The occurrence of oscillatory behaviours in living cells can be viewed as a visible consequence of stable, regulatory homeostatic cycles. Therefore, they may be used as experimental windows on the underlying physiological mechanisms. Recent studies show that growing pollen tubes are an excellent biological model for these purposes. They unite experimental simplicity with clear oscillatory patterns of both structural and temporal features, most being measurable during real‐time in live cells. There is evidence that these cellular oscillators involve an integrated input (...) of plasma membrane ion fluxes, and a cytosolic choreography of protons, calcium and, most likely, potassium and chloride. In turn, these can create positive feedback regulation loops that are able to generate and self‐sustain a number of spatial and temporal patterns. Other features, including cell wall assembly and rheology, turgor, and the cytoskeleton, play important roles and are targets or modulators of ion dynamics. Many of these features have similarities with other cell types, notably with apical‐growing cells. Pollen tubes may thus serve as a powerful model for exploring the basis of cell growth and morphogenesis. BioEssays 23:86–94, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

In this paper, I argue that there are two kinds of epistemic justification: one is objective and the other, subjective. Internalists are interested in the subjective variety of justification. Externalists are interested in the objective notion of justification. A paper by Stewart Cohen fails to distinguish these two varieties of epistemic justification and, as a result, criticizes externalists for failing to address the internalist, subjective notion of epistemic justification. But, since that notion is not the one that externallists care about, (...) I argue that his evil demon example fails to be a counterexample against externalists. (shrink)

Although Aristotle (Metaphysics, Book IV, Chapter 2) was perhaps the first person to consider the part-whole relationship to be a proper subject matter for philosophic inquiry, the Polish logician Stanislow Lesniewski [15] is generally given credit for the first formal treatment of the subject matter in his Mereology.1 Woodger [30] and Tarski [24] made use of a specific adaptation of Lesniewski's work as a basis for a formal theory of physical things and their parts. The term 'calculus of individuals' was (...) introduced by Leonard and Goodman [14] in their presentation of a system very similar to Tarski's adaptation of Lesniewski's Mereology. Contemporaneously with Lesniewski's development of his Mereology, Whitehead [27] and [28] was developing a theory of extensive abstraction based on the two-place predicate, 'x extends over y\ which is the converse of 'x is a part of y\ This system, according to Russell [22], was to have been the fourth volume of their Pήncipia Mathematica, the never-published volume on geometry. Both Lesniewski [15] and Tarski [25] have recognized the similarities between Whitehead's early work and Lesniewski's Mereology. Between the publication of Whitehead's early work and the publication of Process and Reality [29], Theodore de Laguna [7] published a suggestive alternative basis for Whitehead's theory. This led Whitehead, in Process and Reality, to publish a revised form of his theory based on the two-place predicate, 'x is extensionally connected with y\ It is the purpose of this paper to present a calculus of individuals based on this new Whiteheadian primitive predicate. (shrink)

In this defense of Reliabilism, I argue that there has been 'selection for' accurate indexical beliefs. I offer empirical evidence and examples to suggest that Steve Stich's defense of the opposite claim in The Fragmentation of Reason is misguided.

This comprehensive study offers a balanced assessment of libertarian accounts of free will. Bringing to bear recent work on action, causation, and causal explanation, Clarke defends a type of event-causal view from popular objections concerning rationality and diminished control. He subtly explores the extent to which event-causal accounts can secure the things for the sake of which we value free will, judging their success here to be limited. Clarke then sets out a highly original agent-causal account, one that (...) integrates agent causation and nondeterministic event causation. He defends this view from a number of objections but argues that we should find the substance causation required by any agent-causal account to be impossible. Clarke concludes that if a broad thesis of incompatibilism is correct--one on which both free will and moral responsibility are incompatible with determinism--then no libertarian account is entirely adequate. (shrink)

Biological theory demands a clear organism concept, but at present biologists cannot agree on one. They know that counting particular units, and not counting others, allows them to generate explanatory and predictive descriptions of evolutionary processes. Yet they lack a unified theory telling them which units to count. In this paper, I offer a novel account of biological individuality, which reconciles conflicting definitions of ‘organism’ by interpreting them as describing alternative realisers of a common functional role, and then defines individual (...) organisms as essentially possessing some mechanisms that play this role. (shrink)

