Recoverin is a 23 kDa Ca2+binding protein that has been detected primarily in vertebrate photoreceptors. The role of recoverin in phototransduction has been investigated using a variety of biochemical methods. Initial reports suggesting that recoverin regulates photoreceptor guanylyl cyclase have not been confirmed. Instead, recoverin appears to determine the lifetime of lightstimulated phosphodiesterase activity, perhaps by regulating rhodopsin phosphorylation. Retinal recoverin is heterogeneously fatty acylated at its ammo-terminus. The amino-terminal fatty acid appears to be involved in the interaction of recoverin (...) with photoreceptor membranes. (shrink)

Recoverin is a Ca2+-binding protein found primarily in vertebrate photoreceptors. The proposed physiological function of recoverin is based on the finding that recoverin inhibits light-stimulated phosphorylation of rhodopsin. Recoverin interacts with rod outer segment membranes in a Ca2+-dependent manner. This interaction requires N-terminal acylation of recoverin. Four types of fatty acids have been detected on the N-terminus of recoverin, but the functional significance of this heterogeneous acylation is not yet clear.

Our intention in this brief article is to explore the idea of what it means to be a 'good' manager. We discuss some of the dilemmas faced by managers seeking to define their role performance in terms additional to those of organizational effectiveness and efficiency. To do this, we describe critical aspects of the contemporary context. We propose that the changes we are experiencing give organiza tions a central role in how people define their personal and social well-being. Our contention (...) is that in this central role organizations will be faced with situations requiring solutions of fundamental value conflicts. This means that the nature of the question as to what it means to be a 'good' manager will become both increasingly important and increasingly complex. Further, the exploration of the issue can no longer be limited to operational efficiency, but must include the manager's capacity to conceptualise both his own role and that of the organization within the broader socio-environmental context. We contribute to the dialogue by proposing that being 'good' will involve on the part of the manager an awareness of the values involved in a decision and an alignment of action with what Erich Fromm has called 'life-giving' values. This approach in no way diminishes the requirement that a manager be competent in the fullest sense of the word; it requires, however, a deeper understanding of competence and of the commitment a manager will need to act justly, fairly and with care. (shrink)

This article develops how wider understandings of time may help inform managers’ communication decisions. Using Peter F. Drucker as an initial touchstone—but going much deeper—the article employs an applied liberal arts methodology to establish a time-minded attitude toward communication. Applying perspectives from both classical philosophy (specifically Plato and Aristotle) as well as twentieth century rhetoricians (specifically Richard Weaver, James Kinneavy, and Walter Beale), this article celebrates both physical and metaphysical structures of reality. To this end, it proposes a theoretical (...) equation to help calibrate communication management under a more holistic banner. The equation acknowledges the typical appropriateness of occasion-directed communication (kairos); however, it also distinctively acknowledges the grand fabric of temporal reality (chronos). The output of this equation can be understood as the “chronos principle.” The article concludes that a more complete understanding of time-mindedness can elevate empathy, foster respect, and assist social relationality within any given organization’s communication culture. (shrink)

Former Google advertising strategist, now Oxford-trained philosopher James Williams launches a plea to society and to the tech industry to help ensure that the technology we all carry with us every day does not distract us from pursuing our true goals in life. As information becomes ever more plentiful, the resource that is becoming more scarce is our attention. In this 'attention economy', we need to recognise the fundamental impacts of our new information environment on our lives in order (...) to take back control. Drawing on insights ranging from Diogenes to contemporary tech leaders, Williams's thoughtful and impassioned analysis is sure to provoke discussion and debate. Williams is the inaugural winner of the Nine Dots Prize, a new Prize for creative thinking that tackles contemporary social issues. This title is also available as Open Access. (shrink)

This is the first critical study of The Logic of Sense, Gilles Deleuze's most important work on language and ethics, as well as the main source of his vital philosophy of the event.James Williams explains the originality of Deleuze's work with careful definitions of all his innovative terms and a detailed description of the complex structure he constructs. This reading makes connections to his ground-breaking work on literature, to his critical but also progressive relation to the sciences, and to (...) his controversial denial of the priority of standard logics, human values and 'meaning' in thinking.This book will open new debates and develop current ones around Deleuze's work in philosophy, politics, literature, linguistics, cultural studies and sociology. (shrink)

A revised, expanded and fully up-to-date critical introduction to Deleuze's most important work of philosophyBy critically analysing Deleuze's methods, principles and arguments, James Williams helps readers to engage with the revolutionary core of Deleuze's philosophy and take up positions for or against its most innovative and controversial ideas.

