full Hilbert-space formalism. But it is a formalized phenomenological theory that is applicable whenever the core element of a quantum theory needs to be captured, namely in the presence of incompatible or non-commuting operations. As a consequence, it also predicts nonlocal, generalized entanglement correlations in systems other than proper quantum systems. In this paper we summarize the specific scientific evidence relating to the quantum-like mental, behavioral and physiological nonlocal correlations. Such non-local, generalized entanglement correlations are expected, both in space and time, between subsystems of a larger system, whenever observables pertaining to the global system are incompatible or complementary to observables pertaining to subsystems, as predicted by GQT. The result is a coherent explanation of a significant amount of controversial and seemingly weird occurrences that cannot be explained by classical physical laws. This review also offers a new perspective of the human mind’s potential. (shrink)

We may now ask the question: In what historical perspective should we place the work of Richard Goldschmidt? There is no doubt that in the period 1910–1950 Goldschmidt was an important and prolific figure in the history of biology in general, and of genetics in particular. His textbook on physiological genetics, published in 1938, was an amazing compendium of ideas put forward in the previous half-century about how genes influence physiology and development. His earlier studies on the genetic and (...) geographic distribution of the various species and races of Lymantria contributed soundly to an understanding of the inheritance and development of sex, as well as the genetics of speciation. He was a curious mixture of the experimentalist, empiricist, and theorizer, who could grasp both the large and the small at once and wrap them into the same integrated and coherent package.In insisting on trying to relate genetics to development, Goldschmidt was continually forced to speculate and to forsake experimental fact for generalized theory. In refusing to reconcile a physiological and developmental conception with a corpuscular theory of the gene, he forced himself to substitute for a large body of experimentally verified evidence, vague and general speculations which did not lead in any precise direction. L. C. Dunn summarizes succinctly the effect of Goldschmidt's thinking on the development of genetic theory: Although Goldschmidt's ideas had a considerable influence in directing attention to the developmental processes intervening between genes and characters, they did not lead to the establishment of a general theory of development in genetical terms. In fact, at the end of the period, as signalized by Goldschmidt's book of 1938 [Physiological Gentics] doubt remained whether there was a field with a defined problem which could be identified as developmental genetics.Yet the frequency with which Goldschmidt is cited by later writers suggests that there is a more positive side to his contribution than this. The early Mendelians had recognized the genic constitution of organisms and the Drosophila workers had uncovered in detail the chromosomal mechanism of heredity. These great discoveries were of classical character, solidly based on a multitude of well established facts. By themselves, however, they would not have been sufficient to place genetics in the central position within biology which it was to assume. Beyond the “static” analysis of gene transmission an insight was needed into the dynamic role of genes in cellular physiology, biochemistry, and development. Goldschmidt recognized this aspect and outlined in brilliant generalizations a physiological theory of genetics. Necessarily the prophetic nature of this achievement — romantic in the sense of Ostwald's classification of great scientists and their discoveries — transcended its factual basis. It was the audacity of the theoretician unimpeded by the still scanty data which gave a new focus to biological thought.Some have called Goldschmidt an “obstructionist” in the history of genetics—one whose efforts were largely directed toward useless and continual criticism — challenge for the sake of challenge. As this line of argument goes, time wasted answering Goldschmidt's poorly conceived criticisms could have been better used to pursue new lines of thought within the classical gene theory. Sometimes historians are upbraided for studying the work of such “obstructionists,” or even the work of those whose ideas have later proved to be inadequate. This argument misses the point of history and the lessons which it can teach. Perhaps Goldschmidt did take the time of a number of the classical geneticists who tried to answer his objections to the gene theory; and perhaps many of his own ideas about genes were, by today's view, “wrong.” These are always easier judgments to make by hindsight than at the moment. But that is not the point. Goldschmidt had a considerable influence on his contemporaries, and to dismiss him as an obstructionist because his opponents later proved to be more nearly right, distorts history and obscures significant questions which we might well be asking. It might be valuable to know why Goldschmidt felt compelled to be an iconoclast —and how that impulse, psychological in orgin, led him to overlook critical items of evidence which his opponents considered more carefully. It might also be valuable to try and understand how a contemporary of Goldschmidt or. Morgan really viewed the gene theory — what were its strong and weak point? Such questions are not readily answered by studying the work of only those men who were correct by later standards.Answers to some of the above questions can be gleaned from this study of Goldschmidt — though the first, and most psychologically oriented, question is largely untouched here.On the one hand, Goldschmidt forced classical geneticists to reexamine the foundation of their ideas about the nature, inviolability, and even physical dimensions of genes. He also kept alive the very real problems of gene physiology and its relations to development — a relationship that was given less attention by the Drosophila school in their pursuit of the transmission process. On a broader level he emphasized to the biological community a principle that was in danger of being lost in the enthusiasm surrounding the expansion of the Mendelian-chromosome theory. The point was that all theories in science are transient, logical constructs which should not be held as sacred. Time and again, as the history of science has shown, theories become rigid structures which retard new modes of thought. From Goldschmidt's perspective, the gene theory was in danger of performing just that function, for it was preventing workers from viewing the gene in a functional as well as a structural light.On the other hand, examining the work of critics (or even of outright “obstructionists”) gives the historian an opportunity to observe how the more established community of scholars at some point in time reacts to challenges of its cherished ideas. The fact that many workers in his own day (such as Beadle, Luria, Delbruck, Sturtevant, Bridges, and others), as well as most geneticists today, saw Goldschmidt as having been largely “obstructionist” is useful historical (and/or sociological) data. Clearly, as this paper has tried to show, Goldschmidt's ideas were not all obstructionist, and his viewpoint that genes must be considered functionally was one which was clearly valid, premature as it may have been from an experimental and technique point of view. Perhaps Goldschmidt's major fault was that he developed alternative theories which were not easily testable. Nonetheless, his challenge to a fundamental and established idea brought forth a reaction from many members of the genetic community which indicates how unwilling they were to reconsider the formalized theory on which their work was based. While many of Goldschmidt's criticisms — and particularly his way of making them — arose out of his own idiosyncrasies, they were also a product of his times. His view of the nature of theory-construction, and his rejection of old-style reductionism and mechanism, were part of a growing awareness within the world scientific community that explanations based on reducing complex phenomena to ultimate particles or units were clearly inadequate. The success of the Mendelian-chromosome theory had obscured that fact for many geneticists, but to Goldschmidt it was a point that could not be allowed to pass unnoticed. (shrink)