It is widely agreed that the intelligibility of modal metaphysics has been vindicated. Quine's arguments to the contrary supposedly confused analyticity with metaphysical necessity, and rigid with non-rigid designators.2 But even if modal metaphysics is intelligible, it could be misconceived. It could be that metaphysical necessity is not absolute necessity – the strictest real notion of necessity – and that no proposition of traditional metaphysical interest is necessary in every real sense. If there were nothing otherwise “uniquely metaphysically significant” about (...) metaphysical necessity, then paradigmatic metaphysical necessities would be necessary in one sense of “necessary”, not necessary in another, and that would be it. The question of whether they were necessary simpliciter would be like the question of whether the Parallel Postulate is true simpliciter – understood as a pure mathematical conjecture, rather than as a hypothesis about physical spacetime. In a sense, the latter question has no objective answer. In this article, I argue that paradigmatic questions of modal metaphysics are like the Parallel Postulate question. I then discuss the deflationary ramifications of this argument. I conclude with an alternative conception of the space of possibility. According to this conception, there is no objective boundary between possibility and impossibility. Along the way, I sketch an analogy between modal metaphysics and set theory. (shrink)

In a recent paper, Berger and Nanay consider, and reject, three ways of addressing the phenomenon of unconscious perception within a naïve realist framework. Since these three approaches seem to exhaust the options open to naïve realists, and since there is said to be excellent evidence that perception of the same fundamental kind can occur, both consciously and unconsciously, this is seen to present a problem for the view. We take this opportunity to show that all three approaches considered remain (...) perfectly plausible ways of addressing unconscious perception within a naïve realist framework. So far from undermining the credibility of naïve realism, Berger and Nanay simply draw our attention to an important question to be considered by naïve realists in future work. Namely, which of the approaches considered is most likely to provide an accurate account of unconscious perception in each of its purported incarnations? (shrink)

An autonomous reason for intending to A would be a reason for so intending that is not, and will not be, a reason for A-ing. Some puzzle cases, such as the one that figures in the toxin puzzle, suggest that there can be such reasons for intending, but these cases have special features that cloud the issue. This paper describes cases that more clearly favour the view that we can have practical reasons of this sort. Several objections to this view (...) are considered and rejected. Finally, it is considered whether the existence of such reasons would conflict with an attractive coherence principle linking the rationality of intending with that of acting as intended. The paper concludes with a qualified affirmation of autonomous reasons for intending. (shrink)

The preface paradox does not show that it can be rational to have inconsistent beliefs, because preface writers do not have inconsistent beliefs. I argue, first, that a fully satisfactory solution to the preface paradox would have it that the preface writer's beliefs are consistent. The case here is on basic intuitive grounds, not the consequence of a theory of rationality or of belief. Second, I point out that there is an independently motivated theory of belief – sensitivism – which (...) allows such a solution. I sketch a sensitivist account of the preface writer's doxastic state. (shrink)

How do axioms, or first principles, in ethics compare to those in mathematics? In this companion piece to G.C. Field's 1931 "On the Role of Definition in Ethics", I argue that there are similarities between the cases. However, these are premised on an assumption which can be questioned, and which highlights the peculiarity of normative inquiry.

The topic of this paper is Aristotle’s ‘proof by refutation’ of the Principle of Non-Contradiction (Metaphysics Γ 4, 1006a11–1007a20). I consider a worry which has often been raised in connection with this proof. The worry is that, faced with an opponent who is prepared to tolerate contradictions, the argument is dialectically powerless: it is incapable of getting them to abandon their position. In reply, I argue that the proof needs to be seen in its proper context, that is, as part (...) of Aristotle’s response to an opponent who demands a demonstration of the principle. This allows us to clarify the purpose of the argument and answer the worry about its effectiveness. (shrink)

In an influential book, Gilbert Harman writes, "In explaining the observations that support a physical theory, scientists typically appeal to mathematical principles. On the other hand, one never seems to need to appeal in this way to moral principles [1977, 9 – 10]." What is the epistemological relevance of this contrast, if genuine? In this article, I argue that ethicists and philosophers of mathematics have misunderstood it. They have confused what I will call the justificatory challenge for realism about an (...) area, D – the challenge to justify our D-beliefs – with the reliability challenge for D-realism – the challenge to explain the reliability of our D-beliefs. Harman’s contrast is relevant to the first, but not, evidently, to the second. One upshot of the discussion is that genealogical debunking arguments are fallacious. Another is that indispensability considerations cannot answer the Benacerraf-Field epistemological challenge for mathematical realism. (shrink)