The infant mortality rate in Liberia is 50 times higher than it is in Sweden, whilst a child born in Japan has a life expectancy at birth of more than double that of one born in Zambia. 1 And within countries, we see differences which are nearly as great. For example, if you were in the USA and travelled the short journey from the poorer parts of Washington to Montgomery County Maryland, you would find that ‘for each mile travelled life (...) expectancy rises about a year and a half. There is a twenty-year gap between poor blacks at one end of the journey and rich whites at the other’. (Marmot, 2004, p.2). There are two types of questions which it is important to ask about inequalities in health such as these. The first are social scientific questions about the extent of inequalities in health and the factors which are causally responsible for these inequalities. Examples of social scientific questions to ask might be: how do infant mortality rates in the UK differ according to social class? What is the difference in life expectancy between Japanese who emigrate to the US and those who remain in Japan? Why do civil servants in higher ranked jobs tend to live longer than civil servants in lower ranked jobs? The second type are normative questions about the reasons we have to care about inequalities in health. Important normative questions to answer are: which inequalities in health should we care about (all inequalities or merely some of them)? When is an inequality in health unjust? How should we weigh our concern for equality in health against other factors such as maximising the.. (shrink)

Patients -- Clients -- Welfare assessment -- Clinical choices -- Achieving animal welfare goals -- Beyond the clinic.

A number of philosophers with a metaphysical orientation have criticized Making Things Happen for its failure to provide an account of the metaphysical foundations or grounds or truth-makers for causal and explanatory claims. This dialog attempts to respond to these objections and to raise some general concerns about some of the rhetoric and argumentative strategies employed in contemporary analytic metaphysics. It also explores some issues having to do with the relationship between methodology, understood as a core concern of philosophy of (...) science, and analytic metaphysics. (shrink)

Discusses the work of G.I. Gurdjieff and his establishment of the Institute for the Harmonious Development of man, and examines the contributions of Gurdjieff's two major disciples, P.D. Ouspensky and A.R. Orage.

This book presents a comprehensive, accessible survey of Western philosophy of music from Pythagoras to the present. Its narrative traces themes and schools through history, in a sequence of five chapters that survey the ancient, medieval, early modern, modern and contemporary periods. Its wide-ranging coverage includes medieval Islamic thinkers, Continental and analytic thinkers, and neglected female thinkers such as Vernon Lee (Violet Paget). All aspects of the philosophy of music are discussed, including music and the cosmos, music's value, music's relation (...) to the other arts, the problem of opera, the origins of musical genius, music's emotional impact, the moral effects of music, the ontology of musical works, and the relevance of music's historical context. The volume will be valuable for students and scholars in philosophy and musicology, and all who are interested in the ways in which philosophers throughout history have thought about music. (shrink)

Animal behaviour and welfare research are part of a wider endeavour to optimize the health and wellbeing of humans, animals and ecosystems. As such, it is part of the One Health research agenda. This article applies ethical principles described by the One Health High Level Expert Panel to animal behaviour and welfare research. These principles entail that animal behaviour and welfare research should be valued equitably alongside other research in transdisciplinary and multisectoral collaboration. It should include and promote a multiplicity (...) of marginalized voices, including those of animals, and it should apply and describe a harmonious balance between human—animal-environment interactions. Lastly, it should describe how humans need to change behaviour, adopt sustainable solutions and recognize the importance of animal welfare and the integrity of the whole ecosystem. (shrink)