This paper highlights the significance of sensory studies and psychophysical investigations of the relations between psychic and physical phenomena for our understanding of the development of the physics discipline, by examining aspects of research on sense perception, physiology, esthetics, and psychology in the work of Gustav Theodor Fechner, Hermann von Helmholtz, Wilhelm Wundt, and Ernst Mach between 1860 and 1871. It complements previous approaches oriented around research on vision, Fechner’s psychophysics, or the founding of experimental psychology, by charting Mach’s (...) engagement with psychophysical experiments in particular. Examining Mach’s study of the senses and esthetics, his changing attitudes toward the mechanical worldview and atomism, and his articulation of comparative understandings of sensual, geometrical, and physical spaces helps set Mach’s emerging epistemological views in the context of his teaching and research. Mach complemented an analytic strategy focused on parallel psychic and physical dimensions of sensation, with a synthetic comparative approach – building analogies between the retina, the individual, and social life, and moving between abstract and sensual spaces. An examination of the broadly based critique that Mach articulated in his 1871 lecture on the conservation of work shows how his historical approach helped Mach cast what he now saw as a narrowly limiting emphasis on mechanics as a phase yet to be overcome. (shrink)

I argue that Descartes explains physiology in terms of whole systems, and not in terms of the size, shape and motion of tiny corpuscles (corpuscular mechanics). It is a standard, entrenched view that Descartes’ proper means of explanation in the natural world is through strict reduction to corpuscular mechanics. This view is bolstered by a handful of corpuscular–mechanical explanations in Descartes’ physics, which have been taken to be representative of his treatment of all natural phenomena. However, Descartes’ explanations of (...) the ‘principal parts’ of physiology do not follow the corpuscular–mechanical pattern. Des Chene has identified systems in Descartes’ account of physiology, but takes them ultimately to reduce down to the corpuscle level. I argue that they do not. Rather, Descartes maintains entire systems, with components selected from multiple levels of organization, in order to construct more complete explanations than corpuscular mechanics alone would allow. (shrink)

While genomic and proteomic information describe the overall cellular machinery available to an organism, the metabolic profile of an individual at a given time provides a canvas as to the current physiological state. Concentration levels of relevant metabolites vary under different conditions, in particular, in the presence or absence of different disorders. Metabolite concentrations thus mediate an important link between chemistry and biology, contributing to a systems-wide understanding of biological processes and pathways. However, there are a number of challenges (...) in the ontological representation of such information. Firstly, concentration information is numeric and ranges over continuous values, while ontologies consist of discrete classes. Secondly, ontologies usually model only what is certain, and their logical formalisms are adapted to reasoning from certain axioms to logical deductions, however, the link between chemicals and diseases via concentration levels, like many threshold phenomena, is both uncertain and vague. In this paper we evaluate the representation of this knowledge using a combination of concrete domains and probabilistic reasoning. We parse concentration values from HMDB and create an ontology able to distinguish normal from abnormal concentrations and able to evaluate a probabilistic risk category for the presence of an associated disorder. (shrink)