What changes when an evolutionary transition in individuality takes place? Many different answers have been given, in respect of different cases of actual transition, but some have suggested a general answer: that a major transition is a change in the extent to which selection acts at one hierarchical level rather than another. The current paper evaluates some different ways to develop this general answer as a way to characterise the property ‘evolutionary individuality’; and offers a justification of the option taken (...) in Clarke :413–435, 2013)—to define evolutionary individuality in terms of an object’s capacity to undergo selection at its own level. In addition, I suggest a method by which the property can be measured and argue that a problem which is often considered to be fatal to that method—the problem of ‘cross-level by-products’—can be avoided. (shrink)

This paper argues for two theses: that degrees of belief are context sensitive; that outright belief is belief to degree 1. The latter thesis is rejected quickly in most discussions of the relationship between credence and belief, but the former thesis undermines the usual reasons for doing so. Furthermore, identifying belief with credence 1 allows nice solutions to a number of problems for the most widely-held view of the relationship between credence and belief, the threshold view. I provide a sketch (...) of a formal framework on which both theses are true. This is a modified Bayesian framework; I argue that despite making credences context-sensitive, the framework lets Bayesians hold on to their signature explanatory successes. The sort of context-sensitivity claimed for credences here mirrors the sort of context-sensitivity I have elsewhere claimed for outright belief: one's credences depend, in part, on the space of alternative possibilities one takes seriously in a context. (shrink)

It is often assumed that adaptation — a temporary change in sensitivity to a perceptual dimension following exposure to that dimension — is a litmus test for what is and is not a “primary visual attribute”. Thus, papers purporting to find evidence of number adaptation motivate a claim of great philosophical significance: That number is something that can be seen in much the way that canonical visual features, like color, contrast, size, and speed, can. Fifteen years after its reported discovery, (...) number adaptation’s existence seems to be nearly undisputed, with dozens of papers documenting support for the phenomenon. The aim of this paper is to offer a counterweight — to critically assess the evidence for and against number adaptation. After surveying the many reasons for thinking that number adaptation exists, we introduce several lesser-known reasons to be skeptical. We then advance an alternative account — the old news hypothesis — which can accommodate previously published findings while explaining various (otherwise unexplained) anomalies in the existing literature. Next, we describe the results of eight pre-registered experiments which pit our novel old news hypothesis against the received number adaptation hypothesis. Collectively, the results of these experiments undermine the number adaptation hypothesis on several fronts, whilst consistently supporting the old news hypothesis. More broadly our work raises questions about the status of adaptation itself as a means of discerning what is and is not a visual attribute. (shrink)

Microbes are generally thought of as unicellular organisms, but we know that many microbes live as parts of biofilms—complex, surface-attached microbial communities numbering millions of cells. Some authors have recently argued in favour of reconceiving biofilms as biological entities in their own right. In particular, some have claimed that multispecies biofilms are evolutionary individuals : 10126–10132 2015). Against this view, I defend the conservative consensus that selection acts primarily upon microbial cells.

The prevalence and complexity of local sustainable development challenges require coordinated action from multiple actors in the business, public, and civil society sectors. Large multi-stakeholder partnerships that build capacity by developing and leveraging the diverse perspectives and resources of partner organizations are becoming an increasingly popular approach to addressing such challenges. Multi-stakeholder partnerships are designed to address and prioritize a social problem, so it can be challenging to define the value proposition to each specific partner. Using a resource-based view, this (...) study examines partner outcomes from the perspective of the strategic interest of the partner as distinct from the strategic goal of the partnership. Based on 47 interviews with representatives of partner organizations in four Canadian case studies of community sustainability plan implementation, this article details 10 resources partners can gain from engaging in a multi-stakeholder partnership. (shrink)

A growing number of philosophers now hold that agent causation is required for agency, or free will, or moral responsibility. To clarify what is at issue, this paper begins with a distinction between agent causation that is ontologically fundamental and agent causation that is reducible to or realized in causation by events or states. It is widely accepted that agency presents us with the latter; the view in question claims a need for the former. The paper then examines a “disappearing (...) agent” argument from Derk Pereboom that is aimed at showing that free will requires agent causation that is ontologically fundamental. It is argued that the argument fails. Further, it is argued that, contrary to Pereboom’s claim, the issue raised by his disappearing agent argument is distinct from the problem of present luck that libertarian theories of free will face. The paper concludes with an assessment of the prospects for success of a disappearing agent argument showing that agent causation that is ontologically fundamental is required for agency tout court. (shrink)

This paper argues for a treatment of belief as essentially sensitive to certain features of context. The first part gives an argument that we must take belief to be context-sensitive in the same way that assertion is, if we are to preserve appealing principles tying belief to sincere assertion. In particular, whether an agent counts as believing that p in a context depends on the space of alternative possibilities the agent is considering in that context. One and the same doxastic (...) state may amount to belief that p in one context but not another. The second part of the paper gives a formal treatment of doxastic states, according to which belief is context-sensitive along just these lines. The model is applied to characterize (but not to refute) skeptical arguments. (shrink)

ONE Introduction Rene Descartes is, in many ways, a victim of his own success as a philosopher. He notoriously wrote a small number of readily accessible, ...