Amie Thomasson’s work provides numerous ways to rethink and improve our approach to metaphysics. This chapter is my attempt to begin to sketch why I still think the easy approach leaves room for substantive metaphysical work, and why I do not think that metaphysics need rely on any ‘epistemically metaphysical’ knowledge. After distinguishing two possible forms of deflationism, I argue that the easy ontologist needs to accept (implicitly or explicitly) that there are worldly constraints on what sorts of entities could (...) exist, and could co-exist. I argue this leaves room for a substantive role for metaphysics if (following the work of E.J. Lowe) we take metaphysics to be concerned with the possible ways that reality could be. I explain how this conception does not need to appeal to any ‘epistemically metaphysical’ knowledge, and need only make use of conceptual and/or empirical means to arrive at views on what could exist (and co-exist). Thus, the answer I propose to the question posed in the title, at least in my view, is no-one. Or, at least, no-one should be afraid of conceptual analysis. Not even metaphysicians. (shrink)

Organ donation after the circulatory determination of death requires the permanent cessation of circulation while organ donation after the brain determination of death requires the irreversible cessation of brain functions. The unified brain-based determination of death connects the brain and circulatory death criteria for circulatory death determination in organ donation as follows: permanent cessation of systemic circulation causes permanent cessation of brain circulation which causes permanent cessation of brain perfusion which causes permanent cessation of brain function. The relevant circulation that (...) must cease in circulatory death determination is that to the brain. Eliminating brain circulation from the donor ECMO organ perfusion circuit in thoracoabdominal NRP protocols satisfies the unified brain-based determination of death but only if the complete cessation of brain circulation can be proved. Despite its medical and physiologic rationale, the unified brain-based determination of death remains inconsistent with the Uniform Determination of Death Act. (shrink)

We are immersed within an odorous sea of chemical currents that we parse into individual odors with complex structures. Odors have been posited as determined by the structural relation between the molecules that compose the chemical compounds and their interactions with the receptor site. But, naturally occurring smells are parsed from gaseous odor plumes. To give a comprehensive account of the nature of odors the chemosciences must account for these large distributed entities as well. We offer a focused review of (...) what is known about the perception of odor plumes for olfactory navigation and tracking, which we then connect to what is known about the role odorants play as properties of the plume in determining odor identity with respect to odor quality. We end by motivating our central claim that more research needs to be conducted on the role that odorants play within the odor plume in determining odor identity. (shrink)

While substantial progress has been made in the field known as artificial consciousness, at the present time there is no generally accepted phenomenally conscious machine, nor even a clear route to how one might be produced should we decide to try. Here, we take the position that, from our computer science perspective, a major reason for this is a computational explanatory gap: our inability to understand/explain the implementation of high-level cognitive algorithms in terms of neurocomputational processing. We explain how addressing (...) the computational explanatory gap can identify computational correlates of consciousness. We suggest that bridging this gap is not only critical to further progress in the area of machine consciousness, but would also inform the search for neurobiological correlates of consciousness and would, with high probability, contribute to demystifying the “hard problem” of understanding the mind–brain relationship. We compile a listing of previously proposed computational correlates of consciousness and, based on the results of recent computational modeling, suggest that the gating mechanisms associated with top-down cognitive control of working memory should be added to this list. We conclude that developing neurocognitive architectures that contribute to bridging the computational explanatory gap provides a credible and achievable roadmap to understanding the ultimate prospects for a conscious machine, and to a better understanding of the mind–brain problem in general. (shrink)

This chapter provides an account of sexual ontology, grounded in and responsive to Irigaray’s philosophy, that focuses on the question of possibility. I first consider possibility in terms of the ontological negativity of sexuate beings, whereby one sex or sexuate morphology does not exhaust all that that kind of being is or can be. Second, I consider how sexual difference, as a relational structure of being, engenders possibilities for sexuate beings to develop as irreducible individuals. With particular focus on the (...) human being and the looming question of transhumanist technologies, I argue that these principles develop a sexual ontology that recognizes determinate limits between sexes while allowing for varied and creative expressions of sexuate life. (shrink)