The first part of this paper highlights some key aspects of the differences in the use of mathematical tools in physics and in biology. Scientific knowledge is viewed as a network of interactions, some than as a hierarchically organized structure where mathematics would display the essence of phenomena. The concept of "unity" in the biological phenomenon is then discussed. In the second part, a foundational issue in mathematics is revisited, following recent perspective in the physiology of action. The relevance (...) of the historical formation of mathematical concepts is stressed in several parts. (shrink)

Designing models of complex phenomena is a difficult task in engineering that can be tackled by composing a number of partial models to produce a global model of the phenomena. We propose to embed the partial models in software agents and to implement their composition as a cooperative negotiation between the agents. The resulting multiagent system provides a global model of a phenomenon. We applied this approach in modelling two complex physiological processes: the heart rate regulation and (...) the glucose-insulin metabolism. Beyond the effectiveness demonstrated in these two applications, the idea of using models associated to software agents to give reason of complex phenomena is in accordance with current tendencies in epistemology, where it is evident an increasing use of computational models for scientific explanation and analysis. Therefore, our approach has not only a practical, but also a theoretical significance: agents embedding models are a technology suitable both to representing and to investigating reality. (shrink)

At various points in his work on physiology and medicine, Descartes refers to a “principle of life.” The exact term changes—sometimes, it is the “principle of movement and life”, sometimes the “principle underlying all [the] functions” of the body —but the message seems consistent: the phenomena of living bodies are the product of a single, underlying principle. That principle is generally taken to be cardiac heat.1 The literature has, quite reasonably, taken this message at face value. Thus, Shapiro: “Descartes (...) insists again and again that the human body is properly to be described as a machine whose workings are […] driven by the heat in the heart that... (shrink)

This dissertation seeks to substantiate the thesis that Nietzsche's physiological thinking constitutes a radicalisation of Kantian critique. To this end it attempts to mark out some of the salient points of the latter project and to examine the ways in which it falls short of its own potential radicality. In chapters one and two the categories of relation - in which Kant articulates his theory of the temporal connection of phenomena explicitly - are traced through the Analytic and (...) Dialectic of the Critique of Pure Reason and are read against the Deduction of the Pure Concepts of the Understanding which implicitly contains another theory of time. Since the Critique of the Teleological Faculty of Judgement complements Kant's theory of the temporal cohesion of phenomena, the third chapter offers a reading of it under the aspect of its relation to the wider project of critique. Chapter four draws together the multiple strands around which Kantian critique can be shown to mutate into Nietzsche's philosophical physiology and the theory of temporality implicit in it. Finally, Nietzschean physiology is presented in terms of his thinking of the becoming of matter, in terms of the will to power as eternal recurrence. (shrink)

The issue of materialism has recently been raised again. Mr. Putnam argues against philosophical behaviorism [4]. Such a position holds, as he construes it, that statements like ‘Jones is angry’ can be analyzed in solely behavioral terms. When one argues against philosophical behaviorism, he might be expected to distinguish this metaphysical position from behavior science. Putnam, however, does not make the distinction. Consequently he argues against both. I shall first state the distinction between these two different things, namely, philosophical behaviorism (...) and behavior science, as I see it. The behavior scientist adopts the thesis that in principle it is possible to predict future behavior on the basis of data concerning environmental, behavioral, and physiological variables. All three of these he considers in physical terms. The behavior scientist thus speaks about physical objects and properties of such. Talking in such terms, he believes that it is in principle possible to coordinate to statements asserting that person X has or is in state of mind Y another statement, employing only the above mentioned physical terms, such that either both are true or both are false. The reasons for the behavior scientist's program are the well known quandaries involved in the observation of other people's minds and the need for intersubjective verification in science. One can further distinguish between a narrower and a broader view of behavior science. The former restricts itself to environmental and behavioral variables at what some call the macro level; the latter includes, or even concentrates upon, physiological variables. As scientists neither the behaviorist nor the physiologist asks or answers philosophical questions, either epistemological or ontological, about minds, bodies, and mental contents. (shrink)