Mechanistic philosophy of science views a large part of scientific activity as engaged in modelling mechanisms. While science textbooks tend to offer qualitative models of mechanisms, there is increasing demand for models from which one can draw quantitative predictions and explanations. Casini et al. (Theoria 26(1):5–33, 2011) put forward the Recursive Bayesian Networks (RBN) formalism as well suited to this end. The RBN formalism is an extension of the standard Bayesian net formalism, an extension that allows for modelling the hierarchical (...) nature of mechanisms. Like the standard Bayesian net formalism, it models causal relationships using directed acyclic graphs. Given this appeal to acyclicity, causal cycles pose a prima facie problem for the RBN approach. This paper argues that the problem is a significant one given the ubiquity of causal cycles in mechanisms, but that the problem can be solved by combining two sorts of solution strategy in a judicious way. (shrink)

These are the Aquinas Lectures for 1993 given at Marquette University by Jesuit priest W. Norris Clarke. There is an Introduction, two main sections, and ten chapters, including "The Meaning of Person" and "The Problem of Evil".

Free will is often said—by compatibilists and incompatibilists alike—to be a power (or complex of powers) of agents. This paper offers proposals for, and examines the prospects of, a powers-conception of free will that takes the powers in question to be causal dispositions. A difficulty for such an account stems from the idea that when one exercises free will, it is up to oneself whether one wills to do this or that. The paper also briefly considers whether a powers-conception that (...) invokes powers of a different kind, such as agent-causal or noncausal powers, might fare better with respect to this problem. (shrink)

This paper argues that agents can be directly blameworthy for unwitting omissions. The view developed focuses on the capacities and abilities of agents.

Most philosophers now accept that an agent may be responsible for an action even though she could not have acted otherwise. However, many who accept such a view about responsibility for actions nevertheless maintain that, when it comes to omissions, an agent is responsible only if she could have done what she omitted to do. If this Principle of Possible Action (PPA), as it is sometimes called, is correct, then there is an important asymmetry between what is required for responsibility (...) for actions and what is required for responsibility for omissions. However, I argue here that PPA is in fact false. It has been advanced on the basis of an insufficiently varied group of examples. Examination of a broader range of cases shows that responsibility for an omission sometimes is, and it sometimes is not, undermined by an inability to have acted. In Sections II and III, I offer two alternative principles to PPA governing ability and responsibility for omissions. (shrink)

Some explanations are relatively abstract: they abstract away from the idiosyncratic or messy details of the case in hand. The received wisdom in philosophy is that this is a virtue for any explanation to possess. I argue that the apparent consensus on this point is illusory. When philosophers make this claim, they differ on which of four alternative varieties of abstractness they have in mind. What’s more, for each variety of abstractness there are several alternative reasons to think that the (...) variety of abstractness in question is a virtue. I identify the most promising reasons, and dismiss some others. The paper concludes by relating this discussion to the idea that explanations in biology, psychology and social science cannot be replaced by relatively micro explanations without loss of understanding. (shrink)

We humans can enhance some of our mental and physical abilities above the normal upper limits for our species with the use of particular drug therapies and medical procedures. We will be able to enhance many more of our abilities in more ways in the near future. Some commentators have welcomed the prospect of wide use of human enhancement technologies, while others have viewed it with alarm, and have made clear that they find human enhancement morally objectionable. The Ethics of (...) Human Enhancement examines whether the reactions can be supported by articulated philosophical reasoning, or perhaps explained in terms of psychological influences on moral reasoning. An international team of ethicists refresh the debate with new ideas and arguments, making connections with scientific research and with related issues in moral philosophy. (shrink)