Many people attempt to give meaning to their lives by pursuing projects that they believe will bear fruit after they have died. Knowing that their death will preclude them from protecting or promoting such projects people who draw meaning from them will often attempt to secure their continuance by securing promises from others to serve as their caretakers after they die. But those who rely on such are faced with a problem: None of the four major accounts that have been (...) developed to explain directed promissory obligation (the Authority View, the Trust View, the Assurance View, and the Reliance View) support the view that we are obligated to keep our promises to persons who are now dead. But I will provide hope for those who wish to use such promises to protect the meaning with which they have endowed their lives. I will argue that while we cannot wrong a person who is now dead by breaking a promise made to her during her life, we could wrong the living by so doing. We thus (might) have reason to keep the promises that we made to those who are now dead. (shrink)

An important question facing contemporary philosophy of science is whether the natural sciences in terms of their historical records exhibit distinguishing developmental patterns or structures. At least two philosophical stances are possible in answering this question. The first pertains to the plurality of the individual sciences. From this stance, the various sciences are analyzed individually and compared with one another in order to derive potential commonalities, if any, among them. The second stance involves a general philosophy of science in which (...) a thorough theory of the natural sciences is developed. The latter stance strives to account for more than possible commonalities among the sciences but also to provide a broad-spectrum philosophical framework to account for, or to explicate, the nature of science itself and its progress. In this paper, the second stance is taken in which an evolutionary philosophy of science is proposed. To that end, Thomas Kuhn’s evolutionary philosophy of science is initially discussed and critiqued. An evolutionary philosophy of science is then proposed based on a revision of Kuhn’s evolutionary philosophy of science in terms of George Gaylord Simpson’s various tempos and modes for biological evolution. Next, two historical case studies from the biological sciences are reconstructed to illustrate the robustness of the proposed evolutionary philosophy of science for explicating the progress of the natural sciences. A concluding section discusses the proposed evolutionary philosophy of science with respect to providing a broad-spectrum framework or general philosophy of science for understanding the nature and progress of the natural sciences. (shrink)

This article develops an interpretation and defense of Husserl’s account of the omnitemporality of idealities. I first examine why Husserl rejects the atemporality and temporal individuation of idealities on phenomenological grounds, specifically that these attributions prove countersensical in how they relate idealities to consciousness. As an alternative to these conceptions, I develop a two-sided interpretation of omnitemporality expressed in modal terms of actuality and possibility, the actual referring to appearances in time and the possible, to reactivation at any time. In (...) defense of this interpretation of omnitemporality, I consider influential criticisms against Husserl’s account of idealities as they concern time, particularly whether the historical genesis of idealities compromises their omnitemporality by binding them to time. Ultimately, I argue that the transcendental historicity of idealities, despite being relevant to the question of validity and access, proves indifferent to their omnitemporality. (shrink)

The Gifford Lectures were established in 1885 at the universities of St Andrews, Glasgow, Aberdeen and Edinburgh to promote the discussion of 'Natural Theology in the widest sense of the term - in other words, the knowledge of God', and some of the world's most influential thinkers have delivered them. The 1901–2 lectures given in Edinburgh by American philosopher William James are considered by many to be the greatest in the series. The lectures were published in book form in (...) 1902 and have been reprinted many times. James, who was educated in the United States and Europe, and spent much of his career teaching philosophy at Harvard, was very influential in the development of modern psychology, and in these twenty lectures he explores the personal experience of religion. Some of the topics include religion and neurology, 'the sick soul', saintliness, and mysticism. (shrink)

Challenging the paradigm in ethics -- The spirit of the enterprise -- Social artifacts and ethical criticism -- General and particular in practical knowledge -- Virtues of benevolence and justice.

In this chapter I argue that writers on metaphor have misunderstood Aristotle on metaphor. Aristotle is not an elitist about metaphor and does not consider metaphors to be merely ornamental. Rather, Aristotle believes that metaphors are ubiquitous and believes that people can express themselves in a clearer and more attractive way through the use of metaphors and that people learn and understand things better through metaphor. He also distinguishes between the use of metaphor and the coinage of metaphor, and believes (...) that the ability to coin marvelous new metaphors is a form of literary genius, and he provided an entirely natural origin of metaphor coinage. (shrink)