Biological organisms appear to have agency, goals, and meaningful behaviour. One possibility is that this is mere appearance, where such properties are not real, but only ‘as if’ consequences of the physiological structure of organisms. Another possibility is that these properties are real, as emerging from the organism's structure and from how the organism interacts with its environment. Here I will discuss a recent theory showing that the latter position is most likely correct, and argue that the theory is (...) largely consistent with the basics of the field of biosemiotics. The theory can be represented as a triad that resembles the semiotic triad proposed by Peirce, which connects a sign with its object through a process of interpretation. In the theory presented, the sign is an internalized version of fitness which refers to the true fitness through a feedback loop that in effect produces interpretation. The feedback loop entangles deterministic and stochastic forms of causation in such a way that genuine agency, goal-directedness, and their associated meaning emerge. It produces a strong form of emergence not reducible to its constituents. The result is that novel phenomena arise that are real and necessary components for a complete understanding of living organisms. (shrink)

1. The restless mind[1] Like us, early modern philosophers, both natural and moral, didn’t always understand the springs of their own actions. They didn’t want to feel everything they felt, and couldn’t trace the sources of all their thoughts and imaginings. Events from past experience come to mind again unwilled: abstract thought is interrupted by fantastical images, like the ‘winged horses, fiery dragons, and monstrous giants’ by which Hume exemplified ‘the liberty of the imagination’[2]. Then, as now, a failure to (...) keep a train of thought on track could be blamed for both personal and social ills, for wasted lives and erratic policies. The ongoing struggle to distinguish the deliverances of reason from what Hume called ‘the loose and indolent reveries of a castle-builder’ (1739/ 1978, p.624) thus required scrutiny of daydream and fancy as much as belief and knowledge (see also Tierney- Hynes 2007 on the ‘castle-builder’). The mind’s tendencies to float and to roam were of great interest to early modern philosophers as well as to others concerned with medicine, mental health, morals, education, and taste. This paper sketches one local line of thinking and theorizing about ‘mind-wandering’ and its bodily causes in British philosophy over the first decades of the 18th century, as a small exemplar of a form of cognitive history intended to illuminate independent historical and contemporary concerns about our understanding of mental life. The dual aim is to see problems in our historical material that we might otherwise miss, and to use history to explore phenomena more or less marginalized by modern psychology[3]. (shrink)

. G. W. Leibniz did not contribute directly to scientific discoveries in the life sciences, but he provided several relevant analyses on methods of investigation applicable to complex, and in particular organic, phenomena. Leibniz's theory of organic bodies and his methodological model had deep and broad implications for the development of physiology at the turn of the seventeenth and eighteenth centuries. This paper focuses on a methodological issue which divided natural philosophers and physiologists during the early Enlightenment—about which Leibniz (...) supported original viewpoints which have kept a certain relevance, mutatis mutandis, in later contexts. The issue in question concerns the relation between the surface organization of phenomena and the deeper organization of underlying micro-structures and micro-processes. In a search for the sufficient reason for phenomena, hypothetical models are called upon to provide determining reasons for surface effects. These reasons represent processes involving micro-mechanisms combined so as to account for the emerging organization. (shrink)

The quantum-like approach of psychosomatic phenomena suggests an explanation of the correlations between mind and body in terms of quantum-like entanglement, that is, without appealing to any concept of psychophysical, efficient causality. This approach is developed within the Hilbert space formalism and its general consequences are drawn. It is first illustrated by a simple, qualitative model of the placebo effect which shows that representing psychosomatic states by entangled states can explain that purely psychological factors can produce a-causal changes of (...) physiological parameters. Then, a dynamical, quantitative and predictive model of bipolar disorder which makes use of the unitarity of the temporal evolution of psychosomatic states due to biological and psychological rhythms is worked out. This model can explain some current observations, like for example the severe fluctuations in mood between depression and mania, and it can forecast the moment of shifting. In addition, it justifies the efficiency of chronotherapy on theoretical basis. (shrink)

One of the aims of this book is to bring contemporary research in the neurological and physiological sciences into relationship with discussions in the philosophy of mind. The author does not deny the significance of ordinary talk about the mind, including talk about actions, intentions, beliefs and the like, but he wants to see how this language is compatible with evolutionary and neurophysiological accounts of man. He frequently refers to and accepts Charles Taylor's arguments that "peripheralist" or S-R behavioral (...) theories fail to account for the intentionality of mental states and the teleology of behavior. In fact, one way of reading this book is to see it as an attempt to answer a question raised by Taylor's book: If "peripheralist" theories of behavior cannot account for intentionality and teleology, can a "centralist" or neurophysiological theory of man account for these characteristics? The key chapters of the book attempt to answer this question in the affirmative. The author thinks of the intentionalist characterization of the physical structures of behavior as a "heuristic overlay" on the extensional account of functioning. But the two descriptions, intentional and extensional, are linked together by a series of hypotheses describing the evolutionary source of the functioning. The important problem is to explain how conceptual content or information gets into the neurophysiological picture. The author attempts to deal with this as well as with other problems about the nature of mind including introspection, consciousness, imagery, reasoning, intention, action and language. His discussion of the neurophysiological background for his speculations is purposely general in order to free his conclusions from specific empirical hypotheses about the nervous system which may turn out to be false. This purposeful limitation makes his argument less convincing in some places than it might have been. But he is asking important questions and offering answers to them which deserve careful consideration.--R. H. K. (shrink)

Where Medicine Went Wrong explores how the idea of an average value has been misapplied to medical phenomena, distorted understanding and lead to flawed medical ...