How are justifications for religious violence developed and dothey differ from secular justifications for violence? Can liberalsocieties tolerate potentially violent religious groups? Can thosewho accept religious justifications for violence be dissuaded fromacting violently? Including six in-depth contemporary case studies,The Justification of Religious Violence is the first book toexamine the logical structure of justifications of religiousviolence. The first book specifically devoted to examining the logicalstructure of justifications of religious violence Seeks to understand how justifications for religious violenceare developed and how or (...) if they differ from ordinary secularjustifications of violence Examines 3 widely employed premises used in religiousjustifications of violence – ‘cosmic war’, theimportance of the afterlife, and ‘sacred values’ Considers to what extent liberal democratic societies shouldtolerate who hold that their religion justifies violent acts Reflects on the possibility of effective policy measures topersuade those who believe that violent action is justified byreligion, to refrain from acting violently Informed by recent work in psychology, cognitive science,neuroscience and evolutionary biology Part of the Blackwell Public Philosophy Series. (shrink)

This major new study of Descartes explores a number of key issues, including his use of experience and reason in science; the metaphysical foundations of Cartesian science; the Cartesian concept of explanation and proof; and an empiricist interpretation of the _Regulae_ and the _Discourse_. Dr. Clarke argues that labels such as empiricism and rationalism are useless for understanding Descartes because, at least in his scientific methodology, he is very much an Aristotelian for whom reflection on ordinary experience is the (...) primary source of scientific hypotheses. Descartes traditionally has been presented as a classic example of rationalism in science, especially by philosophers who concentrated their attention on the _Meditations_ or the _Discourse_. A different perspective is gained by reading Descartes as a practicing scientist and by examining his scientific work and correspondence with other seventeenth-century scientists. These texts suggest that the author relies very much on experience, and in some cases on scientific experiments to support his theories or to dispute those of others. Descartes scientific practice is even consistent with a less rationalistic interpretation of the _Regulae_ and the _Discourse_ than is normally defended. (shrink)

I discuss the structure of genealogical debunking arguments. I argue that they undermine our mathematical beliefs if they undermine our moral beliefs. The contrary appearance stems from a confusion of arithmetic truths with (first-order) logical truths, or from a confusion of reliability with justification. I conclude with a discussion of the cogency of debunking arguments, in light of the above. Their cogency depends on whether information can undermine all of our beliefs of a kind, F, without giving us direct reason (...) to doubt that our F-beliefs are modally secure. (shrink)

This paper defends a minimal desert thesis, according to which someone who is blameworthy for something deserves to feel guilty, to the right extent, at the right time, because of her culpability. The sentiment or emotion of guilt includes a thought that one is blameworthy for something as well as an unpleasant affect. Feeling guilty is not a matter of inflicting suffering on oneself, and it need not involve any thought that one deserves to suffer. The desert of a feeling (...) of guilt is a kind of moral propriety of that response, and it is a matter of justice. If the minimal desert thesis is correct, then it is in some respect good that one who is blameworthy feel guilty—there is some justice in that state of affairs. But if retributivism concerns the justification of punishment, the minimal desert thesis is not retributivist. Its plausibility nevertheless raises doubt about whether, as some have argued, there are senses of moral responsibility that are not desert-entailing. (shrink)

This book analyses the concept of scientific explanation developed by French disciples of Descartes in the period 1660-1700. Clarke examines the views of authors such as Malebranche and Rohault, as well as those of less well-known authors such as Cordemoy, Gadroys, Poisson and R'egis. These Cartesian natural philosophers developed an understanding of scientific explanation as necessarily hypothetical, and, while they contributed little to new scientific discoveries, they made a lasting contribution to our concept of explanation--generations of scientists in subsequent (...) centuries followed their lead. (shrink)

I argue for the usefulness of the evolutionary kind of biological individual.

This essay examines several varieties of libertarian accounts of free will. Some require free actions to be uncaused, some require agent causation, and some require non-deterministic event causation. Difficulties are raised for all of these varieties.

Some explanations in social science, psychology and biology belong to a higher level than other explanations. And higher explanations possess the virtue of abstracting away from the details of lower explanations, many philosophers argue. As a result, these higher explanations are irreplaceable. And this suggests that there are genuine higher laws or patterns involving social, psychological and biological states. I show that this ‘abstractness argument’ is really an argument schema, not a single argument. This is because the argument uses the (...) ‘is lower than’ relation, and this relation admits of different readings. I then suggest four rigorous definitions of the ‘is lower than’ relation, and show that the abstractness argument’s prospects are much brighter for some of these definitions than for others. To show this, I evaluate the so-called ‘disjunctive threat’ to the abstractness argument. (shrink)