Mathematicians often speak of conjectures as being confirmed by evidence that falls short of proof. For their own conjectures, evidence justifies further work in looking for a proof. Those conjectures of mathematics that have long resisted proof, such as the Riemann hypothesis, have had to be considered in terms of the evidence for and against them. In recent decades, massive increases in computer power have permitted the gathering of huge amounts of numerical evidence, both for conjectures in pure mathematics and (...) for the behavior of complex applied mathematical models and statistical algorithms. Mathematics has therefore become (among other things) an experimental science (though that has not diminished the importance of proof in the traditional style). We examine how the evaluation of evidence for conjectures works in mathematical practice. We explain the (objective) Bayesian view of probability, which gives a theoretical framework for unifying evidence evaluation in science and law as well as in mathematics. Numerical evidence in mathematics is related to the problem of induction; the occurrence of straightforward inductive reasoning in the purely logical material of pure mathematics casts light on the nature of induction as well as of mathematical reasoning. (shrink)

This publication is an abridged translation of two lectures given by James Scott, a Sterling Professor of Political Science and Anthropology at Yale University, within «The Tanner Lectures» project as the Director of the Agrarian Studies Program and a leading expert in the study of peasantry of the Southeast Asia and Africa. Seeking to answer the question why throughout the entire course of human history all states seemed to pursue in fact the only one goal – to ensure by (...) all possible means the sedentary life of their citizens – Scott suggests an «alternative» version of historical process. On the one hand, he rejects the dominant «civilizational narrative» about the backwardness, barbarity, savagery, and other derogatory features of non-state communities; on the other hand, he develops quite another model and interpretation of the first agrarian states emergence referring to exactly the same set of historical evidence. (shrink)

For more than forty years, The Universe Next Door has set the standard for an introduction to worldviews. This sixth edition uses James Sire's widely influential model of eight basic worldview questions to examine prominent worldviews that have shaped the Western world, critiquing each worldview within its own frame of reference and in comparison to others.

A fresh explication of the Thomist justification of self-defense casts off the hobbles of the principle of double effects to find a more secure footing in the historicaldevelopment of subjective natural rights by medieval jurists, and a straight-forward application to the latent threat of death in childbirth posed by non-consensual pregnancy. By articulating the implicit Thomistic right to defensive abortion in terms of conditional rights bestowed in Creation as correlative to particular natural law duties, justly proportionate limits to defensive abortion (...) are identified, and balanced against the forfeited or reserved natural rights variously imputed to conceptus and embryo in non-consensual pregnancies. Subsequently, the varieties of involuntary consent are examined from a Thomist perspective with a view to their relevance in justifying recourse to a rehabilitated practice of defensive abortion when free and full consent to impregnation and childbirth is absent. (shrink)

This paper interprets the influential colony management simulator ‘Dwarf Fortress’ existentially, in terms of finitude, absurdity, and narrative. It applies Aarseth/Möring’s proposed method of game interpretation, adopting their definition of ‘cybermedia’ as a generalized game ontology, then providing a specialized ontology of ‘Dwarf Fortress’ which describes its genre and salient gameplay features, incorporating Ian Bogost’s concept of ‘procedural rhetoric’. It then gives an existentialist interpretation of ‘Dwarf Fortress’ which centres on ‘finitude’, ‘absurdity’, and ‘narrative’, showing that ‘Dwarf Fortress’ is a (...) game about the existential tensions involved in being human. We live knowing our lives and civilizations are finite, that there are radical limits on what we can know and do. There is no meaning inherent in the world, or in history, so it is up to us to create our own, and one of our most powerful ways of doing this is narrative. (shrink)

This scarce antiquarian book is a facsimile reprint of the original. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment for protecting, preserving, and promoting the world's literature in affordable, high quality, modern editions that are true to the original work.