What, in essence, characterizes the mind? According to Searle, the potential to be conscious provides the only definitive criterion. Thus, conscious states are unquestionably "mental"; "shallow unconscious" states are also "mental" by virtue of their capacity to be conscious (at least in principle); but there are no "deep unconscious mental states" - i.e. those rules and procedures without access to consciousness, inferred by cognitive science to characterize the operations of the unconscious mind are not mental at all. Indeed, according to (...) Searle, they have no ontological status - they are simply ways of describing some interesting facets of purely physiological phenomena. (shrink)

Most scholars who presently deal with the Mind-Body problem consider themselves monist materialists. Nevertheless, many of them also assume that there exist (in some sense of existence) mental entities. But since these two positions do not harmonize quite well, the literature is full of discussions about how to reconcile the positions. In this paper, I will defend a materialist theory that avoids all these problems by completely rejecting the existence of mental entities. This is Quine's repudiation theory. According to the (...) theory, there are no mental entities, and the behavioral or physiological phenomena that have been attributed to mental entities, or that point to the existence of these entities, are exclusively caused by physiological factors. To be sure, several objections have been raised to materialist theories that do not assign some role to mental entities. But we will see that Quine is able to give convincing replies to these objections. (shrink)

While there is a great deal to agree with in the essay Expanded Terminal Sedation in End-of-Life Care there is, we think, a need to more fully appreciate the humanistic side of both palliative and end-of-life care.1 Not only does the underlying philosophy of palliative care arguably differ from that which guides curative medicine,2 dying patients are in a uniquely vulnerable position given our cultural disinclination towards open discussions of death and dying. In this brief response, we critically engage Gilbertson (...) et al ’s essay and seek to contextualise the perspective they put forward. According to Cassell, we should distinguish between pain and suffering.3 The former often gives rise to the latter, but suffering has other causes. This includes existential distress, indicating that, unlike pain, suffering is not simply physiological phenomena. Suffering involves the disintegration of the person, meaning that it can impact patient autonomy. Certainly, that a patient is suffering does not equate to a lack autonomy. Nevertheless, we should take care when making decisions in circumstance where the integrity of our embodied personhood is under threat, something that is clearly the case for those who are dying, particularly those who have refractory symptoms while doing so. Generally speaking, refractory symptoms are those which are intractable. They persist despite attempts at palliation. While this implies that such symptoms—and the suffering they cause—cannot be reversed this is not necessarily the case. Not only can the symptoms experienced by dying patients change …. (shrink)

One way of studying emotions which is sensitive to cultural differences is to analyze the vocabularies people use to describe their own and other’s emotions, which can be called the local emotionology. Wittgenstein’s concepts of language game and family resemblance can be used in this project. The result of research in this mode is a three-factor account of emotions, involving bodily perturbations, judgments of meanings, and the social force of emotion displays. This treatment of a psychological phenomenon is typical of (...) recent conceptions of psychology as a hybrid science, linking cognitive, cultural, and physiological phenomena. It can be seen as a further development of the cognitive account of emotions that has appeared in the last century. (shrink)

Anthropologists and linguists have long been aware that the body is explicitly referred to in conventional description of emotion in languages around the world. There is abundant linguistic data showing expression of emotions in terms of their imagined ‘locus’ in the physical body. The most important methodological issue in the study of emotions is language, for the ways people talk give us access to ‘folk descriptions’ of the emotions. ‘Technical terminology’, whether based on English or otherwise, is not excluded from (...) this ‘folk’ status. It may appear to be safely ‘scientific’ and thus culturally neutral, but in fact it is not: technical English is a variety of English and reflects, to some extent, culture-specific ways of thinking (and categorising) associated with the English language. People — as researchers studying other people, or as people in real-life social association — cannot directly access the emotional experience of others, and language is the usual mode of ‘packaging’ one’s experience so it may be accessible to others. Careful description of linguistic data from as broad as possible a cross-linguistic base is thus an important part of emotion research. All people experience biological events and processes associated with certain thoughts (or, as psychologists say, ‘appraisals’), but there is more to ‘emotion’ than just these physiological phenomena. Speakers of some languages talk about their emotional experiences as if they are located in some internal organ such as ‘the liver’, yet they cannot localise feeling in this physical organ. This phenomenon needs to be understood better, and one of the problems is finding a method of comparison that allows us to compare descriptions from different languages which show apparently great formal and semantic variation. Some simple concepts including feel and body are universal or near-universal, and as such are good candidates for terms of description which may help to eradicate confusion and exoticism from cross-linguistic comparison and semantic typology. Semantic analysis reveals great variation in concepts of emotion across languages and cultures — but such analysis requires a sound and well-founded methodology. While leaving room for different approaches to the task, we suggest that such a methodology can be based on empirically established linguistic universal (or near-universal) concepts, and on ‘cognitive scenarios’ articulated in terms of these concepts. Also, we warn against the danger of exoticism involved in taking all body part references ‘literally’. Above all, we argue that what is needed is a combination of empirical cross-linguistic investigations and a theoretical and methodological awareness, recognising the impossibility of exploring other people’s emotions without keeping language in focus: both as an object and as a tool of study. (shrink)

Following the general program, outlined in a previous paper on the Foundations of Mathematical Biophysics, we shall outline some physico-mathematical aspects of the Gestalt-problem. Faithful to the principles laid down before, we shall not attempt to give a theory of such and such psycho-physiological phenomena connected with our problem, but we shall investigate in a preliminary way the abstract conceptual basis, which must underlie the construction of any concrete theory. To make our aim quite clear and to avoid (...) at the same time unnecessary repetition, we refer the reader to our previous paper. Furthermore we shall give here only an outline of the physico-mathematical aspects; and of necessity we must leave a number of details untouched and unanswered. (shrink)

Anthropologists and linguists have long been aware that the body is explicitly referred to in conventional description of emotion in languages around the world. There is abundant linguistic data showing expression of emotions in terms of their imagined ¿locus¿ in the physical body. The most important methodological issue in the study of emotions is language, for the ways people talk give us access to ¿folk descriptions¿ of the emotions. ¿Technical terminology¿, whether based on English or otherwise, is not excluded from (...) this ¿folk¿ status. It may appear to be safely ¿scientific¿ and thus culturally neutral, but in fact it is not: technical English is a variety of English and reflects, to some extent, culture-specific ways of thinking (and categorising) associated with the English language. People ¿ as researchers studying other people, or as people in real-life social association ¿ cannot directly access the emotional experience of others, and language is the usual mode of ¿packaging¿ one¿s experience so it may be accessible to others. Careful description of linguistic data from as broad as possible a cross-linguistic base is thus an important part of emotion research. All people experience biological events and processes associated with certain thoughts (or, as psychologists say, ¿appraisals¿), but there is more to ¿emotion¿ than just these physiological phenomena. Speakers of some languages talk about their emotional experiences as if they are located in some internal organ such as ¿the liver¿, yet they cannot localise feeling in this physical organ. This phenomenon needs to be understood better, and one of the problems is finding a method of comparison that allows us to compare descriptions from different languages which show apparently great formal and semantic variation. Some simple concepts including feel and body are universal or near-universal, and as such are good candidates for terms of description which may help to eradicate confusion and exoticism from cross-linguistic comparison and semantic typology. Semantic analysis reveals great variation in concepts of emotion across languages and cultures ¿ but such analysis requires a sound and well-founded methodology. While leaving room for different approaches to the task, we suggest that such a methodology can be based on empirically established linguistic universal (or near-universal) concepts, and on ¿cognitive scenarios¿ articulated in terms of these concepts. Also, we warn against the danger of exoticism involved in taking all body part references ¿literally¿. Above all, we argue that what is needed is a combination of empirical cross-linguistic investigations and a theoretical and methodological awareness, recognising the impossibility of exploring other people¿s emotions without keeping language in focus: both as an object and as a tool of study. (shrink)

The fact that monstrous births were not represented in independent learned publications of the eighteenth century, except for the case of hermaphrodites, does not mean that the interest in them had disappeared or that they were no more considered proper objects of inquiry. This paper focuses on the medical understanding of monstrosity at the Royal Society of London. I point to the use of monstrous births in strengthening the authority of medical practitioners and lecturers. I also show some of their (...) uses in providing new questions for the scenes of medical inquiry of the period and as crucial evidence in the understanding of regular physiological phenomena. I discuss some of the reasons why monstrous formations continued to defy an 'Enlightenment' approach to nature based on the search for order and regularity. (shrink)