This article critically analyzes Rawls’s attitude toward envy. In A Theory of Justice, Rawls is predominantly concerned with the threat that class envy poses to political stability. Yet he also briefly discusses the kind of envy that individuals experience toward their social peers, which he calls particular envy, and which I refer to as peer envy. He quickly concludes, however, that particular envy would not present a serious risk to the stability of his just society. In this article, I contest (...) this claim by arguing that the principles that structure Rawls’s ideal society are likely to exacerbate particular envy to a politically risky extent. Section 1 reconstructs his account of envy, giving special attention to his belief that competition kindles envy between peers. Section 2 then examines the way in which Rawls often endorses rivalry within the body politic. I argue that the society governed by justice as fairness is, on account of this rivalry, likely to generate a politically problematic degree of particular envy. In Section 3, I invoke ancient Greece as an example of a society that was, as a result of its intense competitiveness, often imperiled by dangerously elevated levels of peer envy. I then survey the key institutional mechanisms by which the ancient Greeks sought to manage this hazardous emotion. It turns out, however, that most of these mechanisms would be unavailable to Rawls insofar as they starkly contravene his principles of justice. I conclude that if Rawlsians wish to establish a society that fosters rivalry, they would do well to reflect on the means by which peer envy can be effectively harnessed. (shrink)

One of the most important topics that Thomas Aquinas discusses in his extensive corpus is the love of friendship, which is a unique form of love aimed at persons. Yet Aquinas's teachings on this are perplexing, for he claims that this love always produces union between lover and beloved, and that it is always a mutual love. This implies that one's love depends on reciprocation from the beloved, which seems implausible given the possibility of phenomena such as unrequited love. A (...) common interpretation of Aquinas's account of the love of friendship maintains that it is enough that one desires union and mutuality for such love to obtain even if such desires remain unrealized, but in this paper I reject this reading and argue that achieving union and mutuality is essential to this form of love. This novel interpretation ultimately reveals that the love of friendship is an intrinsically interpersonal act. (shrink)

Beginning right at the start of the recently published volume II of Donner le temps, at its ‘bord’ or ‘boarding’ upon or out of a calmy oceanic surface, this essay examines the functions and movements of distinct surfaces in between Heidegger and Derrida. Confronting thus the tradition of the ‘Grund’, ‘Abgrund’, ‘Urgrund’, ‘Ungrund’, with the khôra-like surface of archi-writing and dissemination, the essay proposes an investigation of the philosophical and writerly space of Derrida/Heidegger not through their marks and letters, but (...) instead through the different surfaces of inscription and – simultaneous – effacement as the ‘proper places’ of thought and experience, of Destruktion and deconstruction. (shrink)

J. L. Schellenberg's Philosophy of Religion argues for a specific brand of sceptical religion that takes ‘Ultimism’ – the proposition that there is a metaphysically, axiologically, and soteriologically ultimate reality – to be the object to which the sceptical religionist should assent. In this article I shall argue that Ietsism – the proposition that there is merely something transcendental worth committing ourselves to religiously – is a preferable object of assent. This is for two primary reasons. First, Ietsism is far (...) more modest than Ultimism; Ietsism, in fact, is open to the truth of Ultimism, while the converse does not hold. Second, Ietsism can fulfil the same criteria that compel Schellenberg to argue for Ultimism. (shrink)

Linguistic anthropologists have studied emotion in societies around the world for several decades. This article defines the discipline, introduces its general relevance to emotion theory, then presents five of the most important contributions linguistic anthropology has made to the study of emotion.

In this paper we explain our pretense account of truth-talk and apply it in a diagnosis and treatment of the Liar Paradox. We begin by assuming that some form of deflationism is the correct approach to the topic of truth. We then briefly motivate the idea that all T-deflationists should endorse a fictionalist view of truth-talk, and, after distinguishing pretense-involving fictionalism (PIF) from error- theoretic fictionalism (ETF), explain the merits of the former over the latter. After presenting the basic framework (...) of our PIF account of truth-talk, we demonstrate a few advantages it offers over T-deflationist accounts that do not explicitly acknowledge pretense at work in the discourse. In turning to the Liar Paradox, we explain how the quasi-anaphoric functioning that our account attributes to truth-talk provides a diagnosis of the Liar Paradox (and other instances of semantic pathology) as having no content—in the sense of not specifying any of what we call M-conditions. At the same time, however, we vindicate the intuition that we can understand liar sentences, thereby avoiding one standard objection to “meaningless strategy” responses to the Liar Paradox. With this diagnosis in place, we then, by way of treatment, introduce a new predicate, ‘semantically defective’, and show how the explanation we give for its application allows for a consistent, yet revenge-immune, (dis)solution of the Liar Paradox, and semantic pathology generally. (shrink)