Long‐term potentiation and long‐term depression are thought to be cellular mechanisms contributing to learning and memory. Although the physiological phenomena have been well characterized, little consensus of their underlying molecular mechanisms has emerged. One reason for this may be the under‐appreciated complexity of the signaling pathways that can arise if key signaling molecules are discretely localized within the synapse. Recent findings suggest an unanticipated degree of structural organization at the synapse, and improved methods in cellular imaging of living (...) tissue have provided much‐needed information about the intracellular dynamics of Ca2+, thought to be critical for both LTP and LTD. In this review, we briefly summarize some of these developments, and show that a more complete understanding of cellular signaling depends on the successful integration of traditional biochemistry and molecular biology with the spatial and temporal details of synaptic ultrastructure. Biophysically realistic computer simulations can have an important role in bridging these disciplines. BioEssays 24:1130–1144, 2002. © 2002 Wiley‐Periodicals, Inc. (shrink)

Different approaches have been proposed in order to achieve knowledge integration for coronary care monitoring applications, usually in the form of expert systems. The clinical impact of these expert systems, which are based only on "shallow" knowledge, has not been remarkable due to the difficulties associated with the construction and maintenance of a complete knowledge base. Model-based systems represent an alternative to these problems because they allow efficient integration of the "deep" knowledge on the underlying physiological phenomena being (...) monitored. In this work, a brief review of existing model-based systems for cardiac rhythm interpretation is presented, followed by the description of a new system forCardiac Arrhythmia Recognition by Model-Based ECG Matching (CARMEM). Fundamental characteristics of CARMEM are presented; in particular, its ability to provide on-line parameter adaptation to simulate complex rhythms and to match observed ECG signals. The proposed model can be useful for the explanation of the origin of cardiac arrhythmias and contribute towards their robust characterization in the context of coronary care units. (shrink)

Purpose. The purpose is to prove the synchronicity of anthropogenesis, noogenesis and sociogenesis based on emotions, which are their self-organizational principles, as well as to reveal the synergistic essence of these processes. Theoretical basis. The study is based on the self-organizational paradigm, the theory of autopoiesis, labour theory, pananthropological concept, as well as on the concept of synergy of biological and mental phenomena. Originality. The concept of synchronicity of anthropogenesis, noogenesis and sociogenesis based on the emotions is substantiated. The (...) concept of self-organizational emergence of emotions on the basis of hormones is developed. It is established that anthropogenesis is a process of anthropologisation of life based on biochemical reactions in the form of hormones and emotions, which are a synergy of genetic information, biochemical processes, instincts, and physiological phenomena. It was outlined that noogenesis has an emotional dimension, because emotions are the basis for self-organization of rationality, which begins at the level of emotional consciousness. The author shows the specifics of sociogenesis, which self-organizes based on social emotions, which in their turn "distinguish" a man from the sphere of natural existence based on the ability to control emotions. Conclusions. Emotions arise self-organizationally on the basis of hormones. They are self-organizational factors of anthropogenesis, noogenesis and sociogenesis based on the synergistic effect that arises through the combination of emotions and hormones at the biochemical level. The basic principle of anthropology is emotions that synchronize anthropogenesis, noogenesis and sociogenesis, which manifests themselves on the physical, mental, and spiritual levels. At the bodily level, emotions are expressed as biochemical and hormonal reactions. At the spiritual level emotions create the basis for the development of the mind, which originates as emotional consciousness. Emotions self-organize the process of anthropologisation of life, which is possible based on the synergy of human genome, biochemical, physiological phenomena and instincts. The concepts of synchronicity of anthropogenesis, noogenesis and sociogenesis and self-organizational emergence of emotions based on hormones initiate a promising direction of further research of the role of emotions in the processes of self-organization of social phenomena. (shrink)

Spiritualist mediums are sought out from a variety of cultures for their advanced spirit communication healing techniques. Otherworldly spirits use mediums to create spirit art, which guides an individual to discover their authentic self and work through self‐limiting beliefs. To serve as a bridge for the spirit world, the medium develops an ability to enter an altered state of consciousness and use a multisensory embodied language to communicate with spirits. I describe this language as “dancing with spirits.” To investigate this (...) language, I use my own spirit art as an innovative experiential ethnographic tool that blends auto‐ethnographic perceptions of spirits with sensory and artistic ethnography, and cultural healing techniques. I provide three case studies of how my spirit art provides unique insights into the less explored experiential dimensions of spirit communication. I layer my experimental ethnographic approach with Deleuze and Guattari's “rhizome” to show that spirit communication overcomes limitations of normal linguistic models. The spirit language serves as a rupture for unconscious forces to offer individually tailored healing and insight to a recipient through heightened sensory and physiological phenomena. Art, altered states of consciousness, and anomalous sensory experiences may offer insights to address a pressing global challenge, mental ill‐health. (shrink)

One of the most surprising features of the final part of the fourth book of the De rerum natura is the peculiar way Lucretius introduces the topic he intends to examine at length. We approach the extensive treatment of love from merely physiological phenomena. The terms libido and amor are mentioned for the first time at 1045 and 1046 respectively; I would like to focus on the interpretation of those lines and on the meaning of the clausula dira (...) libido in the context of the final section of Book Four. Lucretius is talking of semen: quod simul atque suis eiectum sedibus exit, per membra atque artus decedit corpore toto, in loca conveniens nervorum certa cietque continuo partis genitalis corporis ipsas. irritata tument loca semine fitque voluntas 1045 eicere id quo se contendit dira libido, idque petit corpus mens unde est saucia amore. (shrink)

Introductory essay: the privacy of physiological phenomena, by H. Morick.--Meditations I, II, and VI, by R. Descartes.--Descartes' myth, by G. Ryle.--I think, therefore I am, by A. J. Ayer.--Of personal identity, by D. Hume.--Hume on personal identity, by T. Penelhum.--Paralogisms of pure reason, by I. Kant.--Self, mind, and body, by P. F. Strawson.--Soul, by P. F. Strawson.--The distinction between mental and physical phenomena, by F. Brentano.--Brentano on descriptive psychology and the intentional, by R. Chisholm.--Note on the text, (...) by R. Rhees.--Notes for lectures on "Private experience" and "Sense data," by L. Wittgenstein.--Consciousness and self, by J.-P. Sartre.--Self knowledge, by G. Ryle.--Wittgenstein's philosophical investigations, by N. Malcolm.--Is consciousness a brain process? By U. T. Place.--Persons, by P. F. Strawson.--Further readings (p. 309-311). (shrink)

Due to the wide array of phenomena that are of interest to them, psychologists offer highly diverse and heterogeneous types of explanations. Initially, this suggests that the question "What is psychological explanation?" has no single answer. To provide appreciation of this diversity, we begin by noting some of the more common types of explanations that psychologists provide, with particular focus on classical examples of explanations advanced in three different areas of psychology: psychophysics, physiological psychology, and information-processing psychology. To (...) analyze what is involved in these types of explanations, we consider the ways in which law-like representations of regularities and representations of mechanisms factor in psychological explanations. This consideration directs us to certain fundamental questions, e.g., "To what extent are laws necessary for psychological explanations?" and "What do psychologists have in mind when they appeal to mechanisms in explanation?" In answering such questions, it appears that laws do play important roles in psychological explanations, although most explanations in psychology appeal to accounts of mechanisms. Consequently, we provide a unifying account of what psychological explanation is. (shrink)

The aim of this paper is to propose a systematic classification of emotions which can also characterize their nature. The first challenge we address is the submission of clear criteria for a theory of emotions that determine which mental phenomena are emotions and which are not. We suggest that emotions as a subclass of mental states are determined by their functional roles. The second and main challenge is the presentation of a classification and theory of emotions that can account (...) for all existing varieties. We argue that we must classify emotions according to four developmental stages: 1. pre-emotions as unfocussed expressive emotion states, 2. basic emotions, 3. primary cognitive emotions, and 4. secondary cognitive emotions. We suggest four types of basic emotions (fear, anger, joy and sadness) which are systematically differentiated into a diversity of more complex emotions during emotional development. The classification distinguishes between basic and non-basic emotions and our multi-factorial account considers cognitive, experiential, physiological and behavioral parameters as relevant for constituting an emotion. However, each emotion type is constituted by a typical pattern according to which some features may be more significant than others. Emotions differ strongly where these patterns of features are concerned, while their essential functional roles are the same. We argue that emotions form a unified ontological category that is coherent and can be well defined by their characteristic functional roles. Our account of emotions is supported by data from developmental psychology, neurobiology, evolutionary biology and sociology. (shrink)

This chapter examines the relations between psychology and neuroscience. There is a strong philosophical intuition that direct study of the brain can and will constrain the development of psychological theory. When this intuition is tested against case studies from the psychology of perception and memory, it turns out that psychology has led the way toward knowledge of neurophysiology. The chapter presents an abstract argument to show that psychology can and must lead the way in neuroscientific study of mental function. The (...) opposing intuition is based on mainly weak arguments about the fundamentality or objectivity of physics or physiology in relation to psychology. The chapter argues that psychological phenomena are methodologically prior to neurophysiological concepts and descriptions, that psychology provides the functional descriptions that guide the behavioral brain sciences, that psychological concepts are not reducible, but that neurophysiological data and concepts are nonetheless evidentially and explanatorily relevant for psychology. (shrink)